LOCUS       NM_001159634           10704 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus proline-rich coiled-coil 2B (Prrc2b), transcript
            variant 1, mRNA.
ACCESSION   NM_001159634
VERSION     NM_001159634.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 10704)
  AUTHORS   Martinez-Mayer,J., Brinkmeier,M.L., O'Connell,S.P., Ukagwu,A.,
            Marti,M.A., Miras,M., Forclaz,M.V., Benzrihen,M.G., Cheung,L.Y.M.,
            Camper,S.A., Ellsworth,B.S., Raetzman,L.T., Perez-Millan,M.I. and
            Davis,S.W.
  TITLE     Knockout mice with pituitary malformations help identify human
            cases of hypopituitarism
  JOURNAL   Genome Med 16 (1), 75 (2024)
   PUBMED   38822427
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10704)
  AUTHORS   Zhang,Y., Song,Z., Wu,R., Kong,X., Zhang,H., Li,S., Gong,X.,
            Gong,S., Cheng,J., Yuan,F., Wu,H., Wang,S. and Yuan,Z.
  TITLE     PRRC2B modulates oligodendrocyte progenitor cell development and
            myelination by stabilizing Sox2 mRNA
  JOURNAL   Cell Rep 43 (3), 113930 (2024)
   PUBMED   38507412
REFERENCE   3  (bases 1 to 10704)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 10704)
  AUTHORS   Li,S., Hu,W., Gong,S., Zhang,P., Cheng,J., Wang,S., Wang,Y.,
            Shi,W., Li,Q., Wang,F. and Yuan,Z.
  TITLE     The Role of PRRC2B in Cerebral Vascular Remodeling Under Acute
            Hypoxia in Mice
  JOURNAL   Adv Sci (Weinh) 10 (25), e2300892 (2023)
   PUBMED   37395402
  REMARK    GeneRIF: The Role of PRRC2B in Cerebral Vascular Remodeling Under
            Acute Hypoxia in Mice.
REFERENCE   5  (bases 1 to 10704)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 10704)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   7  (bases 1 to 10704)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   8  (bases 1 to 10704)
  AUTHORS   Thuret,S., Bhatt,L., O'Leary,D.D. and Simon,H.H.
  TITLE     Identification and developmental analysis of genes expressed by
            dopaminergic neurons of the substantia nigra pars compacta
  JOURNAL   Mol Cell Neurosci 25 (3), 394-405 (2004)
   PUBMED   15033168
REFERENCE   9  (bases 1 to 10704)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   10 (bases 1 to 10704)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK147677.1, BC055116.1 and BP753788.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147271.1, AK147677.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5212              AK147677.1         1-5212
            5213-6313           BC055116.1         3146-4246
            6314-10072          AK147677.1         6313-10071
            10073-10652         BC055116.1         7924-8503
            10653-10704         BP753788.1         1-52                c
FEATURES             Location/Qualifiers
     source          1..10704
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 22.05 cM"
     gene            1..10704
                     /gene="Prrc2b"
                     /gene_synonym="5830434P21Rik; Bat2l; Bat2l1; D430039P21;
                     mKIAA0515"
                     /note="proline-rich coiled-coil 2B"
                     /db_xref="GeneID:227723"
                     /db_xref="MGI:MGI:1923304"
     exon            1..144
                     /gene="Prrc2b"
                     /gene_synonym="5830434P21Rik; Bat2l; Bat2l1; D430039P21;
                     mKIAA0515"
                     /inference="alignment:Splign:2.1.0"
     exon            145..313
                     /gene="Prrc2b"
                     /gene_synonym="5830434P21Rik; Bat2l; Bat2l1; D430039P21;
                     mKIAA0515"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..6891
                     /gene="Prrc2b"
                     /gene_synonym="5830434P21Rik; Bat2l; Bat2l1; D430039P21;
                     mKIAA0515"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein BAT2-like 1; protein PRRC2B; HLA-B-associated
                     transcript 2-like 1; proline-rich coiled-coil protein 2B"
                     /codon_start=1
                     /product="protein PRRC2B isoform 1"
                     /protein_id="NP_001153106.1"
                     /db_xref="CCDS:CCDS50565.1"
                     /db_xref="GeneID:227723"
                     /db_xref="MGI:MGI:1923304"
                     /translation="MSDRLGQITQGKDGKSKYSTLSLFDKYKGRSVGAVRSSVIPRHG
                     LQSLGKVATARRMPPPANLPSLKSENKGNDPNIVIVPKDGTGWANKQDQQDPKSSSVT
                     ASQPPESQPQPGLQKSVSNLQKPTQSISQENTNSVPGGPKSWAQLSGKPVGHEGGLRG
                     SSRLLSFSPEEFPTLKAAGGQDKAGKEKGALDLSYGPGPSLRPQNVTSWREGGGRNII
                     SAASLSASPTELGSRNASGADGAPSLACTSDSKEPSLRPAQPSRRGASQFMGHGYQPP
                     TYHDMLPAFMCSPQSSENQTTVERSSFPLPQLRLEPRVPFRQFQMNDQDGKERPGVAR
                     PVRPLRQLVERAPRPTIINAENLKGLDDLDTDADDGWAGLHEEVDYSEKLKFSDDEDE
                     EDVVKDGRSKWNNWDPRRQRALSLSSADSTDAKRTQEEGKDWSGTAGGSRVIRKVPEP
                     QPPSRKLHSWASGPDYQKPTMGSMFRQHSAEDKEDKPPPRQKFIQSEMSEAVERARKR
                     REEEERRAREERLAACAAKLKQLDQKCRQAQKANETPKPVEKEVPRSPGIEKVSPPEN
                     GPVVRKGSPEFPVQEAPTMFLEETPATSPTVAQSNSSSSSSSSSSIEEEVRESGSPAQ
                     EFSKYQKSLPPRFQRQQQQQQQQQQQQQQQEQLYKMQHWQPVYPPPSHPQRTFYPHHP
                     QMLGFDPRWMMMPSYMDPRITPTRTPVDFYPSALHPSGLMKPMMPQESLSGTGCRSED
                     QNCVPSLQERKVTALDPAPVWSPEGYMALQNKGYSLPHPKSADTLAMGMHVRNERSYC
                     ASPGRPGGISAQRDLFEERGEEFLSAFDKKAQADFDSCISSQRIGQELLFPPQENVQE
                     VGAPGGCTPNLRCSPLEPDFVPAEKKPEYGSWDVGHQPKAADTANGVELEAPRQEPSF
                     HVSSWEKEGSPKKQPNPEPEWTPEPRSSSGQHQEQPGRTRRSGPIKKPVLKALKVEEK
                     EKALERGRQGLREESSQRAPEKEPVGRAEEDEENNPALANASSALEDKAASRAGFAHE
                     ASKLDEDEKADKTWESRPSREASDIPPTKRNNWIFIDEEQAFGGRGQARSRGRGFREF
                     TFRGGRPAGSSTSGLCGTGVLGSRGMYSSGQRSNRGRGLRDFPPPEDCPRAKPRRRIA
                     SETHSEGSEYEELPKRRRQRGSEHSHEGMLTERDEGALKDSWRSNRTYTEDQGGIDTR
                     SRGSRTCGRALPPRLSNCSYGRRTFVAKEPPHWQSRSPGSSWQEYGSSDPCGPRRGTD
                     RDYIPDSYRQSDTFGSRLFEDSRTEDKRSFFQDDHGADSENAENRPFRRRRPPRQDKP
                     PRFRRLRQERESLGLWGPEEESHLLASQWPGRSKLCPGDKSGPGGHRSPELSYQNSSD
                     HANEEWETASESSDFSERRERREGLVAEPEAQGDGGLSGSSLGEKKELAKRSFSSQRP
                     LADRQSRKLEPGGFGEKPVRPGGGEPSPRCESQQSGTPLKVKRSPDEALPGGLGSHSP
                     YALERTTHASSDGPETPSKKSEREVSLPTQRASEQEEARKQFDLGYGNALIDNCASSP
                     GEENEASSVVGEGFIEVLTKKQRRLLEEERRKKEQAAQVPVKGRGLSSRIPPRFAKKQ
                     NGLCLEQDVTVPGSSLGTEIWENSSQALPVQGAASDSWRTAVTAFSSTEPGTSEGFKS
                     SQGDSGVDLSAESRESSATSSQRSSPYGTLKPEEISGPGLAESKADSHKDQAQKQAEH
                     KDSEQGSAQSKEHRPGPIGNERSLKNRKGSEGAERLPGAVVPPVNGVEIHVDSVLPVP
                     PIEFGVSPKDSDFSLPPGSVSGPVGNPVAKLQDVLASNAGLTQSIPILRRDHHMQRAI
                     GLSPMSFPTADLTLKMESARKAWENSPSLPEQSSPGGAGSGIQPPSSVGASNGVNYSS
                     FGGVSMPPMPVASVAPSASIPGSHLPPLYLDGHVFASQPRLVPQTIPQQQSYQQAATA
                     QQIPISLHTSLQAQAQLGLRGGLPVSQSQEIFSSLQPFRSQVYMHPSLSPPSTMILSG
                     GTALKPPYSAFPGIQPLEMVKPQSGSPYQPMSGNQALVYEGQLGQAAGLGTSQMLDSQ
                     LPQLTMPLPRYGSGQQPLILPQSIQLPPGQSLSVGAPRRVPPPGSQPPVLNTSRESAP
                     MELKGFHFADSKQNVPTGGSAPSPQAYRPSSASPSGKPSGSAVNMGSVQGHYVQQAKR
                     VDEKPGLGTVKLQEASSATSQMKRTGAIKPRAVKVEGSKA"
     exon            314..491
                     /gene="Prrc2b"
                     /gene_synonym="5830434P21Rik; Bat2l; Bat2l1; D430039P21;
                     mKIAA0515"
                     /inference="alignment:Splign:2.1.0"
     exon            492..594
                     /gene="Prrc2b"
                     /gene_synonym="5830434P21Rik; Bat2l; Bat2l1; D430039P21;
                     mKIAA0515"
                     /inference="alignment:Splign:2.1.0"
     exon            595..667
                     /gene="Prrc2b"
                     /gene_synonym="5830434P21Rik; Bat2l; Bat2l1; D430039P21;
                     mKIAA0515"
                     /inference="alignment:Splign:2.1.0"
     exon            668..811
                     /gene="Prrc2b"
                     /gene_synonym="5830434P21Rik; Bat2l; Bat2l1; D430039P21;
                     mKIAA0515"
                     /inference="alignment:Splign:2.1.0"
     exon            812..1053
                     /gene="Prrc2b"
                     /gene_synonym="5830434P21Rik; Bat2l; Bat2l1; D430039P21;
                     mKIAA0515"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1175
                     /gene="Prrc2b"
                     /gene_synonym="5830434P21Rik; Bat2l; Bat2l1; D430039P21;
                     mKIAA0515"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1315
                     /gene="Prrc2b"
                     /gene_synonym="5830434P21Rik; Bat2l; Bat2l1; D430039P21;
                     mKIAA0515"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1406
                     /gene="Prrc2b"
                     /gene_synonym="5830434P21Rik; Bat2l; Bat2l1; D430039P21;
                     mKIAA0515"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1599
                     /gene="Prrc2b"
                     /gene_synonym="5830434P21Rik; Bat2l; Bat2l1; D430039P21;
                     mKIAA0515"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1915
                     /gene="Prrc2b"
                     /gene_synonym="5830434P21Rik; Bat2l; Bat2l1; D430039P21;
                     mKIAA0515"
                     /inference="alignment:Splign:2.1.0"
     exon            1916..2160
                     /gene="Prrc2b"
                     /gene_synonym="5830434P21Rik; Bat2l; Bat2l1; D430039P21;
                     mKIAA0515"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..2356
                     /gene="Prrc2b"
                     /gene_synonym="5830434P21Rik; Bat2l; Bat2l1; D430039P21;
                     mKIAA0515"
                     /inference="alignment:Splign:2.1.0"
     exon            2357..2573
                     /gene="Prrc2b"
                     /gene_synonym="5830434P21Rik; Bat2l; Bat2l1; D430039P21;
                     mKIAA0515"
                     /inference="alignment:Splign:2.1.0"
     exon            2574..4634
                     /gene="Prrc2b"
                     /gene_synonym="5830434P21Rik; Bat2l; Bat2l1; D430039P21;
                     mKIAA0515"
                     /inference="alignment:Splign:2.1.0"
     exon            4635..4822
                     /gene="Prrc2b"
                     /gene_synonym="5830434P21Rik; Bat2l; Bat2l1; D430039P21;
                     mKIAA0515"
                     /inference="alignment:Splign:2.1.0"
     exon            4823..4968
                     /gene="Prrc2b"
                     /gene_synonym="5830434P21Rik; Bat2l; Bat2l1; D430039P21;
                     mKIAA0515"
                     /inference="alignment:Splign:2.1.0"
     exon            4969..5107
                     /gene="Prrc2b"
                     /gene_synonym="5830434P21Rik; Bat2l; Bat2l1; D430039P21;
                     mKIAA0515"
                     /inference="alignment:Splign:2.1.0"
     exon            5108..5190
                     /gene="Prrc2b"
                     /gene_synonym="5830434P21Rik; Bat2l; Bat2l1; D430039P21;
                     mKIAA0515"
                     /inference="alignment:Splign:2.1.0"
     exon            5191..5379
                     /gene="Prrc2b"
                     /gene_synonym="5830434P21Rik; Bat2l; Bat2l1; D430039P21;
                     mKIAA0515"
                     /inference="alignment:Splign:2.1.0"
     exon            5380..5577
                     /gene="Prrc2b"
                     /gene_synonym="5830434P21Rik; Bat2l; Bat2l1; D430039P21;
                     mKIAA0515"
                     /inference="alignment:Splign:2.1.0"
     exon            5578..5664
                     /gene="Prrc2b"
                     /gene_synonym="5830434P21Rik; Bat2l; Bat2l1; D430039P21;
                     mKIAA0515"
                     /inference="alignment:Splign:2.1.0"
     exon            5665..5769
                     /gene="Prrc2b"
                     /gene_synonym="5830434P21Rik; Bat2l; Bat2l1; D430039P21;
                     mKIAA0515"
                     /inference="alignment:Splign:2.1.0"
     exon            5770..5962
                     /gene="Prrc2b"
                     /gene_synonym="5830434P21Rik; Bat2l; Bat2l1; D430039P21;
                     mKIAA0515"
                     /inference="alignment:Splign:2.1.0"
     exon            5963..6060
                     /gene="Prrc2b"
                     /gene_synonym="5830434P21Rik; Bat2l; Bat2l1; D430039P21;
                     mKIAA0515"
                     /inference="alignment:Splign:2.1.0"
     exon            6061..6188
                     /gene="Prrc2b"
                     /gene_synonym="5830434P21Rik; Bat2l; Bat2l1; D430039P21;
                     mKIAA0515"
                     /inference="alignment:Splign:2.1.0"
     exon            6189..6429
                     /gene="Prrc2b"
                     /gene_synonym="5830434P21Rik; Bat2l; Bat2l1; D430039P21;
                     mKIAA0515"
                     /inference="alignment:Splign:2.1.0"
     exon            6430..6585
                     /gene="Prrc2b"
                     /gene_synonym="5830434P21Rik; Bat2l; Bat2l1; D430039P21;
                     mKIAA0515"
                     /inference="alignment:Splign:2.1.0"
     exon            6586..6677
                     /gene="Prrc2b"
                     /gene_synonym="5830434P21Rik; Bat2l; Bat2l1; D430039P21;
                     mKIAA0515"
                     /inference="alignment:Splign:2.1.0"
     exon            6678..6759
                     /gene="Prrc2b"
                     /gene_synonym="5830434P21Rik; Bat2l; Bat2l1; D430039P21;
                     mKIAA0515"
                     /inference="alignment:Splign:2.1.0"
     exon            6760..10686
                     /gene="Prrc2b"
                     /gene_synonym="5830434P21Rik; Bat2l; Bat2l1; D430039P21;
                     mKIAA0515"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8911..8916
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prrc2b"
                     /gene_synonym="5830434P21Rik; Bat2l; Bat2l1; D430039P21;
                     mKIAA0515"
                     /note="hexamer: AATAAA"
     regulatory      8920..8925
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prrc2b"
                     /gene_synonym="5830434P21Rik; Bat2l; Bat2l1; D430039P21;
                     mKIAA0515"
                     /note="hexamer: AAGAAA"
     polyA_site      8930
                     /gene="Prrc2b"
                     /gene_synonym="5830434P21Rik; Bat2l; Bat2l1; D430039P21;
                     mKIAA0515"
                     /note="major polyA site"
     polyA_site      8937
                     /gene="Prrc2b"
                     /gene_synonym="5830434P21Rik; Bat2l; Bat2l1; D430039P21;
                     mKIAA0515"
     regulatory      8979..8984
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prrc2b"
                     /gene_synonym="5830434P21Rik; Bat2l; Bat2l1; D430039P21;
                     mKIAA0515"
                     /note="hexamer: AGTAAA"
     polyA_site      9003
                     /gene="Prrc2b"
                     /gene_synonym="5830434P21Rik; Bat2l; Bat2l1; D430039P21;
                     mKIAA0515"
     regulatory      10663..10668
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prrc2b"
                     /gene_synonym="5830434P21Rik; Bat2l; Bat2l1; D430039P21;
                     mKIAA0515"
                     /note="hexamer: AATAAA"
     polyA_site      10686
                     /gene="Prrc2b"
                     /gene_synonym="5830434P21Rik; Bat2l; Bat2l1; D430039P21;
                     mKIAA0515"
ORIGIN      
        1 gaggaggagg aggaggcaga ggcaggagcg cagagcgccg agccccgcgc cgccgccgcg
       61 caatccgccg ccatccgccg cccccgcgcc cggccgccgc ccgaccgcca tcgcccgggc
      121 ccgtcgcgcg cggacgcaga ccaggcaaat cgggagcggt gccgagaaaa tttccttact
      181 agatgacatt tcatcgcaat gtccgatcgt ttggggcaaa taacccaggg caaggatggg
      241 aaaagcaagt actcgactct cagcctgttt gacaagtata aagggaggtc agtaggcgct
      301 gtcaggtcct cagttattcc tagacatggc ttacagagtc tcgggaaagt tgccacagcc
      361 cggcgtatgc caccgcctgc aaacctgcca agcctgaagt ctgaaaacaa aggaaacgac
      421 cccaacatcg tgatagttcc caaggacggg acaggatggg ccaacaagca ggaccagcaa
      481 gacccaaaga gttccagtgt gacggcctct cagccgccgg agtcgcagcc gcagccgggt
      541 ttgcagaaat ctgtctccaa tttgcagaaa ccgacacagt ctatcagtca ggagaacaca
      601 aattcagtgc caggtggacc aaagtcatgg gcacagctga gtggaaagcc agtcggacac
      661 gaaggtggtt taaggggctc aagccgactg ttatccttct ctcccgagga atttccgacg
      721 ctgaaagcag ctggagggca ggacaaggct ggcaaagaaa agggcgcctt agatctgtcg
      781 tatgggccag gaccaagcct ccgccctcag aatgtgacaa gctggaggga gggcggtggg
      841 cggaacatca tttctgccgc ctctctgagc gcctccccaa cagagctggg cagcaggaac
      901 gccagtgggg cagacggagc cccttccttg gcatgcacca gcgattctaa ggagccctct
      961 ctccgcccag ctcagcccag ccgcagaggg gcctcccaat tcatggggca cggttaccag
     1021 ccacccacgt accatgacat gctcccagcg tttatgtgtt caccacagtc atcagagaac
     1081 cagactacgg tggaacgaag ctcttttccc cttcctcagc tccgcctgga accccgtgtt
     1141 cctttcagac agttccagat gaacgaccaa gatgggaaag aaaggccagg cgtggcacgg
     1201 ccagtgcgcc cactgaggca gctggtggag agggcaccaa ggcccaccat catcaacgcg
     1261 gaaaacctga agggcttgga tgatctggac actgatgcgg atgatgggtg ggcaggcctc
     1321 cacgaggaag tggactattc cgagaaactg aagttcagtg atgatgaaga tgaggaggat
     1381 gttgtgaagg atggccggtc aaagtggaac aactgggatc caaggcggca gcgggcgctg
     1441 tcattgagct ctgcagacag cactgacgcc aagcgcactc aggaggaagg gaaggactgg
     1501 agtggaacag caggtggatc ccgtgtcatc cgaaaggtgc cagagcctca gcctccttcc
     1561 aggaagcttc acagttgggc ctctgggcct gactaccaga aacccacaat gggcagcatg
     1621 ttccgccagc actccgctga ggacaaggag gacaagccac ccccacggca gaagttcatc
     1681 cagtcagaga tgtccgaggc cgtggaacga gcccgaaagc gcagggaaga agaagagcgc
     1741 cgggcccgag aggagaggct ggctgcctgt gctgccaaac tcaagcagct agaccagaag
     1801 tgcaggcagg ctcagaaggc caatgagacc ccgaagccag tggaaaagga agtcccccga
     1861 tccccgggca ttgagaaggt ctccccgcca gagaatgggc ctgttgtccg caaaggctcc
     1921 ccagagttcc ctgtccaaga agcacccacc atgttcttgg aagagacacc tgcaacatcc
     1981 ccaacagtcg ctcagagcaa tagcagcagc agcagtagca gcagtagcag catcgaggag
     2041 gaagtccggg agtccgggtc ccctgcacag gagttcagca agtaccagaa gtcccttcct
     2101 ccccgtttcc agcgccagca gcagcagcaa cagcagcaac agcagcagca gcagcagcag
     2161 gagcagctgt acaagatgca gcactggcag ccggtctacc ccccaccttc tcacccccag
     2221 cgcaccttct acccacacca cccccagatg ctgggctttg acccacggtg gatgatgatg
     2281 ccttcctaca tggacccacg catcaccccg acacggacgc ccgtggactt ctacccctca
     2341 gccctgcatc cttcaggact gatgaagccc atgatgcccc aagagtccct cagtgggact
     2401 ggctgtcgct ctgaagatca aaactgtgtg ccctcgctcc aagaacggaa agtgaccgcc
     2461 ctcgacccag ctcctgtgtg gagcccagag ggctacatgg cactgcagaa caaaggctac
     2521 tcactgcccc acccgaagtc tgctgacact ctggccatgg gcatgcatgt caggaatgaa
     2581 aggtcttact gtgcctcccc cggaaggcca gggggcataa gtgcccagcg cgatctcttt
     2641 gaggagagag gggaggagtt cttgagtgct tttgacaaga aggcccaagc agactttgac
     2701 agctgtatct cttctcaaag aataggccag gagcttttat ttccacccca ggaaaatgtt
     2761 caggaggtgg gtgctcctgg gggttgtacc ccaaacctca ggtgttcccc attggagcct
     2821 gactttgtcc cagctgagaa aaagccagag tatggcagct gggatgttgg ccaccagcca
     2881 aaggccgccg acacagccaa cggtgtcgag ctggaggctc cccgacagga gccttccttt
     2941 catgtttcct cttgggagaa ggaagggagc cccaagaaac agccaaaccc ggagcctgag
     3001 tggacacctg agccccggag ctccagcggc cagcaccagg agcagccggg caggacccgg
     3061 aggtcaggac ccatcaagaa accagttctt aaggccctga aggtagaaga gaaggagaag
     3121 gccctggaga gaggcaggca ggggcttaga gaggagagct cacagcgggc cccagagaaa
     3181 gaacccgtgg gcagggccga ggaggacgaa gagaacaacc ctgccctagc caatgcctcc
     3241 tccgccctgg aggacaaggc tgcctcccgg gctggttttg cccacgaggc tagcaagctg
     3301 gatgaagatg aaaaggcaga taagacctgg gagagcaggc cctcaaggga ggccagtgac
     3361 attcccccaa ccaagagaaa caactggatc ttcattgatg aggaacaggc ctttggggga
     3421 cggggccagg cccgtagccg tggccgcggc ttcagagagt tcaccttccg gggcggccgg
     3481 cctgcaggca gcagcacaag tggtctttgt ggcacgggtg tccttgggtc tcgtggcatg
     3541 tacagtagtg gccagcgcag taaccgaggc aggggcctgc gtgacttccc cccaccagaa
     3601 gactgcccca gagccaagcc aaggcgtcgc attgccagcg agactcacag cgagggctct
     3661 gagtatgaag agctgcccaa gaggcgccgg cagcggggct ctgagcatag ccacgagggc
     3721 atgctcacgg agagggacga gggtgccctg aaggactcat ggcgctccaa cagaacttac
     3781 accgaggacc agggcggtat agacacccgc agccggggat cccggacatg cgggagagcc
     3841 ctcccacccc gcctgagcaa ctgcagctat ggccgcagaa cctttgttgc caaagaacct
     3901 ccccactggc agagcaggag cccaggcagc tcctggcagg aatatggctc ctctgacccg
     3961 tgtggcccac ggcgaggcac cgacagagac tacataccag actcctaccg acaatctgac
     4021 acatttggaa gcaggctttt tgaggacagc cgcacggagg acaagaggtc ctttttccaa
     4081 gatgaccatg gggcagattc tgaaaatgca gaaaacaggc ccttccgtag gaggcggccc
     4141 ccacgccaag acaagccccc tcgcttccgg cgcctccgtc aagagcggga gtccctgggc
     4201 ctgtggggac ctgaggagga gtcccatctg ctggcaagcc agtggccagg ccggtccaaa
     4261 ctctgtcctg gggacaagag tggtcctgga ggtcacagat ccccagagct ttcctaccag
     4321 aattcctctg atcatgccaa cgaggagtgg gagaccgcct ccgagagtag tgacttcagc
     4381 gagcgtaggg agcggcgaga aggcctcgtg gctgaacccg aagcgcaagg ggatggtggc
     4441 ctctctgggt ccagtttggg tgaaaagaag gagctggcca agaggagctt ctccagccag
     4501 aggcccctgg ccgacagaca gagccgcaag ctggagccgg gagggtttgg ggagaagcct
     4561 gttaggccag gtgggggtga gccttccccc cgctgcgaga gccagcagag cgggacgcct
     4621 ctgaaagtca aaaggtctcc agatgaggcc ttgcctggag gccttggcag ccattcaccc
     4681 tatgccttgg agagaaccac tcacgccagc tctgacggtc ctgaaacccc cagtaagaaa
     4741 tcagagagag aggtttcttt gcctacccag agggctagtg agcaggaaga ggcccggaag
     4801 cagtttgacc tgggctatgg aaatgctctc attgacaact gcgcctccag ccctggggaa
     4861 gagaatgaag caagctctgt ggtgggtgaa ggcttcattg aagtcctgac caagaagcag
     4921 cgtcgcctgc tggaggagga gagaagaaaa aaagaacagg ctgctcaggt gcctgtcaaa
     4981 ggtcggggcc tttcatcccg gattcctcct cggtttgcta aaaagcagaa cggcctgtgt
     5041 ctggagcaag atgtgactgt gcctggcagc agcctgggca ctgagatctg ggagaacagc
     5101 agccaagccc tccctgtgca gggcgccgcc agtgactcat ggaggacagc tgtcactgcc
     5161 ttcagcagta ctgagcctgg cacctcagag gggtttaaga gcagccaggg agatagtggc
     5221 gttgacttga gtgctgagtc tcgggagtcg tctgcgacct cctcacagcg cagttcccca
     5281 tatggcactc tcaagcctga ggaaattagc gggcctggcc tggcggaatc taaggccgac
     5341 agccacaagg accaagctca gaagcaggcg gagcacaagg actcagaaca aggctctgca
     5401 cagagcaagg agcacagacc aggacccatc ggcaacgagc ggtctctgaa aaacagaaag
     5461 ggctctgagg gggccgagcg gctgccaggg gccgttgtcc cgcctgttaa tggggtggag
     5521 attcacgtgg actccgtgct gccggtgccg cccattgagt tcggagtcag tccaaaagac
     5581 tctgatttca gcctgccacc cgggtctgtt tctggtcctg tagggaatcc agtggccaag
     5641 cttcaggacg tcttggctag taatgcagga ctgacgcaga gtattcccat cctgcggcgg
     5701 gatcaccaca tgcagagagc catcggcctc tctcccatgt ctttccccac cgcagacctc
     5761 acactaaaga tggagtctgc acgcaaggct tgggaaaact cccccagttt gccagagcag
     5821 agctctccag gaggtgcagg ctcgggcatc cagcctccat cctctgtggg cgcctccaat
     5881 ggggtcaact acagctcctt tggtggagtg tcgatgccgc ccatgcccgt ggcttctgta
     5941 gcgccttctg cttcgatacc aggcagccac ctcccacctc tgtacctgga tggccacgtg
     6001 tttgcaagtc agccccgact ggttcctcaa acgatacctc agcagcagag ctaccagcag
     6061 gccgccactg cccagcagat cccgatatcc cttcacacgt ctctgcaggc ccaggcccag
     6121 cttgggctga gaggtgggct ccccgtctcc cagtcccagg agatcttcag ctccctgcag
     6181 cccttcaggt ctcaggtgta catgcacccc agcctgtcac cacccagcac gatgatcctc
     6241 tcagggggta cagccttgaa gcccccatac tctgcatttc ctggcataca gcccttggag
     6301 atggtgaagc cccagtctgg ctcaccctac cagcccatga gtggaaacca ggccctggtc
     6361 tacgagggcc agcttggcca ggctgccggg ctgggcacct cccagatgct ggattcccag
     6421 ctcccacagc tcactatgcc actgcctcgg tatggctccg ggcagcagcc actgatcctg
     6481 ccacagtcca tccagctgcc tccaggacag agtctctctg ttggagcccc ccggagggtt
     6541 cctccacctg gctcccaacc tcccgtcctg aacaccagca gagagtccgc tccgatggag
     6601 ttgaaaggct tccactttgc cgacagtaaa cagaatgttc ctactggagg gtccgcacca
     6661 tccccgcagg catacaggcc tagctctgct agccccagtg ggaagccctc tggatcagca
     6721 gttaacatgg gctctgtgca gggacactac gttcaacagg caaagcgagt ggatgaaaaa
     6781 cccggcctgg gaaccgtgaa gctgcaggag gcctcatcag ccacctccca gatgaagcga
     6841 accggagcaa tcaagcctcg ggcagtcaag gtggagggaa gcaaagcctg aaggtgcctg
     6901 ggtctcttgc ctcacctaac agggacggtg cgccccacac cctaacaggg atggtgtgcc
     6961 acaccagcct ggacagccac cgcctggctt ggacagagct ctcttccatt cacgaaagct
     7021 cctgagagtt ccatcgtcag ccagcctgca tcgtggacat gtggctttga cctgcttgct
     7081 ttggtacaaa agagcagact tcctccttcc cacccctctg cccagtgact gtggagtgag
     7141 cctcctgtgc agtgcagacc tgcccgcccg cccgcccgcc cagttcccta ggcacagtgg
     7201 tttggcagca gggtcatttt agctggaggc tttttgtttt aaaaagcagc taaggttttt
     7261 acaaagggga aatgagaaca aaatgctagc tacatctgta tagctgaact tttatatggt
     7321 cctcgctgtc ctctctctgc tctgctgtcc ccagtggtca ccttttatct ccgtcctgtt
     7381 tgacatgtca cagtgctacc ttaagaggtg attcttaaga gtcacacaca cacacacaca
     7441 cacacacaca cacacacaca cacaccccgg ttggctaacc gttggggttt ggaggatgtg
     7501 attggacatt ctggttggtc cctcaccacc ttgggcactg tgaagttggt atctgagttt
     7561 agttccctgg tgtggagtta atgtttcaga ataagaatta tctgttcagg gcccttttgc
     7621 tgtcattgga cacagtgagt attgagcacc ggaggaattg tggagttttg taatccagat
     7681 tggccccact tggggactgc atcttgggct ccgtgcttta gccccctggg tggctttgtt
     7741 ccccactcat ttcctttcct ctttgtggag cctgctgtgt ccctctggat ccctgtccat
     7801 tcactcctca cagcttatca ccaaaatcaa tataaggaca caggtgaaca cctattagtc
     7861 aagtttgcga caggaaagac tatgtatggc acattcatct tccgtccttc actcctggta
     7921 acagggcagg gtgttgggta gggtttctaa gctataggtg tgttaccctt ccttagagaa
     7981 ctggacaggg tcaaggtata agtggcctac agagaaacct atgcagcctc aaaggaggct
     8041 ggtggtgtct aaagggtggt gtcttggggc tactgcttgc aggttttgtg tgagcacctg
     8101 tatgcgaggc ttcttgcttt cactaagaac aaggaaaatt tcccattgct caaaggaaaa
     8161 tgaagtgaat ttcagggtgc tcagctgctg cttaggaccc ccatttaatc acccatctgg
     8221 ggtgttggag acagcctgct tcagagagct catagttggt ggcagggctg ggacaagcat
     8281 gtgggtctgt cctcaagtgt caccatgggc atgagagcag agaagcagct tagaagctct
     8341 gaagtggctt cgccctgcct agttggttgt tgaaggaagc agaagtctgt ttcccccggc
     8401 aggtactgcc acactgtccc cagcattacc agtcagggca gccttggtgc agtttcattg
     8461 caactgcagc cctcggctcc ttccttccca cctccgacac atctcctctc ttctcgcatc
     8521 cctcctcaga agcactgtcc acttaggagt ccccagcaca gatctgcctg tgcccctatc
     8581 agcccttcca ccccccggaa gtgaccgagt cctctgcccc actgccaagc tctaccccat
     8641 aagtctcact cagtaaaagc cacacagtca cctcttagaa atgcggccag acccacctca
     8701 cccaatgctt ggtgggcatt atgtgtcaaa agaagcaaac atttttctct ttcagaattt
     8761 cacaggatgc tgttacaaac tcaaaatgtg ccctttaggt gagcctgctg tcagaatggc
     8821 agtactccct gttttaagaa gaaaaattag gaggtcacct gttttcagtc ctttctctaa
     8881 ccctgtattt ccctcctgcc tcccacccta aataaaaaca agaaacacta gaatttattt
     8941 atatgtattg atgttgtagg tctagatgga aaaaaaaaag taaatgtccc actgctctgt
     9001 ttatataatg tctgaattac tctgtgcagg aaaggccagg aaattgcatg tgaaatttgg
     9061 tgtgctcacc acctctgtga tctcagctgt gggctctacc cctctgagag gcacatttgc
     9121 aactagacgc tgaggacaga gggcaggctt caggccaaat gtccctactc ctcggatgat
     9181 ctggtcaagc caagttttta gtacagaggt gttttaaggt gcaatatctc tttgtgtggt
     9241 ttttagagtc aagctcaaag tataatagaa cttgggcctt attttggttt caaaccccca
     9301 tctttagatc acacataaaa acaggagcgt ctgtcagggt gccatggcct ttggtgggaa
     9361 caggtaaagt ccagccctgc cttttctact gctgagatgg gtggaggtgg gcagaatctt
     9421 ttactcctgc ctgctgaagt cacctcctac tgctggtggc tttgttggtg ccactgatgg
     9481 tgaaatccat ggtttggcaa ccaggactct tcagtctgtt ggtcctgatg cggcgtgtag
     9541 catctgtcgg tgaagacttc tgccgactgc atttagtctg gtctcttaac agttgctttc
     9601 cttgtctgat tcccaagttt agcattttca aattcagagt tcacagaaca cttctgggtc
     9661 taagcttcct taagggggat aaacaaagga tgattgcagt acacatttag aaatgctggt
     9721 tcacatccaa agccacgctt gctctgccac ttctagagat acttggataa cactgtccac
     9781 cttgctgtcc tgtcctctgg agccaccttc cagatggtca gtgatgaagt cgtgaatgat
     9841 ttgacactca gggcccaggg cacaagagtg tacccgctga ggccatgagg caactctggc
     9901 taagtccgcc ccccaacatc cactggggtc cccactctgc caggtacctg catgttaact
     9961 ttcatgttcg ccttgccctc atttccagca agtctgggtt agagggtatg ttgggaatct
    10021 ttcacaggca agggcacaga agtctggctt ctgtattctt tgatgagtgg aaaagccagc
    10081 tctttgtgag atggctctaa gacaagttag gtcatgtgga acagagtggt cagcgttggg
    10141 gatgagcaca gtcacccagc tgtgctctcc actgtctacc agctctgact agtgatcttc
    10201 caggtgcatg acacctgcag cccccagctg cttgcttcag acctgcaacc tccccaggcc
    10261 ccatctttgg catgtcacaa tcctggagca gcagttcctg tgaaggctcc ttagctgaag
    10321 ggtcctgtgc tctaggcttt ccacctcaaa ccttttatag aaaaggactt gggggattgt
    10381 tctttttgag ggtccttttg ttttcctttg cttttctttt ggccttccct ctgtctttca
    10441 cttagaccag ctatttgaaa gggcagacga tgctaaaggt gtactgtgca gcttgtttag
    10501 acgtgatatg gggaacttct tcggatggga aatggaatcg tgaattcacc ctcccttccc
    10561 tccgggtcag tccctgttgt ttctcctttc aaatatgtga ttgtactagg tctttccata
    10621 cgaaagaact ctccttattt aaataaaaaa aaagtataaa aaaataaagc caaacatgct
    10681 ttctcaaaaa aaaaaaaaaa aaaa
//
