LOCUS       NM_175181               4245 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus proline rich 5 like (Prr5l), transcript variant 2,
            mRNA.
ACCESSION   NM_175181
VERSION     NM_175181.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4245)
  AUTHORS   Gan,X., Wang,J., Wang,C., Sommer,E., Kozasa,T., Srinivasula,S.,
            Alessi,D., Offermanns,S., Simon,M.I. and Wu,D.
  TITLE     PRR5L degradation promotes mTORC2-mediated PKC-delta
            phosphorylation and cell migration downstream of Galpha12
  JOURNAL   Nat Cell Biol 14 (7), 686-696 (2012)
   PUBMED   22609986
  REMARK    GeneRIF: PRR5L degradation promotes mTORC2-mediated PKC-delta
            phosphorylation and cell migration downstream of Galpha12 in
            fibroblasts and pulmonary fibrosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4245)
  AUTHORS   Pearce,L.R., Sommer,E.M., Sakamoto,K., Wullschleger,S. and
            Alessi,D.R.
  TITLE     Protor-1 is required for efficient mTORC2-mediated activation of
            SGK1 in the kidney
  JOURNAL   Biochem J 436 (1), 169-179 (2011)
   PUBMED   21413931
REFERENCE   3  (bases 1 to 4245)
  AUTHORS   Hecht,J., Seitz,V., Urban,M., Wagner,F., Robinson,P.N., Stiege,A.,
            Dieterich,C., Kornak,U., Wilkening,U., Brieske,N., Zwingman,C.,
            Kidess,A., Stricker,S. and Mundlos,S.
  TITLE     Detection of novel skeletogenesis target genes by comprehensive
            analysis of a Runx2(-/-) mouse model
  JOURNAL   Gene Expr Patterns 7 (1-2), 102-112 (2007)
   PUBMED   16829211
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY737227.1, BC048394.1, AL929571.10 and BB166811.1.
            
            On Nov 27, 2007 this sequence version replaced NM_175181.4.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1-4 all encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145981.1, BC048394.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                BY737227.1         1-90
            91-1798             BC048394.1         1-1708
            1799-4205           AL929571.10        48064-50470         c
            4206-4245           BB166811.1         271-310
FEATURES             Location/Qualifiers
     source          1..4245
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 53.93 cM"
     gene            1..4245
                     /gene="Prr5l"
                     /gene_synonym="2600010E01Rik; 4833411O04Rik; Protor-2;
                     Protor2"
                     /note="proline rich 5 like"
                     /db_xref="GeneID:72446"
                     /db_xref="MGI:MGI:1919696"
     exon            1..236
                     /gene="Prr5l"
                     /gene_synonym="2600010E01Rik; 4833411O04Rik; Protor-2;
                     Protor2"
                     /inference="alignment:Splign:2.1.0"
     exon            237..515
                     /gene="Prr5l"
                     /gene_synonym="2600010E01Rik; 4833411O04Rik; Protor-2;
                     Protor2"
                     /inference="alignment:Splign:2.1.0"
     exon            516..596
                     /gene="Prr5l"
                     /gene_synonym="2600010E01Rik; 4833411O04Rik; Protor-2;
                     Protor2"
                     /inference="alignment:Splign:2.1.0"
     exon            597..645
                     /gene="Prr5l"
                     /gene_synonym="2600010E01Rik; 4833411O04Rik; Protor-2;
                     Protor2"
                     /inference="alignment:Splign:2.1.0"
     exon            646..703
                     /gene="Prr5l"
                     /gene_synonym="2600010E01Rik; 4833411O04Rik; Protor-2;
                     Protor2"
                     /inference="alignment:Splign:2.1.0"
     exon            704..795
                     /gene="Prr5l"
                     /gene_synonym="2600010E01Rik; 4833411O04Rik; Protor-2;
                     Protor2"
                     /inference="alignment:Splign:2.1.0"
     exon            796..936
                     /gene="Prr5l"
                     /gene_synonym="2600010E01Rik; 4833411O04Rik; Protor-2;
                     Protor2"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1063
                     /gene="Prr5l"
                     /gene_synonym="2600010E01Rik; 4833411O04Rik; Protor-2;
                     Protor2"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..4245
                     /gene="Prr5l"
                     /gene_synonym="2600010E01Rik; 4833411O04Rik; Protor-2;
                     Protor2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2282
                     /gene="Prr5l"
                     /gene_synonym="2600010E01Rik; 4833411O04Rik; Protor-2;
                     Protor2"
                     /note="major polyA site"
ORIGIN      
        1 gtaagttgag agaggaggga aacagtcacc agcctgactc tgagagctac ggcggagaga
       61 aacctgggca ggacgcgacc cggcgtaggg cagagctggg agaggacctg gggagggcga
      121 gcgagcgagc gaggcgagaa ccagccgaat cgctagtttc tctccagcaa gaaaactttc
      181 cctggaacac cggaaacttt ttcctgagcg ctcagagtcc gagacggagg cgagcgggct
      241 tggctgagta gggttttcag acaccccagc agcagcgttg agagacacct ttcctgtggg
      301 tggccagaag cttctggtcc tgaagacaca gctccatcct cacctggacc tatgacccgc
      361 ggcctcgctc ccctcctgcc cattgaattc cacaagatgg gctccttccg ccggcctaga
      421 ccacgcttta tgagctcccc tgtgctcagc gagctgcccc gcttccaggc tgcccggcag
      481 gctctgcagc taagttccaa ctctgcctgg aacagtgtgc agacagctgt gatcaacgtt
      541 ttcaaagggg gcggcttgca gagcaatgag ctgtatgcac tgaacgaaag catcaggcgg
      601 ctgctgaaga gtgaacttgg atcattcatt actgactatt tccagaacca gcttcttgca
      661 aaaggactgt cctttgtgga ggagaagatc aagctgtgtg aaggtgacaa tcggattgag
      721 gttctggctg aagtctggga ccacttcttc accgagactc tccctaccct gcaggcaata
      781 ttttatccgg ttcagggaca ggagctgacc atccgccaga tctccctgct gggcttccgg
      841 gacctggtct tgctgaaggt gaagctgggt gacgtgctgc tgttggcaca gtccaagttg
      901 ccttcttctg ttatacaaat gctgctcatt ctgcagagtg ttcacgagcc cacaggccca
      961 agtgagggct acttgcagct ggaggagctg gtgaagcaag tggtgtctcc ctttctcagc
     1021 atcagcgggg accgcagctg ctcaggcccc acgtactcac tggccaggag gcattccagg
     1081 gtccggccca aggtgactgt cctgaactat gcctctctga tgaccacggt tggccggcca
     1141 ctgaacgaga tggtcttgac ccctctaaca gaacaggaag gggaggcata cctggagaag
     1201 tgtggcagtg tccggcggca cacagtggcc aacgcccact cagacatcca gctgctggcg
     1261 atggccacca tgatgcactc agggttgggg gaggaggctg gcggcgagga caaacacctg
     1321 ctcttgccac ccagcttccc cccaccacac cgccagtgct ccagtgaacc cagcatcctc
     1381 gacagccccg atgaactgga actagaagac gtggcaagtg gcagccagga ggactcagag
     1441 ctgaactgtg cttccctcag ctgagccgcc acctccagga acccgttcct actttagagc
     1501 taggatgagg gcacctctcc tcctccatgg atcaccaagg gggctcttgc attgagcaat
     1561 attgccttat ttactttagg gcacaagcca agtcttcatg cctttgggaa acatctgtcg
     1621 gcctccccac tctggtgtct atgactggct cctcatacca ctgttttcct gacttccagc
     1681 cttgcctgac tcaccgggat ccttatgttt gggccttccc catcctattg gactggctga
     1741 tgctcctagt ttataatgtt ctggcgttgt agcagaaggt tggatgacac acaagcatct
     1801 gaaacgtgcc agcctctgcg gttcccgtta tcatcttagg gggcagaagc caatgggtgg
     1861 aaagaacagt agaggttctg tatagcatgg aagtcaactg cagcccatat cacacctggt
     1921 cctgggaatg tgtcctcatc actttaattg cagagttact gggaaatcat tgtgctactc
     1981 tgtggatgag ggttcattct tatgtatgtt cagatgtcat gtgctgtcta catcatgagc
     2041 tttggcttag gagaacctac aaagctggca gagttttgtc ttgcattgcg cctctcagtg
     2101 aaccttctca gtaaatggtg ccttaccgtc actccagttt caggaaccag ccacatttct
     2161 ggtgtgtata tgagagggtg gctgatagca actgacttag acctgtacct ggatttcact
     2221 tgaatttata aaatgtgtat tgctcaaaaa aaaaaaaaag gtttgcaaat atttgcacat
     2281 aagatcttgc actgttcatt tccagtgagt gtgtttgcag actaaacaca agtggacccc
     2341 ttcaaaaggc taccgcttag ctccgaacaa aaggatcagt cgtgggcagg actcacatac
     2401 ctcagctctg gaggagctag cactgtctgg aatggcctgt gttgtaagtg tcttggcctc
     2461 tagggaaggt ttgtgctggc ctcaggagac tgtctcatga gcagggaagt gttgtggccg
     2521 gctggactgt gcctgcttta gagtagacag agagggacgt gggcatgttt tatttggagg
     2581 gatgtttatt ccctgagatt acagaagtac ccagaagtgt ctgggatccc tgtcacatct
     2641 gtgtcatgtt gttatttgaa gcatcagact ttattactat gctaggtcct cactactgcc
     2701 ccctgcaggc tggggaaagg gaactttttg tctacgctaa gtccctggct tcctcttaat
     2761 cggttggtct tgctaattga agctcagaaa aatatagatg gtctctcccg accctgtttg
     2821 tggtgtgtgc tggcctatca ggatctggtt agcctttgga atttttgttg atgaaatctc
     2881 aatacataag gcgtcaacag ggggctggag agatggctca ggagttaaga gccctgactg
     2941 ctcttccaca ggtcctgagt tcaattccca gcaaccacat ggtggttccc aaccatctgt
     3001 aatgggatct gatgccctct tctggtgtgt ctgaagacaa cagtagtgta ctcacgtata
     3061 tgaaataaat aaatcttaaa aaaaaaaata aggtgttaac atgagaagag gcgcttcaag
     3121 ctcttctaag ccttgatggt gtctcccttt aggcaaagat ctgaaatatg actacagttg
     3181 tgctgttgat gggttctgct ttagaaattg tatttttttt taaaaaaatg ttttaatttt
     3241 gtccatccta gagataataa cgaaagagaa atgtctgcat gtgtgcacac acacacatct
     3301 tagatacaca aaaagaaatg ttcagattcc tttgagaatt tcaaatgaaa aataatcttt
     3361 ctgtatgtgg tgtctaacat ctacaaggtg ggggctggag aagtggcttg gtgctcaaag
     3421 gcacttgctg ctcttgcaga aggccaaaag atgtgattta gttcctagcc catcaggcag
     3481 ctcacagcca catgactata actctagacc cagagaatct gatgttcttc tcctctgagg
     3541 gcatctgaat gcatatagtg tgtgtgcatg aacacagcac tggacagtac actctggtgt
     3601 acacacttgc gcacacatat acacacacaa taatttttta aactccataa agttattaac
     3661 atgtcagcag gcagagcatt gcagtttatt taactgatgg ccaggttctt gttagaacac
     3721 caagcacaca cttgagatta tttattgatc gaggcaaagt aattagtcat gtttgggttt
     3781 gctttttttg ttgataagat taacaatgtg tgctttgtaa atgccttttt ccttatcttc
     3841 tatgtctctg tcaaggacag aagttgtcag tttaatacac gagctcttgt gttgaaagtg
     3901 tccaggccgt agaacttcat tgctactgac tttacacagt ttacaagttt ctctttggac
     3961 atatctggta ttattacaga aatctcccag attatacaca taaacatttt atggacattt
     4021 tttgggcatt taagccatca ggcctattgc aagagtgcct cctgtagcag ttttaaccaa
     4081 atttcattcc cctggtaccg tggagcttta ttttgctatt gaacgccaag ctgaatgtga
     4141 gtgacaggga acaatcccag ctctgggctc tgcagaaact cacaaactaa actcctttct
     4201 ggttgtctgt tttcaaaata gatacaataa acattgttta tgtca
//
