LOCUS       NM_178774               3277 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus proline rich 18 (Prr18), transcript variant 1, mRNA.
ACCESSION   NM_178774 XM_974802 XM_974827
VERSION     NM_178774.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3277)
  AUTHORS   Huang,G., Li,Z., Liu,X., Guan,M., Zhou,S., Zhong,X., Zheng,T.,
            Xin,D., Gu,X., Mu,D., Guo,Y., Zhang,L., Zhang,L., Lu,Q.R. and He,X.
  TITLE     DOR activation in mature oligodendrocytes regulates
            alpha-ketoglutarate metabolism leading to enhanced remyelination in
            aged mice
  JOURNAL   Nat Neurosci 27 (11), 2073-2085 (2024)
   PUBMED   39266660
  REMARK    Erratum:[Nat Neurosci. 2024 Nov;27(11):2261. doi:
            10.1038/s41593-024-01785-2.. PMID: 39317798]
REFERENCE   2  (bases 1 to 3277)
  AUTHORS   He,M., Wu,B., Ye,W., Le,D.D., Sinclair,A.W., Padovano,V., Chen,Y.,
            Li,K.X., Sit,R., Tan,M., Caplan,M.J., Neff,N., Jan,Y.N.,
            Darmanis,S. and Jan,L.Y.
  TITLE     Chloride channels regulate differentiation and barrier functions of
            the mammalian airway
  JOURNAL   Elife 9, e53085 (2020)
   PUBMED   32286221
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164431.2, BC060190.1 and AK045379.1.
            
            On Aug 5, 2009 this sequence version replaced NM_178774.3.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript but encodes the functional protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.30677.1,
                                           SRR7345562.2808698.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               AC164431.2         142702-142846
            146-579             BC060190.1         302-735
            580-877             AK045379.1         712-1009
            878-3277            BC060190.1         1034-3433
FEATURES             Location/Qualifiers
     source          1..3277
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 4.92 cM"
     gene            1..3277
                     /gene="Prr18"
                     /gene_synonym="9630019K15Rik"
                     /note="proline rich 18"
                     /db_xref="GeneID:320111"
                     /db_xref="MGI:MGI:2443403"
     exon            1..145
                     /gene="Prr18"
                     /gene_synonym="9630019K15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            146..3252
                     /gene="Prr18"
                     /gene_synonym="9630019K15Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..1076
                     /gene="Prr18"
                     /gene_synonym="9630019K15Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     proline-rich protein 18; proline rich region 18"
                     /codon_start=1
                     /product="proline-rich protein 18 isoform 1"
                     /protein_id="NP_848889.3"
                     /db_xref="CCDS:CCDS28382.1"
                     /db_xref="GeneID:320111"
                     /db_xref="MGI:MGI:2443403"
                     /translation="MLRLLGRVMSFLPMPPPPPPPPPPPRTPGGPAARQLSRRPCAPP
                     APSPPAASAAGGEKKRRPPEMLLSSSWPSATLKRPPVRRGPGLGSGTPQPATSARVPP
                     QPSPGRGGTSTTCSAPRRVACSHIPAGSTASGTSAGAGAGPDDATRFSLNLTPEAILV
                     IQRRHLEKQLLARPRRPFPTPSADPRLPLVPCPRTRASTLRRGGPTSVPNAPLAVAVS
                     SRPPRASLLPGGLQATLPSPCPSSLRPVLKVSLLNEKHKYDDEEYEEEVEVVDEGLVR
                     KCTEWLRGVESAAAARGRTGHLDSLPHLSTL"
     polyA_site      2470
                     /gene="Prr18"
                     /gene_synonym="9630019K15Rik"
                     /note="major polyA site"
     regulatory      3233..3238
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prr18"
                     /gene_synonym="9630019K15Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3252
                     /gene="Prr18"
                     /gene_synonym="9630019K15Rik"
ORIGIN      
        1 agtggggcgg ctgctggcgt gaccgaagga cccagctcgg agcacacgga gggagctccc
       61 ggggttgccg aagcgaggga ggggcgggag gcgccttcgc ttgaaggaac tgggagggag
      121 cgggagatgc tgcggctgct agcaggacac tgatgctccg cttgctcggc agagtcatgt
      181 cattcctgcc tatgccgccg ccgccgccac caccaccgcc gcccccccga actccggggg
      241 gccccgctgc gcgccagcta tcccggagac cctgtgcgcc gcccgcgcct tcaccgcccg
      301 ctgcctccgc cgccggcggc gagaaaaaga ggaggccgcc cgagatgctg ctctccagct
      361 cctggccctc cgccaccttg aagaggcccc cggtacggcg cggccccggc ctgggttcgg
      421 gcaccccaca gccggctacc tccgcacgcg tcccgcccca gccctctccg ggccgtgggg
      481 ggacctcgac cacgtgctcc gcgccccggc gggtcgcctg cagccacatc ccagcgggat
      541 ccaccgcctc ggggacctct gcgggggcgg gggctgggcc cgacgacgcc acgcgcttct
      601 ccttgaacct caccccagaa gccatcctgg tcatccagag gcgccacctg gagaagcagt
      661 tgctggcgcg accccgcagg cccttcccca caccctctgc cgacccgcgg ctcccactgg
      721 taccctgtcc ccggaccagg gcttcgaccc tgcggagggg tggccccacc agtgtcccca
      781 acgcgcctct ggctgtggct gtcagcagcc gccctccccg tgcctcgctg ctgccaggag
      841 gtctgcaggc cactctgccc agcccgtgcc cctccagcct gcgcccagtg cttaaggtgt
      901 cgctgctcaa tgagaagcac aagtacgatg atgaggagta cgaggaggag gtggaggtgg
      961 tggacgaggg cctcgtgcgc aagtgcaccg agtggctgcg tggggtcgag tcggcggcag
     1021 ctgcgagggg ccgcacaggg catctggact cgctgccaca cctgagcacc ctgtgaggct
     1081 aggtgggcct gtgggaccca gcctggcttg aagcccacgg ccgcctcctg ggctccttgc
     1141 acacctgggc tcttgtgaac caggtaggcc agcaagggac aggactattg cctggtacct
     1201 tccccaggtg tgcttattca tgagtgaccc acaggctttt ctaacgcctc accacccacc
     1261 tcctgtgcaa ttaggtcagc gtgggacaca acagactcgc ctgactctag cagctgtccc
     1321 ctgctcctcc tgctccccgc cctccctaat gtgggggtcg ggggaggacc tgtgaaatgc
     1381 cttctaacct ctcaccctaa ctaagtattg gacccagagg tcctctgccc caggtggcat
     1441 tccacttcct ggggactctg caagcctgtg gccaccgagg gtggggtgat cttctgttgc
     1501 agaactagga catggtgcta tctatgtata ggatttgttt ccttacaagt cagaaagatg
     1561 ttaggtattg gaaactggtt aactaaactt gtaatccagc atccctgaaa cagtgtactg
     1621 ttgccactgg gtgatccagg aggacttgtg ctccgcctgc cagctagtac tcagccatcc
     1681 cagacactta cacacactcc actcccatgg ctatgcacag gcaaccccat tccactagct
     1741 gtcatgcgtg catgcatgcc tacatacaca gccacgcaca catgcacacg ataacacaca
     1801 cattggctct cacatacatg tggatatatg gccatgcagg tagtcacagc cacacacagg
     1861 tgtctccaat ggcacagctg gaattgtttt cagaagttgg atcaaggtgg ggacaggagt
     1921 cagggttgtc gtctgctggg attgcagttt ttatttgagg gcacagcaat gtctccctca
     1981 gtagctaggg aaggaacttc tcagcacaga ggacgtcggt gggtgaaagc aaggcagggc
     2041 aagcctgccc acggagcagt ttgaggcgga agcaggaagt agttgtgggc cagggcaggt
     2101 gtctctctct catcactgtg aagaccagtg acaaaggggt tctgtaagct gtaaatagtg
     2161 gcttttaaaa tcctatttat tatttgaatg aagggtaaaa ctcctgtctc ttaatagctg
     2221 agcccttccc attaactgga ggatgattct tttgtatttc ttctgtgcct gagtggattt
     2281 aaccccaagg ataagaagga agtgtttgtt ctaatcagat aaggttgcct gtagaaacgt
     2341 aatgcattac ctcaatattt ttttaactta tcgtatgcaa gtcaataacc agtttaatgt
     2401 ttgtcttgtt agactttaat gtgtcaattc tcgattgtat tttaaatcaa agccttacat
     2461 ttttaaaaga ccaattatat tttttccttg tagagatctt tgcgctctct ctctctctct
     2521 ctctctctgt ctccatctct cctctccatc cttcttggtg caagctttgc caaccaagag
     2581 gccttacaga gggagctaca ttagacacca gatgagttaa aaaaaaaaaa aaaagctact
     2641 tattgatttt aaatggttaa tgccaaaggg gcaaagttag caacactggt gggggagggg
     2701 tggaagggct gttcctctag gcaagttggg tggtgagggc actgcctctg ccctccagcc
     2761 tggcacagca cggctttatc ccgtctgcac tcagcgcaaa tgccagtact tcacgtgctt
     2821 ggcttcctgc ccccagcagc cctaacaaca ccagaaagcg ttcctggtac ctcctaaagg
     2881 agtggcctct agggagatct tccttcccct ttggccatca tggaggtctg cggaccaccc
     2941 tgtccatccc tgtctgtctg ctttggtttt ccctccccac tgctccctct cactttttaa
     3001 ctggcctcag agcaaagctc aacgttctct ctggctggtg atcaaagggg ccccgtgtgc
     3061 ctgcctggct cttcacttca gagatggggg catgtttgtg ttgggcggcc gatgactctc
     3121 tgtaaggaaa ggaaggcctg cacgtgactt gcggggtctc tacctcgttg ctgacattct
     3181 gaggacattt tctagtcact gtgctacaat ttcttaaggt ttaaataata ataataaaaa
     3241 aaagcaattg gaaaaaaaaa aaaaaaaaaa aaaaaaa
//
