LOCUS       NM_144806               1867 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus phosphoribosyl pyrophosphate synthetase-associated
            protein 2 (Prpsap2), transcript variant 1, mRNA.
ACCESSION   NM_144806 XM_913254
VERSION     NM_144806.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1867)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1867)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1867)
  AUTHORS   Bassett,J.H., Gogakos,A., White,J.K., Evans,H., Jacques,R.M., van
            der Spek,A.H., Ramirez-Solis,R., Ryder,E., Sunter,D., Boyde,A.,
            Campbell,M.J., Croucher,P.I. and Williams,G.R.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Rapid-throughput skeletal phenotyping of 100 knockout mice
            identifies 9 new genes that determine bone strength
  JOURNAL   PLoS Genet 8 (8), e1002858 (2012)
   PUBMED   22876197
REFERENCE   4  (bases 1 to 1867)
  AUTHORS   Quina,L.A., Wang,S., Ng,L. and Turner,E.E.
  TITLE     Brn3a and Nurr1 mediate a gene regulatory pathway for habenula
            development
  JOURNAL   J Neurosci 29 (45), 14309-14322 (2009)
   PUBMED   19906978
REFERENCE   5  (bases 1 to 1867)
  AUTHORS   Yan,J., Bi,W. and Lupski,J.R.
  TITLE     Penetrance of craniofacial anomalies in mouse models of
            Smith-Magenis syndrome is modified by genomic sequence surrounding
            Rai1: not all null alleles are alike
  JOURNAL   Am J Hum Genet 80 (3), 518-525 (2007)
   PUBMED   17273973
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY204265.1, AK038680.1 and BY550047.1.
            
            On Aug 28, 2009 this sequence version replaced NM_144806.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC023178.1, AK076811.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                BY204265.1         1-35
            36-1828             AK038680.1         2-1794
            1829-1867           BY550047.1         386-424
FEATURES             Location/Qualifiers
     source          1..1867
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 37.96 cM"
     gene            1..1867
                     /gene="Prpsap2"
                     /gene_synonym="A230054F23Rik; PAP41"
                     /note="phosphoribosyl pyrophosphate synthetase-associated
                     protein 2"
                     /db_xref="GeneID:212627"
                     /db_xref="MGI:MGI:2384838"
     exon            1..135
                     /gene="Prpsap2"
                     /gene_synonym="A230054F23Rik; PAP41"
                     /inference="alignment:Splign:2.1.0"
     exon            136..231
                     /gene="Prpsap2"
                     /gene_synonym="A230054F23Rik; PAP41"
                     /inference="alignment:Splign:2.1.0"
     exon            232..382
                     /gene="Prpsap2"
                     /gene_synonym="A230054F23Rik; PAP41"
                     /inference="alignment:Splign:2.1.0"
     CDS             264..1373
                     /gene="Prpsap2"
                     /gene_synonym="A230054F23Rik; PAP41"
                     /note="isoform a is encoded by transcript variant 1;
                     phosphoribosyl pyrophosphate synthase-associated protein
                     2; PRPP synthetase-associated protein 2; 41 kDa
                     phosphoribosypyrophosphate synthetase-associated protein;
                     PRPP synthase-associated protein 2"
                     /codon_start=1
                     /product="phosphoribosyl pyrophosphate synthase-associated
                     protein 2 isoform a"
                     /protein_id="NP_659055.1"
                     /db_xref="CCDS:CCDS24819.1"
                     /db_xref="GeneID:212627"
                     /db_xref="MGI:MGI:2384838"
                     /translation="MFCVAPPELETKMNITKGGLVLFSANSNSSCMELSKKIAERLGV
                     EMGKVQVYQEPNRETRVQIQESVRGKDVFIIQTISKDVNTTIMELLIMVYACKTSCAK
                     SIIGVIPYFPYSKQCKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPV
                     DNLRASPFLLQYIQEEIPDYRNAVIVAKSPASAKRAQSFAERLRLGIAVIHGEAQDAE
                     SDLVDGRHSPPMVRSVAAIHPSLEIPMLIPKEKPPITVVGDVGGRIAIIVDDIIDDVD
                     SFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEESAIDEVVVTNTIPHEIQKLQCP
                     KIKTVDISMILSEAIRRIHNGESMSYLFRNIGLDD"
     exon            383..435
                     /gene="Prpsap2"
                     /gene_synonym="A230054F23Rik; PAP41"
                     /inference="alignment:Splign:2.1.0"
     exon            436..502
                     /gene="Prpsap2"
                     /gene_synonym="A230054F23Rik; PAP41"
                     /inference="alignment:Splign:2.1.0"
     exon            503..675
                     /gene="Prpsap2"
                     /gene_synonym="A230054F23Rik; PAP41"
                     /inference="alignment:Splign:2.1.0"
     exon            676..791
                     /gene="Prpsap2"
                     /gene_synonym="A230054F23Rik; PAP41"
                     /inference="alignment:Splign:2.1.0"
     exon            792..847
                     /gene="Prpsap2"
                     /gene_synonym="A230054F23Rik; PAP41"
                     /inference="alignment:Splign:2.1.0"
     exon            848..996
                     /gene="Prpsap2"
                     /gene_synonym="A230054F23Rik; PAP41"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1067
                     /gene="Prpsap2"
                     /gene_synonym="A230054F23Rik; PAP41"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1214
                     /gene="Prpsap2"
                     /gene_synonym="A230054F23Rik; PAP41"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1867
                     /gene="Prpsap2"
                     /gene_synonym="A230054F23Rik; PAP41"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1837..1842
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prpsap2"
                     /gene_synonym="A230054F23Rik; PAP41"
                     /note="hexamer: AATAAA"
     polyA_site      1863
                     /gene="Prpsap2"
                     /gene_synonym="A230054F23Rik; PAP41"
                     /note="major polyA site"
ORIGIN      
        1 gcccctggcc tcgcagtctc gaaagacttt ctcgcgctta gagtcgccat tttgctgtaa
       61 gacgccgtgc ggagctctgt gctctcttcc ttcggcagcc gaggctgcgg cgggccgggc
      121 tggggtcggg accaggagga attttgttgt cagagaataa caggaggttg tccataattg
      181 actttaagca gcaaacagta aaacactgag ctcttcagct ccgcctttct tgctctgaga
      241 attggaaagc caagaaggtt ttgatgtttt gtgtggcgcc tcctgaatta gaaaccaaga
      301 tgaacataac caaaggaggc ctcgtgttgt tttcagcaaa ttccaattca tcatgtatgg
      361 agctttcaaa gaaaattgct gagcggctgg gggtggagat gggcaaagtg caggtttacc
      421 aggaacctaa cagagaaaca agagttcaaa tccaggagtc tgtgagagga aaagatgtat
      481 ttatcatcca aaccatctca aaggacgtga acaccaccat catggagctg ctgatcatgg
      541 tatatgcatg taagacctca tgtgccaaga gcatcatcgg agtgatcccc tactttcctt
      601 atagcaagca atgcaaaatg agaaaaaggg gctccattgt ctcaaaattg ctggcttcta
      661 tgatgtgcaa agctggtctg actcatctca tcactatgga tttacaccag aaggaaatcc
      721 agggcttctt caatattcca gtggataatt taagagcctc cccattcctg ttacaatata
      781 ttcaagaaga gatcccagat tataggaatg cagtcatcgt ggccaagtct ccagcctcag
      841 ccaagagggc acaatctttt gcagagcgtc tacgtctggg aatcgcagtg atccatggag
      901 aagcacagga tgctgagtct gacttggtgg atggccggca ctccccacca atggtcagga
      961 gtgtagctgc catccatccc agcctggaga tcccgatgct gattcctaaa gagaagcccc
     1021 caatcacagt tgttggtgat gttggaggaa gaatcgccat cattgtggat gacattattg
     1081 atgatgtgga tagctttctt gctgcagcag agaccctgaa ggaaagaggt gcatacaaga
     1141 tctttgtgat ggccactcac ggcttgttat cctctgatgc tccccggctg attgaagagt
     1201 ctgccattga tgaggtggtg gtcactaaca cgatcccaca cgagatccag aagctgcagt
     1261 gccccaagat caagactgtg gacatcagca tgatcctctc agaagccatc cgccgaattc
     1321 acaacgggga gtccatgtcc taccttttca gaaacatagg cttagatgac tgaacagttc
     1381 tcctatggta gaactcccac aggtcaagtg ggagcccagc gtgtacgctg ggagggccca
     1441 tgcccggcca gacacacgtg accctccctt tcccacatct tcctcattca ttcctgtgaa
     1501 ggtacaagga ccagcttttt aatgttggtt taggtttttg tgagttttag gggtaatttt
     1561 tataacagaa agacctcctc tgaaatgaaa gaagttaaaa cctgattgtt tttagtgtaa
     1621 ccattttaaa taatacactt gtgagatttt taagctcagc ctttttttaa agttgcttga
     1681 tccaactgtt caaaagaatt aaataaaatg atctgctgtc tactacctag aatcaaaaag
     1741 ctactgttgg ttccaacaca tgaccttttt aggaacgctt ttataaatgg gcatatagag
     1801 tatgtggctg tatttatttt ctgcaactaa aaaaagaata aaaccttgtg tttgtttttt
     1861 aaacctc
//
