LOCUS       NM_021463               1998 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus phosphoribosyl pyrophosphate synthetase 1 (Prps1),
            mRNA.
ACCESSION   NM_021463 XM_977960
VERSION     NM_021463.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1998)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1998)
  AUTHORS   Zhao,K., Huang,X., Zhao,W., Lu,B. and Yang,Z.
  TITLE     LONP1-mediated mitochondrial quality control safeguards metabolic
            shifts in heart development
  JOURNAL   Development 149 (6) (2022)
   PUBMED   35237793
REFERENCE   3  (bases 1 to 1998)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1998)
  AUTHORS   Mateos,J., Fafian-Labora,J., Morente-Lopez,M.,
            Lesende-Rodriguez,I., Monserrat,L., Odena,M.A., Oliveira,E., de
            Toro,J. and Arufe,M.C.
  TITLE     Next-Generation Sequencing and Quantitative Proteomics of
            Hutchinson-Gilford progeria syndrome-derived cells point to a role
            of nucleotide metabolism in premature aging
  JOURNAL   PLoS One 13 (10), e0205878 (2018)
   PUBMED   30379953
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1998)
  AUTHORS   Bulusu,V., Prior,N., Snaebjornsson,M.T., Kuehne,A., Sonnen,K.F.,
            Kress,J., Stein,F., Schultz,C., Sauer,U. and Aulehla,A.
  TITLE     Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to
            Mouse Embryo Mesoderm Development
  JOURNAL   Dev Cell 40 (4), 331-341 (2017)
   PUBMED   28245920
REFERENCE   6  (bases 1 to 1998)
  AUTHORS   Dinulos,M.B., Bassi,M.T., Rugarli,E.I., Chapman,V., Ballabio,A. and
            Disteche,C.M.
  TITLE     A new region of conservation is defined between human and mouse X
            chromosomes
  JOURNAL   Genomics 35 (1), 244-247 (1996)
   PUBMED   8661129
REFERENCE   7  (bases 1 to 1998)
  AUTHORS   Sultana,R., Adler,D.A., Edelhoff,S., Carrel,L., Lee,K.H.,
            Chapman,V.C., Willard,H.F. and Disteche,C.M.
  TITLE     The mouse Sb1.8 gene located at the distal end of the X chromosome
            is subject to X inactivation
  JOURNAL   Hum Mol Genet 4 (2), 257-263 (1995)
   PUBMED   7757076
REFERENCE   8  (bases 1 to 1998)
  AUTHORS   Chapman,V.M., Keitz,B.T. and Bishop,D.F.
  TITLE     Genetic linkage of the erythroid-specific delta-aminolevulinate
            synthase gene (Alas2) to the distal region of the mouse X
            chromosome
  JOURNAL   Mamm Genome 5 (11), 741 (1994)
   PUBMED   7873890
REFERENCE   9  (bases 1 to 1998)
  AUTHORS   Lee,K., Keitz,B., Taira,M. and Chapman,V.M.
  TITLE     Linkage of phosphoribosylpyrophosphate synthetases 1 and 2, Prps1
            and Prps2, on the mouse X chromosome
  JOURNAL   Mamm Genome 5 (10), 612-615 (1994)
   PUBMED   7849396
REFERENCE   10 (bases 1 to 1998)
  AUTHORS   Taira,M., Iizasa,T., Yamada,K., Shimada,H. and Tatibana,M.
  TITLE     Tissue-differential expression of two distinct genes for
            phosphoribosyl pyrophosphate synthetase and existence of the
            testis-specific transcript
  JOURNAL   Biochim Biophys Acta 1007 (2), 203-208 (1989)
   PUBMED   2537655
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY003422.1, AK166856.1 and BC054772.1.
            
            On Oct 21, 2009 this sequence version replaced NM_021463.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054772.1, AK089009.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                BY003422.1         2-23
            23-1974             AK166856.1         2-1953
            1975-1998           BC054772.1         1926-1949
FEATURES             Location/Qualifiers
     source          1..1998
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 61.35 cM"
     gene            1..1998
                     /gene="Prps1"
                     /gene_synonym="2310010D17Rik; Prps-1; PRS-I"
                     /note="phosphoribosyl pyrophosphate synthetase 1"
                     /db_xref="GeneID:19139"
                     /db_xref="MGI:MGI:97775"
     exon            1..261
                     /gene="Prps1"
                     /gene_synonym="2310010D17Rik; Prps-1; PRS-I"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..1096
                     /gene="Prps1"
                     /gene_synonym="2310010D17Rik; Prps-1; PRS-I"
                     /EC_number="2.7.6.1"
                     /note="phosphoribosyl pyrophosphate synthetase I;
                     phosphoribosyl pyrophosphate synthase I"
                     /codon_start=1
                     /product="ribose-phosphate pyrophosphokinase 1"
                     /protein_id="NP_067438.1"
                     /db_xref="CCDS:CCDS30439.1"
                     /db_xref="GeneID:19139"
                     /db_xref="MGI:MGI:97775"
                     /translation="MPNIKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEI
                     GESVRGEDVYIVQSGCGEINDNLMELLIMINACKIASASRVTAVIPCFPYARQDKKDK
                     SRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIRENIS
                     EWRNCTIVSPDAGGAKRVTSIADRLNVDFALIHKERKKANEVDRMVLVGDVKDRVAIL
                     VDDMADTCGTICHAADKLLSAGATRVYAILTHGIFSGPAISRINNACFEAVVVTNTIP
                     QEDKMKHCSKIQVIDISMILAEAIRRTHNGESVSYLFSHVPL"
     exon            262..445
                     /gene="Prps1"
                     /gene_synonym="2310010D17Rik; Prps-1; PRS-I"
                     /inference="alignment:Splign:2.1.0"
     exon            446..544
                     /gene="Prps1"
                     /gene_synonym="2310010D17Rik; Prps-1; PRS-I"
                     /inference="alignment:Splign:2.1.0"
     exon            545..669
                     /gene="Prps1"
                     /gene_synonym="2310010D17Rik; Prps-1; PRS-I"
                     /inference="alignment:Splign:2.1.0"
     exon            670..843
                     /gene="Prps1"
                     /gene_synonym="2310010D17Rik; Prps-1; PRS-I"
                     /inference="alignment:Splign:2.1.0"
     exon            844..1003
                     /gene="Prps1"
                     /gene_synonym="2310010D17Rik; Prps-1; PRS-I"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1975
                     /gene="Prps1"
                     /gene_synonym="2310010D17Rik; Prps-1; PRS-I"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1952..1957
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prps1"
                     /gene_synonym="2310010D17Rik; Prps-1; PRS-I"
                     /note="hexamer: AATAAA"
     polyA_site      1975
                     /gene="Prps1"
                     /gene_synonym="2310010D17Rik; Prps-1; PRS-I"
                     /note="major polyA site"
ORIGIN      
        1 gccgcgcgct gggcgggaat gtaagatggc ggagtagcaa cgcggtactg ttggtgttca
       61 gactgcctgc tgacttccgt tcccgtgttg gcagcggcgg cggcggcgac cactgagcac
      121 gttgaggtag ttacccaaga tgccgaatat caaaatcttc agcgggagct cccaccagga
      181 cttatcccag aaaatcgctg accgcctggg ccttgagcta ggcaaggtgg tgactaagaa
      241 attcagcaac caggagacct gtgtggaaat tggcgaaagc gttcgtggag aagatgtcta
      301 cattgttcaa agtgggtgtg gtgagataaa tgacaatcta atggagcttt tgatcatgat
      361 taatgcttgt aagatcgctt cagccagccg ggttactgca gtcatcccat gcttccctta
      421 cgcccgccaa gataagaagg ataagagccg ggctccaatc tcagctaagc ttgttgcaaa
      481 tatgctatct gtagcaggtg cagatcatat tatcaccatg gatctacatg catctcaaat
      541 tcagggtttc tttgatatcc cggtggacaa tttatatgca gagccagctg tcctaaagtg
      601 gatacgggag aatatatctg agtggagaaa ctgtactatt gtctcacctg atgctggtgg
      661 agccaaaaga gtgacctcca ttgcagaccg gctgaatgtg gattttgctt tgattcacaa
      721 ggaacggaag aaggccaatg aagtggaccg catggtactt gtgggagatg tgaaggaccg
      781 tgtggctata cttgtggatg acatggctga cacttgcggt acaatctgtc acgccgctga
      841 caaacttctc tcagctggcg ctaccagagt ttatgctatc ttgacgcatg gaatcttttc
      901 tggccctgcc atttctcgaa tcaacaatgc atgctttgaa gcagtagtag ttaccaatac
      961 catacctcag gaggacaaga tgaaacactg ctccaagata caggtgattg acatctctat
     1021 gatccttgca gaagccatca ggagaaccca caatggagaa tctgtctcct acttgttcag
     1081 ccatgttcct ttataacata acttctgaag cattttgaaa ataaaccaac cccacccctt
     1141 gtttttcttg gtattggtga gttgagcaga agacccagct tgcttcagta tagctttttc
     1201 catctcacat tagctatatt accatttgtc ctaaatggga gaaagacaga ttgctattag
     1261 ctgctaggat gttcaacctg cattgttgta tcctggcttt cttgtttatt ttgtgaacct
     1321 tgcagcttta agttgagctc agctcttgaa aggtgtatag actgttaaga gagtattcca
     1381 caaggtcctt aggacgtgat tggcaaagct catactccat tgcatgtgaa cgctttgggg
     1441 ttttcgtcat tcagaataac tagcaacaaa gccagcccat gtgtaataca ttttcagagg
     1501 tctgcagcaa gaaccctgag catccttaaa catagttgag catcctgtaa ggcaggggca
     1561 ggtagctcaa tgcagtaatt aggttttggg aggaagaagc ctgatccatt gctatttaac
     1621 tcttctctat ctcgcttgga ttctctacac ctattccttt ccagttggct ttacctttag
     1681 ctattgtgac cctttcctgg ccaaatatct tggactcagt gatcattgta acaatatctt
     1741 cggtaataca gacttgcttc ttgctatgta actgctaaca ttcacattag gtaacttgct
     1801 gtagcacgac cttccttagc ctactacctc tgaggtggtg ggtttaggtg gtgtcgcagt
     1861 gccttttgat taatttaagt atttaatttt tatcttcctt ggatccgttt ggcctctcaa
     1921 ttgaacttac tgtattgtgt agaagaaact taataaaatg tctgtcatgt gtgcaaaaaa
     1981 aaaaaaaaaa aaaaaaaa
//
