LOCUS       NM_133701               3071 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus pre-mRNA splicing factor 6 (Prpf6), mRNA.
ACCESSION   NM_133701
VERSION     NM_133701.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3071)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3071)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   3  (bases 1 to 3071)
  AUTHORS   Fan,S., Goto,K., Chen,G., Morinaga,H., Nomura,M., Okabe,T.,
            Nawata,H. and Yanase,T.
  TITLE     Identification of the functional domains of ANT-1, a novel
            coactivator of the androgen receptor
  JOURNAL   Biochem Biophys Res Commun 341 (1), 192-201 (2006)
   PUBMED   16414017
  REMARK    GeneRIF: The existence of these functional domains may further
            support the idea that ANT-1 can function as an AR-AF-1-specific
            coactivator while mediating a transcription-splicing coupling.
REFERENCE   4  (bases 1 to 3071)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3071)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY735790.1, AK081998.1 and CJ228927.1.
            
            On Jan 23, 2007 this sequence version replaced NM_133701.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014869.1, AK145461.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                BY735790.1         1-66
            67-3054             AK081998.1         2-2989
            3055-3071           CJ228927.1         666-682
FEATURES             Location/Qualifiers
     source          1..3071
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 103.67 cM"
     gene            1..3071
                     /gene="Prpf6"
                     /gene_synonym="1190003A07Rik; 2610031L17Rik; ANT-1;
                     U5-102K"
                     /note="pre-mRNA splicing factor 6"
                     /db_xref="GeneID:68879"
                     /db_xref="MGI:MGI:1922946"
     exon            1..213
                     /gene="Prpf6"
                     /gene_synonym="1190003A07Rik; 2610031L17Rik; ANT-1;
                     U5-102K"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..2968
                     /gene="Prpf6"
                     /gene_synonym="1190003A07Rik; 2610031L17Rik; ANT-1;
                     U5-102K"
                     /note="PRP6 homolog; U5-102 kDa protein; U5
                     snRNP-associated 102 kDa protein; PRP6 pre-mRNA splicing
                     factor 6 homolog"
                     /codon_start=1
                     /product="pre-mRNA-processing factor 6"
                     /protein_id="NP_598462.1"
                     /db_xref="CCDS:CCDS38381.1"
                     /db_xref="GeneID:68879"
                     /db_xref="MGI:MGI:1922946"
                     /translation="MNKKKKPFLGMPAPLGYVPGLGRGATGFTTRSDIGPARDANDPV
                     DDRHAPPGKRTVGDQMKKNQAADDDDEDLNDTNYDEFNGYAGSLFSSGPYEKDDEEAD
                     AIYAALDKRMDERRKERREQREKEEIEKYRMERPKIQQQFSDLKRKLAEVTEEEWLSI
                     PEVGDARNKRQRNPRYEKLTPVPDSFFAKHLQTGENHTSVDPRQTQFGGLNTPYPGGL
                     NTPYPGGMTPGLMTPGTGELDMRKIGQARNTLMDMRLSQVSDSVSGQTVVDPKGYLTD
                     LNSMIPTHGGDINDIKKARLLLKSVRETNPHHPPAWIASARLEEVTGKLQVARNLIMK
                     GTEMCPKSEDVWLEAARLQPGDTAKAVVAQAVRHLPQSVRIYIRAAELETDIRAKKRV
                     LRKALEHVPNSVRLWKAAVELEEPEDARIMLSRAVECCPTSVELWLALARLETYENAR
                     KVLNKARENIPTDRHIWITAAKLEEANGNTQMVEKIIDRAITSLRANGVEINREQWIQ
                     DAEECDRAGSVATCQAVMRAVIGIGIEEEDRKHTWMEDADSCVAHNALECARAIYAYA
                     LQVFPSKKSVWLRAAYFEKNHGTRESLEALLQRAVAHCPKAEVLWLMGAKSKWLAGDV
                     PAARSILALAFQANPNSEEIWLAAVKLESENNEYERARRLLAKARSSAPTARVFMKSV
                     KLEWVLGNISAAQELCEEALRHYEDFPKLWMMKGQIEEQGELMEKAREAYNQGLKKCP
                     HSTPLWLLLSRLEEKIGQLTRARAILEKSRLKNPKNPGLWLESVRLEYRAGLKNIANT
                     LMAKALQECPNSGILWSEAVFLEARPQRKTKSVDALKKCEHDPHVLLAVAKLFWSERK
                     ITKAREWFHRTVKIDSDLGDAWAFFYKFELQHGTEEQQEEVRKRCENAEPRHGELWCA
                     VSKDITNWQRKIGEILVLVAARIKNTF"
     exon            214..382
                     /gene="Prpf6"
                     /gene_synonym="1190003A07Rik; 2610031L17Rik; ANT-1;
                     U5-102K"
                     /inference="alignment:Splign:2.1.0"
     exon            383..501
                     /gene="Prpf6"
                     /gene_synonym="1190003A07Rik; 2610031L17Rik; ANT-1;
                     U5-102K"
                     /inference="alignment:Splign:2.1.0"
     exon            502..580
                     /gene="Prpf6"
                     /gene_synonym="1190003A07Rik; 2610031L17Rik; ANT-1;
                     U5-102K"
                     /inference="alignment:Splign:2.1.0"
     exon            581..757
                     /gene="Prpf6"
                     /gene_synonym="1190003A07Rik; 2610031L17Rik; ANT-1;
                     U5-102K"
                     /inference="alignment:Splign:2.1.0"
     exon            758..913
                     /gene="Prpf6"
                     /gene_synonym="1190003A07Rik; 2610031L17Rik; ANT-1;
                     U5-102K"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1008
                     /gene="Prpf6"
                     /gene_synonym="1190003A07Rik; 2610031L17Rik; ANT-1;
                     U5-102K"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1165
                     /gene="Prpf6"
                     /gene_synonym="1190003A07Rik; 2610031L17Rik; ANT-1;
                     U5-102K"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1328
                     /gene="Prpf6"
                     /gene_synonym="1190003A07Rik; 2610031L17Rik; ANT-1;
                     U5-102K"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1447
                     /gene="Prpf6"
                     /gene_synonym="1190003A07Rik; 2610031L17Rik; ANT-1;
                     U5-102K"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1666
                     /gene="Prpf6"
                     /gene_synonym="1190003A07Rik; 2610031L17Rik; ANT-1;
                     U5-102K"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1789
                     /gene="Prpf6"
                     /gene_synonym="1190003A07Rik; 2610031L17Rik; ANT-1;
                     U5-102K"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1911
                     /gene="Prpf6"
                     /gene_synonym="1190003A07Rik; 2610031L17Rik; ANT-1;
                     U5-102K"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..2050
                     /gene="Prpf6"
                     /gene_synonym="1190003A07Rik; 2610031L17Rik; ANT-1;
                     U5-102K"
                     /inference="alignment:Splign:2.1.0"
     exon            2051..2170
                     /gene="Prpf6"
                     /gene_synonym="1190003A07Rik; 2610031L17Rik; ANT-1;
                     U5-102K"
                     /inference="alignment:Splign:2.1.0"
     exon            2171..2347
                     /gene="Prpf6"
                     /gene_synonym="1190003A07Rik; 2610031L17Rik; ANT-1;
                     U5-102K"
                     /inference="alignment:Splign:2.1.0"
     exon            2348..2481
                     /gene="Prpf6"
                     /gene_synonym="1190003A07Rik; 2610031L17Rik; ANT-1;
                     U5-102K"
                     /inference="alignment:Splign:2.1.0"
     exon            2482..2573
                     /gene="Prpf6"
                     /gene_synonym="1190003A07Rik; 2610031L17Rik; ANT-1;
                     U5-102K"
                     /inference="alignment:Splign:2.1.0"
     exon            2574..2688
                     /gene="Prpf6"
                     /gene_synonym="1190003A07Rik; 2610031L17Rik; ANT-1;
                     U5-102K"
                     /inference="alignment:Splign:2.1.0"
     exon            2689..2815
                     /gene="Prpf6"
                     /gene_synonym="1190003A07Rik; 2610031L17Rik; ANT-1;
                     U5-102K"
                     /inference="alignment:Splign:2.1.0"
     exon            2816..3055
                     /gene="Prpf6"
                     /gene_synonym="1190003A07Rik; 2610031L17Rik; ANT-1;
                     U5-102K"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3034..3039
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prpf6"
                     /gene_synonym="1190003A07Rik; 2610031L17Rik; ANT-1;
                     U5-102K"
                     /note="hexamer: ATTAAA"
     polyA_site      3055
                     /gene="Prpf6"
                     /gene_synonym="1190003A07Rik; 2610031L17Rik; ANT-1;
                     U5-102K"
                     /note="major polyA site"
ORIGIN      
        1 tttccgtgac ccagctctct acttccggtg cgcgggtgac gtagtgcctg catctcttac
       61 tgctgcgaca cccggaggac tctgagtctt ctgtcgtata cttgctcccc tgcttttctg
      121 tgtttcggtc aataacaccg ccatgaacaa gaagaagaag ccgttcctgg gcatgcctgc
      181 gccgctgggc tacgtacccg ggctgggcag gggtgccact ggcttcacca cccgatcaga
      241 catcgggcct gctcgggatg caaatgatcc tgtggatgat cgccatgccc caccagggaa
      301 gagaactgtg ggggaccaga tgaagaaaaa tcaggcggct gatgatgatg atgaagatct
      361 gaatgatacc aactacgatg agtttaatgg ctatgctggg agcctcttct caagtgggcc
      421 ctatgaaaaa gatgatgagg aagcagatgc tatttatgca gctctggata aaaggatgga
      481 tgagagaaga aaagagagaa gagagcaaag ggagaaagaa gagattgaga aataccgaat
      541 ggaacgtccc aaaatccagc agcaattttc agaccttaag aggaagctgg cagaagtcac
      601 agaagaagag tggctgagca tcccagaagt tggcgatgcc agaaacaaac gtcaacggaa
      661 cccacgttat gagaagctga ctcctgttcc tgatagtttc tttgccaaac atttacagac
      721 tggagagaac catacttctg tggatccccg acagactcaa tttggaggtc tgaacacacc
      781 ctacccggga ggcctgaaca ctccataccc aggtggaatg acacctggat tgatgacacc
      841 tggtacaggg gagctggaca tgaggaagat tggccaggca aggaataccc tgatggacat
      901 gaggcttagc caggtatctg actcagtgag tgggcagact gttgtggacc ccaaaggcta
      961 cctgacagat ctaaattcca tgatcccaac ccatggcggg gacataaatg acatcaagaa
     1021 agcacgacta cttctcaaat ctgttcgaga aacaaaccct catcacccac cagcttggat
     1081 tgcatcagct cgcctggaag aagtcactgg aaagttacaa gtagctcgaa accttattat
     1141 gaaagggaca gagatgtgcc ccaagagtga agatgtctgg ctagaagcag ctaggttaca
     1201 gcctggggac acagccaagg ctgtggtggc acaagctgtc cgtcatctcc cgcagtctgt
     1261 taggatttac atcagagcag cagagctaga aacagacatt cgagcaaaga agcgtgttct
     1321 tcggaaagca cttgagcatg ttccaaactc tgttcgattg tggaaagcag ctgttgagct
     1381 tgaagagcct gaagatgcta gaatcatgct gagccgagca gtagagtgct gtcccaccag
     1441 tgtagagcta tggcttgctt tggcaagact agaaacttat gaaaatgctc gcaaggtctt
     1501 aaataaagca cgtgagaaca ttcctacaga tcggcacatc tggatcacag ctgccaaact
     1561 ggaggaggcc aatgggaaca ctcagatggt ggaaaagatc attgaccgag ccatcacctc
     1621 cctacgggcc aatggtgtag agatcaaccg cgaacagtgg atccaggatg ctgaggagtg
     1681 tgacagggca gggagtgtgg ccacgtgcca ggctgtcatg cgtgctgtaa tcggtattgg
     1741 gattgaggag gaagatcgca aacacacctg gatggaagac gctgacagtt gtgtggccca
     1801 caatgccctg gagtgtgcac gagccatata tgcctatgcc ctacaagtct tccccagcaa
     1861 gaaaagtgtg tggttacgag ctgcctactt tgagaagaat catggtacca gggagtctct
     1921 ggaagcactc ttgcagaggg ctgtagccca ctgccccaag gcagaggtgc tatggctcat
     1981 gggtgccaag tcaaagtggc tggcagggga tgtacctgca gcaaggagca tcctggccct
     2041 ggcctttcag gccaacccca acagcgaaga gatctggttg gcggctgtga agctggagtc
     2101 agagaacaat gaatacgagc gagcccggag gctactggcc aaggctcgga gcagcgcacc
     2161 cactgcccgt gtattcatga agtctgtgaa gctggagtgg gttctgggga acatctctgc
     2221 ggcgcaggag ctgtgtgagg aggctctgag gcactatgaa gatttcccca agctgtggat
     2281 gatgaagggg cagattgagg agcagggaga actgatggag aaggcccggg aggcctacaa
     2341 ccaggggctg aagaaatgtc ctcattccac accgctttgg ctcttgcttt cccgactaga
     2401 ggaaaagatt gggcagctga cacgtgctcg ggccatttta gagaaatctc gtctgaaaaa
     2461 cccaaagaac cctgggctat ggttggagtc agtgcggctg gagtaccggg cagggctgaa
     2521 gaacattgcc aataccctca tggccaaggc gctgcaggag tgccctaact ctggtatcct
     2581 gtggtctgaa gctgtcttcc ttgaggcaag gccccagaga aagaccaaga gtgtggatgc
     2641 cctgaagaag tgtgaacatg acccccatgt gcttttagct gtggctaagt tgttctggag
     2701 tgaaagaaag atcaccaagg ctcgggagtg gttccatcgc actgtgaaga ttgactcaga
     2761 tctgggggat gcctgggcct tcttctacaa atttgaactg cagcatggaa ctgaggagca
     2821 acaggaggag gtgaggaaac gctgtgagaa tgcagagccc cgacatggag agctgtggtg
     2881 tgctgtgtcc aaggatatca ccaactggca gaggaagatt ggggaaatcc tagtcctggt
     2941 ggccgcccgc atcaaaaata ccttctgata ggaggggtga caataggagc aacacatgga
     3001 caatgggcac aaaccctaca ctgtctttta ctcattaaag gtttttatag agttaaaaaa
     3061 aaaaaaaaaa a
//
