LOCUS       NM_013830               7617 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus pre-mRNA processing factor 4B (Prpf4b), transcript
            variant 1, mRNA.
ACCESSION   NM_013830
VERSION     NM_013830.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7617)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7617)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7617)
  AUTHORS   Kumar,A. and Thakur,M.K.
  TITLE     Analysis of Presenilin 1 and 2 interacting proteins in mouse
            cerebral cortex during development
  JOURNAL   Int J Dev Neurosci 38, 138-146 (2014)
   PUBMED   25196998
REFERENCE   4  (bases 1 to 7617)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   5  (bases 1 to 7617)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7617)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 7617)
  AUTHORS   Dellaire,G., Makarov,E.M., Cowger,J.J., Longman,D.,
            Sutherland,H.G., Luhrmann,R., Torchia,J. and Bickmore,W.A.
  TITLE     Mammalian PRP4 kinase copurifies and interacts with components of
            both the U5 snRNP and the N-CoR deacetylase complexes
  JOURNAL   Mol Cell Biol 22 (14), 5141-5156 (2002)
   PUBMED   12077342
  REMARK    GeneRIF: Mammalian PRP4 kinase copurifies and interacts with
            components of both the U5 snRNP and the N-CoR deacetylase
            complexes.
REFERENCE   8  (bases 1 to 7617)
  AUTHORS   Kojima,T., Zama,T., Wada,K., Onogi,H. and Hagiwara,M.
  TITLE     Cloning of human PRP4 reveals interaction with Clk1
  JOURNAL   J Biol Chem 276 (34), 32247-32256 (2001)
   PUBMED   11418604
REFERENCE   9  (bases 1 to 7617)
  AUTHORS   Tate,P., Lee,M., Tweedie,S., Skarnes,W.C. and Bickmore,W.A.
  TITLE     Capturing novel mouse genes encoding chromosomal and other nuclear
            proteins
  JOURNAL   J Cell Sci 111 (Pt 17), 2575-2585 (1998)
   PUBMED   9701556
REFERENCE   10 (bases 1 to 7617)
  AUTHORS   Gross,T., Lutzelberger,M., Weigmann,H., Klingenhoff,A., Shenoy,S.
            and Kaufer,N.F.
  TITLE     Functional analysis of the fission yeast Prp4 protein kinase
            involved in pre-mRNA splicing and isolation of a putative mammalian
            homologue
  JOURNAL   Nucleic Acids Res 25 (5), 1028-1035 (1997)
   PUBMED   9102632
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132344.3 and AC124537.5.
            
            On Dec 12, 2019 this sequence version replaced NM_013830.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF283466.1, BC080864.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-166               AC132344.3         14314-14479         c
            167-1363            AC132344.3         5581-6777           c
            1364-1537           AC132344.3         3165-3338           c
            1538-1693           AC132344.3         1729-1884           c
            1694-1775           AC132344.3         415-496             c
            1776-1986           AC124537.5         144797-145007       c
            1987-2060           AC124537.5         143339-143412       c
            2061-2151           AC124537.5         141651-141741       c
            2152-2299           AC124537.5         140920-141067       c
            2300-2437           AC124537.5         140046-140183       c
            2438-2591           AC124537.5         139382-139535       c
            2592-2706           AC124537.5         136279-136393       c
            2707-2858           AC124537.5         135520-135671       c
            2859-2945           AC124537.5         135052-135138       c
            2946-7617           AC124537.5         129438-134109       c
FEATURES             Location/Qualifiers
     source          1..7617
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 14.21 cM"
     gene            1..7617
                     /gene="Prpf4b"
                     /gene_synonym="2610037H07; cbp143; Prp4; Prp4k; Prpk"
                     /note="pre-mRNA processing factor 4B"
                     /db_xref="GeneID:19134"
                     /db_xref="MGI:MGI:109584"
     exon            1..166
                     /gene="Prpf4b"
                     /gene_synonym="2610037H07; cbp143; Prp4; Prp4k; Prpk"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..3149
                     /gene="Prpf4b"
                     /gene_synonym="2610037H07; cbp143; Prp4; Prp4k; Prpk"
                     /EC_number="2.7.11.1"
                     /note="PRP4 pre-mRNA-processing factor 4 homolog; pre-mRNA
                     protein kinase; PRP4 pre-mRNA processing factor 4 homolog
                     B"
                     /codon_start=1
                     /product="serine/threonine-protein kinase PRP4 homolog"
                     /protein_id="NP_038858.2"
                     /db_xref="CCDS:CCDS26448.1"
                     /db_xref="GeneID:19134"
                     /db_xref="MGI:MGI:109584"
                     /translation="MAATEPPSLREQAEMDDADNSEKSVNEENGEVSEDQSQNKHSRH
                     KKKKHKHRSKHKKHKHSSEEDRDKKHKHKHKHKKHKRKEVIEASDKEGLSPAKRTKLD
                     DLALLEDLEKQRALIKAELDNELMEGKVQSGMGLILQGYESGSEEEGEIHEKARNGNR
                     SSTRSSSTRGKLEITDNKNSAKKRSKSRSKERTRHRSDKRKSKGAGEMLREKANRSKS
                     KERRKSKSPSKRSKSQDQARKSKSPPLRRRSQEKVGKARSPAEEKMKSEEKGKIKDRK
                     KSPIVNERSRDRSKKSKSPVDLRDKSKDRRSRSKERKSKRSEIDKEKKPIKSPSKDAS
                     SGKENRSPSRRPGRSPKRRSLSPKLRDKSRRSRSPLLNDRRSKQSKSPSRTLSPGRRA
                     KSRSLERKRREPERRRLSSPRTRPRDDILGRCERSKDASPINRWSPTRRRSRSPIRRR
                     SRSPLRRSRSPRRRSRSPRRRDRSRRSRSRLRRRSRSRGGHRRRSRSKVKEDKFKGSL
                     SEGMKVEQESSSDDNLEDFDVEEEDEEALIEQRRIQRQAIVQKYKYLAEDSNISVPSE
                     PSSPQSSTRSRSPSPDDILERVAADVKEYERENVDTFEASVKAKHNLMTVEQNNGSSQ
                     KKILAPDMFTESDDMFAAYFDSARLRAAGIGKDFKENPNLRDNWTDAEGYYRVNIGEV
                     LDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLN
                     DADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQ
                     LFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADNDITPYLVSRFYR
                     APEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIR
                     KGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRKK
                     VHQLKDLLDQILMLDPAKRISINQALQHAFIQEKI"
     exon            167..1363
                     /gene="Prpf4b"
                     /gene_synonym="2610037H07; cbp143; Prp4; Prp4k; Prpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1537
                     /gene="Prpf4b"
                     /gene_synonym="2610037H07; cbp143; Prp4; Prp4k; Prpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1693
                     /gene="Prpf4b"
                     /gene_synonym="2610037H07; cbp143; Prp4; Prp4k; Prpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1775
                     /gene="Prpf4b"
                     /gene_synonym="2610037H07; cbp143; Prp4; Prp4k; Prpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..1986
                     /gene="Prpf4b"
                     /gene_synonym="2610037H07; cbp143; Prp4; Prp4k; Prpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1987..2060
                     /gene="Prpf4b"
                     /gene_synonym="2610037H07; cbp143; Prp4; Prp4k; Prpk"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2151
                     /gene="Prpf4b"
                     /gene_synonym="2610037H07; cbp143; Prp4; Prp4k; Prpk"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2299
                     /gene="Prpf4b"
                     /gene_synonym="2610037H07; cbp143; Prp4; Prp4k; Prpk"
                     /inference="alignment:Splign:2.1.0"
     exon            2300..2437
                     /gene="Prpf4b"
                     /gene_synonym="2610037H07; cbp143; Prp4; Prp4k; Prpk"
                     /inference="alignment:Splign:2.1.0"
     exon            2438..2591
                     /gene="Prpf4b"
                     /gene_synonym="2610037H07; cbp143; Prp4; Prp4k; Prpk"
                     /inference="alignment:Splign:2.1.0"
     exon            2592..2706
                     /gene="Prpf4b"
                     /gene_synonym="2610037H07; cbp143; Prp4; Prp4k; Prpk"
                     /inference="alignment:Splign:2.1.0"
     exon            2707..2858
                     /gene="Prpf4b"
                     /gene_synonym="2610037H07; cbp143; Prp4; Prp4k; Prpk"
                     /inference="alignment:Splign:2.1.0"
     exon            2859..2945
                     /gene="Prpf4b"
                     /gene_synonym="2610037H07; cbp143; Prp4; Prp4k; Prpk"
                     /inference="alignment:Splign:2.1.0"
     exon            2946..7617
                     /gene="Prpf4b"
                     /gene_synonym="2610037H07; cbp143; Prp4; Prp4k; Prpk"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4407..4412
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prpf4b"
                     /gene_synonym="2610037H07; cbp143; Prp4; Prp4k; Prpk"
                     /note="hexamer: AATAAA"
     polyA_site      4429
                     /gene="Prpf4b"
                     /gene_synonym="2610037H07; cbp143; Prp4; Prp4k; Prpk"
     regulatory      7594..7599
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prpf4b"
                     /gene_synonym="2610037H07; cbp143; Prp4; Prp4k; Prpk"
                     /note="hexamer: AATAAA"
     polyA_site      7617
                     /gene="Prpf4b"
                     /gene_synonym="2610037H07; cbp143; Prp4; Prp4k; Prpk"
                     /note="major polyA site"
ORIGIN      
        1 gagtgccgct tttctctacg tgctccgcac atgcgcggct gcctgtccct tcttcctccg
       61 cttccactgg cgtccacggt tcgccgagcc gccgccagca tcgcggagga gtcgggaagt
      121 tcaagatggc cgccacggag cccccgtccc tgcgggagca agctgagatg gatgatgctg
      181 ataattctga aaagagtgta aatgaagaaa atggagaggt atcagaagac caatctcaaa
      241 ataaacacag tcgtcacaaa aaaaagaagc ataaacacag aagtaaacat aagaaacata
      301 aacattcctc agaagaagat agggataaaa aacacaaaca taagcataag cataagaagc
      361 acaaacggaa agaagttatc gaggcttccg acaaagaagg cctgtcccct gcaaaaagaa
      421 ctaagcttga tgatttagct ttgctggaag acttggaaaa gcagagagcc ttgattaaag
      481 ctgagcttga taatgagtta atggagggga aggtccagtc tggaatgggg ctcattttgc
      541 aaggctatga gtctggctcc gaagaagaag gagagattca cgaaaaggca agaaatggga
      601 acaggtccag taccaggtct tccagtactc ggggaaaact tgaaattacg gacaacaaaa
      661 atagtgcaaa gaaacgaagt aagagcagat ccaaagaacg gaccaggcac agatcggaca
      721 aaaggaaaag caagggggct ggggaaatgc tgagagagaa agcaaacagg agcaagtcca
      781 aggagaggag aaaatccaaa agcccatcca aaagaagcaa gtctcaagac caagctagaa
      841 agtcaaagtc ccctccactc agacggcggt cccaagagaa agtggggaag gccagatctc
      901 ctgctgagga gaagatgaag agtgaagaga aaggcaaaat aaaggatagg aaaaaatcac
      961 caattgtaaa tgaaaggagt cgagatagat ctaaaaaatc caagtcccca gttgacttaa
     1021 gagataaatc caaagacaga aggtcaaggt ccaaagagcg gaagtcaaaa cgatctgaaa
     1081 ttgacaaaga aaagaagcca attaaatcac cttcaaagga tgcttcttct gggaaggaaa
     1141 ataggtcacc cagtagaaga cctggccgta gtcctaaaag aagaagtttg tctccaaaac
     1201 tgcgagacaa gtcaagaaga agtaggtctc cgcttctcaa tgacagaaga tctaagcaga
     1261 gcaaatcgcc ttctcgaact ctgtctccag gcagaagggc caagagccga tccttagaaa
     1321 gaaaacggag agaaccagag aggagacgac tttcttctcc gagaacaaga cctcgagatg
     1381 atatccttgg tagatgtgaa cggtcaaaag atgccagccc catcaatagg tggtctccaa
     1441 cccgaagaag aagtaggtct ccaattagaa ggaggtcccg ttccccattg agacgcagca
     1501 ggtctcctag aagaagaagc aggtctcctc ggagaagaga taggagccga aggagcaggt
     1561 cacgcttgag gagaaggtct cgatcacggg gtggtcatag gagaaggagc agaagcaaag
     1621 taaaggaaga taaatttaaa ggaagtctct cagaaggaat gaaagttgag caagagtctt
     1681 catctgatga taaccttgaa gattttgatg tggaggagga agatgaagag gctctaatag
     1741 aacagagaag aatacagagg caagcaattg tgcagaaata taaatatctt gctgaagata
     1801 gcaatatatc tgtgccatct gagccaagca gcccccagag cagcacaaga tcacgatctc
     1861 cttcgccaga cgacatcttg gagcgagttg ctgctgatgt aaaagaatat gagcgggaga
     1921 atgttgacac ctttgaggcc tcagtaaaag ccaagcataa tctaatgaca gttgaacaga
     1981 ataatggctc atctcagaag aagattttgg cacctgacat gtttacagaa tctgatgaca
     2041 tgtttgctgc ttattttgat agtgctcgtc tccgagctgc tggcattggg aaagatttca
     2101 aagaaaatcc caacctcaga gataattgga cagatgcaga aggctattac cgtgtgaaca
     2161 tcggggaagt cctagataaa cgttataatg tgtatggcta cactgggcag ggtgtgttca
     2221 gcaatgttgt gcgtgccagg gataatgcga gagccaacca ggaagtggct gtaaagatca
     2281 tcaggaacaa tgaactcatg caaaagactg gtttaaaaga gctagaattc ttgaaaaaac
     2341 ttaatgatgc tgatcctgat gacaagttcc attgcctgcg cctcttcaga cacttttacc
     2401 acaaacagca cctctgtctc gtctttgaac ctctcagtat gaatttgcga gaggtattaa
     2461 aaaaatatgg taaggatgtc ggtctccata ttaaggctgt acgatcgtac agtcagcagt
     2521 tgttcctggc attgaaactc cttaaaagat gtaatatctt acatgcagat atcaaaccgg
     2581 ataatattct ggttaatgaa tccaaaacaa ttttaaaact ttgtgatttt ggatcggcct
     2641 cacatgttgc agataatgac attacgcctt atcttgtcag tagattttat cgtgctccgg
     2701 agatcattat aggtaaaagc tatgactacg gtatcgatat gtggtctgta ggttgtacct
     2761 tatatgaact ctacactgga aaaatcttat tccctggcaa aactaataac catatgttga
     2821 agctcgccat ggaccttaaa ggaaaaatgc caaataagat gatccggaaa ggtgtattca
     2881 aagatcaaca ttttgaccaa aatctgaact tcatgtacat agaggttgat aaagtgacag
     2941 agagggagaa agttactgtc atgagcacca ttaatccaac taaggacctg ttggctgact
     3001 tgattgggtg ccagcgactt cctgaagatc aacgtaaaaa agtacaccag ctaaaggact
     3061 tgttggacca gatcctaatg ttggacccag ctaagcgaat tagcatcaac caggccctgc
     3121 agcatgcatt catccaggaa aaaatttaaa tgagatgaag aaactccaag ggtttgagta
     3181 attaaataca aagactgaag aaatttcaca gcagtttatt attaatgtat ataaacttat
     3241 aaatatttct gcagcaaatt tgaggaagca tgatatattt gaattaacac cgagggtgat
     3301 atttctttta gaaatgttag ttaatctgtt ttgtgtctta tgtgaaattt cactgtagaa
     3361 atgttttaat tgccaagact gcacagaatt acagtgctaa tgtatatggt tgcagttcac
     3421 ataaaagaca aaagcgtctg ttatgagtgg cagtgctggg tggttgattt gtttttagca
     3481 gacttggctt cagtttgctc ttcagataca atggccagca taaatgctgt ttatattcac
     3541 gttttcctag gtgtgtgtgt gcaggccaca gcagcatgcc cttggtgtag tcagtgccga
     3601 agggagtctg ttccttcttg agcctgcctg cagggatgtc tcctctttta aagcaggttg
     3661 tgtacaacat tcagtacact gaaggtaagc taaaccatca acatcaccag tgttttagat
     3721 gttattttat tggaataact gaaaatgagg gatagctttg tggcagaatt ccctgcatgt
     3781 gtgataactg atcttgtttt attttttcgc atcgcaactg tggcatagtt acagtttctg
     3841 ttctgtcatc acatttaaaa ttggaagcat atgcgcttga tggatagagc gccttcagtg
     3901 tactgtttct tatcaacttt actttttttt aaatcaactt gctatagact ttatacattt
     3961 tgttaaatac agttcttagt gacatagaga ctgcatagtt ttcatttact aattaaaatg
     4021 ttgaggccta cttctgaaag tcctcatatt taaaagatag acaacataat gagattttta
     4081 actatttgta tgtcattttg aaagtgtact gctttatggt aaaagtgttt ttcatttgtt
     4141 cattgtttgc attatttgtg atcatgttgt ctttcaatac aggcataaac cttccactct
     4201 tgaacaaagc agctgctttt taaaagcggt aattgcttct ttacctttta tttcttttgt
     4261 aaatgaagct tttcttttaa aatgtgactt taaagtgttg tctattgcat aaacagttga
     4321 cactcactta ctgtaatgag aagattgttc tgcatgggaa gtgggccgtg cagatctctg
     4381 tatgttctca gtatgcatca ctagataata aagtcttttg tgaacaaggc atttgtagcc
     4441 atttttaaaa gattttgtct tcagtgctgg taagtcaggt aaactgtaaa tagttaaagc
     4501 agtctttgtt tttctcctga aaggattacc tgctaaagat gtaactcagt atagccttat
     4561 ttctaaattg tttttaataa ttaaggtctt aattatttca tccagaaaaa gttcttcaaa
     4621 ttttgtcagc tttcagtgta gtgaggttat tcctcagtgt agtaggttat ggggtctaac
     4681 tcaggattta actaatgttt ctgctatttt ctcacttttc cttttgatgg tgcggaaaga
     4741 gaaaaaggaa aacggggcac aggccattcg acgccttctc caaggggtct gatttgctga
     4801 gacaccagct tcaccttctt aacaaggtta tttctgacag catgtgtaga taaacattta
     4861 gcagcaattt aaaacaaaat catgtaaatc ggcttggttt tgcgacacaa aggattgtgt
     4921 atgtttaaga tggtagagag gatttttaaa tcctgtgtaa tctttactgt ttgggagtgg
     4981 gtcaactcac tgtttgtctc cctgaggatt agggaggaca gtaacatctg ggggtttaaa
     5041 tagtaatttt acattgtaaa tgggattttt ttattcaccc aggcacctaa ttacaacaag
     5101 catgcacatt ttggtgcatt caagaatgga atatcagaat agcagcattc tcctggtggg
     5161 ttatgctcca tttaaagaca tgaaatgaac tacacagcca ggaaggtgat agatgagata
     5221 ataaaccacc tctgaaccta cacccgtctc ctcatggtta gacttactaa aataaacaca
     5281 cggcagtttc cagctacagg tagagtgagg ccttttaaac aaggcatcac gggcgcagcg
     5341 tccaccttaa cgatatgggt agggattttc ccaccatgct tactttactt tggtgctaat
     5401 atgctgcata ttcaggtctt ttatagttgt tttcactcaa aatagtaact gctttcttct
     5461 gatgattttc ctggcttcat tttgtagtta tttaataagt tgatttccac tagaaacagt
     5521 tcatcttatg ccttcaaagc ttttgcttgc tctttaaaaa cacaaagttg cttgttactt
     5581 gttctttgtg ttttaggtgc agatcactgg aagatgacgg cagccagaag acatgagcca
     5641 aggtttctgt cccataaaag atcttttcag ttctcattta gtgtgtgtct gacttgtagt
     5701 ttcagcgtta cagtttgggt ttcattgctg tggtataaga acagtgctgt tgtgcccatc
     5761 tgtaaagtgc tccttgtata tcatagttcc tgcagctaca gccttcctcg aaagtaaaaa
     5821 gcaagtttag tcctaaaaag cccacatttc atagctgtca gaattaggtc ctgaagatca
     5881 ctaagaaaaa aaaatagctg ccaggttagt gtacatttga aaataacctg caagttgcat
     5941 gtgctagcca cacctgtaac ctcagcacgc ttggagtgga ggcagaagga tgtggggttc
     6001 aaggtctgcc tggcctatca gagctctttt tttttaatgc tttggcttta agcaggtgcc
     6061 taaatcataa aagtagccta ggtttaacaa gctggtcaac gcctttaata gctgtgcttt
     6121 gttttagttc gttgtgacca actttttagt gtcagagaca taaaatagta atggcaggtg
     6181 ttgtggaggt gagaaaggcg gtactatacc atcatcttcc cgacctttaa ggaaccgggg
     6241 agctgcacta gagaaacgtc cttctgtttg atgtggtaat gtcactgagg tagagtttgc
     6301 agttgtgtaa gacctctctt aggttgaggt cagttgtgaa tgatcctatt ggacagacct
     6361 gcgttcatgt ttctgattag ctgaaaagtc ttcaggggaa gctgacagga agtttacgct
     6421 ttcatacttt atagcagaaa tgacaagaga tcaccaagcc tgagggccat aaaacttttt
     6481 tgtgtttagg aaatttttaa aggcaaattt atgttcttct taggaaataa agaataccaa
     6541 gatatgtgga tattcacgta atcactatat acatgggcaa ttagtccaaa gaccttctaa
     6601 cattattctg ggcagtccat gcactcacct tgaggagggt tcagaaactc ttaagcattt
     6661 tttctggggt caaaggagga gcaggcagcc aggaagcgtt cgtcatgata ggcctcttgg
     6721 cagacttgtt ctccaggacc ttcagatatg agggacttgg gcagttctga agaggagcag
     6781 cattctgtta gaaacgagga ccttccggtg tttgtattta cgctcaagtc ctgattaaca
     6841 acgttctgtt tcttcattcc cagtggctac ttcctcagct attttatttt taaaagacaa
     6901 tgtgattttt attttaccat tgcaattacc atcttttttt tccccccgta acaagattaa
     6961 atttctcagg acacttttgg gatacaaaat acatatttta tggtatgtag cagagttagt
     7021 gaaatgtaat gttctcattt tggccccaga tttgcatttc ttctagtcta ctctggcatc
     7081 atagggagaa atagactcgg aaatgaaaca aaggaattac atgtgttaaa atttaaatta
     7141 tttaggaaat gagtgtgtat tttttggata agattgtata gtgagatgtg acaatatctc
     7201 cttatggtag catttgggcc ctataggtaa tattttgtgg ctcttataca ttcaacatga
     7261 atttattcta catgcaatgt cctaatataa atgttcactg caaatcattt gtaatttttc
     7321 catgtcagtg ttgaatacag ttgactaaga tttgggattt tttgtttttt gtttgttttg
     7381 gggcttcctt gccataccat tgtagcatcc ttactttttc ttcttctgtg tatagggtaa
     7441 gggactgttc ttctgaagag ccattccatt tagtgatcaa gatacggaag ctgacctaag
     7501 aaaatgttgt gtattctaat tgttcttgat accatttgag ttgtaactta cgttgtagca
     7561 gcaaatgatc ccaaactact taataggaag cttaataaag tgtgcctctt gctacca
//
