LOCUS       NM_018785               7405 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus pre-mRNA processing factor 40A (Prpf40a), transcript
            variant 2, mRNA.
ACCESSION   NM_018785
VERSION     NM_018785.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7405)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7405)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7405)
  AUTHORS   Ramirez-Espain,X., Ruiz,L., Martin-Malpartida,P., Oschkinat,H. and
            Macias,M.J.
  TITLE     Structural characterization of a new binding motif and a novel
            binding mode in group 2 WW domains
  JOURNAL   J Mol Biol 373 (5), 1255-1268 (2007)
   PUBMED   17915251
REFERENCE   4  (bases 1 to 7405)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7405)
  AUTHORS   Sayer,J.A., Manczak,M., Akileswaran,L., Reddy,P.H. and Coghlan,V.M.
  TITLE     Interaction of the nuclear matrix protein NAKAP with HypA and
            huntingtin: implications for nuclear toxicity in Huntington's
            disease pathogenesis
  JOURNAL   Neuromolecular Med 7 (4), 297-310 (2005)
   PUBMED   16391387
REFERENCE   6  (bases 1 to 7405)
  AUTHORS   Mizutani,K., Suetsugu,S. and Takenawa,T.
  TITLE     FBP11 regulates nuclear localization of N-WASP and inhibits
            N-WASP-dependent microspike formation
  JOURNAL   Biochem Biophys Res Commun 313 (3), 468-474 (2004)
   PUBMED   14697212
  REMARK    GeneRIF: FBP11 regulates localization of N-WASP, thus negatively
            regulating the function of N-WASP in the cytoplasm
REFERENCE   7  (bases 1 to 7405)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 7405)
  AUTHORS   Hilditch-Maguire,P., Trettel,F., Passani,L.A., Auerbach,A.,
            Persichetti,F. and MacDonald,M.E.
  TITLE     Huntingtin: an iron-regulated protein essential for normal nuclear
            and perinuclear organelles
  JOURNAL   Hum Mol Genet 9 (19), 2789-2797 (2000)
   PUBMED   11092755
REFERENCE   9  (bases 1 to 7405)
  AUTHORS   Bedford,M.T., Chan,D.C. and Leder,P.
  TITLE     FBP WW domains and the Abl SH3 domain bind to a specific class of
            proline-rich ligands
  JOURNAL   EMBO J 16 (9), 2376-2383 (1997)
   PUBMED   9171351
REFERENCE   10 (bases 1 to 7405)
  AUTHORS   Chan,D.C., Bedford,M.T. and Leder,P.
  TITLE     Formin binding proteins bear WWP/WW domains that bind proline-rich
            peptides and functionally resemble SH3 domains
  JOURNAL   EMBO J 15 (5), 1045-1054 (1996)
   PUBMED   8605874
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL845170.5.
            
            On Jun 21, 2019 this sequence version replaced NM_018785.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            CCDS Note: The coding region has been extended at the 5' end to
            start at an upstream start codon that is supported by conservation
            data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF135439.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-232               AL845170.5         176047-176278       c
            233-364             AL845170.5         174993-175124       c
            365-445             AL845170.5         162377-162457       c
            446-476             AL845170.5         161410-161440       c
            477-493             AL845170.5         160040-160056       c
            494-604             AL845170.5         145800-145910       c
            605-725             AL845170.5         144582-144702       c
            726-779             AL845170.5         144287-144340       c
            780-804             AL845170.5         142917-142941       c
            805-1167            AL845170.5         141647-142009       c
            1168-1276           AL845170.5         138988-139096       c
            1277-1341           AL845170.5         138488-138552       c
            1342-1506           AL845170.5         137982-138146       c
            1507-1615           AL845170.5         137470-137578       c
            1616-1766           AL845170.5         136703-136853       c
            1767-1900           AL845170.5         135662-135795       c
            1901-2015           AL845170.5         131118-131232       c
            2016-2107           AL845170.5         130848-130939       c
            2108-2224           AL845170.5         130644-130760       c
            2225-2362           AL845170.5         130257-130394       c
            2363-2458           AL845170.5         129808-129903       c
            2459-2545           AL845170.5         126967-127053       c
            2546-2642           AL845170.5         126791-126887       c
            2643-2704           AL845170.5         126643-126704       c
            2705-2836           AL845170.5         125485-125616       c
            2837-7405           AL845170.5         119726-124294       c
FEATURES             Location/Qualifiers
     source          1..7405
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 30.69 cM"
     gene            1..7405
                     /gene="Prpf40a"
                     /gene_synonym="2810012K09Rik; FBP-11; FBP11; Fnbp11;
                     Fnbp3"
                     /note="pre-mRNA processing factor 40A"
                     /db_xref="GeneID:56194"
                     /db_xref="MGI:MGI:1860512"
     exon            1..232
                     /gene="Prpf40a"
                     /gene_synonym="2810012K09Rik; FBP-11; FBP11; Fnbp11;
                     Fnbp3"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..2929
                     /gene="Prpf40a"
                     /gene_synonym="2810012K09Rik; FBP-11; FBP11; Fnbp11;
                     Fnbp3"
                     /note="isoform 2 is encoded by transcript variant 2;
                     formin binding protein 11; pre-mRNA-processing factor 40
                     homolog A; formin-binding protein 3; PRP40 pre-mRNA
                     processing factor 40 homolog A"
                     /codon_start=1
                     /product="pre-mRNA-processing factor 40 homolog A isoform
                     2"
                     /protein_id="NP_061255.2"
                     /db_xref="CCDS:CCDS16038.1"
                     /db_xref="GeneID:56194"
                     /db_xref="MGI:MGI:1860512"
                     /translation="MCSGSGRRRSSLSPTMRPGTGAERGGLMVSEMESQPPSRGPGDG
                     ERRLSGSNLCSSSWVSADGFLRRRPSMGHPGMHYAPMGMHPMGQRANMPPVPHGMMPQ
                     MMPPMGGPPMGQMPGMMSSVMSGMMMSHMSQASMQPALPPGVNSMDVAAGAASGAKSM
                     WTEHKSPDGRTYYYNTETKQSTWEKPDDLKTPAEQLLSKCPWKEYKSDSGKPYYYNSQ
                     TKESRWAKPKELEDLEGYQNTIVAGGLITKSNLHAMIKAEESSKQEECTTASTAPVPT
                     TEIPTTMSTMAAAEAAAAVVAAAAAAAAAANANTSTTPTNTVGSVPVAPEPEVTSIVA
                     TAVDNENTVTVSTEEQAQLANTTAIQDLSGDISSNTGEEPAKQETVSDFTPKKEEEES
                     QPAKKTYTWNTKEEAKQAFKELLKEKRVPSNASWEQAMKMIINDPRYSALAKLSEKKQ
                     AFNAYKVQTEKEEKEEARSKYKEAKESFQRFLENHEKMTSTTRYKKAEQMFGEMEVWN
                     AISERDRLEIYEDVLFFLSKKEKEQAKQLRKRNWEALKNILDNMANVTYSTTWSEAQQ
                     YLMDNPTFAEDEELQNMDKEDALICFEEHIRALEKEEEEEKQKTLLRERRRQRKNRES
                     FQIFLDELHEHGQLHSMSSWMELYPTISSDIRFTNMLGQPGSTALDLFKFYVEDLKAR
                     YHDEKKIIKDILKDKGFVVEVNTTFEDFVAIISSTKRSTTLDAGNIKLAFNSLLEKAE
                     AREREREKEEARKMKRKESAFKSMLKQATPPIELDAVWEDIRERFVKEPAFEDITLES
                     ERKRIFKDFMHVLEHECQHHHSKNKKHSKKSKKHHRKRSRSRSGSESDDDDSHSKKKR
                     QRSESHSASERSSSAESERSYKKSKKHKKKSKKRRHKSDSPESDTEREKDKKEKDRDS
                     EKDRSRQRSESKHKSPKKKTGKDSGNWDTSGSELSEGELEKRRRTLLEQLDDDQ"
     exon            233..364
                     /gene="Prpf40a"
                     /gene_synonym="2810012K09Rik; FBP-11; FBP11; Fnbp11;
                     Fnbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            365..445
                     /gene="Prpf40a"
                     /gene_synonym="2810012K09Rik; FBP-11; FBP11; Fnbp11;
                     Fnbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            446..476
                     /gene="Prpf40a"
                     /gene_synonym="2810012K09Rik; FBP-11; FBP11; Fnbp11;
                     Fnbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            477..493
                     /gene="Prpf40a"
                     /gene_synonym="2810012K09Rik; FBP-11; FBP11; Fnbp11;
                     Fnbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            494..604
                     /gene="Prpf40a"
                     /gene_synonym="2810012K09Rik; FBP-11; FBP11; Fnbp11;
                     Fnbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            605..725
                     /gene="Prpf40a"
                     /gene_synonym="2810012K09Rik; FBP-11; FBP11; Fnbp11;
                     Fnbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            726..779
                     /gene="Prpf40a"
                     /gene_synonym="2810012K09Rik; FBP-11; FBP11; Fnbp11;
                     Fnbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            780..804
                     /gene="Prpf40a"
                     /gene_synonym="2810012K09Rik; FBP-11; FBP11; Fnbp11;
                     Fnbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            805..1167
                     /gene="Prpf40a"
                     /gene_synonym="2810012K09Rik; FBP-11; FBP11; Fnbp11;
                     Fnbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1276
                     /gene="Prpf40a"
                     /gene_synonym="2810012K09Rik; FBP-11; FBP11; Fnbp11;
                     Fnbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1341
                     /gene="Prpf40a"
                     /gene_synonym="2810012K09Rik; FBP-11; FBP11; Fnbp11;
                     Fnbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1506
                     /gene="Prpf40a"
                     /gene_synonym="2810012K09Rik; FBP-11; FBP11; Fnbp11;
                     Fnbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1615
                     /gene="Prpf40a"
                     /gene_synonym="2810012K09Rik; FBP-11; FBP11; Fnbp11;
                     Fnbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1766
                     /gene="Prpf40a"
                     /gene_synonym="2810012K09Rik; FBP-11; FBP11; Fnbp11;
                     Fnbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..1900
                     /gene="Prpf40a"
                     /gene_synonym="2810012K09Rik; FBP-11; FBP11; Fnbp11;
                     Fnbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..2015
                     /gene="Prpf40a"
                     /gene_synonym="2810012K09Rik; FBP-11; FBP11; Fnbp11;
                     Fnbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2016..2107
                     /gene="Prpf40a"
                     /gene_synonym="2810012K09Rik; FBP-11; FBP11; Fnbp11;
                     Fnbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2108..2224
                     /gene="Prpf40a"
                     /gene_synonym="2810012K09Rik; FBP-11; FBP11; Fnbp11;
                     Fnbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2225..2362
                     /gene="Prpf40a"
                     /gene_synonym="2810012K09Rik; FBP-11; FBP11; Fnbp11;
                     Fnbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2363..2458
                     /gene="Prpf40a"
                     /gene_synonym="2810012K09Rik; FBP-11; FBP11; Fnbp11;
                     Fnbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2459..2545
                     /gene="Prpf40a"
                     /gene_synonym="2810012K09Rik; FBP-11; FBP11; Fnbp11;
                     Fnbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2546..2642
                     /gene="Prpf40a"
                     /gene_synonym="2810012K09Rik; FBP-11; FBP11; Fnbp11;
                     Fnbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2643..2704
                     /gene="Prpf40a"
                     /gene_synonym="2810012K09Rik; FBP-11; FBP11; Fnbp11;
                     Fnbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2705..2836
                     /gene="Prpf40a"
                     /gene_synonym="2810012K09Rik; FBP-11; FBP11; Fnbp11;
                     Fnbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2837..7405
                     /gene="Prpf40a"
                     /gene_synonym="2810012K09Rik; FBP-11; FBP11; Fnbp11;
                     Fnbp3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2925..2930
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prpf40a"
                     /gene_synonym="2810012K09Rik; FBP-11; FBP11; Fnbp11;
                     Fnbp3"
                     /note="hexamer: AATAAA"
     polyA_site      2944
                     /gene="Prpf40a"
                     /gene_synonym="2810012K09Rik; FBP-11; FBP11; Fnbp11;
                     Fnbp3"
                     /note="major polyA site"
     regulatory      3174..3179
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prpf40a"
                     /gene_synonym="2810012K09Rik; FBP-11; FBP11; Fnbp11;
                     Fnbp3"
                     /note="hexamer: ATTAAA"
     polyA_site      3197
                     /gene="Prpf40a"
                     /gene_synonym="2810012K09Rik; FBP-11; FBP11; Fnbp11;
                     Fnbp3"
     regulatory      3849..3854
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prpf40a"
                     /gene_synonym="2810012K09Rik; FBP-11; FBP11; Fnbp11;
                     Fnbp3"
                     /note="hexamer: ATTAAA"
     polyA_site      3870
                     /gene="Prpf40a"
                     /gene_synonym="2810012K09Rik; FBP-11; FBP11; Fnbp11;
                     Fnbp3"
     regulatory      3935..3940
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prpf40a"
                     /gene_synonym="2810012K09Rik; FBP-11; FBP11; Fnbp11;
                     Fnbp3"
                     /note="hexamer: AATAAA"
     polyA_site      3964
                     /gene="Prpf40a"
                     /gene_synonym="2810012K09Rik; FBP-11; FBP11; Fnbp11;
                     Fnbp3"
     regulatory      5245..5250
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prpf40a"
                     /gene_synonym="2810012K09Rik; FBP-11; FBP11; Fnbp11;
                     Fnbp3"
                     /note="hexamer: TATAAA"
     polyA_site      5268
                     /gene="Prpf40a"
                     /gene_synonym="2810012K09Rik; FBP-11; FBP11; Fnbp11;
                     Fnbp3"
     polyA_site      6378
                     /gene="Prpf40a"
                     /gene_synonym="2810012K09Rik; FBP-11; FBP11; Fnbp11;
                     Fnbp3"
     regulatory      7382..7387
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prpf40a"
                     /gene_synonym="2810012K09Rik; FBP-11; FBP11; Fnbp11;
                     Fnbp3"
                     /note="hexamer: ATTAAA"
     polyA_site      7405
                     /gene="Prpf40a"
                     /gene_synonym="2810012K09Rik; FBP-11; FBP11; Fnbp11;
                     Fnbp3"
ORIGIN      
        1 actcagatcg cttcttgttg gtatgtgcag cggcagtggc cgccgacgga gcagtctgag
       61 cccgacgatg aggccgggga ctggagccga gcgtggaggc ctcatggtga gtgaaatgga
      121 gagccaacct ccctcgcggg gtcccgggga cggggagcgg agattgtccg gctcaaacct
      181 gtgctccagt tcttgggtct ctgctgacgg cttcctgagg agacggccct cgatggggca
      241 tcctggcatg cattatgcac caatgggcat gcaccctatg ggtcagagag caaacatgcc
      301 tcctgtacct catggaatga tgccacagat gatgccccct atgggagggc ctccaatggg
      361 acaaatgcct ggaatgatgt cttcagtaat gtcaggaatg atgatgtctc atatgtctca
      421 ggcttccatg caacctgcct taccgcctgg agtaaatagt atggatgtag cagcaggtgc
      481 agcatctggt gcaaaatcaa tgtggacaga acataaatca cctgatggaa ggacttatta
      541 ttacaatact gaaacaaaac agtctacctg ggaaaagcca gatgatctta aaacacctgc
      601 tgagcaacta ttgtctaaat gcccatggaa agagtacaaa tctgattccg ggaagcctta
      661 ttactataat tctcaaacaa aggagtcccg ctgggccaaa cctaaggaac ttgaagatct
      721 tgaaggatac cagaatacca ttgttgctgg aggtcttatt acaaaatcaa acctgcatgc
      781 catgatcaaa gctgaagaaa gcagcaagca agaagaatgt actacagcat caacagcccc
      841 agttcctaca acagaaattc ctaccactat gagcaccatg gctgctgcag aagcagcggc
      901 tgctgttgtt gcagctgctg cagctgctgc agcagcagct aatgccaata cttccaccac
      961 acctactaat actgtgggaa gtgttccagt tgctcctgaa cctgaggtta cttccattgt
     1021 tgctactgct gtagataatg aaaatacagt aactgtatca actgaagagc aagcacagct
     1081 tgctaatacc acagctattc aagatctcag tggtgatata tccagtaaca ctggagagga
     1141 accagctaaa caagaaactg tctccgattt tactcctaaa aaagaagagg aagagagcca
     1201 accagcaaaa aaaacatata cttggaatac aaaggaggag gcaaagcaag catttaaaga
     1261 attattgaaa gaaaagcggg tgccctccaa tgcttcatgg gagcaggcta tgaaaatgat
     1321 cataaatgat cctcggtaca gtgctttagc aaagctgagt gagaaaaagc aggcctttaa
     1381 tgcctataaa gtccagacgg agaaagagga aaaagaagaa gcaagatcaa aatacaaaga
     1441 agctaaggaa tcttttcagc gttttcttga aaatcatgag aaaatgactt ccacaaccag
     1501 atacaaaaaa gctgagcaaa tgtttgggga gatggaagtt tggaatgcaa tttcagagcg
     1561 tgatcgtcta gaaatctatg aagatgtttt gttcttcctt tcaaagaaag aaaaggaaca
     1621 agcaaagcag ctacgaaaga gaaattggga agccttaaaa aacatacttg acaatatggc
     1681 taacgttaca tactctacca cttggtctga agcccagcag tatctgatgg ataatccaac
     1741 gttcgcagag gatgaagagt tacagaacat ggataaagaa gatgcattaa tatgctttga
     1801 ggaacacatc cgggctttag aaaaggaaga agaagaagaa aaacagaaga ctttgttgag
     1861 agaaaggagg aggcagcgta aaaataggga atcttttcag atctttctgg acgagttgca
     1921 cgagcatggg cagctgcact ctatgtcctc ttggatggag ctgtatccca ccatcagctc
     1981 tgacattcgc ttcactaaca tgctgggtca gccgggatca actgcacttg atcttttcaa
     2041 gttttatgtt gaagatctta aagcacgata tcatgatgaa aagaagataa taaaagacat
     2101 tctgaaggat aaaggatttg tagttgaagt aaacactact tttgaagatt ttgtggcaat
     2161 aatcagttca accaaaagat caactacttt ggatgctgga aatatcaagt tggctttcaa
     2221 tagtttacta gaaaaggcag aagcccgtga acgtgagaga gaaaaagaag aggctcggaa
     2281 aatgaaacgg aaagagtctg cctttaagag tatgttgaaa caggctaccc ctccaataga
     2341 actggatgct gtctgggaag atatccggga aagatttgta aaggaaccag cgtttgagga
     2401 tataactcta gaatctgaaa gaaaaagaat atttaaagat ttcatgcatg tgcttgagca
     2461 tgaatgtcag catcatcatt caaagaacaa gaaacattct aagaaatcta aaaagcacca
     2521 taggaaacgc tcccgctctc gatcgggatc agagtcagat gatgacgaca gccattcaaa
     2581 gaaaaaaagg cagcgatcag agtctcattc tgcttcagag cgttcgtcca gtgctgagtc
     2641 tgagagaagt tacaagaagt caaaaaagca taagaagaaa agcaaaaaga ggaggcataa
     2701 atctgactct ccagaatcag atactgaacg agaaaaggat aaaaaagaaa aagatcggga
     2761 cagtgaaaaa gacagaagta gacagagatc agaatcaaaa cacaaatcac ctaagaaaaa
     2821 gactggaaag gattctggta actgggatac ttctggcagt gaactgagtg aaggggaatt
     2881 ggaaaagcgc agaagaaccc ttttggagca actggatgat gatcaataaa ttataccaaa
     2941 tatatgttta tagtatgatt taaagtctaa ttcagaccag ggattatttt aagtccaatt
     3001 tacataacac tgggttttaa ttgtgtcaca ggaaaaagtg catttatgta ttgttattgt
     3061 ggactttata aaagcaaagg aattgaaaat aacttgattc tgtatcaaga atcatatttt
     3121 cctatggtaa taactgtctt tctgtgaccc tttcacaggg cactacagga tggattaaaa
     3181 gtggcaattt catgatagct gcagacgtct ctactttgtt ctaagtcatg aggtgatttg
     3241 atttccttta tagaagttgg attttgaaga tacaatgaaa atttttgata atgtagtaca
     3301 aaaaaagcac cagcaaccta tgagaagact gcttttttgt gcactactga actggttaaa
     3361 gccaatgtga tcttctgtgg tgagctctta agaaacaggt gtttttgatg gagccttggt
     3421 agacctttaa cagcagtggt gctaacgagc actgctgtaa aaaagccacc attatttttt
     3481 atgaaacatc tgaacatttt aaaaaggctt atgagggcat tattttgagc atctattttg
     3541 aggtgatgtt ttaaaatagc taacatcaag tcaaattgta aattagttga aatatattgc
     3601 cttaaggacc tactaaagaa tgtgccacca aacttttgag taatagttga aatatccttg
     3661 tcaggggtgg gaaatcaatg ttgacttaaa cattttcttt taatttttaa tccaaccttt
     3721 ctcttacact ttttttttaa ttccactgag gaggttgtaa attaccttcc ttactgagaa
     3781 gtattgactt catggtacac attctaaagc atttctgatt tcaatatttt tgtacatttt
     3841 tatctattat taaacttctc ttgtagtgtg cactagtctt tatttctaca taagctgctc
     3901 agctctaagg aaattgtatg atcattttca agataataaa tccctgaaat tttgtttcat
     3961 cgtacccatg gtagctacag tacttttttt taatatttat gaacatcgta aatcagtgca
     4021 tttgaggttc ttaaatgtgt tttcacctat aaatttccta tggaatattt tagaaaggca
     4081 atgactattt tagaaaggca gtggcttaaa gttacaattc tctttacctg ctaactcttg
     4141 aaggttagta atgtgattta tacaatttcc ttcagtgcag gagattttgt ttgttaattc
     4201 ttatgtaaag attagcagtt gttctttagt attctctttg ttcttataat ttggacatgc
     4261 tgagattatc tctttcaagt tgagatttaa atagaatata aattatttca ttgcccttta
     4321 aatgagttag gacagatcag tacagccctt tttccatcct gcccaggttt ttgattaaat
     4381 actggccagg gttttaaaac ctcacaaggg aggtacttta tttctaacct tctcatcgcc
     4441 atgtccattt tctgttgaga tataagacat actttgtgga aaagagcatt ctcttagaga
     4501 aaacgttata tgatcaaatt gcttgcttga gattagttcc tcctcccctc ccccactccc
     4561 cccccccagt tgtatgttat tcaaaatacc taacaacttg caacagaatc tccttgagtt
     4621 taattttcag gggtcctcat ttagcaatag tcaagattgc taatgagtcc cagtacttga
     4681 cacggaggtc agagatagtc tttaaatcat gcttattttt ggaaacaaac cagtagtatt
     4741 tcataagaga aattagaatc tgtaaaatat gttttaattc catgaataat gatttttaaa
     4801 gtacaacatt aaatttttga tatatttgaa taaaaagcta ttgatgtttt agcatgtcct
     4861 caaaatagat ttctgtgctt cttataattt cttcacatct tcagagtctt ataaaacatg
     4921 atcaattaaa ctatccctgc aatgaaccta tgcaaatcag acacagcaaa agacataaag
     4981 tgattctctt gactaaaaca gtttttttgt tgttgttttg gttttggttt tttggagata
     5041 gggcttttgt gtagcagcag ctgtcttgga actctgtagg ccaacaggcc ccaaactcag
     5101 agatccccct gcctctgcct cttttcttgt aaatgttact gtgaacagat caatatcata
     5161 acagaaccaa attgatttaa atagaagttt tatatcagtg tgttgaattt tgactttagg
     5221 tacctggaaa tgtaatatcc ttgctataaa acatgtaaat ccagtctact ctattgtctt
     5281 gttttgatta taccatcaga cacattgtag ttgctagacg tagtatgaag gcacaggtga
     5341 tggggcagtc ctaaatttct gactcttaaa tccagtagat catgtttcta catcttcagt
     5401 ttgacaaagg cagatgtatc tttgaatgct tgttcttcta gagttacttc tggagttact
     5461 caaatagcca agcagttaat ataagtttat atatttcact taagactagg agtctaatgc
     5521 tgatactgtg ttgtcctcag catcactaat actgatcaaa cttgctaata tattcatatc
     5581 aagcaaaatc atgacctcag atacttgacg ttcttatttt ctcttatcac taccatgttg
     5641 ggaaaatttg taagggaagt tagtatggcc aatttagcat gtggattatc tgtcagcttc
     5701 acaaatgaat ttaatgtgac agaagcatag atttttcatt tcagcttgta aaacttcgtc
     5761 ttttggattt ttcttaagtg ggcctggtgt atagctataa atgaaagtat gtacctggta
     5821 taaggcagtt catatagatc agtaatcgca actaaaaagt ctatgcattt tcctgtaaac
     5881 cctgtgtagt ttgaggctat agtgcactgt tttcattcat ttatatgctt aactaagcat
     5941 ttgctgaatg ctacttactg gttttactcc agtgtttaaa gttgactaag tgttcagtag
     6001 acattttgca tccagaagag aaaaattaga tttatgtatt ctgatcagat aatacctagg
     6061 gaagagttat gaagaatgct ttcatttgtg ctcatagaat tttaacataa aatgatgtaa
     6121 acttaaatat aaacttgtaa agtttttgaa acaagaaaac aaactagatt aagttaaata
     6181 gattttcctt tgggaaaatt tttaatttaa cccacctttc tcctctaggt taaatacact
     6241 tactatattt acaaaaaggg aaaagaaaaa tgatgcgcgg tgggaggttt tttgttgttg
     6301 ttttgttttt catggaacta caaggggttt atgttttcat tttatgtttc tgctaataac
     6361 atttgccact cttaacaatt ctctttatca tcctgtgtgt tttaagtcct ctgtttattc
     6421 tgatgacaca ttttgtagtc ttgcaaaatc ttcgggtggg atttatctgt ttcattcact
     6481 agtgtgagag tgtgtgtgtg tgtgtgtggt atatacatac atacatgtct tgattaggac
     6541 tctgactgca cttaacagat ataaaatgtc aattgacata tgtagtcata tatatcccat
     6601 catccataca agagagctta aaagaggcat catggcaatt aaagcatccc actgagaact
     6661 gatgcttcat ccataaagtc cacttacagg aaagtctagt tactgtaact taggacatgc
     6721 caaaaagctt aaaaaggaaa ttcatacctg tgagataaaa aatataaagg gatgagtcat
     6781 ggtaacactg ttgcactcca tgtcttgggg ctcctttcaa tgtaagaatg aaagataaca
     6841 tacactttgt tgagctgtcc tccattttag acccgacccc cccccccccc cgtttaagtt
     6901 ccttaataag atgctattcc taaacctgct gtatgtgctc aacagctgca tttgagaatg
     6961 agtggattca gttcaaggtc atcggtggaa ccagtctttg acagtgatga ccctagtata
     7021 attaatgttt acatttcaaa gaaacaggct agtccataac gctgctcttc aatctgggct
     7081 atggagcaga tcacattcaa gctaagccat tttttgatac tatgctgtga ctgttactag
     7141 agtatctcct ggttactgaa atctttggtt tttggtcctg actactaaca tatttgggta
     7201 ggtgttagtg tagtcatctt gccttcctct acaactaaac aggatttgtt cagaaaggta
     7261 attggcaaaa ggtttatctt ttctatgcaa tcaccagatt tttatttgtt tttatatttg
     7321 tgtgatgtat ggaacctcat agatacaacg gaccttttgt aaatagagca atggcatatt
     7381 tattaaataa gttggatttg tgtca
//
