LOCUS       NM_027297               5237 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus pre-mRNA processing factor 4 (Prpf4), mRNA.
ACCESSION   NM_027297 XM_131444
VERSION     NM_027297.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5237)
  AUTHORS   Cao,H., Wu,J., Lam,S., Duan,R., Newnham,C., Molday,R.S.,
            Graziotto,J.J., Pierce,E.A. and Hu,J.
  TITLE     Temporal and tissue specific regulation of RP-associated splicing
            factor genes PRPF3, PRPF31 and PRPC8--implications in the
            pathogenesis of RP
  JOURNAL   PLoS One 6 (1), e15860 (2011)
   PUBMED   21283520
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5237)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732548.9, AK167216.1 and AL732594.5.
            
            On Jan 13, 2006 this sequence version replaced NM_027297.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK085174.1, AK169532.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               AL732548.9         99512-99630
            120-2723            AK167216.1         98-2701
            2724-5237           AL732594.5         17132-19645
FEATURES             Location/Qualifiers
     source          1..5237
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 33.13 cM"
     gene            1..5237
                     /gene="Prpf4"
                     /gene_synonym="1600015H11Rik; bN189G18.1"
                     /note="pre-mRNA processing factor 4"
                     /db_xref="GeneID:70052"
                     /db_xref="MGI:MGI:1917302"
     exon            1..119
                     /gene="Prpf4"
                     /gene_synonym="1600015H11Rik; bN189G18.1"
                     /inference="alignment:Splign:2.1.0"
     exon            120..297
                     /gene="Prpf4"
                     /gene_synonym="1600015H11Rik; bN189G18.1"
                     /inference="alignment:Splign:2.1.0"
     exon            298..484
                     /gene="Prpf4"
                     /gene_synonym="1600015H11Rik; bN189G18.1"
                     /inference="alignment:Splign:2.1.0"
     exon            485..572
                     /gene="Prpf4"
                     /gene_synonym="1600015H11Rik; bN189G18.1"
                     /inference="alignment:Splign:2.1.0"
     exon            573..652
                     /gene="Prpf4"
                     /gene_synonym="1600015H11Rik; bN189G18.1"
                     /inference="alignment:Splign:2.1.0"
     exon            653..746
                     /gene="Prpf4"
                     /gene_synonym="1600015H11Rik; bN189G18.1"
                     /inference="alignment:Splign:2.1.0"
     exon            747..841
                     /gene="Prpf4"
                     /gene_synonym="1600015H11Rik; bN189G18.1"
                     /inference="alignment:Splign:2.1.0"
     exon            842..900
                     /gene="Prpf4"
                     /gene_synonym="1600015H11Rik; bN189G18.1"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1024
                     /gene="Prpf4"
                     /gene_synonym="1600015H11Rik; bN189G18.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1114
                     /gene="Prpf4"
                     /gene_synonym="1600015H11Rik; bN189G18.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1237
                     /gene="Prpf4"
                     /gene_synonym="1600015H11Rik; bN189G18.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1345
                     /gene="Prpf4"
                     /gene_synonym="1600015H11Rik; bN189G18.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1464
                     /gene="Prpf4"
                     /gene_synonym="1600015H11Rik; bN189G18.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..5237
                     /gene="Prpf4"
                     /gene_synonym="1600015H11Rik; bN189G18.1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2699..2704
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prpf4"
                     /gene_synonym="1600015H11Rik; bN189G18.1"
                     /note="hexamer: ATTAAA"
     polyA_site      2725
                     /gene="Prpf4"
                     /gene_synonym="1600015H11Rik; bN189G18.1"
                     /note="major polyA site"
     regulatory      2829..2834
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prpf4"
                     /gene_synonym="1600015H11Rik; bN189G18.1"
                     /note="hexamer: AGTAAA"
     regulatory      2842..2847
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prpf4"
                     /gene_synonym="1600015H11Rik; bN189G18.1"
                     /note="hexamer: TATAAA"
     polyA_site      2849
                     /gene="Prpf4"
                     /gene_synonym="1600015H11Rik; bN189G18.1"
     polyA_site      2862
                     /gene="Prpf4"
                     /gene_synonym="1600015H11Rik; bN189G18.1"
     regulatory      5182..5187
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prpf4"
                     /gene_synonym="1600015H11Rik; bN189G18.1"
                     /note="hexamer: AATAAT"
     polyA_site      5200
                     /gene="Prpf4"
                     /gene_synonym="1600015H11Rik; bN189G18.1"
ORIGIN      
        1 agtgacgcac ttccactttg ctaggcgcgc ggttcccggt ctgaaaagta gaacgcggat
       61 ttggctaggg cctcgcgtct ccgccgcccg gcatggcctc ctcacgagcc tcctccacga
      121 caaccaaaac caaagcgcct gacgatttag ttgctcccgt tgtgaagaaa ccacacatct
      181 actatggaag cttggaagag aaagagcggg aacgcctggc caaaggagag tctgggattt
      241 tgggaaaaga aggactcaaa gccggcattg aagcaggaaa tattaatata acatccggag
      301 aagtgtttga aattgaggag cacatcagtg agcggcaggc agaagtcttg gcagagtttg
      361 aaagaagaaa gcgagcccgg cagatcaatg tttccacaga tgactcagag gtcaaggctt
      421 gccttcgagc cttgggagag cctatcacgc tttttggaga gggccctgct gaacgaagag
      481 aaaggttaag aaatattctc tcagtggtcg ggactgatgc cttaaaaaag acgaaaaaag
      541 atgatgaaaa gtctaagaag tcaaaggagg agtatcagca aacctggtac catgaagggc
      601 caaatagcct gaaggtggcc agattgtgga ttgctaatta ttcactcccc agggcaatga
      661 aacgcttaga ggaggcccgt ctccataagg agattcctga gacaaccaga acctcccaga
      721 tgcaggagct gcacaagtct ctccggtctt tgaataattt ctgcagtcag attggagatg
      781 accggccgat ctcctactgc cacttcagcc ccaattctaa aatgctagcc acagcttgtt
      841 ggagtgggct ttgcaagctc tggtctgtcc ctgactgcag cctccttcac actcttcgag
      901 gccataacac aaatgtagga gcaattgtat tccatcccaa atccactgtc tcgttggacc
      961 agaaggatgt caacctggcc tcttgtgctg ctgatggttc tgtgaagctt tggagccttg
     1021 acagcgatga accagtggca gatattgaag gccatacagt gcgtgtagct cgggtaatgt
     1081 ggcatccatc agggcgtttc ctgggcacaa cctgttatga ccgttcatgg cgcttatggg
     1141 atttagaggc tcaagaggag atcctgcacc aggaaggcca cagcatgggt gtgtatgaca
     1201 ttgccttcca tcaagatggc tctttggctg gcactggggg actggatgca tttggccggg
     1261 tttgggacct acgcacagga cgctgcatta tgttcctgga aggccacctg aaggaaatct
     1321 atgggataaa tttcagcccc aatggctacc acattgccac tggcagtggt gacaacacct
     1381 gcaaagtgtg ggaccttcgg cagcgacgct gtgtctacac catccccgcc catcagaact
     1441 tagtgaccgg tgtcaaattt gagcctatcc atggggactt cttgctcaca ggtgcctatg
     1501 acaatacagc caagatctgg acccacccag gctggtcccc actgaagacc ctggctggtc
     1561 atgagggcaa agtgatgggc ctggacattt cttctgatgg gcagctcata gccacgtgct
     1621 cctatgacag aaccttcaag ctctggatgg cagagtaggc cagaccacgg aaggactcag
     1681 aacttgtgtt ctcacgacgg agccatttcc tcaaaggaaa agaattgtat tgtgttctat
     1741 catgtttcct gccaaatacc atgtgttgga ttggattttc acatcagccc actcttgagg
     1801 aagcctgtct ttaggtggta gcaagccctt cgtggttaga acaaaattct catctcaggt
     1861 tctgccaaaa actgtagatg ttgtatagac tcaacacttt tcagtgccct gcctcctccc
     1921 tcacactcag gattgtgacc gttctttcat ttttgttttt tttatttggc attttgagac
     1981 agaatctgta agtatatccc tgactgtccc ggaagcctta cattgtaagt aatcctcctg
     2041 tcctgccctt cgagtgatgg cattatggaa atgtgctgct gtgcctggca gttgtatttt
     2101 tagtgcttga acttggctct ctataacatg gtatgtgctt gggactacgg gtgattcagc
     2161 aagcaagata gctggactgg ctaggcagtg gtggcgcatg cctttaatcc cagcttggga
     2221 ggcagaggcg ggcagatctc ttgagtttga ggccagcctg gtctacagag caagttcaag
     2281 gacagccttt tctctaccct gtctcgagga aaaaagaaaa aaaagatagc tggactgtat
     2341 ttgaaatctc cccagttatg aggacatgtc accaccattt gtggcgagct cctttcctga
     2401 cgccgagaat gaaaccagag ccatagactg cagctgtgtg atagctccac agtaaaaaag
     2461 attttccctt tctgtggtgt tcacgaagga tgttcactgc agctgggact cagaactgca
     2521 cacttggcct tgttagagcc aagttagagc ctcttccttt tggctttgaa gtttgatatc
     2581 cttcatgaca aaacaatctg gccattgtat ccagattcaa aggggtttta aaaacaaaca
     2641 tgatgtctgt gttgtacagc ctccttcctg ttggttattt aaagggtgta ccttatgtat
     2701 taaagaacac ttcatgtcaa aggaactgga aaaaatccta atttatgttt gggtgttacc
     2761 aaacataaac ttttatatat aaatacacac acacatacat acatacacac acacacacac
     2821 ttgctgagag taaaatctta ctataaaaac tctttgaaag gattattttc tatttcagca
     2881 ttttgtgaac ctaaccattt gtccaaagag atccccttct ttagttttga gatctaatgt
     2941 aattctaggc ctgaattgtt ccactttctg ttactttatt cagatgttta ttgtggtgtt
     3001 ttttgagggg ggaggaagta gcaggttttt gtgacaaagg gtcttactgt gtagctcaga
     3061 ttggcctcag agtcaaaatc ctcctgcctc tgcatctcaa gtcctgtaag ttgtaggtgt
     3121 aagccatcag tcacatccag acactaacag cttctttacg tagagttgtt ggcccaggag
     3181 aacaccaggt tttcaggtgt gtctgggttc catagttctt cctcatcagt cagtgattgg
     3241 cttcaccttg ctgcactcca gaactgcacg gtaaatccgc acagagcagt aatttcagag
     3301 aaggttgtgt atagtgtgaa attccctctc cagaattgga agtttacaca ccatcggctt
     3361 cctgttctgc cctgctcttc tgtagatcat gaatatatgg tatataacaa aacatttggg
     3421 gaggggctgg tttctctgtg aagcccaggc tgtcctagaa ctcactgtag accaggctgg
     3481 cctcaaactc agagatccgc ttgcctctgc cttctaagtt aaaagtatgc tcaccacacc
     3541 cagctaaaca tgtgattcca gtcataacca agtatattcc gtatatgtgg ctgttacgcc
     3601 attcaggcct tcccttcact tggcacttaa ccacccttaa cctgttctat gaaattacca
     3661 ttttcttgac atcttacagt gtttgtaaaa tgatgagact ggcatagagc cctgcattcg
     3721 ggatctggca catttgagtt ctctggtctg aaccttacta ggaacttaat tttcggttga
     3781 tccaagagag cattcgagtt ggaaatgttc catgtaagcc ttaggccgag caagtgtctg
     3841 gggaagtaat ccatttcttc aaccactgta agaaaatagt ggattctgaa tggcagaacc
     3901 actgtcattt aaccctacct cagtggtgca tcaggcacat taagagaatt cattctttta
     3961 aggttgctgg gtggacttga ataactgctg aattacccag ctgtaagcag tggaactatg
     4021 tgaaccagta tgaaatgatt gcacagtgct ttatggagaa cgttggccat tggcaagacc
     4081 aggaccgggc atgtggcctg attgctgact ggtcagcctt tttacctctc tgcctgtgga
     4141 tgccatggac aaatcactga ctttatgaac agtggacttt tcccactcct gtgtcttgat
     4201 ttggagctta gcagagttga atcttaggat aggtgatact tcttaggcac cgctgcaggc
     4261 ctccgtccct aatctaagca cacccagtgg aagtgctgcc aatgtaagtg ggtgagactg
     4321 cttgctagga tttgattctg aaatatcccg gcactgttgt gccattaaac cctcaggaca
     4381 taggacctgg ctggtacaaa taagtcacca acacagggtt gtcggaagtt tttagcccag
     4441 cttctatctc cagctgccct ctgcttcctg gtatgctctg gtgtggtgag catctgctac
     4501 aggctcctcc ctgtgctctg taccctctga aaccttgagc cccaatcaac ctcccctcca
     4561 gctgtctcta acaggtattg tggtgactaa cactgcccca aggttagaac taacaaatgc
     4621 taagtaagag ctaagatcct aaccctctgt ctcaaaaaaa aaaaaaggaa ggaagaagaa
     4681 aagaaaatct gttcagtata acaaactact agtttttggt actccccggc atcctgagaa
     4741 tgtaagttgt attctgaagg aaagggactc caaggttaac cctaggctga gcctcggctc
     4801 cagcatctgc ttccttgggc cagggtctct ggaggaggag aaattccttc ttggactttt
     4861 tccatttctt ctctgcccct gtccctctta gttcatagaa tatagagaga tgttgccaga
     4921 cgtgcttgct acaaaggtaa gcaaaaatgt gtagagaagt gaagttgata ggaaatgtga
     4981 ggttcactat cagtgcaatt acctgatgag gtcaatggag acaggtgata gtctcaggag
     5041 gaaatgtggg tacctttaca gttttctagt ggagaaatct ccacatcgga gcttaaaact
     5101 gtctggtttt actaaatcaa aatataattt atatatttta taatatctta ctcctttgtg
     5161 cctctaagga agttataaat aaataatact tctgtggaaa tattctttag agcaaataaa
     5221 actgactcaa gttctga
//
