LOCUS       NP_081573                521 aa            linear   ROD 04-JUN-2024
DEFINITION  U4/U6 small nuclear ribonucleoprotein Prp4 [Mus musculus].
ACCESSION   NP_081573 XP_131444
VERSION     NP_081573.1
DBSOURCE    REFSEQ: accession NM_027297.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 521)
  AUTHORS   Cao,H., Wu,J., Lam,S., Duan,R., Newnham,C., Molday,R.S.,
            Graziotto,J.J., Pierce,E.A. and Hu,J.
  TITLE     Temporal and tissue specific regulation of RP-associated splicing
            factor genes PRPF3, PRPF31 and PRPC8--implications in the
            pathogenesis of RP
  JOURNAL   PLoS One 6 (1), e15860 (2011)
   PUBMED   21283520
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 521)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732548.9, AK167216.1 and AL732594.5.
            
            On Nov 26, 2004 this sequence version replaced XP_131444.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK085174.1, AK169532.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..521
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 33.13 cM"
     Protein         1..521
                     /product="U4/U6 small nuclear ribonucleoprotein Prp4"
                     /note="WD splicing factor Prp4; U4/U6 snRNP 60 kDa
                     protein"
                     /calculated_mol_wt=58239
     Site            26
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (Q9DAW6.1)"
     Region          102..140
                     /region_name="SFM"
                     /note="Splicing Factor Motif, present in Prp18 and Pr04;
                     smart00500"
                     /db_xref="CDD:128776"
     Region          <228..518
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          228..267
                     /region_name="WD 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9DAW6.1)"
     Region          233..270
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          270..317
                     /region_name="WD 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9DAW6.1)"
     Region          284..320
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          320..359
                     /region_name="WD 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9DAW6.1)"
     Region          325..361
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          362..401
                     /region_name="WD 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9DAW6.1)"
     Region          368..403
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          404..443
                     /region_name="WD 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9DAW6.1)"
     Region          409..443
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          446..486
                     /region_name="WD 6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9DAW6.1)"
     Region          451..488
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          489..521
                     /region_name="WD 7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9DAW6.1)"
     Region          494..518
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..521
                     /gene="Prpf4"
                     /gene_synonym="1600015H11Rik; bN189G18.1"
                     /coded_by="NM_027297.3:93..1658"
                     /db_xref="CCDS:CCDS18239.1"
                     /db_xref="GeneID:70052"
                     /db_xref="MGI:MGI:1917302"
ORIGIN      
        1 massrasstt tktkapddlv apvvkkphiy ygsleekere rlakgesgil gkeglkagie
       61 agninitsge vfeieehise rqaevlaefe rrkrarqinv stddsevkac lralgepitl
      121 fgegpaerre rlrnilsvvg tdalkktkkd dekskkskee yqqtwyhegp nslkvarlwi
      181 anyslpramk rleearlhke ipettrtsqm qelhkslrsl nnfcsqigdd rpisychfsp
      241 nskmlatacw sglcklwsvp dcsllhtlrg hntnvgaivf hpkstvsldq kdvnlascaa
      301 dgsvklwsld sdepvadieg htvrvarvmw hpsgrflgtt cydrswrlwd leaqeeilhq
      361 eghsmgvydi afhqdgslag tggldafgrv wdlrtgrcim fleghlkeiy ginfspngyh
      421 iatgsgdntc kvwdlrqrrc vytipahqnl vtgvkfepih gdflltgayd ntakiwthpg
      481 wsplktlagh egkvmgldis sdgqliatcs ydrtfklwma e
//
