LOCUS       NM_134129               6161 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus pre-mRNA processing factor 19 (Prpf19), transcript
            variant 2, mRNA.
ACCESSION   NM_134129 XM_984379
VERSION     NM_134129.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6161)
  AUTHORS   Zhang,L., Hao,P., Chen,X., Lv,S., Gao,W., Li,C., Li,Z. and Zhang,W.
  TITLE     CRL4B E3 ligase recruited by PRPF19 inhibits SARS-CoV-2 infection
            by targeting ORF6 for ubiquitin-dependent degradation
  JOURNAL   mBio 15 (2), e0307123 (2024)
   PUBMED   38265236
  REMARK    GeneRIF: CRL4B E3 ligase recruited by PRPF19 inhibits SARS-CoV-2
            infection by targeting ORF6 for ubiquitin-dependent degradation.
REFERENCE   2  (bases 1 to 6161)
  AUTHORS   Yao,X., Wang,C., Yu,W., Sun,L., Lv,Z., Xie,X., Tian,S., Yan,L.,
            Li,L. and Liu,J.
  TITLE     BCAS2 regulates oocyte meiotic prophase I by participating in mRNA
            alternative splicing
  JOURNAL   FASEB J 38 (1), e23361 (2024)
   PUBMED   38085152
REFERENCE   3  (bases 1 to 6161)
  AUTHORS   Zhang,J., Liu,W., Li,G., Xu,C., Nie,X., Qin,D., Wang,Q., Lu,X.,
            Liu,J. and Li,L.
  TITLE     BCAS2 is involved in alternative splicing and mouse oocyte
            development
  JOURNAL   FASEB J 36 (2), e22128 (2022)
   PUBMED   34972250
REFERENCE   4  (bases 1 to 6161)
  AUTHORS   Monteforte,R., Beilhack,G.F., Grausenburger,R., Mayerhofer,B.,
            Bittner,R., Grillari-Voglauer,R., Sibilia,M., Dellago,H.,
            Tschachler,E., Gruber,F. and Grillari,J.
  TITLE     SNEV(Prp19/PSO4) deficiency increases PUVA-induced senescence in
            mouse skin
  JOURNAL   Exp Dermatol 25 (3), 212-217 (2016)
   PUBMED   26663487
  REMARK    GeneRIF: SNEV(P) (rp19/) (PSO) (4) deficiency increases
            PUVA-induced senescence in mouse skin
REFERENCE   5  (bases 1 to 6161)
  AUTHORS   Chanarat,S. and Strasser,K.
  TITLE     Splicing and beyond: the many faces of the Prp19 complex
  JOURNAL   Biochim Biophys Acta 1833 (10), 2126-2134 (2013)
   PUBMED   23742842
  REMARK    Review article
REFERENCE   6  (bases 1 to 6161)
  AUTHORS   Cho,S.Y., Park,P.J., Lee,J.H., Kim,J.J. and Lee,T.R.
  TITLE     Identification of the domains required for the localization of
            Prp19p to lipid droplets or the nucleus
  JOURNAL   Biochem Biophys Res Commun 364 (4), 844-849 (2007)
   PUBMED   17964290
  REMARK    GeneRIF: Immunofluorescence microscopy revealed that a domain of
            amino acids 167-250 is necessary for the recruitment of Prp19p to
            lipid droplets and that a domain of amino acids 1-166 is necessary
            for the recruitment of Prp19p to a nucleus.
REFERENCE   7  (bases 1 to 6161)
  AUTHORS   Sihn,C.R., Cho,S.Y., Lee,J.H., Lee,T.R. and Kim,S.H.
  TITLE     Mouse homologue of yeast Prp19 interacts with mouse SUG1, the
            regulatory subunit of 26S proteasome
  JOURNAL   Biochem Biophys Res Commun 356 (1), 175-180 (2007)
   PUBMED   17349974
REFERENCE   8  (bases 1 to 6161)
  AUTHORS   Fortschegger,K., Wagner,B., Voglauer,R., Katinger,H., Sibilia,M.
            and Grillari,J.
  TITLE     Early embryonic lethality of mice lacking the essential protein
            SNEV
  JOURNAL   Mol Cell Biol 27 (8), 3123-3130 (2007)
   PUBMED   17283042
  REMARK    GeneRIF: SNEV protein is essential, functionally nonredundant, and
            indispensable for mouse development.
            GeneRIF: SNEV is indispensable for early mouse development; MEFs
            (mouse embryonic fibroblasts) with reduced SNEV levels have lowered
            proliferative potential.
REFERENCE   9  (bases 1 to 6161)
  AUTHORS   Cho,S.Y., Shin,E.S., Park,P.J., Shin,D.W., Chang,H.K., Kim,D.,
            Lee,H.H., Lee,J.H., Kim,S.H., Song,M.J., Chang,I.S., Lee,O.S. and
            Lee,T.R.
  TITLE     Identification of mouse Prp19p as a lipid droplet-associated
            protein and its possible involvement in the biogenesis of lipid
            droplets
  JOURNAL   J Biol Chem 282 (4), 2456-2465 (2007)
   PUBMED   17118936
  REMARK    GeneRIF: Down-regulation of Prp19p expression with RNA interference
            in 3T3-L1 cells repressed lipid droplet formation with the
            reduction in the level of expression of perilipin and S3-12
REFERENCE   10 (bases 1 to 6161)
  AUTHORS   Urano,Y., Iiduka,M., Sugiyama,A., Akiyama,H., Uzawa,K.,
            Matsumoto,G., Kawasaki,Y. and Tashiro,F.
  TITLE     Involvement of the mouse Prp19 gene in neuronal/astroglial cell
            fate decisions
  JOURNAL   J Biol Chem 281 (11), 7498-7514 (2006)
   PUBMED   16352598
  REMARK    GeneRIF: the alpha-variant of Prp19 gene plays a pivotal role in
            neural differentiation and that the beta-variant participates in
            neuronal/astroglial cell fate decisions
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132402.3 and AK164681.1.
            
            On Dec 8, 2011 this sequence version replaced NM_134129.3.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the central coding region, compared to variant 1.
            This results in a shorter protein (isoform 2), compared to isoform
            1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK164681.1, AK088769.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AC132402.3         45957-45968         c
            13-2131             AK164681.1         1-2119
            2132-6161           AC132402.3         31640-35669         c
FEATURES             Location/Qualifiers
     source          1..6161
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 7.33 cM"
     gene            1..6161
                     /gene="Prpf19"
                     /gene_synonym="D19Wsu55e; NMP200; Prp19; PSO4; Snev"
                     /note="pre-mRNA processing factor 19"
                     /db_xref="GeneID:28000"
                     /db_xref="MGI:MGI:106247"
     exon            1..238
                     /gene="Prpf19"
                     /gene_synonym="D19Wsu55e; NMP200; Prp19; PSO4; Snev"
                     /inference="alignment:Splign:2.1.0"
     CDS             220..1734
                     /gene="Prpf19"
                     /gene_synonym="D19Wsu55e; NMP200; Prp19; PSO4; Snev"
                     /EC_number="2.3.2.27"
                     /note="isoform 2 is encoded by transcript variant 2;
                     nuclear matrix protein SNEV; prp19 beta; senescence
                     evasion factor; nuclear matrix protein 200; PRP19/PSO4
                     homolog; PRP19/PSO4 pre-mRNA processing factor 19 homolog;
                     RING-type E3 ubiquitin transferase PRP19"
                     /codon_start=1
                     /product="pre-mRNA-processing factor 19 isoform 2"
                     /protein_id="NP_598890.1"
                     /db_xref="CCDS:CCDS79687.1"
                     /db_xref="GeneID:28000"
                     /db_xref="MGI:MGI:106247"
                     /translation="MSLICSISNEVPEHPCVSPVSNHVYERRLIEKYIAENGTDPINN
                     QPLSEEQLIDIKVAHPIRPKPPSATSIPAILKALQDEWDAVMLHSFTLRQQLQTTRQE
                     LSHALYQHDAACRVIARLTKEVTAAREALATLKPQAGLIVPQAVPSSQPSVVGAGEPM
                     DLGELVGMTPEIIQKLQDKATVLTTERKKRGKTVPEELVKPEELSKYRQVASHVGLHS
                     ASIPGILALDLCPSDTNKILTGGADKNVVVFDKSTEQILATLKGHTKKVTSVVFHPSQ
                     ELVFSASPDATIRIWSVPNTSCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSD
                     IQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHS
                     GPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYL
                     ALGGTDVQIYICKQWTEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYSL"
     exon            239..388
                     /gene="Prpf19"
                     /gene_synonym="D19Wsu55e; NMP200; Prp19; PSO4; Snev"
                     /inference="alignment:Splign:2.1.0"
     exon            389..465
                     /gene="Prpf19"
                     /gene_synonym="D19Wsu55e; NMP200; Prp19; PSO4; Snev"
                     /inference="alignment:Splign:2.1.0"
     exon            466..607
                     /gene="Prpf19"
                     /gene_synonym="D19Wsu55e; NMP200; Prp19; PSO4; Snev"
                     /inference="alignment:Splign:2.1.0"
     exon            608..681
                     /gene="Prpf19"
                     /gene_synonym="D19Wsu55e; NMP200; Prp19; PSO4; Snev"
                     /inference="alignment:Splign:2.1.0"
     exon            682..744
                     /gene="Prpf19"
                     /gene_synonym="D19Wsu55e; NMP200; Prp19; PSO4; Snev"
                     /inference="alignment:Splign:2.1.0"
     exon            745..786
                     /gene="Prpf19"
                     /gene_synonym="D19Wsu55e; NMP200; Prp19; PSO4; Snev"
                     /inference="alignment:Splign:2.1.0"
     exon            787..861
                     /gene="Prpf19"
                     /gene_synonym="D19Wsu55e; NMP200; Prp19; PSO4; Snev"
                     /inference="alignment:Splign:2.1.0"
     exon            862..937
                     /gene="Prpf19"
                     /gene_synonym="D19Wsu55e; NMP200; Prp19; PSO4; Snev"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1047
                     /gene="Prpf19"
                     /gene_synonym="D19Wsu55e; NMP200; Prp19; PSO4; Snev"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1203
                     /gene="Prpf19"
                     /gene_synonym="D19Wsu55e; NMP200; Prp19; PSO4; Snev"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1273
                     /gene="Prpf19"
                     /gene_synonym="D19Wsu55e; NMP200; Prp19; PSO4; Snev"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1359
                     /gene="Prpf19"
                     /gene_synonym="D19Wsu55e; NMP200; Prp19; PSO4; Snev"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1530
                     /gene="Prpf19"
                     /gene_synonym="D19Wsu55e; NMP200; Prp19; PSO4; Snev"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1636
                     /gene="Prpf19"
                     /gene_synonym="D19Wsu55e; NMP200; Prp19; PSO4; Snev"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..6161
                     /gene="Prpf19"
                     /gene_synonym="D19Wsu55e; NMP200; Prp19; PSO4; Snev"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2109..2114
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prpf19"
                     /gene_synonym="D19Wsu55e; NMP200; Prp19; PSO4; Snev"
                     /note="hexamer: ATTAAA"
     polyA_site      2134
                     /gene="Prpf19"
                     /gene_synonym="D19Wsu55e; NMP200; Prp19; PSO4; Snev"
                     /note="major polyA site"
     regulatory      5984..5989
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prpf19"
                     /gene_synonym="D19Wsu55e; NMP200; Prp19; PSO4; Snev"
                     /note="hexamer: AATAAA"
     polyA_site      6018
                     /gene="Prpf19"
                     /gene_synonym="D19Wsu55e; NMP200; Prp19; PSO4; Snev"
     regulatory      6135..6140
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prpf19"
                     /gene_synonym="D19Wsu55e; NMP200; Prp19; PSO4; Snev"
                     /note="hexamer: AATAAA"
     polyA_site      6161
                     /gene="Prpf19"
                     /gene_synonym="D19Wsu55e; NMP200; Prp19; PSO4; Snev"
ORIGIN      
        1 atgctgggaa agggcagttt ccgttagctg cagaaggctg aggcgcgcca ccggccacct
       61 ccccacgtga agcagttgtg cgagcatcgc cacgctgggc agctgtctac ccgcgtccga
      121 gcgctccgga agcggcgggg gaccggaagt ggcccgcgga ggctgcagag aaccgggaac
      181 cctctgtgag gcgactggca gcagcgctac gacggcgcca tgtccctgat ctgctcgatc
      241 tccaatgaag tgccagagca cccgtgcgtg tcccctgtct ctaatcatgt gtatgagcgg
      301 cgactcattg agaagtacat tgcagagaat ggcacagatc ctatcaacaa ccagcctctc
      361 tcagaggagc agctcatcga catcaaagtt gctcacccaa tccgacccaa gcctccctcc
      421 gccaccagca tcccagccat tctgaaagcc ttgcaggatg agtgggatgc agtcatgctg
      481 cacagcttca ctcttcgcca gcaactgcag acaacccgcc aggagctgtc ccatgctctg
      541 taccaacacg atgctgcctg ccgagtcatt gcccggctca ccaaagaggt cactgctgct
      601 cgagaagctc tggctactct gaaaccacag gctgggctta ttgtacctca ggctgtgcca
      661 agctcacagc ccagtgttgt gggtgcagga gagcccatgg atttgggtga gctggtggga
      721 atgacccctg agattatcca gaagcttcaa gacaaggcta ctgtgctaac cacggagcgt
      781 aagaagagag gaaagactgt ccccgaggag ctggtgaaac ctgaagagct cagcaagtac
      841 cggcaggtgg catcccatgt gggtctacac agtgctagca ttcctgggat tctcgctctg
      901 gacctgtgtc cctcagacac caacaagatt ctcactggtg gggcagataa aaatgttgtt
      961 gtctttgata agagtactga gcaaatattg gccactctca aaggccatac caagaaggtc
     1021 accagtgtgg tgtttcatcc ttctcaggaa ctggtgtttt ctgcgtcccc tgatgctact
     1081 atcaggattt ggtcagtccc gaacacttcc tgcgtacagg ttgttcgggc ccatgagagt
     1141 gcagtgacag gcctcagcct ccatgctact ggagactatc tcctgagctc ctctgatgat
     1201 cagtactggg ccttctctga catccagaca gggcgtgtgc tcactaaggt gacagatgag
     1261 acctccggct gctctcttac ctgtgcacag ttccaccctg atgggctcat ctttggaaca
     1321 ggaaccatgg actcccagat caagatctgg gacttgaagg agcgtaccaa tgtggccaac
     1381 ttccctggcc attctggccc cattaccagc atcgccttct ctgagaatgg gtactacctg
     1441 gccacagcag ctgatgattc ctcagtcaag ctctgggact tacgcaagtt gaagaacttc
     1501 aagacattgc agctggacaa caactttgag gtgaagtcac taatctttga ccagagcggt
     1561 acctacctgg cgcttggggg tacagatgtc cagatctaca tctgcaaaca atggacagag
     1621 attcttcact ttacagagca cagtggcctg accactggag tggcctttgg acaccatgcc
     1681 aagttcatcg cttcaactgg catggacagg agcctcaaat tctacagtct gtaggcccta
     1741 tgccttctca cagttctggg cctcatctca gtagtgggtt agagttagag ggtgggggtg
     1801 ggggtgggac tttaggagga gagggaggtc tggttggggg gggacattca catcatttca
     1861 ttttggtctg gatgatggtc tgagccaggg cacatagaac attgctatcc atgcagcctt
     1921 tgggccccag ggaacggtca ccctgtaaag tgctcagagt cggagtccag cacctccccc
     1981 agtggtggca gctgttccat gcctgctctg tttcagctct tctgagacag ggaggaggag
     2041 ccaagggagc tgtgaagggg aggggcagga ggactcttgc agggttttgt aagcagcgat
     2101 ctagtttcat taaaaaaaaa agctacacag taaacagtca gcttcttgtg tctgtctgcc
     2161 agaaaccctg actggggaag gtcatgggag agggagccca gtgtgggaca gcagaaatgg
     2221 gacacgagtg accaggaagc ctcccctgca gcagaaatga gggaaagcct gaaagccgtc
     2281 tgtcagaggc ctccatgctc cggaagcctt gaccttgttt ccagggcctc tgtcacttgt
     2341 gctgtgcttg ctccctgact tggcctctct tacaagccgg aaaggtagcg aggcgctaga
     2401 agattagtct tagcctgctg gtgggttgct gtgagtcgat tgctagggat aatacttcag
     2461 gggcgatgat acacactgat tcctggctgg cttgactggc agctaatctg ttgaagtaga
     2521 gctgttccca gggcagacag ctagactaga gcacagtaaa taaaacatta gatgataaaa
     2581 acaggagggg attaatgtgg gctcctgtgg ctgcttgaca tttagaagtt acctggtact
     2641 aaaggagggg agaattgtag gtagaaggaa ggaaggctct gaggttgagg taagtgaggt
     2701 atgggcagca ggaggtcctg ctgctgtcca agggtaagga accattagct gtgccttggg
     2761 gatccttagg gccggagtag ggccacccca atggaatgtt ggcatttgga gcctgctttg
     2821 aggttaggag tgtggcaaga tgagggagga gggggggggg ggacaggggg agggttggtg
     2881 agttcacaga gaaactcttg ggaaggaaga cctgagaagt gagctatcgc ctaaaaggct
     2941 atggggaagc tagggggtcc tgataacaca acagaacaac tgggtatgtt ctgtcaggct
     3001 gtcctgtggg caaggagatt ggaatttacc ctatctgtga ttactatgta gcccactgct
     3061 ccctagaagt gtatccggta aacctacagg ggctggggag acagctccgt tagtaaagtg
     3121 ctttctaggt caccatgagc tgaatttaat ccccagcacc taatgtagaa aagccaagca
     3181 tggtgagccc ttcctctcag tgctggggag gcagagacac aaggagccca ggagttcaca
     3241 cacaaattga actgacctaa ctagtgggcc ctagactaaa accctgtttc aaaacaactc
     3301 ctaaggatga tatccaaagt aatcaagcct ctgccctcta catgcatatg tacgtatctg
     3361 tattccccgt acgaatacac aggattacaa agggccaaga gatgactgag tgatcatgtt
     3421 cactgtgatg gagcttgctc tagactgttg taagcagcag tgagcatgcc agggtcggtg
     3481 ggcatcctgg gccatgacgc tcagtgggtt gctgagttgt ggtaggtgac catagaagct
     3541 ggagcggtga ggcagtcagt gctggagtgc gttctcacaa gttcctcaca ctgacatcca
     3601 ttctggactg aagaagctgt ggcttctcgt gggattgctc tagttgaaca tgccctcaag
     3661 cagttttatt tcctttttct ttgaaggctg ggtttctctt tatagccctg gctgtcctag
     3721 aactcactct gtctcctgag tgctgggatt aaaggcatgt gccaccattg cccagtgaag
     3781 tgtggtcttt aaaaaattgt gtcttacagt tcttcggtaa cagggtaaat gtgaaatccg
     3841 tttcaacaac taagtaagag atgggctgat gtctgcaggt gtctgcaggt gctagtgcag
     3901 tgccagtgaa gggagagggg aggttgaggg catggcctgg gacatcctgg gcataaactg
     3961 gtccccaaag ctggccagta caaagccatt gagtggttgt tagatgttaa tgtgcagttt
     4021 tatgatccac ctaaaaagat agtgaaagac aagatgtggg aaagcctttc tggtcagcct
     4081 gaagttgtgt gtgaagtgtg tggcatgtgc acaggggagc cctgacatac accagagatg
     4141 taaacacata gccacccctc cttatagggc atagtttgta tagtaccacc tcacaggaca
     4201 gtgagagagt gcatgcagtt agggcaggaa gtacaggaac ggatgtctgg aagtccgctg
     4261 agtgacccct ccacccaccc cttgtatgag ggagcattcc cagtcagcct aatcttgaag
     4321 gtttcttgct agtagttgca gctactgtga tggaaggtga cacaataaaa gcaagctttc
     4381 atttggggct tgatggatcc taaagggctc catcttcctg gactcatttg taggccacac
     4441 aatcctagta ggtagggtct aggagcatca cagggtctgg tgccaaagag aatgtgtttg
     4501 ctatgaagtg ggtcagtgct tactgtaccc gatgaacatt tgaacctctg gatgttcaaa
     4561 actatgtccc ttagctgttg aactgacagc ttgaacttgc gcttgaactt ggagtgccaa
     4621 ctacaaggtc acctaggtgc agggaaatta acactagctc ccaaccaacc tagtaccttg
     4681 gctgagctgc aaagcatgcc tctagccagc aggcggtgct aattcctttc tgcaggtgaa
     4741 tgtcagagaa gcctaagact tggcctttgc ctgtgatttt aaagcatagt ttcagagaca
     4801 aagctgagac agcaatggat agctaatgac ctccttcatg ggtcttggga gtgtagggtc
     4861 atagttagta tggactttgg catcaagcct cagtttaact cctaactata cctttttaca
     4921 atgagtcttg tgtctgtctc tacctgtttg tggtgcctac ctggtagtgc taagagagct
     4981 ggtagtaagc tattgcaagg agcacagggt ggccctcagt aaccagtgac tgtccctgct
     5041 ttggtatggc tgttggtaac agttaaggtg gcccttagtg cttgacccta atggtgttaa
     5101 ggtttgacct aacttctcca tctttttttt tttcttggtt tttcgcaaca gggcagggat
     5161 tctctatata gcactggttg tcctggaact ctgtagtcca ggctggcctc aatctcagaa
     5221 atctgcctgc ctctgcctgc ctctgcctac caagtgctgg gattaaaggc ctgcaccacc
     5281 attctctggc tgacttctcc atctttaagc ccgatgttaa aacttaatca atccagctga
     5341 gtgtagtggt gcacacctta aatgccagca ctcagtggta ggcagatctg agttcaaggc
     5401 cagcctggtc tacagagtga gatccaggac aactaggact acatagagag tcctgtcttg
     5461 caaaagcaaa aagcaagctg cacaaaacca acagctcatc agtccagcca gggaggcaag
     5521 atgaagcagg atccaggcag gactgaagct tgaaggattc ctctgcccgc ctagccccac
     5581 gctaaggatt tggatggcac acattggaaa gagagattac agttctcatt gttacagcag
     5641 aattctctct agtccacacc agcacctgac aggcaattcc tcaccgccta cattggtgct
     5701 ctggtctgtc ctcttgccct aagtctgtgg attgagtctc tgcaggctcc cctctcagag
     5761 gcctacatct agacttctgc ctttggcagg ctccccgttc tcatccaggc ggaatgtcaa
     5821 cattgtcagc attctgaaga aggcccccac cccaaccccc agagttccca aattagaagc
     5881 tgtttttact tcccagaggt tttgttttta ttttcatcac atctgtgtga ctttctcccc
     5941 accacccccc acgttagttc aacagtgact taaaggatat aaaaataaaa tttggcattt
     6001 ttgttgttta cttttaaaga ctggtctggt attgctgccc attattggaa cagaaaaggc
     6061 cttttgcatt aaatgtgcct gcaggaatgc ctggatagaa gccacatacc ttaagctgta
     6121 gcagtgaact ctgcaataaa gtatcattta tttttatctt a
//
