LOCUS       NM_026045               3587 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus pre-mRNA processing factor 18 (Prpf18), transcript
            variant 2, mRNA.
ACCESSION   NM_026045
VERSION     NM_026045.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3587)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3587)
  AUTHORS   Nakano,Y., Wiechert,S. and Banfi,B.
  TITLE     Overlapping Activities of Two Neuronal Splicing Factors Switch the
            GABA Effect from Excitatory to Inhibitory by Regulating REST
  JOURNAL   Cell Rep 27 (3), 860-871 (2019)
   PUBMED   30995482
REFERENCE   3  (bases 1 to 3587)
  AUTHORS   Ye,A., He,H. and Kim,J.
  TITLE     PEG3 binds to H19-ICR as a transcriptional repressor
  JOURNAL   Epigenetics 11 (12), 889-900 (2016)
   PUBMED   27824289
REFERENCE   4  (bases 1 to 3587)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 3587)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI789029.1, BC058631.1 and BQ176788.1.
            
            On Oct 5, 2017 this sequence version replaced NM_026045.3.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon compared to variant 1. The resulting isoform (2) has the same
            N- and C-termini but is shorter compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC004573.1, AK135707.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                AI789029.1         1-54
            55-3087             BC058631.1         1-3033
            3088-3587           BQ176788.1         1-500               c
FEATURES             Location/Qualifiers
     source          1..3587
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 2.79 cM"
     gene            1..3587
                     /gene="Prpf18"
                     /gene_synonym="2810441A10Rik"
                     /note="pre-mRNA processing factor 18"
                     /db_xref="GeneID:67229"
                     /db_xref="MGI:MGI:1914479"
     exon            1..220
                     /gene="Prpf18"
                     /gene_synonym="2810441A10Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..1183
                     /gene="Prpf18"
                     /gene_synonym="2810441A10Rik"
                     /note="isoform 2 is encoded by transcript variant 2;
                     pre-mRNA-splicing factor 18; HPRP18 homolog; PRP18
                     homolog; PRP18 pre-mRNA processing factor 18 homolog"
                     /codon_start=1
                     /product="pre-mRNA-splicing factor 18 isoform 2"
                     /protein_id="NP_080321.2"
                     /db_xref="CCDS:CCDS15657.1"
                     /db_xref="GeneID:67229"
                     /db_xref="MGI:MGI:1914479"
                     /translation="MDILKSEILRKRQLVEDRNLLVENKKYFKRSELARKEEEAYYER
                     CGYKIQPKEDDQKPLTSSNPVLELELAEEKLPMTLSRQEVIRRLRERGEPIRLFGETD
                     YDAFQRLRKIEILTPEVNKGLRNDLKAALDKIDQQYLNEIVGGQEPGEEDTQNDLKVH
                     EENTTIEELEALGESLGKGDDHKDMDIITKFLKFLLGVWAKELNAREDYVKRSVQGKL
                     NSATQKQTESYLRPLFRKLRKRNLPADIKESITDIIKFMLQREYVKANDAYLQMAIGN
                     APWPIGVTMVGIHARTGREKIFSKHVAHVLNDETQRKYIQGLKRLMTICQKHFPTDPS
                     KCVEYNAL"
     exon            221..298
                     /gene="Prpf18"
                     /gene_synonym="2810441A10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            299..403
                     /gene="Prpf18"
                     /gene_synonym="2810441A10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            404..517
                     /gene="Prpf18"
                     /gene_synonym="2810441A10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            518..664
                     /gene="Prpf18"
                     /gene_synonym="2810441A10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            665..733
                     /gene="Prpf18"
                     /gene_synonym="2810441A10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            734..874
                     /gene="Prpf18"
                     /gene_synonym="2810441A10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            875..946
                     /gene="Prpf18"
                     /gene_synonym="2810441A10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1102
                     /gene="Prpf18"
                     /gene_synonym="2810441A10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..3571
                     /gene="Prpf18"
                     /gene_synonym="2810441A10Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3378..3383
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prpf18"
                     /gene_synonym="2810441A10Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      3411
                     /gene="Prpf18"
                     /gene_synonym="2810441A10Rik"
                     /note="major polyA site"
     regulatory      3441..3446
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prpf18"
                     /gene_synonym="2810441A10Rik"
                     /note="hexamer: AACAAA"
     polyA_site      3474
                     /gene="Prpf18"
                     /gene_synonym="2810441A10Rik"
                     /note="major polyA site"
     regulatory      3544..3549
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prpf18"
                     /gene_synonym="2810441A10Rik"
                     /note="hexamer: AGTAAA"
     polyA_site      3571
                     /gene="Prpf18"
                     /gene_synonym="2810441A10Rik"
                     /note="major polyA site"
ORIGIN      
        1 gatttccgcc ggaagcggct ccggcagttg ttgttttccg ataattgggc tctggttgct
       61 tcgtggtttg tcctcttccc cctcccctgg cgggtgaggt taccgccgag gagctgggga
      121 gtcaaagtga agacacttag accctgggag cgagatggac atcctgaaat ccgagattct
      181 gcggaagcgg cagctggtgg aggacaggaa cctgctggtg gaaaataaaa aatacttcaa
      241 gcggagtgaa ctggcgagaa aagaagagga agcgtattac gaaagatgtg gctacaagat
      301 acagccaaaa gaggatgacc agaaaccact aacatcgtca aatccagtgc tggaacttga
      361 actagcagag gaaaaacttc ctatgactct ttctaggcaa gaggtcatca gaagactgag
      421 agaaagagga gagccgatta gactgtttgg ggaaaccgac tatgatgctt tccagcgttt
      481 aaggaagata gagattctta caccagaagt taacaagggc ttaaggaatg atctgaaagc
      541 agctttggac aagattgacc agcagtactt gaatgagatt gtgggtggtc aggaacctgg
      601 agaggaggac acccagaatg acctgaaagt tcacgaggaa aacaccacca ttgaagaatt
      661 agaggcactg ggggagtcct tagggaaagg tgacgatcat aaggacatgg acatcatcac
      721 caagttcctg aagtttcttc ttggtgtttg ggctaaagaa ctgaatgcca gagaggacta
      781 cgtgaaacgc agtgtgcagg gcaaactgaa cagtgctacc cagaagcaga cggagtccta
      841 cctcagaccg cttttcagaa agctccggaa aaggaatctt cctgctgata ttaaagaatc
      901 aataacagat attattaagt tcatgttgca gagagagtac gtgaaggcga atgatgctta
      961 ccttcagatg gccattggca atgccccctg gcctatcggt gtcaccatgg ttggtatcca
     1021 tgccagaact ggcagggaga agatcttttc caagcatgtt gcgcatgttt taaatgatga
     1081 aacccaacgg aaatacattc agggactgaa gaggttaatg acaatttgcc agaagcactt
     1141 tcctacagat ccgtcaaaat gtgtggagta taatgcacta tgagatctgc acacagtgtg
     1201 tgtgtcagga agcctccgct cgctcgatcc ctcgcagcat gaggactccg gccttaccac
     1261 agctacgagg gaagagctcc accgtggggt cttcctggtg cagttcttgt tgactttaag
     1321 aactgtgttg gctttcacat ggaactggac tgcaaactaa tttttgtgtc ttgatttcat
     1381 tttaatgagt tgaaaaatta agttgtaaag atattatccg tagtttaagt gtgtagacaa
     1441 ccaccactca ggaaaggggg ttggaaatga ccattgtcaa gatcccagtg tgtcgttgat
     1501 acttaggaac atttgaaggt ggctttgaac tttctgtaaa ttattgtgat ttgcacattt
     1561 ttctatgtgg tatttataga aaatattttt tatatttcag caaaagtatg ggtcattgaa
     1621 tgctccttta gagttttctg tggtcttgga ccttctgcca tcttgtaata gagtgtgtgg
     1681 aatgttgctg ttaagtgtta tttgtcttgt gtttcagact tgcttttctt tctaagcaga
     1741 gtatggttgt catctttctg gacagatgaa ttgataggag atagaaggtc gaaagatggc
     1801 tgttatacca gcctaagttc agaacaccag catatcaagg acagggtgag gaagtggccg
     1861 tggatccagc tgagagtggc agcctcggga ctggatgccg gagagttgtg gcgttcctgg
     1921 cttccctgtg cctcacttgg tcctcactcg cctcacaaca tgacttgctc tagggcttac
     1981 agaatggagc tttggtcacc gtgaccactc tgtgctgcaa tgctgagagg tctggactag
     2041 ttcactgatg tgtgcagatg ggttgggtgt ggtgtcagag aaggaagagg gagtgggcca
     2101 aaccaggact gacagcttct caaggacatg ctcgatctaa ctacagcttt gggcatgtgg
     2161 gtccatctcg ctgagctttg gcttctttgt ctgacattga tgctaagagt ccatacctca
     2221 catcgatatt gtgtaagatg ctgagtctgc tgcctggcag atgataagag atcattatta
     2281 ttgcttatta cagtgtagac ccagggcctt tacggggccc tgtggctacc ctgggatagt
     2341 atgtactcat gtaacaacaa caacaacaac tgagttagca gcaatagtaa gtgaaggagt
     2401 cattattagg tttctctacc ccccgccccc catctttact ttcagtcagg tccaagttta
     2461 ggagtgcaga gaacaggacc tgggggctgc tgtaggtggc tcagattcac agttgcttat
     2521 gctggcccct cctgagaaag ccactttggg ctccttaagg tccaaggcat gcatagatag
     2581 gatagcttct gccagttgtt tgcagggtgg tggctgtctt gggttgaatc agtgttccct
     2641 tgcactccag ctgaagcctt ttcctaagat gaaagcaggt gtaccttggg acttacttga
     2701 caaagaagaa actctcataa gatgtgcagc aaatccctac tgtgacatgt ggtttggtca
     2761 taaaagtctt ctttataaat actatcagaa atgcccaaat cactcattct tcatccactg
     2821 ttaggccaca cagcatggta agtcatttta tgttgtcttc tcttgttaat attccacata
     2881 aaggggctgg agaaatggct cagcgggtaa gagcactgac tcttcttcct gaggtcctga
     2941 gttcaatacc cagcaatcac atggtggctc ataaccatct gtaatggaat ctgatgccct
     3001 cttctggtgt gtctgaagac agctacaatg tactcatata cataaaaaaa taaataaaat
     3061 ctttttttaa aaattccaca taaagaagaa actatatcat atgacatcag tacttcctaa
     3121 aattgatctg tgtgggctgg ggttttgttt tgttatttgt ttgtttgtct gtttgttttt
     3181 tgagcttgct ttgtctgcag gggaattcgt attctccagg actgggactg tggccattct
     3241 gaagctgggt ggagagaagc atgttcacga atgtggctct cagtcaagtt tttcataacc
     3301 gaaattaaaa agctatgtac aaattaaaga agctacatag aaactcctgg gatatgtagg
     3361 aagatgacct ttctttcatt aaatggaaat tttacttttg cctatactat atatttttgt
     3421 ttcaagattg tttttaaaac aacaaagatt tcttttaaac aagttacaac tctattgact
     3481 gtgtccgttt ctctcctccc catccttcca tcacaagaac tgggattctc tgtattcaca
     3541 tttagtaaaa aaccctttcc ttagaaatca aaaaaaaaaa aaaaaaa
//
