LOCUS       NM_031499                986 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus proline rich protein 2 (Prp2), mRNA.
ACCESSION   NM_031499
VERSION     NM_031499.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 986)
  AUTHORS   Azen,E.A., Johnson,E.B. and Sekhon,G.S.
  TITLE     Assignment of the proline-rich protein gene Prp2 (alias D6Mit13) to
            mouse chromosome 6G1 by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 89 (1-2), 14-15 (2000)
   PUBMED   10894928
REFERENCE   2  (bases 1 to 986)
  AUTHORS   Roberts,S.G., Layfield,R., Bannister,A.J. and McDonald,C.J.
  TITLE     Gene sequence of mouse B-type proline-rich protein MP4.
            Transcriptional start point and an upstream phylogenetic footprint
            with ets-like and rel/NFkB-like elements
  JOURNAL   Eur J Biochem 202 (3), 969-974 (1991)
   PUBMED   1765104
REFERENCE   3  (bases 1 to 986)
  AUTHORS   Ann,D.K., Smith,M.K. and Carlson,D.M.
  TITLE     Molecular evolution of the mouse proline-rich protein multigene
            family. Insertion of a long interspersed repeated DNA element
  JOURNAL   J Biol Chem 263 (22), 10887-10893 (1988)
   PUBMED   2839509
REFERENCE   4  (bases 1 to 986)
  AUTHORS   Ann,D.K. and Carlson,D.M.
  TITLE     The structure and organization of a proline-rich protein gene of a
            mouse multigene family
  JOURNAL   J Biol Chem 260 (29), 15863-15872 (1985)
   PUBMED   2999141
REFERENCE   5  (bases 1 to 986)
  AUTHORS   Clements,S., Mehansho,H. and Carlson,D.M.
  TITLE     Novel multigene families encoding highly repetitive peptide
            sequences. Sequence analyses of rat and mouse proline-rich protein
            cDNAs
  JOURNAL   J Biol Chem 260 (25), 13471-13477 (1985)
   PUBMED   3840480
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC124523.5.
            
            On Mar 7, 2019 this sequence version replaced NM_031499.2.
            
            Summary: This gene encodes a member of the heterogeneous family of
            proline-rich salivary glycoproteins. The expression of this gene is
            dramatically induced in the parotid and submandibular glands of
            mice by beta-adrenergic stimulation. The encoded protein serves an
            important dental function by protecting mice against toxic dietary
            polyphenols such as tannins and influence the visco-elastic
            properties of the mucus. This gene is located in a cluster of
            closely related salivary proline-rich proteins on chromosome 6.
            [provided by RefSeq, Nov 2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-99                AC124523.5         72440-72538
            100-986             AC124523.5         76345-77231
FEATURES             Location/Qualifiers
     source          1..986
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 64.03 cM"
     gene            1..986
                     /gene="Prp2"
                     /gene_synonym="MP14"
                     /note="proline rich protein 2"
                     /db_xref="GeneID:83380"
                     /db_xref="MGI:MGI:1932491"
     exon            1..99
                     /gene="Prp2"
                     /gene_synonym="MP14"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..986
                     /gene="Prp2"
                     /gene_synonym="MP14"
                     /note="proline-rich protein MP-3"
                     /codon_start=1
                     /product="proline-rich protein 2 precursor"
                     /protein_id="NP_113687.2"
                     /db_xref="CCDS:CCDS51931.1"
                     /db_xref="GeneID:83380"
                     /db_xref="MGI:MGI:1932491"
                     /translation="MLVVLFTVALLALSSAQEPREELQNQIQIPNQRPPPSGSQPRPP
                     VNGSQQGPPPPGGPQPRPPQGPPPPGGPQPRPPQGPPPPGGPQPRPPQGPPPPGGPQP
                     RPPQGPPPPGGPQPRPPQGPPPPGGPQQRPPQGPPPPGGPQQRPPQGPPPPGGPQPRP
                     PQGPPPPAGPQPRPPQGPPPPGPHLRPTQGPPPTGGPQQRYPQSPPPPGGPQPRPPQG
                     PPPPGGPHPRPTQGPPPTGPQPRPTQGPPPTGGPQQRPPQGPPPPGGPQPRPPQGPPP
                     PTGPQPRPTQGPHPTGGPQQTPPLAGNPQGPPQGRPQGPQ"
     exon            100..986
                     /gene="Prp2"
                     /gene_synonym="MP14"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagactcgg gagaaactcc agagcctctt ccaagatgct ggtggtcctg tttacagtgg
       61 ccctgctggc cctgagctct gctcaggaac cccgtgaaga acttcagaat caaatccaga
      121 tcccgaatca aaggccacct ccttcagggt cccaaccaag accgcctgtt aatgggagcc
      181 agcaaggccc accaccacca ggaggcccac agccgagacc ccctcaaggc ccaccaccac
      241 caggaggccc acagccgaga ccccctcaag gcccaccacc accaggaggc ccacagccga
      301 gaccccctca aggcccacca ccaccaggag gcccacagcc gagaccccct caaggcccac
      361 caccaccagg aggcccacag ccgagacccc ctcaaggccc accaccacca ggaggcccac
      421 agcagagacc ccctcaaggc ccaccaccac caggaggccc acagcagaga ccccctcaag
      481 gcccaccacc accaggaggc ccacagccga gaccccctca aggcccacca ccaccagcag
      541 gtccacagcc gagaccccct caaggcccac caccacccgg cccacacctg agacccactc
      601 aaggcccacc cccaacagga ggcccacagc agcgataccc tcaaagccca ccaccaccag
      661 gaggcccaca gccgagaccc cctcaaggcc caccaccacc aggaggccca cacccgagac
      721 ccactcaagg cccaccccca acaggcccac agccgagacc cactcaaggc ccacccccaa
      781 caggaggccc acagcagcga ccccctcaag gcccaccacc accaggtggc ccacagccga
      841 gaccccctca aggcccacca cccccaacag gcccacagcc gagacccact caaggcccac
      901 acccaacagg aggcccacag caaacacctc ctctggctgg aaacccacaa ggcccaccac
      961 aaggcagacc ccagggacct cagtaa
//
