LOCUS       NM_025834               3418 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus protein Z, vitamin K-dependent plasma glycoprotein
            (Proz), transcript variant 1, mRNA.
ACCESSION   NM_025834
VERSION     NM_025834.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3418)
  AUTHORS   Suzuki,T., Kikuguchi,C., Nishijima,S., Nagashima,T., Takahashi,A.,
            Okada,M. and Yamamoto,T.
  TITLE     Postnatal liver functional maturation requires Cnot
            complex-mediated decay of mRNAs encoding cell cycle and immature
            liver genes
  JOURNAL   Development 146 (4) (2019)
   PUBMED   30733279
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3418)
  AUTHORS   Butschkau,A., Wagner,N.M., Genz,B. and Vollmar,B.
  TITLE     Protein z exerts pro-angiogenic effects and upregulates CXCR4
  JOURNAL   PLoS One 9 (12), e113554 (2014)
   PUBMED   25474349
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3418)
  AUTHORS   Butschkau,A., Wagner,N.M., Bierhansl,L., Genz,B. and Vollmar,B.
  TITLE     Protein Z-deficiency is associated with enhanced neointima
            formation and inflammatory response after vascular injury in mice
  JOURNAL   Int J Clin Exp Pathol 7 (9), 6064-6071 (2014)
   PUBMED   25337252
  REMARK    GeneRIF: PZ contributes to a reduced neointima formation after
            vascular injury, underlining the modulatory role of the coagulation
            cascade in vascular homeostasis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3418)
  AUTHORS   Butschkau,A., Nagel,P., Grambow,E., Zechner,D., Broze,G.J. Jr. and
            Vollmar,B.
  TITLE     Contribution of protein Z and protein Z-dependent protease
            inhibitor in generalized Shwartzman reaction
  JOURNAL   Crit Care Med 41 (12), e447-e456 (2013)
   PUBMED   23963134
REFERENCE   5  (bases 1 to 3418)
  AUTHORS   Girard,T.J., Lasky,N.M., Tuley,E.A. and Broze,G.J. Jr.
  TITLE     Protein Z, protein Z-dependent protease inhibitor (serpinA10), and
            the acute-phase response
  JOURNAL   J Thromb Haemost 11 (2), 375-378 (2013)
   PUBMED   23205927
  REMARK    GeneRIF: Letter: protein Z is not a typical acute phase reactant.
REFERENCE   6  (bases 1 to 3418)
  AUTHORS   Zhang,J., Tu,Y., Lu,L., Lasky,N. and Broze,G.J. Jr.
  TITLE     Protein Z-dependent protease inhibitor deficiency produces a more
            severe murine phenotype than protein Z deficiency
  JOURNAL   Blood 111 (10), 4973-4978 (2008)
   PUBMED   18344422
  REMARK    GeneRIF: PZ and ZPI deficiency would be associated with a modest
            thrombotic risk with ZPI deficiency producing a more severe
            phenotype.
REFERENCE   7  (bases 1 to 3418)
  AUTHORS   Zhang,J. and Broze,G.J. Jr.
  TITLE     Mouse protein Z-dependent protease inhibitor cDNA
  JOURNAL   Thromb Haemost 85 (5), 861-865 (2001)
   PUBMED   11372680
REFERENCE   8  (bases 1 to 3418)
  AUTHORS   Yin,Z.F., Huang,Z.F., Cui,J., Fiehler,R., Lasky,N., Ginsburg,D. and
            Broze,G.J. Jr.
  TITLE     Prothrombotic phenotype of protein Z deficiency
  JOURNAL   Proc Natl Acad Sci U S A 97 (12), 6734-6738 (2000)
   PUBMED   10829076
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127308.3, AK008819.1 and AK005011.2.
            
            On Oct 24, 2017 this sequence version replaced NM_025834.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK008819.1, AK005011.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               AC127308.3         189706-189805
            101-2398            AK008819.1         102-2399
            2399-3174           AK005011.2         2343-3118
            3175-3418           AC127308.3         204581-204824
FEATURES             Location/Qualifiers
     source          1..3418
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 5.73 cM"
     gene            1..3418
                     /gene="Proz"
                     /gene_synonym="1300015B06Rik"
                     /note="protein Z, vitamin K-dependent plasma glycoprotein"
                     /db_xref="GeneID:66901"
                     /db_xref="MGI:MGI:1860488"
     exon            1..192
                     /gene="Proz"
                     /gene_synonym="1300015B06Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..1322
                     /gene="Proz"
                     /gene_synonym="1300015B06Rik"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; vitamin K-dependent protein Z"
                     /codon_start=1
                     /product="vitamin K-dependent protein Z isoform 1
                     precursor"
                     /protein_id="NP_080110.1"
                     /db_xref="CCDS:CCDS22105.1"
                     /db_xref="GeneID:66901"
                     /db_xref="MGI:MGI:1860488"
                     /translation="MAGCILLLRGFILTLILHQVELSVFLPAPKANNVLRRWRRGSSY
                     FLEEIFQGNLEKECYEEVCNYEEAREVFENDVITDEFWRQYGGGSPCVSQPCLNNGTC
                     EDHIRSYSCTCSPGYEGKTCAMAKNECHLERTDGCQHFCHPGQSSYMCSCAKGYKLGK
                     DQKSCGPSDKCACGALTSEHIRMTKSSQSQPSFPWQVRLTNSEGEDFCAGVLLQEDFV
                     LTTAKCSLLHSNISVKANVDQRIRIKSTHVHMRYDEESGENDVSLLQLEEPLQCPSSG
                     LPVCVPERDFAEHVLIPGTEGLLSGWMLNGTHLATTPMLLSVTQADGEECGQTLNVTV
                     TTRTSCEKGSVVMGPWVEGSVVTREHKGTWFLTGILGSPPPPGQSQMLLLTAVPRYSM
                     WFKQIMK"
     exon            193..356
                     /gene="Proz"
                     /gene_synonym="1300015B06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            357..381
                     /gene="Proz"
                     /gene_synonym="1300015B06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            382..495
                     /gene="Proz"
                     /gene_synonym="1300015B06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            496..627
                     /gene="Proz"
                     /gene_synonym="1300015B06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            628..710
                     /gene="Proz"
                     /gene_synonym="1300015B06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            711..828
                     /gene="Proz"
                     /gene_synonym="1300015B06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            829..3418
                     /gene="Proz"
                     /gene_synonym="1300015B06Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3392..3397
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Proz"
                     /gene_synonym="1300015B06Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3418
                     /gene="Proz"
                     /gene_synonym="1300015B06Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggtcatctag gctagcctct gtgtgttctg aggcacacac tgaccgcagt gcttcccagg
       61 gccctggact ttggctgttt gcagactttg ctctgcctgg gccagccagg ctctgggtta
      121 gcatggctgg ctgcatcttg ctgctccggg gcttcatcct taccctcatc ctgcaccagg
      181 tggagctttc cgtgtttctt ccagccccga aggcaaacaa cgttctgcgg aggtggaggc
      241 ggggtagttc gtacttcctg gaagaaatct tccagggaaa cttggagaag gagtgttatg
      301 aggaagtctg caactacgag gaggcaagag aagtgtttga aaatgacgtc atcacggatg
      361 agttctggag acagtatggg ggtggctctc cgtgcgtctc ccagccctgc ctcaacaacg
      421 ggacatgcga ggaccacatc cgcagctaca gctgcacgtg ctctccgggc tatgagggca
      481 agacctgtgc aatggctaaa aatgaatgtc acctagagag gacggatgga tgccagcatt
      541 tctgccaccc ggggcagtca tcttacatgt gcagttgtgc aaagggctac aagctgggca
      601 aggaccagaa atcatgtggt ccaagtgaca aatgcgcatg cggggccctg acttccgaac
      661 acatcagaat gacaaaaagc agccagagtc agcctagctt cccttggcag gtcagattaa
      721 caaattcgga aggagaagac ttctgtgccg gcgtgttact acaggaagac ttcgtgttga
      781 caacagcaaa gtgttcgtta ttgcacagca acatcagtgt aaaagcaaat gttgaccaga
      841 ggatcaggat caagagcact cacgtgcaca tgcgttatga cgaggagtcg ggggagaacg
      901 acgtgtcact gttgcagttg gaggagccct tgcagtgccc cagttctggt ctcccggtct
      961 gcgtcccaga gagggacttt gcagagcatg tcctcatccc tggaacggag ggtctcctca
     1021 gtggctggat gcttaatggc acacacctgg ctaccacacc gatgctgctg tcggtcacac
     1081 aagcagatgg cgaggaatgc ggacagaccc tgaatgtaac ggtcactacg aggacaagct
     1141 gtgagaaggg cagtgtggtg atggggcctt gggtggaagg aagtgtggtg acccgagaac
     1201 acaagggcac ctggttcctc acggggatcc taggctcgcc accaccacca gggcaatcgc
     1261 aaatgctcct cctcaccgca gtcccgagat actccatgtg gtttaaacag atcatgaagt
     1321 agctgaaatc caacaacatg gctgccagag ggtcgaatcc ggtcacagtt agcactggaa
     1381 gatgacctct tattccttgg aactttacat ttttctttac tcttgagaat ttcatacaca
     1441 catataatga aatgtgacta cacccacatc ccatttccct tctccaactc cacttatatt
     1501 tcctgagact ccactaagtt cagttagcac tacctctgtg tgtatggtgt ggggccatcc
     1561 actagagcac cctcaggact acacaatttt ccctccctca gcagctatca actgccaaca
     1621 gctcctcagt ggggagtgtg gcagggacca ccccccatct atgtcagaat ctggcttgat
     1681 cttgtgcagt cttgaccagg tcaccccagc tgctgagtct gttcccacta gaaggcactc
     1741 ttctcgacat ccctcccacc tctcagctgt atgtttttcc ccattctctt ggacgatttt
     1801 ccctaagcct tgatggaggt ggaggtgtag gtgcaagaga aagggagttg gggcctgttg
     1861 attaagatgt cccccatagg cctgagccct cagcccctac tctaacgctt tgactaatta
     1921 tacatctttg cattaactgc ggcccattat gaaaagaggg ttctttgacc aaagctgcca
     1981 acagcccagc tctatggtat gagcatatat atttagaagg taatttttaa catgaccttt
     2041 tagcaaagta acactagcag cttctacccc aggcctgtga cctccccagt cacaagcttt
     2101 tggccgagat tatagcttca ggcatggaat ccctgtgaag caggcctcac aatcagccag
     2161 aaagcagttc tgtacccaca attgcaccaa tgtgcacatc ttgcctggca tgtcagtgtt
     2221 gtggacgagg gcccagcact gggtaagacc attgttgcct ccgctgttcc tgtagctagc
     2281 acaggcttct ggccttatga aagctagcca gcaaggcgtt tctttggtaa tttttatcca
     2341 aacagaggcc ttaagggaaa aaaaaatagg atttgtgaaa taaaagcagt gtcagtcgta
     2401 aactggccga gttactgagt ggaagctgag tggagagagg ctgtgaacac ccgtggttgt
     2461 gtcacagttg gtgtgtcgaa cactggaaca ggaggtgcaa gggcagcctc attctggttc
     2521 tgctagggag aggagagcaa gcttagtact gaagagggcc ctggacctcc tgacaaggct
     2581 gtagctagac acgctgggcg aagccctcag cggattccag gagtgcggca gcctctcaac
     2641 tcagccctgt ggttggggaa gctgtgctta cgcaagacct tagtttcctg tgcctcagca
     2701 ccttcatctc taagaggaat agctcaactg tggctatgat gacatttaaa aggggaggaa
     2761 aaggtaaact gagccccaag tctgaagata gactgggctg tgaaataagg cactgtctca
     2821 aacgaacaaa tataaggggc caaagcagtg tgcccttagg caagagataa gtgtgagtat
     2881 ttaatgttga tgcaaactag ttacaataat gtatgggtct gtgtgcccac gaactaggac
     2941 accagagaca gcacacagca cagtgtggag acagcacaca gacacacact gtggagacat
     3001 cacacagcac acactgtgga gacatcacac agacacacag tgtggagaca gcacacagac
     3061 acacactgtg gagacatcac acagacacac actgtggaga cagcacacag tgtgaagaca
     3121 gcacacagtg tggagacagc acacagcaca cactgtggag acatcacaca gacaaacagt
     3181 gtggagacag cacacagaca cacactgtgg acacagcaca cagtgtggag acagcacaca
     3241 gacacacact gtggacacag cacacagtgt ggagacagca cacagacaca tactgtggac
     3301 acagcacaca ctgtagagag gttgcttctt taatttctaa attcaactat tcgtcacttc
     3361 aatcaggttc tgacttacga cgtcactgtt taataaatta cctggagcag cctgaaaa
//
