LOCUS       NM_175198               4327 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus prospero homeobox 2 (Prox2), transcript variant 1,
            mRNA.
ACCESSION   NM_175198 XM_006516278
VERSION     NM_175198.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4327)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4327)
  AUTHORS   Lowenstein,E.D., Ruffault,P.L., Misios,A., Osman,K.L., Li,H.,
            Greenberg,R.S., Thompson,R., Song,K., Dietrich,S., Li,X.,
            Vladimirov,N., Woehler,A., Brunet,J.F., Zampieri,N., Kuhn,R.,
            Liberles,S.D., Jia,S., Lewin,G.R., Rajewsky,N., Lever,T.E. and
            Birchmeier,C.
  TITLE     Prox2 and Runx3 vagal sensory neurons regulate esophageal motility
  JOURNAL   Neuron 111 (14), 2184-2200 (2023)
   PUBMED   37192624
  REMARK    GeneRIF: Prox2 and Runx3 vagal sensory neurons regulate esophageal
            motility.
REFERENCE   3  (bases 1 to 4327)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   4  (bases 1 to 4327)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4327)
  AUTHORS   Lanier,J., Dykes,I.M., Nissen,S., Eng,S.R. and Turner,E.E.
  TITLE     Brn3a regulates the transition from neurogenesis to terminal
            differentiation and represses non-neural gene expression in the
            trigeminal ganglion
  JOURNAL   Dev Dyn 238 (12), 3065-3079 (2009)
   PUBMED   19877281
REFERENCE   6  (bases 1 to 4327)
  AUTHORS   Kirjavainen,A., Sulg,M., Heyd,F., Alitalo,K., Yla-Herttuala,S.,
            Moroy,T., Petrova,T.V. and Pirvola,U.
  TITLE     Prox1 interacts with Atoh1 and Gfi1, and regulates cellular
            differentiation in the inner ear sensory epithelia
  JOURNAL   Dev Biol 322 (1), 33-45 (2008)
   PUBMED   18652815
REFERENCE   7  (bases 1 to 4327)
  AUTHORS   Nishijima,I. and Ohtoshi,A.
  TITLE     Characterization of a novel prospero-related homeobox gene, Prox2
  JOURNAL   Mol Genet Genomics 275 (5), 471-478 (2006)
   PUBMED   16470382
  REMARK    GeneRIF: Compared to mouse Prox1, mouse Prox2 is dispensable for
            embryonic development, retinal horizontal cell generation, and
            fertility.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127582.4.
            
            On or before Sep 28, 2022 this sequence version replaced
            XM_006516278.5, NM_175198.5.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2 and 3 encode the same protein.
            
            ##Evidence-Data-START##
            CDS exon combination :: AK051700.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-106               AC127582.4         88430-88535
            107-798             AC127582.4         92253-92944
            799-2279            AC127582.4         103604-105084
            2280-2387           AC127582.4         109471-109578
            2388-2582           AC127582.4         111115-111309
            2583-4327           AC127582.4         111665-113409
FEATURES             Location/Qualifiers
     source          1..4327
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 39.54 cM"
     gene            1..4327
                     /gene="Prox2"
                     /gene_synonym="1700058C01Rik"
                     /note="prospero homeobox 2"
                     /db_xref="GeneID:73422"
                     /db_xref="MGI:MGI:1920672"
     exon            1..106
                     /gene="Prox2"
                     /gene_synonym="1700058C01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            107..798
                     /gene="Prox2"
                     /gene_synonym="1700058C01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            799..2279
                     /gene="Prox2"
                     /gene_synonym="1700058C01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2280..2387
                     /gene="Prox2"
                     /gene_synonym="1700058C01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2388..2582
                     /gene="Prox2"
                     /gene_synonym="1700058C01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2583..4327
                     /gene="Prox2"
                     /gene_synonym="1700058C01Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3735..3740
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prox2"
                     /gene_synonym="1700058C01Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3767
                     /gene="Prox2"
                     /gene_synonym="1700058C01Rik"
                     /note="major polyA site"
     regulatory      4305..4310
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prox2"
                     /gene_synonym="1700058C01Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      4327
                     /gene="Prox2"
                     /gene_synonym="1700058C01Rik"
                     /note="major polyA site"
ORIGIN      
        1 gcgaaccact aaccgtgctg ggtgccgggc ggtgtgagcc gggctcgcat ccttagcggt
       61 cccagcgcgg ggcatctgtg gcgctgtcaa gagaaggcca acttgggttg aagtggagaa
      121 gatggaaaat tctgggtgat gttttgggcg taggccagtt ctcctcaact ctatcagaga
      181 tgggtctatc ggcaactggc cagtgttcca acttcttcta ctgctggggc agcctcgcag
      241 cctgttcttc ctgagatctg aggtgcgaga ttttagtgct agatagaact cagccccctg
      301 agattgctgg aggggtctga agaaagatga tcactttgga ggtgtctcac aacggggaac
      361 ttggaggccg agatcaggag ctgacacaca gcagtggaga agccaagcaa atccatgctc
      421 cagatcttca aagggctctg aaaattctta gcggagatgg aacagaaggc ttttcaagaa
      481 actgtctgag cggggctttc agagaacctg gcttgccctg gaggtgggaa atcacggggg
      541 tcagccaacc agctcggggg ctccaatttg catattcata ggccctcatg ctggttggct
      601 gtgcttagta gcccaccggc ccccagtaag gttgggtctg tcagatagtg acttgcctta
      661 agaaggggca ggaggctccc ctcgcccagc cacagcacga ggaagaaagg aaaccaaaat
      721 cacttcctga ccctcgctct gtctgcccaa ggctggtgaa gacaccaatg gagagcagac
      781 ctcgctgagg acttctcaga gtctgtccca ggggttccat cactctggcc ttcctgaacc
      841 ccaggagcag ttgatgttca ctctctgcgt gtgaagaaga cccttcagca cgctctggcc
      901 cacctctcgc tgctcaattt agcagggctc tcaaaggccc tgggctcctc ctgggagctc
      961 tgcatgagca tccggagagg caggacatgg atccacctgc tgctgtcttg cttcctcctc
     1021 agtctcggac ctgcacccac ctggcagaag aaacctgcat ggaccaggag agaagcccag
     1081 ccaccgcaga ggcaggcaga gactcgtttc ccagtggtca gctgcccagc tccagcctca
     1141 ctgaagctga ctggttttgg gacgagcaca tccaggctaa gagggccaga gtagagacca
     1201 ttgtccgagg catgtgtctc tctcctagct cgtcggtgtc aggcagagcc agggagagct
     1261 tgcgctgtcc agaaaagggt cgggagcgga agagaaagca gagccttccc atgcaccaag
     1321 gtcccctgaa atctagccct gcctgggagc gagggcccaa gaaggggggg acccgggtga
     1381 aagaacagct tcatctactg aagcaacagc taagacattt gcaggagcat gtcctacagg
     1441 ccacagagcc cagagcacca gcacagagcc caggaggaac tgagccaaga agctccccga
     1501 gggcaaggcc gaggaacagc tgctcatctg gtgcctggac cgtggagaac gagcctcacc
     1561 agagttctag caaggacctc tgtggagcag taaagcccgg agcagctgag gtcctacagt
     1621 actcagagga gccgatgctc tgtccttctg gcccacgggc cttggtggag actctgagga
     1681 aagaactgag cagggccgtg tcccaagctg tggactccgt attacagcaa gtgctatttg
     1741 atccacagag acatctcacg cagcaggagc gaagctgcca ggggctagca tcagagggca
     1801 gaaaccagcc ttcacctcca gggagaagtg cctataagga cccacttgct cttgccaccc
     1861 tgcccagaaa gatccagcca caagctgggg ttcccttggg caattcaaca ctggcaaggc
     1921 ctctagattc tcctatgtgt cctgtctctc caagaggagt ccctagatca tatcagagtc
     1981 ccctaccaaa ttgtcccttg acaaatgtac cttcccacac ctgggaaaat cagatgctta
     2041 ggcagcttct gggtcgtggg cccgatggcc aatggagtgg cagccctccc caggacgcag
     2101 ctttccaaag tcatacctcc ccagagtctg cccagcaacc gtgggggctg agccagcagc
     2161 agctccccct gtctctcacc ccggtccatc tggaaagccg gcccctccca ccgcctgtga
     2221 agatggagca gggcgtgctg cggggcgtgg ctgactcact tcctttttct tccatccaca
     2281 tccaggaagg cctgagccct ggtcacctga agaaggccaa actaatgttt ttcttcacgc
     2341 ggtaccccag ctccagcctc ctgaaagctt atttccctga tgttcagttc aaccgctgca
     2401 tcacctccca gatgatcaag tggttcagca acttccgtga attttattac atccagatgg
     2461 aaaagtatgc ccggcaagca ctttcagacg gtatcacgaa cgcccaagca ctggctgtcc
     2521 tccgagactc ggagcttttc cgagttctca atacacacta taacaagggg aatgactttg
     2581 aggtcccaga ctgcttcttg gagattgccg ccctgacact gaaggagttc ttcagggctg
     2641 tcttggcagg gaaagattca gatccttcct ggaagaaacc catttacaag gttatctcaa
     2701 aactcgacag tgacgtccca gagatgctca aatcacccag cttcctcccg ggactgttcc
     2761 cgagttaaca ttgaacagaa tgagggcaag tatgatggca caggcctggg agtccaaggt
     2821 gagaggtgga ggcaggtgga tcaggaactt agggacagcc ttggccacaa agacaaagat
     2881 caaacaaaat gagtagaacg gcccagggtg gctcaagctt tgtcataaat ggcagtttag
     2941 ctgtagtcac atcaaagcac aagaggaacc cctcccatag atgcaactgc cgttctgaat
     3001 actcgttttc ttgtccagaa ttatcagaga cttaacctta accacagtcc atcagctaaa
     3061 tctagcagtg tgtttgtaga ctattgggaa aggaacacaa gtttgcaatc agaagactta
     3121 aaagtcatta agtgctgtgg cagtgataat ttcctggtat tcctttaact ctggaaggag
     3181 attcatagcc aagtggtggt ggtaaacagg tttaatccct gcacggagag gcagagatag
     3241 gtggatctgt gaattggagg ccagcctggt ctacaaagtg agttccagga cagccagagc
     3301 tacacagaga aaccatgtct cggaaaacaa aaacaaacaa aacaaaacaa aaaatcaaaa
     3361 aagccccaag aaattttgaa gtgtgggtac ctcgttgatt cttacgccag ggcacaggat
     3421 cagtcaggac tatgaaggaa ccgatggctg tgtacgctgg actcatgctg tcacttggga
     3481 tctccaacag gaaaaatcca tgctagcagg gcacccgtgg attggcactg ccatctgatc
     3541 aggttggcac tcaggagcgc ttcatcatcc aagacgttca ctgatggctt cggcaaactt
     3601 cctaaagaac ctcggtcggc actgctgtgg cttgcatctg tctgctggaa cactgggtct
     3661 gctaacagtc ctaacagtcc tacttgacct atatactggt gccccaactg cccatgcata
     3721 caaaaatata tataaataaa aaatggaact tcataatgag aaagccagag gggcctcgag
     3781 gacgatctgg tccaccttgt ttaacctgtg gaggaaactg agactagcat acactctaca
     3841 gggctcacag gccatgaatg gcaagggctg ggacaaaggc agagattttc ctacttcaaa
     3901 atggttacag tctatgattg aatttgcaca gatgaacaaa tgacatccaa gttttccccc
     3961 ttgggtccaa cacagttgtg actgacgctg agcaccatta ggcgaggaac ccatatagtg
     4021 gaacaactgt cttctagtca gaaccaagcc tgtaagcact gctgaaggtg ggcaggacga
     4081 agtagacttc aggttttaca gtgttaaatg aggggcaacc gtgcctacag tagctccctt
     4141 ccctgccttc aacctccaac aagctccaca tctagctcct ctaccttcat aacttgatgg
     4201 gtggtggtgt tggctattgc tagacatgtc agactacacc aatacaaaca aagtctttcc
     4261 tctcaagttt ctgttcaaat agtggagaac agtaacaaaa cataattaaa tctaatcgat
     4321 tacttaa
//
