LOCUS       NM_008937               8026 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus prospero homeobox 1 (Prox1), transcript variant 1,
            mRNA.
ACCESSION   NM_008937
VERSION     NM_008937.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8026)
  AUTHORS   Carlantoni,C., Liekfeld,L.M.H., Hemkemeyer,S.A., Schreier,D.,
            Saygi,C., Kurelic,R., Cardarelli,S., Kalucka,J., Schulte,C.,
            Beerens,M., Mailer,R.K., Schaffer,T.E., Naro,F., Pellegrini,M.,
            Nikolaev,V.O., Renne,T. and Frye,M.
  TITLE     The phosphodiesterase 2A controls lymphatic junctional maturation
            via cGMP-dependent notch signaling
  JOURNAL   Dev Cell 59 (3), 308-325 (2024)
   PUBMED   38159569
REFERENCE   2  (bases 1 to 8026)
  AUTHORS   Deska-Gauthier,D., Borowska-Fielding,J., Jones,C., Zhang,H.,
            MacKay,C.S., Michail,R., Bennett,L.A., Bikoff,J.B. and Zhang,Y.
  TITLE     Embryonic temporal-spatial delineation of excitatory spinal V3
            interneuron diversity
  JOURNAL   Cell Rep 43 (1), 113635 (2024)
   PUBMED   38160393
REFERENCE   3  (bases 1 to 8026)
  AUTHORS   Munoz-Gallardo,M.D.M., Garcia-Padilla,C., Vicente-Garcia,C.,
            Carvajal,J., Arenega,A. and Franco,D.
  TITLE     miR-195b is required for proper cellular homeostasis in the elderly
  JOURNAL   Sci Rep 14 (1), 810 (2024)
   PUBMED   38191655
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8026)
  AUTHORS   Sun,Q., Li,J., Ma,J., Zheng,Y., Ju,R., Li,X., Ren,X., Huang,L.,
            Chen,R., Tan,X. and Luo,L.
  TITLE     JAM-C Is Important for Lens Epithelial Cell Proliferation and Lens
            Fiber Maturation in Murine Lens Development
  JOURNAL   Invest Ophthalmol Vis Sci 64 (15), 15 (2023)
   PUBMED   38095908
REFERENCE   5  (bases 1 to 8026)
  AUTHORS   Subileau,M. and Vittet,D.
  TITLE     Ontogenesis of the Mouse Ocular Surface Lymphatic Vascular Network
  JOURNAL   Invest Ophthalmol Vis Sci 64 (15), 7 (2023)
   PUBMED   38054922
REFERENCE   6  (bases 1 to 8026)
  AUTHORS   Stoykova,A., Fritsch,R., Walther,C. and Gruss,P.
  TITLE     Forebrain patterning defects in Small eye mutant mice
  JOURNAL   Development 122 (11), 3453-3465 (1996)
   PUBMED   8951061
REFERENCE   7  (bases 1 to 8026)
  AUTHORS   Sanz,L., Moscat,J. and Diaz-Meco,M.T.
  TITLE     Molecular characterization of a novel transcription factor that
            controls stromelysin expression
  JOURNAL   Mol Cell Biol 15 (6), 3164-3170 (1995)
   PUBMED   7760812
REFERENCE   8  (bases 1 to 8026)
  AUTHORS   Rex,M., Uwanogho,D., Cartwright,E., Pearl,G., Sharpe,P.T. and
            Scotting,P.J.
  TITLE     Sox gene expression during neuronal development
  JOURNAL   Biochem Soc Trans 22 (3), 252S (1994)
   PUBMED   7821514
REFERENCE   9  (bases 1 to 8026)
  AUTHORS   Oliver,G., Sosa-Pineda,B., Geisendorf,S., Spana,E.P., Doe,C.Q. and
            Gruss,P.
  TITLE     Prox 1, a prospero-related homeobox gene expressed during mouse
            development
  JOURNAL   Mech Dev 44 (1), 3-16 (1993)
   PUBMED   7908825
REFERENCE   10 (bases 1 to 8026)
  AUTHORS   Wolff,G.L., Greenman,D.L., Frigeri,L.G., Morrissey,R.L., Suber,R.L.
            and Felton,R.P.
  TITLE     Diabetogenic response to streptozotocin varies among obese yellow
            and among lean agouti (BALB/c x VY)F1 hybrid mice
  JOURNAL   Proc Soc Exp Biol Med 193 (2), 155-163 (1990)
   PUBMED   2137249
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC026911.16, AK052889.1 and AC126032.4.
            
            [WARNING] On Apr 10, 2024 this sequence was replaced by
            NM_008937.4.
            
            On Feb 15, 2018 this sequence version replaced NM_008937.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 both encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051411.1, AK052889.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               AC026911.16        111001-111115
            116-3610            AK052889.1         3-3497
            3611-8026           AC126032.4         35992-40407
FEATURES             Location/Qualifiers
     source          1..8026
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 95.85 cM"
     gene            1..8026
                     /gene="Prox1"
                     /gene_synonym="A230003G05Rik; PROX-1"
                     /note="prospero homeobox 1"
                     /db_xref="GeneID:19130"
                     /db_xref="MGI:MGI:97772"
     exon            1..560
                     /gene="Prox1"
                     /gene_synonym="A230003G05Rik; PROX-1"
                     /inference="alignment:Splign:2.1.0"
     exon            561..2352
                     /gene="Prox1"
                     /gene_synonym="A230003G05Rik; PROX-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             628..2841
                     /gene="Prox1"
                     /gene_synonym="A230003G05Rik; PROX-1"
                     /note="homeobox prospero-like protein PROX1;
                     prospero-related homeobox 1"
                     /codon_start=1
                     /product="prospero homeobox protein 1"
                     /protein_id="NP_032963.1"
                     /db_xref="CCDS:CCDS35822.1"
                     /db_xref="GeneID:19130"
                     /db_xref="MGI:MGI:97772"
                     /translation="MPDHDSTALLSRQTKRRRVDIGVKRTVGTASAFFAKARATFFSA
                     MNPQGSEQDVEYSVVQHADGEKSNVLRKLLKRANSYEDAMMPFPGATIISQLLKNNMN
                     KNGGTEPSFQASGLSSTGSEVHQEDICSNSSRDSPPECLSPFGRPTMSQFDVDRLCDE
                     HLRAKRARVENIIRGMSHSPSVALRGNENEREMAPQSVSPRESYRENKRKQKLPQQQQ
                     QSFQQLVSARKEQKREERRQLKQQLEDMQKQLRQLQEKFYQVYDSTDSENDEDGDLSE
                     DSMRSEILDARAQDSVGRSDNEMCELDPGQFIDRARALIREQEMAENKPKREGSNKER
                     DHGPNSLQPEGKHLAETLKQELNTAMSQVVDTVVKVFSAKPSRQVPQVFPPLQIPQAR
                     FAVNGENHNFHTANQRLQCFGDVIIPNPLDTFGSVQMPSSTDQTEALPLVVRKNSSEQ
                     SASGPATGGHHQPLHQSPLSATAGFTTPSFRHPFPLPLMAYPFQSPLGAPSGSFSGKD
                     RASPESLDLTRDTTSLRTKMSSHHLSHHPCSPAHPPSTAEGLSLSLIKSECGDLQDMS
                     DISPYSGSAMQEGLSPNHLKKAKLMFFYTRYPSSNMLKTYFSDVKFNRCITSQLIKWF
                     SNFREFYYIQMEKYARQAINDGVTSTEELSITRDCELYRALNMHYNKANDFEVPERFL
                     EVAQITLREFFNAIIAGKDVDPSWKKAIYKVICKLDSEVPEIFKSPNCLQELLHE"
     exon            2353..2460
                     /gene="Prox1"
                     /gene_synonym="A230003G05Rik; PROX-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2461..2655
                     /gene="Prox1"
                     /gene_synonym="A230003G05Rik; PROX-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2656..8026
                     /gene="Prox1"
                     /gene_synonym="A230003G05Rik; PROX-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcttgcctc gctatccccc cttgaatccg aaggcgcctc gcgattgggt gctgggaccg
       61 ggtacgtcag tgggactgtg acgtgcagtc ttcctgtttc cttcagctgt gtcttaaagt
      121 aaatcttgtt gtggagcgga gccctcagct gagagagcgc tgggaaagcg acggccactg
      181 cagccgggga agccgcgcgg cgcacacaag cctctccgcc gtgcccgctg ctcctcgggc
      241 caccgctccg cgctccagcc ctcgccgcct tctccgctct ctctcccctt ctttccccgg
      301 gctcccggct ctgccctgcg cgcctctccc ctcccctccc tcctttctcc cctcgcctct
      361 cagcactcgc ccagatcact cgctcccgca cagactcacc gacccctggg ccaattatca
      421 ccagtaagac atcaccgcgt gcgcgcgtgg gtttcttctc tgcccgcaag agaagaagag
      481 agggggagag agagagagag tgaaaagaaa gagagagaga aagagagaga gtggctgcgc
      541 cccgctgctg cccgcaccgc ggtcccggga ttcttgagct gtgcccagct gacgagcttt
      601 tgaagatggc acaataactg tccagtgatg cctgaccatg acagcacagc cctcttaagc
      661 cggcaaacca agaggagaag ggttgacatt ggagtgaaaa ggacggtagg gacagcatct
      721 gcattttttg ctaaggcaag ggcaacattt ttcagtgcca tgaatcccca aggttcagag
      781 caggatgttg aatattctgt ggtgcaacac gcagatgggg aaaagtcgaa cgtactccgc
      841 aagctgctga agagggcgaa ctcgtatgaa gatgccatga tgccttttcc aggagcaact
      901 ataatttccc agctgttgaa aaataacatg aacaaaaacg gtggcaccga gcccagtttc
      961 caagccagcg gactctctag cacaggctcc gaagtacatc aggaggatat atgtagcaac
     1021 tcttcaagag acagcccccc agagtgtctt tccccttttg gcaggcctac tatgagccag
     1081 tttgatgtgg atcgcttatg tgatgagcac ctgagagcaa agcgcgcccg ggttgagaat
     1141 atcattcggg gtatgagcca ttcccccagt gtggcattaa ggggcaatga aaacgaaaga
     1201 gagatggccc cgcagtctgt gagtccccga gaaagttaca gagaaaacaa acgcaagcag
     1261 aagctgcccc agcagcagca acagagtttc cagcagctgg tttcagcccg aaaagaacag
     1321 aagcgagagg agcgccgaca gctgaaacag cagctggaag acatgcagaa gcagctgcgc
     1381 cagctgcagg agaagttcta ccaggtctat gacagcacag actccgaaaa tgatgaagat
     1441 ggcgacctgt ctgaagacag catgcgctcg gagatcctgg atgcacgggc ccaggactcg
     1501 gtggggcgct cagacaatga gatgtgtgag ctggacccag ggcagttcat cgacagggcc
     1561 cgagccctaa tcagggagca ggagatggct gagaacaagc ctaagcgaga aggcagcaac
     1621 aaagaaagag accacgggcc aaactccttg cagccagaag gcaagcatct ggcagagacc
     1681 ttaaaacagg agctgaacac ggccatgtcg caggttgtgg acacggtggt caaagtcttc
     1741 tcagccaaac cctctcgcca ggttcctcag gtcttcccac ctctccagat cccccaggcc
     1801 agattcgcag tcaacgggga aaaccacaat ttccacacgg ccaaccagcg cctgcaatgc
     1861 tttggtgatg tcatcattcc gaaccccttg gacacctttg gcagtgtgca gatgcctagt
     1921 tccacagacc agacggaagc ccttcccctg gtggtccgaa aaaactcatc cgagcaatct
     1981 gcctctggcc cggccactgg cggccaccac cagcccctgc accagtcacc cctctccgcc
     2041 actgcaggct tcaccacccc tagcttccgc catccctttc ccctgccctt gatggcttat
     2101 ccatttcaga gtccactagg tgctccctcc ggctccttct cggggaagga cagagcctct
     2161 cctgagtcct tagacttgac tcgggacaca acaagtctga ggaccaagat gtcatcacac
     2221 catctgagcc accacccctg ttcaccagca cacccaccca gcaccgcaga aggactctct
     2281 ttgtcactca taaagtctga gtgtggagat cttcaagata tgtccgacat ctcaccttat
     2341 tcaggaagcg caatgcagga agggctatca cccaatcact tgaaaaaggc aaaactcatg
     2401 ttcttttaca cccgctaccc cagctccaac atgctgaaga cctacttctc ggacgtgaag
     2461 ttcaacagat gcattacctc gcagctcatc aagtggttca gcaatttccg tgagttttac
     2521 tatatccaga tggagaagta tgcgcgtcaa gccatcaatg atggagtcac cagtacagaa
     2581 gagctctcca tcaccaggga ttgtgagcta taccgagccc tcaacatgca ctacaacaaa
     2641 gcaaatgact ttgaggttcc agagagattc ctggaagttg cgcagatcac gttacgggag
     2701 tttttcaatg ccatcatcgc gggcaaagat gttgatcctt cctggaagaa ggccatttac
     2761 aaggtcatct gcaagctgga tagtgaagtt cctgagattt tcaaatcccc taactgccta
     2821 caagaactcc ttcacgagta gagattgcaa cgctcttttg aatgtatgga tagaagaatt
     2881 cccccttgga tgtccaactt ctctgtgtct agattttggt tttatatatt tgtgtggggg
     2941 aggcatggat atgttgtgat gtcagctgtt ggttcctgct catctctggg ttccttttct
     3001 tttccttcat cacaagggga tgggatgggc gttttccttt agtttacttt tgcccaaggc
     3061 ccttaatatt tggagactta aggtagggtt ggttttcagg agaagggaat gtcagcctgt
     3121 gtaaagtgca cgtgagctat ggagtgagcc agtgactgtg acacagctca catgcatacc
     3181 ccatgctgtg tctcctgttt ctctagggtt aagaagttct ggaagaaccc gaggaaaaca
     3241 cttcacacac tggaatacct tgtttgattt gagcctgata agcaagcttt tcttaaacat
     3301 ccaaaccaat gccctcggca gctgggtagc tcacatctca aaagtatcct caaaagacag
     3361 agttttagaa agattgtcac caagtccttt gtaagagaaa tggcataaac ccccagaccc
     3421 aagtttgtac aaaaccgact ctcctgagac aaggctggga acgcacgcag gccaacctgc
     3481 tgtctctgtg aactttagaa caggctcgtg gtgagatgtg agcttggccg tgtggactta
     3541 gaggaaaccc tgtgctttgt cactagttgc tatttacttt gcttcagata ttaaaaggca
     3601 tgaactttcc aaatgtatcc tttgcttgac tctctttata cgcttagcat tgctgttgct
     3661 gtttaacctt ctttcttctc ctaaaacact aatttctaga tacctttcta cagtaaggaa
     3721 ttaagaagtc ccactgacta cgaaaccctt gcccactctt ggagcacgct ggcagctgct
     3781 agtggacctg atctttactt cctgtgagga catcacccag gaatggctca tttgcatatg
     3841 ggtatggagg gtggctgtct gtcttttccc tctgggttgt aatatcttaa agcagctgac
     3901 caggtctctt ctactacaga agctaatatt gacccaagtg tgtacaatag gttagtttgg
     3961 ggttacccaa aaagacacaa ctccagcata ctgagaaagc cgacttctct ctctcccact
     4021 ctcagatggc tctttccaaa cacccaggtt tttgataatg taccacctcc tacacgtgca
     4081 tgctaactat cgctcacgtt tgttttctta gctggatttt tgtgtacggg tgcagtaaac
     4141 agcactgttc actctaagag tgtgatccag gcccctactt ccccttagac aatctgatgt
     4201 gcacactgta aaaatgacac agcaacagat ccagtattta aaacataaag gacagaaatg
     4261 ccatttcccc ttaatttctt aaaaaataaa aatcagcgtt tgactttgga ggactcgggt
     4321 cagcccttgt gactgtctag ctggctgcaa cgctgtaatt caacatcatt tataaattct
     4381 gctgatgggc agggatgtat gaacacaatt attgtcagca caaagcctta aaacctgctg
     4441 acttcaagct aaactgtgaa gccctgcgag gcccagcatc ttccgggaga ccagaaggcc
     4501 ccggcaatac ggacagagta tggattagca tgctcaacac tgtccactca ctacagtagc
     4561 atctcctcgt ctcacgcacc cactcctgaa tagacaattg ttagagtata tttgttattt
     4621 ttctggctgt ctttaaaaca aaaaggccaa ggtagtcaat cataccagtg agataaatgt
     4681 tacagattaa acagcagaac caggaaccca atcaatacaa gttatggaag tctttgacat
     4741 gcttcatttg caaagctggg gcactgtggt tcctgcaagg gtccatcagg gtcctagctg
     4801 ttctgagtca catgctaatc agatctcccc cacgttaccc tttgcaaggt caaaggcaaa
     4861 gctgcagtgt cgtcagttgg gtagacagat agctaggtat cttcgtaatc tggggcaaat
     4921 aaatattgac tctagactta atcttgattt ttaaaatatt gttttcctct gcctttctga
     4981 tttaaataga caaatttagc aaaaaaagaa aaatgtcttt tctactgaat gtcagtgccc
     5041 ttagctacct agactctcct cctggtgttc tctgagatga acagatgatc tcactctgtc
     5101 agcctgagga cagacagctc gatgacagaa gcagctctcc acagctttgc actgaggtgg
     5161 ttgcccctag tcgagccact ggatcaagca tctcccggtg agatagtaga tgacagaagc
     5221 ctgtctttca atacccctac cacgcagtta gttcttaaat aaaacaaaaa ccaccaaata
     5281 aataaataag aataaaataa cctagtattg ttcacatctt aattcagttc tcaccaagtg
     5341 aaaaccgctt tgtgcacagg agaaagttaa cttttcgtgg tgggaacctg gggaccattt
     5401 ctaaatgctg tgttgcaatt ccacatggcc acttctttta tgctaatcct gtattatttg
     5461 tgtgtgtgca ctcaaggtga tagtctgtgc ctagatctaa actacaccag cgtggggatt
     5521 taaaaaaaaa atccttcaaa acaccagttc tttcccccca taagtacaaa tgtccttgtg
     5581 ccttctgtgg ctttctgtct tcttttcact ttatttccaa gtacagctgc aataaacact
     5641 aatttctttt cctggccgtt tgacatgatg ttgatagcta tgcatatttt gcgtcttttt
     5701 aaaacaaagc gggagaataa tgtttttgaa gaagagaaat ttttagaaca gtttgataca
     5761 ccgcaaatta tttttttttc tcaattgtct gagcagcatt cgcgtttttg agattcttgt
     5821 agaagccgat ttttttgtaa ctgtggtgta gctctcgtgt gttattagcc taatgagaag
     5881 cactatagaa gcaatatttc ataccatgtg caatgtgtgt gcagaagtgt gggcgtgagc
     5941 acgcaggcac acacatgtaa aaatatacat atgtatgcgt gtgaagtgga aagcttacct
     6001 tttcttatct agactttaag aacctatttt aggcatttgt tatgttttgt gtaaagaatg
     6061 ttctatttgc aacaacacga ccctgacttc ttaccgtctc tctggcagtt caatggaggt
     6121 gttttgcatt aaatggtaaa attgcgtgga agatgttagg atctagtaat tatttcagtg
     6181 aatgttcata ccatattcct gaagtttgct ttgtgcctct gagtgttact taattgaagt
     6241 attttatgtt tgaagaatcc ttgttactgt gctaggaata tgggtgacta tcatttttaa
     6301 aatattttaa aaacatcaaa acaaaaaaaa aacactaaag caaaggggaa cttttataag
     6361 gaaatgtaaa tatttaacct catggccgtt gttacgtaag acagacatga gatcttaata
     6421 aatagctaca gtctcacagc atctgttgaa tttattaggg acattacact gactgtacag
     6481 gcagttgaac gcatctcaaa agtcctgctc ttgcaaaaga taccagtttc tctctatcag
     6541 agggcaaggg caaggataca ggcgactctg taaatctatg acatttcttt tctgtgtaca
     6601 tgaagacatt tagtaagtaa tcccccaagt ccccacacat gcaggttaat atcaatcaat
     6661 taattaaaga gttgggggtt aaccataggc tgctccccaa aagcaaccat aaattaatca
     6721 aagccagagt ggtttacaga tatcccccca aaagcagcaa tgtgtgtaag gacatgaaca
     6781 atccctttgc catgtgtatt atagagaatt cattggtgtg aacagcacaa ccgtttccta
     6841 ctggtgtaaa ctccgtgtct gcagatttac agcgttgttt tcaaaggctc ccttcggaac
     6901 gtgtaacggt tggtttgtgt cgctgtgtca cacttacacg caaggaagct gagttttgcc
     6961 tctgtagatc tgttggtttt aaaccgtcta aaagactaaa gctaaaatgc tcctcttcag
     7021 agctgaggtc caagccagtg tttaatcttt gcatcctttt gagtgatcct tctaagacta
     7081 agtggaagca tgtggacttt gagtcttttc aaccgagcgc tctctcaaat cagacacccc
     7141 ctaatgtgca gacacgggaa tgagcaggca aatggttggc ctgtctttgg gaaaacggat
     7201 tcactttttt aaataaccaa ttcctctgca tatggggggg aataaagcag tttaaagttg
     7261 tatattgcca cttcaaattg aggggaaaaa tttaatgtat ttggagttgg tctcagatct
     7321 ctaaaagagt caaaggtcac agcttccccc aacattgtcc cagccatttc tcatatgtat
     7381 atagtataaa ccgtgacaaa cactgccttt atattattta gcaatatgtt gtaaatagca
     7441 ttatgaagct ctttttttgt aataaagacc ctatgatttg aatatagtac aataactgag
     7501 ctgataaagt caatttttga attttttttt agctagaggc aatttcaatt gtgcattttt
     7561 gttattgtct attgttctga agactgcata atttattggt ttaatttatc ctaatttatt
     7621 tgatgaaggt gtacaatttt gtattaccaa ggatgtactg taatattaat tgataggatt
     7681 aaaaacagtg agactccctg tccatattca aaagaaaaca aaaaggtgcc gtagacaatt
     7741 gattttaaag taaaaagtaa aaacaattta gtttggcagc tactaaattt taaaacaagg
     7801 aaaaaaaaaa aaaacctaaa ggacaatgtt gtcgtggggg ggcggggagg gtttctgttg
     7861 tgtgttttaa gcttttctat attctccgaa ctttgaccgt ttgctttgta ccactaaagg
     7921 gtgcagtagt ccaactgcct tgtgtgcctt ccatcttctc ctaaactgaa tgtatgtgca
     7981 gtatatatgc aagcttgtgc aaaataaaat atacattaca agctca
//
