LOCUS       NM_011173               3314 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus protein S (alpha) (Pros1), mRNA.
ACCESSION   NM_011173
VERSION     NM_011173.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3314)
  AUTHORS   Xia,Y., Xu,Y., Liu,Q., Zhang,J., Zhang,Z., Jia,Q., Tang,Q.,
            Jing,X., Li,J., Chen,J., Xiong,Y., Li,Y. and He,J.
  TITLE     Glutaredoxin 1 regulates cholesterol metabolism and gallstone
            formation by influencing protein S-glutathionylation
  JOURNAL   Metabolism 145, 155610 (2023)
   PUBMED   37277061
  REMARK    GeneRIF: Glutaredoxin 1 regulates cholesterol metabolism and
            gallstone formation by influencing protein S-glutathionylation.
REFERENCE   2  (bases 1 to 3314)
  AUTHORS   Li,C., Chen,X., Zhang,S., Liang,C., Ma,X., Zhang,R. and Yan,H.
  TITLE     Glutaredoxin 1 protects lens epithelial cells from
            epithelial-mesenchymal transition by preventing casein kinase
            1alpha S-glutathionylation during posterior capsular opacification
  JOURNAL   Redox Biol 62, 102676 (2023)
   PUBMED   36989576
  REMARK    GeneRIF: Glutaredoxin 1 protects lens epithelial cells from
            epithelial-mesenchymal transition by preventing casein kinase
            1alpha S-glutathionylation during posterior capsular opacification.
REFERENCE   3  (bases 1 to 3314)
  AUTHORS   Luo,S., Kong,C., Zhao,S., Tang,X., Wang,Y., Zhou,X., Li,R., Liu,X.,
            Tang,X., Sun,S., Xie,W., Zhang,Z.R., Jing,Q., Gu,A., Chen,F.,
            Wang,D., Wang,H., Han,Y., Xie,L. and Ji,Y.
  TITLE     Endothelial HDAC1-ZEB2-NuRD Complex Drives Aortic Aneurysm and
            Dissection Through Regulation of Protein S-Sulfhydration
  JOURNAL   Circulation 147 (18), 1382-1403 (2023)
   PUBMED   36951067
  REMARK    GeneRIF: Endothelial HDAC1-ZEB2-NuRD Complex Drives Aortic Aneurysm
            and Dissection Through Regulation of Protein S-Sulfhydration.
REFERENCE   4  (bases 1 to 3314)
  AUTHORS   Maimon,A., Levi-Yahid,V., Ben-Meir,K., Halpern,A., Talmi,Z.,
            Priya,S., Mizraji,G., Mistriel-Zerbib,S., Berger,M., Baniyash,M.,
            Loges,S. and Burstyn-Cohen,T.
  TITLE     Myeloid cell-derived PROS1 inhibits tumor metastasis by regulating
            inflammatory and immune responses via IL-10
  JOURNAL   J Clin Invest 131 (10) (2021)
   PUBMED   33848267
  REMARK    GeneRIF: Myeloid cell-derived PROS1 inhibits tumor metastasis by
            regulating inflammatory and immune responses via IL-10.
REFERENCE   5  (bases 1 to 3314)
  AUTHORS   Calzavarini,S., Prince-Eladnani,R., Saller,F., Bologna,L.,
            Burnier,L., Brisset,A.C., Quarroz,C., Reina Caro,M.D.,
            Ermolayev,V., Matsumura,Y., Fernandez,J.A., Hackeng,T.M.,
            Griffin,J.H. and Angelillo-Scherrer,A.
  TITLE     Platelet protein S limits venous but not arterial thrombosis
            propensity by controlling coagulation in the thrombus
  JOURNAL   Blood 135 (22), 1969-1982 (2020)
   PUBMED   32276277
REFERENCE   6  (bases 1 to 3314)
  AUTHORS   Jones,L.C., McCarthy,K.A., Beard,J.L., Keen,C.L. and Jones,B.C.
  TITLE     Quantitative genetic analysis of brain copper and zinc in BXD
            recombinant inbred mice
  JOURNAL   Nutr Neurosci 9 (1-2), 81-92 (2006)
   PUBMED   16910173
REFERENCE   7  (bases 1 to 3314)
  AUTHORS   Ong,K., Horsfall,W., Conway,E.M. and Schuh,A.C.
  TITLE     Early embryonic expression of murine coagulation system components
  JOURNAL   Thromb Haemost 84 (6), 1023-1030 (2000)
   PUBMED   11154109
REFERENCE   8  (bases 1 to 3314)
  AUTHORS   Lahbib-Mansais,Y., Leroux,S., Milan,D., Yerle,M., Robic,A.,
            Jiang,Z., Andre,C. and Gellin,J.
  TITLE     Comparative mapping between humans and pigs: localization of 58
            anchorage markers (TOASTs) by use of porcine somatic cell and
            radiation hybrid panels
  JOURNAL   Mamm Genome 11 (12), 1098-1106 (2000)
   PUBMED   11130978
REFERENCE   9  (bases 1 to 3314)
  AUTHORS   Lu,D., Schmidel,D.K. and Long,G.L.
  TITLE     Structure of mouse protein S as determined by PCR amplification and
            DNA sequencing of cDNA
  JOURNAL   Thromb Res 74 (2), 135-142 (1994)
   PUBMED   8029814
REFERENCE   10 (bases 1 to 3314)
  AUTHORS   Chu,M.D., Sun,J. and Bird,P.
  TITLE     Cloning and sequencing of a cDNA encoding the murine vitamin
            K-dependent protein S
  JOURNAL   Biochim Biophys Acta 1217 (3), 325-328 (1994)
   PUBMED   8148380
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK163032.1, AK145501.1 and
            BE949628.1.
            
            On Oct 7, 2015 this sequence version replaced NM_011173.2.
            
            Summary: This gene encodes a vitamin K-dependent protein with key
            roles in multiple biological processes including coagulation,
            apoptosis and vasculogenesis. The encoded protein undergoes
            proteolytic processing to generate a mature protein which is
            secreted into the plasma. Mice lacking the encoded protein die in
            utero from a fulminant coagulopathy and associated hemorrhages.
            [provided by RefSeq, Oct 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.151161.1, AK145501.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                AK163032.1         2-28
            28-3297             AK145501.1         1-3270
            3298-3314           BE949628.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..3314
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 36.43 cM"
     gene            1..3314
                     /gene="Pros1"
                     /note="protein S (alpha)"
                     /db_xref="GeneID:19128"
                     /db_xref="MGI:MGI:1095733"
     exon            1..198
                     /gene="Pros1"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..2150
                     /gene="Pros1"
                     /note="vitamin K-dependent protein S"
                     /codon_start=1
                     /product="vitamin K-dependent protein S preproprotein"
                     /protein_id="NP_035303.1"
                     /db_xref="CCDS:CCDS28263.1"
                     /db_xref="GeneID:19128"
                     /db_xref="MGI:MGI:1095733"
                     /translation="MRVLSARFRVLLACLALVIPVSETNFLSKERASQVLVRKRRANT
                     LFEETMKGNLERECIEELCNKEEAREVFENNPETDYFYPKYLGCLGAFRVGSFHAARQ
                     SANAYPDLRSCVKAISDQCDPIPCNEDGYLACQDGQAAFTCFCKPGWQGDRCQYDVNE
                     CKDPSNVNGGCSQICDNTPGSYHCSCKRGFAMLPNKKDCKDLDECALKPSVCGTAVCK
                     NIPGDFECECPDGYRYDPSSKSCKDVDECSENMCAQLCVNFPGGYSCYCDGKKGFKLA
                     QDQKSCEGIPVCLSLDLDKNYELLYLAEQFAGVVLYLKFRLPDITRFSAEFDFRTYDS
                     EGIILYAESLDHSNWLLIALRDGKIEVQFKNEFSTQITTGGNVINNGIWNMVSVEELD
                     DSVSIKIAKEAVMNINKLGSLFKPTDGFLDTKIYFAGLPRKVESALIKPINPRLDGCI
                     RGWNLMKQGALGAKEIIEGKQNKHCFLNVEKGSYYPGSGIAQFSIDYNNVTNAEGWQM
                     NVTLNIRPSTGTGVMLALVSGGTVPFALSLVDSRSGTSQDIVVFVENSVVARLEAVSL
                     CSDQQSQLKCNVNRNGLELWTPLRKDVIYSKDLQRQLAVLDKAMKRTVATYLGGIPDI
                     SFSATPVNAFYSGCMEVNINGVQLDLDEAISKHKDIRAHSCPSVRKIQKNF"
     exon            199..356
                     /gene="Pros1"
                     /inference="alignment:Splign:2.1.0"
     exon            357..381
                     /gene="Pros1"
                     /inference="alignment:Splign:2.1.0"
     exon            382..468
                     /gene="Pros1"
                     /inference="alignment:Splign:2.1.0"
     exon            469..591
                     /gene="Pros1"
                     /inference="alignment:Splign:2.1.0"
     exon            592..723
                     /gene="Pros1"
                     /inference="alignment:Splign:2.1.0"
     exon            724..849
                     /gene="Pros1"
                     /inference="alignment:Splign:2.1.0"
     exon            850..971
                     /gene="Pros1"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1087
                     /gene="Pros1"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1277
                     /gene="Pros1"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1445
                     /gene="Pros1"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1614
                     /gene="Pros1"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1763
                     /gene="Pros1"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1989
                     /gene="Pros1"
                     /inference="alignment:Splign:2.1.0"
     exon            1990..3301
                     /gene="Pros1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2287..2292
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pros1"
                     /note="hexamer: TATAAA"
     polyA_site      2307
                     /gene="Pros1"
     regulatory      2340..2345
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pros1"
                     /note="hexamer: AATGAA"
     polyA_site      2355
                     /gene="Pros1"
ORIGIN      
        1 gctcgggctg ggccgcggca gagctgggag agcagagccc gggctcgcag cttccctcgg
       61 ccgccctagc gcaggcacgg tccccgctgc gccagccctg acccccggcc atcctctcag
      121 caatgagggt cctgagcgca cgctttcggg tgctactggc ctgcctcgcc ctggtgatcc
      181 ctgtctcaga gacaaacttc ttgtccaaag agcgtgcttc acaagtcctg gtgaggaagc
      241 gccgtgcaaa taccttgttc gaagaaacta tgaagggcaa ccttgaacga gagtgcattg
      301 aagaactctg caataaggag gaagccaggg aggtctttga aaataatccc gagacggatt
      361 atttttatcc aaaatattta ggttgtctgg gggcattccg tgttggctca ttccatgctg
      421 cgaggcagtc agctaatgct tatcctgacc tcagaagctg tgtcaaagcc atctcagacc
      481 aatgtgaccc tataccatgc aatgaagatg ggtatctggc ctgccaagat ggccaagctg
      541 cttttacttg cttctgtaag cccggctggc aaggagacag gtgtcagtat gatgtaaatg
      601 aatgtaaaga tccctcaaat gtcaatggag gctgcagcca gatttgtgac aacactcctg
      661 gaagttacca ctgctcctgt aaaagaggct ttgctatgct cccaaataag aaagactgca
      721 aagatttgga tgaatgcgct ctaaagccaa gtgtctgtgg cacagctgtg tgcaagaaca
      781 ttccaggaga cttcgaatgt gaatgtcccg acggctaccg atatgatccc tcatcaaaat
      841 cttgtaaaga tgttgatgag tgctctgaga acatgtgtgc tcaactgtgt gtcaatttcc
      901 ctggaggcta ctcttgttac tgtgatggga agaaaggatt caaacttgcc caagatcaga
      961 agagttgtga gggtatccca gtgtgccttt ccttggacct tgacaaaaac tatgaattat
     1021 tatacttggc cgagcagttt gcaggagttg tcttatatct gaaatttcga ttgccagata
     1081 tcacgaggtt ttcagctgaa tttgattttc gcacatatga ttcagagggc atcatactgt
     1141 atgcagaatc tctcgaccac tccaattggc tcctgattgc gcttcgtgat gggaagattg
     1201 aagttcagtt taagaatgag ttttcgaccc aaatcacaac tggaggcaat gttattaaca
     1261 acggtatatg gaatatggtg tctgtggaag aattagacga cagtgttagc attaaaatag
     1321 ctaaggaggc cgtgatgaat attaataaac ttggcagcct ttttaagcct accgatggat
     1381 ttctggacac caaaatatac ttcgcaggct tacctcggaa ggtggaaagc gcactcatta
     1441 aaccgattaa tcctcgtctg gatggatgta tacgaggctg gaatctgatg aaacaaggag
     1501 ctttaggtgc caaggaaata attgaaggaa aacaaaataa acactgcttc ctcaatgtgg
     1561 agaagggctc ctactaccct ggttccggaa ttgctcagtt cagcatagac tacaataatg
     1621 taactaatgc agagggttgg caaatgaatg tgaccttgaa tatccgccct tccactggca
     1681 ctggagtcat gctggctttg gtttctgggg gcacagtgcc ctttgccttg tccttggtgg
     1741 attctcgctc tggaacgtct caggatattg tggtatttgt tgaaaattca gtggtggctc
     1801 gattggaggc ggtatctctg tgctcggatc agcaatccca actgaaatgc aatgttaaca
     1861 gaaatggact ggaactgtgg accccactta gaaaagatgt catttactct aaagatcttc
     1921 aaaggcaact cgccgtcttg gacaaagcaa tgaaaagaac cgtggccact tacctgggtg
     1981 gcatcccaga tatttccttc agtgccacac cagtgaatgc cttttacagt ggctgcatgg
     2041 aagtgaacat caatggggtg cagttggacc tggatgaagc catttctaaa cataaggaca
     2101 ttagagctca ctcgtgcccg tcagtgagga agatccagaa gaatttttag actctgtttc
     2161 ctgttcttct aatatctctt ttctcgttgt aattatgctc acattcctat caccagctgg
     2221 caggtgttac ctgtgacgtg caatgtttaa atatgacgtg gtactttgtc cttcagattt
     2281 ttgttatata aatcacattt ttgaaaagtc ttgcactcat tgctgtctag aaattaaata
     2341 atgaaacaca tgaaacactt aaatttcaat ttatttccta taaatgacac tgcttttttt
     2401 gtttttttgt tttgttttgt attgttttgt tttcttttaa aagtaagact tatcatcatg
     2461 gaactagtat ttaaatgtcc tgtttttctc agaagacgaa tcagtttaaa cccaaacaaa
     2521 agtccacgtg actaaatgct aacagttgca gggaaacact gtatttttgt tgttgttttt
     2581 tgtctgtgaa agtggcagag ctgatagcat atcacaggtg aattgaatgg aaggtctcga
     2641 agctctattt caaagtattt cctttgactg aggcgcgtag ctcctttagg cttcattttt
     2701 cttttacctg gctttccact tgagccaaca ccttcactga aatatagaac aagggcagat
     2761 tttccacggg agcagcacat gaatgttgtc tcaatcaggt ttctatcaga gacatcaggt
     2821 tatgctgtaa gaggtgtgaa cattgggtgg acagatcact caacctaagc tgctgagagc
     2881 acacaaggtc agagtcagaa tggcggccat ccttaatggt gggaaggagg gtgaagccat
     2941 caagaagttc atagttgtct ttcatattgg gttttaatta ctataggtgg cttgaatgtg
     3001 attgttaaag ttaaaaaagt gatggaaagt agagtagatt tttaacaaaa tgataataat
     3061 aatagagatg ctggataaag ttacatgttc tatctttgta atgaaagaag ttacagaggt
     3121 aagattgtcc aatatttgat gatagtgcat tgcaagtggc tggccgcttt gctgttcttc
     3181 ctggattgat cgtttcaggg gtgcatcaga cgcttcgttg ccattggaga aattggattt
     3241 tattttattg tagatatttt gcatcacatg aaacataata aaatgataca tatttttaaa
     3301 aaaaaaaaaa aaaa
//
