LOCUS       NM_008936               1125 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus paired like homeodomain factor 1 (Prop1), mRNA.
ACCESSION   NM_008936 XM_981372
VERSION     NM_008936.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1125)
  AUTHORS   Yoshida,S., Tsuneoka,Y., Tsukada,T., Nakakura,T., Kawamura,A.,
            Kai,W. and Yoshida,K.
  TITLE     Primary Cilia are Required for Cell-Type Determination and
            Angiogenesis in Pituitary Development
  JOURNAL   Endocrinology 165 (8) (2024)
   PUBMED   39001875
REFERENCE   2  (bases 1 to 1125)
  AUTHORS   Iwasaki,K., Lalani,B., Kahng,J., Carapeto,P., Sanjines,S., Hela,F.,
            Abarca,C., Tsuji,T., Darcy,J., Bartke,A., Tseng,Y.H., Kulkarni,R.N.
            and Aguayo-Mazzucato,C.
  TITLE     Decreased IGF1R attenuates senescence and improves function in
            pancreatic beta-cells
  JOURNAL   Front Endocrinol (Lausanne) 14, 1203534 (2023)
   PUBMED   37441495
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1125)
  AUTHORS   Bando,H., Brinkmeier,M.L., Castinetti,F., Fang,Q., Lee,M.S.,
            Saveanu,A., Albarel,F., Dupuis,C., Brue,T. and Camper,S.A.
  TITLE     Heterozygous variants in SIX3 and POU1F1 cause pituitary hormone
            deficiency in mouse and man
  JOURNAL   Hum Mol Genet 32 (3), 367-385 (2023)
   PUBMED   35951005
REFERENCE   4  (bases 1 to 1125)
  AUTHORS   Winningham,A.H. and Camper,S.A.
  TITLE     Pituitary Stem Cell Regulation by Zeb2 and BMP Signaling
  JOURNAL   Endocrinology 164 (3) (2023)
   PUBMED   36683433
REFERENCE   5  (bases 1 to 1125)
  AUTHORS   Li,X., McPherson,M., Hager,M., Fang,Y., Bartke,A. and Miller,R.A.
  TITLE     Transient early life growth hormone exposure permanently alters
            brain, muscle, liver, macrophage, and adipocyte status in
            long-lived Ames dwarf mice
  JOURNAL   FASEB J 36 (7), e22394 (2022)
   PUBMED   35704312
REFERENCE   6  (bases 1 to 1125)
  AUTHORS   Voss,J.W. and Rosenfeld,M.G.
  TITLE     Anterior pituitary development: short tales from dwarf mice
  JOURNAL   Cell 70 (4), 527-530 (1992)
   PUBMED   1505020
  REMARK    Review article
REFERENCE   7  (bases 1 to 1125)
  AUTHORS   Buckwalter,M.S., Katz,R.W. and Camper,S.A.
  TITLE     Localization of the panhypopituitary dwarf mutation (df) on mouse
            chromosome 11 in an intersubspecific backcross
  JOURNAL   Genomics 10 (3), 515-526 (1991)
   PUBMED   1889803
REFERENCE   8  (bases 1 to 1125)
  AUTHORS   Li,S., Crenshaw,E.B. 3rd, Rawson,E.J., Simmons,D.M., Swanson,L.W.
            and Rosenfeld,M.G.
  TITLE     Dwarf locus mutants lacking three pituitary cell types result from
            mutations in the POU-domain gene pit-1
  JOURNAL   Nature 347 (6293), 528-533 (1990)
   PUBMED   1977085
REFERENCE   9  (bases 1 to 1125)
  AUTHORS   Simmons,D.M., Voss,J.W., Ingraham,H.A., Holloway,J.M., Broide,R.S.,
            Rosenfeld,M.G. and Swanson,L.W.
  TITLE     Pituitary cell phenotypes involve cell-specific Pit-1 mRNA
            translation and synergistic interactions with other classes of
            transcription factors
  JOURNAL   Genes Dev 4 (5), 695-711 (1990)
   PUBMED   2379827
REFERENCE   10 (bases 1 to 1125)
  AUTHORS   Bartke,A., Goldman,B.D., Bex,F. and Dalterio,S.
  TITLE     Effects of prolactin (PRL) on pituitary and testicular function in
            mice with hereditary PRL deficiency
  JOURNAL   Endocrinology 101 (6), 1760-1766 (1977)
   PUBMED   590190
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ165772.1 and U77946.1.
            
            On Feb 23, 2018 this sequence version replaced NM_008936.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U77946.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               CJ165772.1         2-126
            126-1125            U77946.1           1-1000
FEATURES             Location/Qualifiers
     source          1..1125
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 30.95 cM"
     gene            1..1125
                     /gene="Prop1"
                     /gene_synonym="df; Prop-1"
                     /note="paired like homeodomain factor 1"
                     /db_xref="GeneID:19127"
                     /db_xref="MGI:MGI:109330"
     exon            1..462
                     /gene="Prop1"
                     /gene_synonym="df; Prop-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             354..1025
                     /gene="Prop1"
                     /gene_synonym="df; Prop-1"
                     /note="pituitary specific homeodomain factor; Ames dwarf;
                     prophet of Pit-1"
                     /codon_start=1
                     /product="homeobox protein prophet of Pit-1"
                     /protein_id="NP_032962.1"
                     /db_xref="CCDS:CCDS24643.1"
                     /db_xref="GeneID:19127"
                     /db_xref="MGI:MGI:109330"
                     /translation="MEAQRRSHQEKQTKGHACGRSLPEPRVASGTLISTVDRSSEAYR
                     RLSGTELGRPKLCPQRGRPHSRRRHRTTFNPAQLEQLESAFGRNQYPDIWAREGLAQD
                     TGLSEARIQVWFQNRRAKQRKQERSLLQPIAHLSTATFSGFLPESSAYPYTYGTPPPP
                     APCFPHPYSHSLPSQPSTAASLALPPQPEDWYPTLHPAPTGHLPCPPPPPMFPLSLET
                     PKSWN"
     exon            463..686
                     /gene="Prop1"
                     /gene_synonym="df; Prop-1"
                     /inference="alignment:Splign:2.1.0"
     exon            687..1125
                     /gene="Prop1"
                     /gene_synonym="df; Prop-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtaaatagag aaaacagagc agcatcggga agtagaggca gagagaaaac tgggcaaagc
       61 caagagagag agagaatgag atgtcaattc agaggaagga tgcagggtta ggaaaagggg
      121 aaactgtgag aaaacaggta tctagctata tctagctata ctacacacac acacacacac
      181 acacacacac acacacacag agcaagggac agactcagaa aaaggtagaa ggtagaaaca
      241 gggagaagag agaacagaag acaagacaag atagacagaa gcagagaaag acttcgggga
      301 gtcacagact agaggacagc aggctagacc atctttggtt tgggtggcta gccatggaag
      361 ctcaaagaag gagccatcag gaaaagcaaa cgaagggtca tgcctgtggc cgatccctgc
      421 ctgagccacg agtggcctct gggactctga tctccacggt agacaggagc tctgaggctt
      481 ataggaggct ctctggtaca gagctgggga gacctaagct ttgcccacag agaggccgtc
      541 cccactcccg gcgccgccac cgcaccacct tcaacccagc acagctggaa cagctggagt
      601 cagcctttgg gaggaaccag tatcctgaca tctgggctcg agaggggctt gcccaagaca
      661 ctggcctcag tgaagccaga atccaggtct ggttccagaa ccgcagggct aagcaacgga
      721 agcaagagcg gtcacttctc cagccgatag cccatctatc tacggccacc ttctctggct
      781 tcttgccaga atcctctgcc tatccctaca cctatgggac accacctcca ccagcgccct
      841 gcttccctca tccctacagc cactctctcc cctcccagcc ctctacggct gcctcactcg
      901 ctcttcctcc ccagcctgag gactggtacc ccaccttgca cccagccccc actggtcatc
      961 tgccctgtcc cccaccccca cccatgtttc ccctcagcct tgagacgcca aagtcctgga
     1021 actaagtggt gataaggcac cctctctcca taaccctctt gaaacacgag aaaattgggg
     1081 gctctctttt cctcctaagg gtgaacctag aaacgggggt ggggg
//
