LOCUS       NM_138750               4266 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus prominin 2 (Prom2), transcript variant 1, mRNA.
ACCESSION   NM_138750
VERSION     NM_138750.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4266)
  AUTHORS   An,J., Shi,J., Yang,C., Luo,J., Li,Y., Ren,J., Lv,Y. and Zhang,Y.
  TITLE     Regulation of tumorigenesis and ferroptosis in non-small cell lung
            cancer by a novel BBOX1-AS1/miR-326/PROM2 axis
  JOURNAL   Mol Cell Biochem 479 (8), 2143-2155 (2024)
   PUBMED   37639200
  REMARK    GeneRIF: Regulation of tumorigenesis and ferroptosis in non-small
            cell lung cancer by a novel BBOX1-AS1/miR-326/PROM2 axis.
REFERENCE   2  (bases 1 to 4266)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4266)
  AUTHORS   Sundberg,J.P., Dadras,S.S., Silva,K.A., Kennedy,V.E., Garland,G.,
            Murray,S.A., Sundberg,B.A., Schofield,P.N. and Pratt,C.H.
  TITLE     Systematic screening for skin, hair, and nail abnormalities in a
            large-scale knockout mouse program
  JOURNAL   PLoS One 12 (7), e0180682 (2017)
   PUBMED   28700664
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4266)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 4266)
  AUTHORS   Walentin,K., Hinze,C., Werth,M., Haase,N., Varma,S., Morell,R.,
            Aue,A., Potschke,E., Warburton,D., Qiu,A., Barasch,J., Purfurst,B.,
            Dieterich,C., Popova,E., Bader,M., Dechend,R., Staff,A.C.,
            Yurtdas,Z.Y., Kilic,E. and Schmidt-Ott,K.M.
  TITLE     A Grhl2-dependent gene network controls trophoblast branching
            morphogenesis
  JOURNAL   Development 142 (6), 1125-1136 (2015)
   PUBMED   25758223
REFERENCE   6  (bases 1 to 4266)
  AUTHORS   Jaszai,J., Farkas,L.M., Fargeas,C.A., Janich,P., Haase,M.,
            Huttner,W.B. and Corbeil,D.
  TITLE     Prominin-2 is a novel marker of distal tubules and collecting ducts
            of the human and murine kidney
  JOURNAL   Histochem Cell Biol 133 (5), 527-539 (2010)
   PUBMED   20333396
  REMARK    GeneRIF: Data show the distribution and subcellular localization of
            prominin-2 within the kidney in situ.
REFERENCE   7  (bases 1 to 4266)
  AUTHORS   Jaszai,J., Fargeas,C.A., Haase,M., Farkas,L.M., Huttner,W.B. and
            Corbeil,D.
  TITLE     Robust expression of Prominin-2 all along the adult male
            reproductive system and urinary bladder
  JOURNAL   Histochem Cell Biol 130 (4), 749-759 (2008)
   PUBMED   18536929
  REMARK    GeneRIF: Prominin-2 is widely and abundantly expressed along the
            epithelia of various segments of the adult male genitourinary
            tract.
REFERENCE   8  (bases 1 to 4266)
  AUTHORS   Jaszai,J., Janich,P., Farkas,L.M., Fargeas,C.A., Huttner,W.B. and
            Corbeil,D.
  TITLE     Differential expression of Prominin-1 (CD133) and Prominin-2 in
            major cephalic exocrine glands of adult mice
  JOURNAL   Histochem Cell Biol 128 (5), 409-419 (2007)
   PUBMED   17874118
  REMARK    GeneRIF: expression Prominin-2, in the three pairs of major
            salivary glands, i.e., submandibular-, major sublingual-, and
            parotid glands in adult mice.
REFERENCE   9  (bases 1 to 4266)
  AUTHORS   Florek,M., Bauer,N., Janich,P., Wilsch-Braeuninger,M.,
            Fargeas,C.A., Marzesco,A.M., Ehninger,G., Thiele,C., Huttner,W.B.
            and Corbeil,D.
  TITLE     Prominin-2 is a cholesterol-binding protein associated with apical
            and basolateral plasmalemmal protrusions in polarized epithelial
            cells and released into urine
  JOURNAL   Cell Tissue Res 328 (1), 31-47 (2007)
   PUBMED   17109118
  REMARK    GeneRIF: These data show that all the characteristics of prominin-1
            are shared by prominin-2, which is in agreement with a possible
            redundancy in their role as potential organizers of plasma membrane
            protrusions.
REFERENCE   10 (bases 1 to 4266)
  AUTHORS   Fargeas,C.A., Florek,M., Huttner,W.B. and Corbeil,D.
  TITLE     Characterization of prominin-2, a new member of the prominin family
            of pentaspan membrane glycoproteins
  JOURNAL   J Biol Chem 278 (10), 8586-8596 (2003)
   PUBMED   12514187
  REMARK    GeneRIF: identification as well as molecular and cell biological
            characterization
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ045574.1, AK137749.1 and AK029851.1.
            
            On Mar 14, 2009 this sequence version replaced NM_138750.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029851.1, AK137749.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                CJ045574.1         1-23
            24-4253             AK137749.1         2-4231
            4254-4266           AK029851.1         4236-4248
FEATURES             Location/Qualifiers
     source          1..4266
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 62.04 cM"
     gene            1..4266
                     /gene="Prom2"
                     /gene_synonym="Prom-rp"
                     /note="prominin 2"
                     /db_xref="GeneID:192212"
                     /db_xref="MGI:MGI:2138997"
     exon            1..341
                     /gene="Prom2"
                     /gene_synonym="Prom-rp"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..2605
                     /gene="Prom2"
                     /gene_synonym="Prom-rp"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; PROM-2; mPROML2; prominin-like protein 2;
                     prominin-related protein"
                     /codon_start=1
                     /product="prominin-2 isoform 1 precursor"
                     /protein_id="NP_620089.2"
                     /db_xref="CCDS:CCDS16704.1"
                     /db_xref="GeneID:192212"
                     /db_xref="MGI:MGI:2138997"
                     /translation="MTRSPGLMVPLLGLSLGLALSLPEAVTDDCGSLGRVEHLAFARV
                     PRTRELAPLVRASGPLNSLYGTVRRFLSVVQLNPFPAELIKTLLNDPSSVKTDEVVRY
                     EAGYVVCAVIAGLYLLLVPITGLCFCCCRCRQRCGGRVKTEHKAMACERGTLMIFLLL
                     TTLVLLIGMVCAFATNQHTHSQTGPSVKAVPETLLSLRGLVSDVPEELRAIAEQFSVP
                     QKQVSKELDGVGENLGNVIHNRLKSTVYPVLASVHSLGQALQVSIDHLRALNTTSVEL
                     QEAQRHLEPPVQAHRERLLALLQDSWCHEENCKRVLSQAGALQLGADFSQTPPVDDVL
                     HRLKDVPETNFSSMVQEEKATFNNLPLLVQVQAVSVVKDVKKALAEQPEGLRMLAQAF
                     PGSEAASRWSQALEGLEQRSRPYLQEVQQYETYRWILGCVLCSAILLVVICNLLGLSL
                     GIWGLFAREDPSHSETKGEAGARLLMAGVAFSFLFAVPLILLVFVTFLVGGNVQTLVC
                     RSWESGELYEFADTPGNLPPSMNLSYLLGLKKNISIVQAYRQCKAGAVLWKVLQLNDS
                     YDLDKHLDIKQYTHKIQQELQSFQVDLKELDLLSPTARQDLEALQRSGLEKIHYRGFL
                     VQIQKPVVNTDMWQLAQELEGLAQAQNDSLLRQQLREEARELRSLYQEKVVPQESLVT
                     KLNFSVKTLESLAPSLQVNTSDFLDSVTRLKGELPVQINHILRNATECFLTREMGYFS
                     QYVTWVRAEVTQRIATCQPFSTALDNGHVILCDMMADPWNAFWFCLGWCTFFLIPSII
                     FAVKTSKYFRPIRKRLSSTSSEETQLFHIPRVTSLKL"
     exon            342..391
                     /gene="Prom2"
                     /gene_synonym="Prom-rp"
                     /inference="alignment:Splign:2.1.0"
     exon            392..594
                     /gene="Prom2"
                     /gene_synonym="Prom-rp"
                     /inference="alignment:Splign:2.1.0"
     exon            595..715
                     /gene="Prom2"
                     /gene_synonym="Prom-rp"
                     /inference="alignment:Splign:2.1.0"
     exon            716..779
                     /gene="Prom2"
                     /gene_synonym="Prom-rp"
                     /inference="alignment:Splign:2.1.0"
     exon            780..869
                     /gene="Prom2"
                     /gene_synonym="Prom-rp"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1075
                     /gene="Prom2"
                     /gene_synonym="Prom-rp"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1150
                     /gene="Prom2"
                     /gene_synonym="Prom-rp"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1214
                     /gene="Prom2"
                     /gene_synonym="Prom-rp"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1374
                     /gene="Prom2"
                     /gene_synonym="Prom-rp"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1527
                     /gene="Prom2"
                     /gene_synonym="Prom-rp"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1651
                     /gene="Prom2"
                     /gene_synonym="Prom-rp"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1743
                     /gene="Prom2"
                     /gene_synonym="Prom-rp"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1828
                     /gene="Prom2"
                     /gene_synonym="Prom-rp"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..1975
                     /gene="Prom2"
                     /gene_synonym="Prom-rp"
                     /inference="alignment:Splign:2.1.0"
     exon            1976..2047
                     /gene="Prom2"
                     /gene_synonym="Prom-rp"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2140
                     /gene="Prom2"
                     /gene_synonym="Prom-rp"
                     /inference="alignment:Splign:2.1.0"
     exon            2141..2194
                     /gene="Prom2"
                     /gene_synonym="Prom-rp"
                     /inference="alignment:Splign:2.1.0"
     exon            2195..2275
                     /gene="Prom2"
                     /gene_synonym="Prom-rp"
                     /inference="alignment:Splign:2.1.0"
     exon            2276..2344
                     /gene="Prom2"
                     /gene_synonym="Prom-rp"
                     /inference="alignment:Splign:2.1.0"
     exon            2345..2434
                     /gene="Prom2"
                     /gene_synonym="Prom-rp"
                     /inference="alignment:Splign:2.1.0"
     exon            2435..2541
                     /gene="Prom2"
                     /gene_synonym="Prom-rp"
                     /inference="alignment:Splign:2.1.0"
     exon            2542..2614
                     /gene="Prom2"
                     /gene_synonym="Prom-rp"
                     /inference="alignment:Splign:2.1.0"
     exon            2615..4266
                     /gene="Prom2"
                     /gene_synonym="Prom-rp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacggaggga agaaggctac agaaggatgc acggcctgcc ccgtgctggt ccgcactgtc
       61 cgctgcctga acctgtgccg cccacccgcc cgaactcatg acgcgctcac ccggcctcat
      121 ggtgcccctg ctgggcctga gcctgggact ggccctgagc ctgcccgaag ctgtgacaga
      181 cgactgcggg tccctcgggc gcgtggagca cctggcattc gctcgggtgc ccaggacacg
      241 agagctggcc cctcttgttc gcgcgtcggg gcccctgaac tccctctatg gcaccgtgcg
      301 acgattcctc tccgtggttc aacttaaccc cttcccggca gagttgataa agaccctgct
      361 gaatgaccca tcttctgtga agacagatga ggtggttcga tatgaggcag gctacgtggt
      421 gtgtgctgtg attgctggcc tctacctcct attggtgccc atcactgggc tctgcttctg
      481 ttgctgtcgc tgccgccagc gctgtggggg cagagtgaag acggagcaca aggccatggc
      541 ctgtgaacgt ggtaccctca tgatcttcct gctgctgacc accctcgtgc ttctgattgg
      601 tatggtctgt gcttttgcta caaaccaaca cacacatagt cagacggggc ccagtgtgaa
      661 agctgtccct gagaccctgc tcagcctaag aggcctggtc tctgatgtcc ctgaagagct
      721 gcgggccatt gctgagcagt tctctgtgcc tcagaagcaa gtctcaaagg agctggatgg
      781 tgttggtgag aaccttggga acgtaattca taaccggctc aagagcacag tgtacccagt
      841 gctagcctca gtgcacagcc tgggccaggc cctgcaggtc tccatagacc accttcgagc
      901 cctgaacacc acctcagtgg agctgcagga ggctcagcgg cacctggagc cacctgtgca
      961 ggcgcaccgg gaacgcctgc tcgccctgct tcaggacagc tggtgccacg aggagaattg
     1021 caagcgggtg ctcagccagg ccggtgctct gcaactgggc gctgacttta gccagacgcc
     1081 ccctgtggat gatgtcctgc atcggctgaa ggatgtccca gaaaccaact tctccagcat
     1141 ggtccaggag gagaaagcca ccttcaataa cctcccgctc ctggttcaag tgcaggcggt
     1201 cagtgtggtc aaagatgtga aaaaggcact ggctgagcag cctgaagggt tgaggatgct
     1261 ggcccaagcg ttcccaggtt cagaggcagc ctcccgctgg agccaggcac tggaggggct
     1321 ggaacagcgc agccgcccct acttgcagga ggtgcaacaa tatgagacat acaggtggat
     1381 tttgggatgc gtgctgtgct ctgccatcct gcttgtggtg atctgtaacc tgctgggcct
     1441 cagcctgggc atctgggggt tgtttgccag ggaggacccc agccactctg aaaccaaggg
     1501 cgaggctgga gcccgcctcc tcatggcagg tgtggccttc agcttcctct tcgcagtccc
     1561 cctcatcctc ctcgtcttcg tcactttcct ggtgggtggc aatgtgcaga cgctggtgtg
     1621 ccggagctgg gagagtggag agctgtatga gtttgcagac actccgggga acttgccacc
     1681 atccatgaac ctatcctatc ttcttggcct gaagaaaaac atcagcatcg tccaggccta
     1741 tcgacagtgt aaggcagggg cagtactctg gaaggttcta cagctcaatg actcgtatga
     1801 cctggataag cacctggata tcaaacagta tacccacaag attcagcagg agcttcagag
     1861 cttccaagta gatttgaagg agctagacct gttgagcccc actgcccgcc aggacctgga
     1921 ggctttgcag aggagcgggc tggagaaaat ccactacaga ggcttccttg tgcagatcca
     1981 gaagcctgtg gtgaacactg acatgtggca gctggcgcag gagctggaag gactggccca
     2041 ggcccaaaat gactctttac tgaggcagca gctacgggag gaggccagag aacttcgaag
     2101 cctctaccag gagaaggttg tcccccagga gagccttgtg accaagctca acttcagtgt
     2161 caagaccttg gagtccttgg ccccaagtct gcaggtgaat acctcagact ttcttgacag
     2221 tgtcactcgt ctaaaaggag agctgcctgt gcagatcaac cacatcctga ggaatgccac
     2281 tgagtgtttc ctgaccaggg aaatgggcta cttctctcag tatgtgacct gggtgagagc
     2341 agaggtgact cagcgcatcg ccacctgcca gcccttctct acagccctgg acaatggtca
     2401 tgtgatcctg tgtgacatga tggctgaccc ctggaacgcc ttctggtttt gcctggggtg
     2461 gtgcaccttc ttcctcatcc ccagcatcat cttcgctgtc aagacctcca agtacttccg
     2521 tcccatccgg aaacgcctca gctccaccag ctctgaagag acacaacttt tccatatccc
     2581 cagggtcacc tctctgaagc tatagaaccc accgggcaag gtgattcctg ggggcttcct
     2641 gtcctttgtc cttgtctcag cctggaccag aagacatctg taacctctgt cccagagccc
     2701 aggctggcct ctagggctgg gctgtcccct ccacttctct agcttaccca gttcacgttt
     2761 gcactttctc ctcatgaccc caatcactcc cagtctttac agagctaaca ggttcttctg
     2821 cgtgtctagt cttgtcctcc tcactgtggt atctcagcaa caggaaaggc ctcttcacta
     2881 cccatgggag ttctttctcc agccccctcc atttgccttg tttctttccc ccctctccta
     2941 tctaagctcc tttccccttg tctaagtttg gtccccccac ctgccccaac atccttcttg
     3001 ctcccttccc cagaccattg cttgctctct ccatggaggt cctgcctcct ccccttgtcc
     3061 cctttacctt gcccttactg ccaccttgct ggctcccagg cctccctaca cagaacaaac
     3121 atcacggttg aggttgtgac ctctgaacct tctgcagctc tcttctgaat ctcctgttcc
     3181 cagtggggta agacaggcct gtctgagagc tgagctgtcc tgtctgcatt ctaggttaga
     3241 aataccagtg ctgaatattg cctcctaaga gagaaccagg gatgtgggcc atgctggggc
     3301 tcccccttgc cttgtagaca gtagcatggg tggtcccact gtcttcccag gatggatctg
     3361 gtggtaagaa cagggttttg cacttcccct gccatactgc acatatggcc tgggaccacc
     3421 cctcacttat ctctggatgg tccctatgtg ctgggcatta agtccagaaa ggacaaagaa
     3481 aagagagaca atatggaccg atctctgctc caatcacagg ttcttacttt cctatgcttt
     3541 ggttctgggt ccctgaagct gggtctctaa ggcaaaggct cagcatacaa ttggtgttta
     3601 atgagcattt gtgggaagaa ctgcaaggcc tctctaactg cagacgtcct gggactgcta
     3661 tagcaattca ggaggaggag cagagcctgc cttagccatg tgattcacgg cctgatgctg
     3721 ttcgctaggg tacctcaaac acgtgacata ggcgcccagc ctcgattaat tttattataa
     3781 aatggagagg ttcctcaggg cctgtgtgca gggttgtgaa agtcaaacac tgtgatgggc
     3841 agaaccccct gacaggcctg gtgccaagca agtacaattc gtgcagcaca ggaggtgaga
     3901 gccaggctga gggcagagcc agggtttggt gtgaagaggg tgagtgccct ttatggtggt
     3961 aattctccct atctctgggc atgttgatgt ggaattacat tatgaatgta caagcaagtt
     4021 ttgctgctag gactaaggat ggtggtaccc aaagtacgaa cgtacaaaga ctccagcaag
     4081 cacactctca aacaggcatc ctgggatgtg ctttctatcc ccagaagttg gaaggttttg
     4141 ttttgttgtt tgtttgtttt cagttgttac tgatttgtta acttgggggt gaggaagtga
     4201 caccctgatt tttttaatgc aactgattgg atttaaacaa atgaaataaa agcaataaaa
     4261 aaaatc
//
