LOCUS       NM_008935               3739 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus prominin 1 (Prom1), transcript variant 1, mRNA.
ACCESSION   NM_008935
VERSION     NM_008935.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3739)
  AUTHORS   Jasmine, Baraiya,D.H., Kavya,T.T., Mandal,A., Chakraborty,S.,
            Sathish,N., Francis,C.M.R. and Binoy Joseph,D.
  TITLE     Epithelial and mesenchymal compartments of the developing bladder
            and urethra display spatially distinct gene expression patterns
  JOURNAL   Dev Biol 520, 155-170 (2025)
   PUBMED   39798644
REFERENCE   2  (bases 1 to 3739)
  AUTHORS   Lo Giudice,Q., Wagener,R.J., Abe,P., Frangeul,L. and Jabaudon,D.
  TITLE     Developmental emergence of first- and higher-order thalamic neuron
            molecular identities
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39348458
REFERENCE   3  (bases 1 to 3739)
  AUTHORS   Seidemann,S., Salomon,F., Hoffmann,K.B., Kurth,T., Sbalzarini,I.F.,
            Haase,R. and Ader,M.
  TITLE     Automated quantification of photoreceptor outer segments in
            developing and degenerating retinas on microscopy images across
            scales
  JOURNAL   Front Mol Neurosci 17, 1398447 (2024)
   PUBMED   38854587
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3739)
  AUTHORS   Yanardag,S., Rhodes,S., Saravanan,T., Guan,T. and Ramamurthy,V.
  TITLE     Prominin 1 is crucial for the early development of photoreceptor
            outer segments
  JOURNAL   Sci Rep 14 (1), 10498 (2024)
   PUBMED   38714794
  REMARK    GeneRIF: Prominin 1 is crucial for the early development of
            photoreceptor outer segments.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3739)
  AUTHORS   D'Ambrosio,A., Bressan,D., Ferracci,E., Carbone,F., Mule,P.,
            Rossi,F., Barbieri,C., Sorrenti,E., Fiaccadori,G., Detone,T.,
            Vezzoli,E., Bianchi,S., Sartori,C., Corso,S., Fukuda,A.,
            Bertalot,G., Falqui,A., Barbareschi,M., Romanel,A., Pasini,D. and
            Chiacchiera,F.
  TITLE     Increased genomic instability and reshaping of tissue
            microenvironment underlie oncogenic properties of Arid1a mutations
  JOURNAL   Sci Adv 10 (11), eadh4435 (2024)
   PUBMED   38489371
REFERENCE   6  (bases 1 to 3739)
  AUTHORS   Zhu,G., Chang,Y., Zuo,J., Dong,X., Zhang,M., Hu,G. and Fang,F.
  TITLE     Fudenine, a C-terminal truncated rat homologue of mouse prominin,
            is blood glucose-regulated and can up-regulate the expression of
            GAPDH
  JOURNAL   Biochem Biophys Res Commun 281 (4), 951-956 (2001)
   PUBMED   11237753
REFERENCE   7  (bases 1 to 3739)
  AUTHORS   Maw,M.A., Corbeil,D., Koch,J., Hellwig,A., Wilson-Wheeler,J.C.,
            Bridges,R.J., Kumaramanickavel,G., John,S., Nancarrow,D., Roper,K.,
            Weigmann,A., Huttner,W.B. and Denton,M.J.
  TITLE     A frameshift mutation in prominin (mouse)-like 1 causes human
            retinal degeneration
  JOURNAL   Hum Mol Genet 9 (1), 27-34 (2000)
   PUBMED   10587575
REFERENCE   8  (bases 1 to 3739)
  AUTHORS   Zhadanov,A.B., Provance,D.W. Jr., Speer,C.A., Coffin,J.D., Goss,D.,
            Blixt,J.A., Reichert,C.M. and Mercer,J.A.
  TITLE     Absence of the tight junctional protein AF-6 disrupts epithelial
            cell-cell junctions and cell polarity during mouse development
  JOURNAL   Curr Biol 9 (16), 880-888 (1999)
   PUBMED   10469590
REFERENCE   9  (bases 1 to 3739)
  AUTHORS   Miraglia,S., Godfrey,W., Yin,A.H., Atkins,K., Warnke,R.,
            Holden,J.T., Bray,R.A., Waller,E.K. and Buck,D.W.
  TITLE     A novel five-transmembrane hematopoietic stem cell antigen:
            isolation, characterization, and molecular cloning
  JOURNAL   Blood 90 (12), 5013-5021 (1997)
   PUBMED   9389721
REFERENCE   10 (bases 1 to 3739)
  AUTHORS   Weigmann,A., Corbeil,D., Hellwig,A. and Huttner,W.B.
  TITLE     Prominin, a novel microvilli-specific polytopic membrane protein of
            the apical surface of epithelial cells, is targeted to plasmalemmal
            protrusions of non-epithelial cells
  JOURNAL   Proc Natl Acad Sci U S A 94 (23), 12425-12430 (1997)
   PUBMED   9356465
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ054003.1, AK029921.1, AC102476.14, EH108160.1 and BC028286.1.
            
            On Jul 24, 2009 this sequence version replaced NM_008935.1.
            
            Transcript Variant: This variant (1) lacks an alternative in-frame
            exon in the 5' coding region, compared to variant 2. The resulting
            isoform (s1) lacks a 9 aa segment near the N-terminus, compared to
            isoform s2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF026269.1, SRR17784643.290152.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-314               CJ054003.1         2-315
            315-2711            AK029921.1         778-3174
            2712-2723           AC102476.14        81316-81327
            2724-3137           EH108160.1         43-456              c
            3138-3739           BC028286.1         3100-3701
FEATURES             Location/Qualifiers
     source          1..3739
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 23.97 cM"
     gene            1..3739
                     /gene="Prom1"
                     /gene_synonym="4932416E19Rik; AC133; CD133; Prom; Prom-1;
                     Proml1"
                     /note="prominin 1"
                     /db_xref="GeneID:19126"
                     /db_xref="MGI:MGI:1100886"
     exon            1..89
                     /gene="Prom1"
                     /gene_synonym="4932416E19Rik; AC133; CD133; Prom; Prom-1;
                     Proml1"
                     /inference="alignment:Splign:2.1.0"
     exon            90..463
                     /gene="Prom1"
                     /gene_synonym="4932416E19Rik; AC133; CD133; Prom; Prom-1;
                     Proml1"
                     /inference="alignment:Splign:2.1.0"
     CDS             244..2820
                     /gene="Prom1"
                     /gene_synonym="4932416E19Rik; AC133; CD133; Prom; Prom-1;
                     Proml1"
                     /note="isoform s1 precursor is encoded by transcript
                     variant 1; prominin-like 1; antigen AC133 homolog;
                     prominin-like protein 1"
                     /codon_start=1
                     /product="prominin-1 isoform s1 precursor"
                     /protein_id="NP_032961.2"
                     /db_xref="CCDS:CCDS39082.1"
                     /db_xref="GeneID:19126"
                     /db_xref="MGI:MGI:1100886"
                     /translation="MALVFSALLLLGLCGKISSEGQPAFHNTPGAMNYELPTTKYETQ
                     DTFNAGIVGPLYKMVHIFLNVVQPNDFPLDLIKKLIQNKNFDISVDSKEIALYEIGVL
                     ICAILGLLFIILMPLVGCFFCMCRCCNKCGGEMHQRQKQNAPCRRKCLGLSLLVICLL
                     MSLGIIYGFVANQQTRTRIKGTQKLAKSNFRDFQTLLTETPKQIDYVVEQYTNTKNKA
                     FSDLDGIGSVLGGRIKDQLKPKVTPVLEEIKAMATAIKQTKDALQNMSSSLKSLQDAA
                     TQLNTNLSSVRNSIENSLSSSDCTSDPASKICDSIRPSLSSLGSSLNSSQLPSVDREL
                     NTVTEVDKTDLESLVKRGYTTIDEIPNTIQNQTVDVIKDVKNTLDSISSNIKDMSQSI
                     PIEDMLLQVSHYLNNSNRYLNQELPKLEEYDSYWWLGGLIVCFLLTLIVTFFFLGLLC
                     GVFGYDKHATPTRRGCVSNTGGIFLMAGVGFGFLFCWILMILVVLTFVVGANVEKLLC
                     EPYENKKLLQVLDTPYLLKEQWQFYLSGMLFNNPDINMTFEQVYRDCKRGRGIYAAFQ
                     LENVVNVSDHFNIDQISENINTELENLNVNIDSIELLDNTGRKSLEDFAHSGIDTIDY
                     STYLKETEKSPTEVNLLTFASTLEAKANQLPEGKLKQAFLLDVQNIRAIHQHLLPPVQ
                     QSLNTLRQSVWTLQQTSNKLPEKVKKILASLDSVQHFLTNNVSLIVIGETKKFGKTIL
                     GYFEHYLHWVFYAITEKMTSCKPMATAMDSAVNGILCGYVADPLNLFWFGIGKATVLL
                     LPAVIIAIKLAKYYRRMDSEDVYDDVETVPMKNLEIGSNGYHKDHLYGVHNPVMTSPS
                     RY"
     exon            464..522
                     /gene="Prom1"
                     /gene_synonym="4932416E19Rik; AC133; CD133; Prom; Prom-1;
                     Proml1"
                     /inference="alignment:Splign:2.1.0"
     exon            523..728
                     /gene="Prom1"
                     /gene_synonym="4932416E19Rik; AC133; CD133; Prom; Prom-1;
                     Proml1"
                     /inference="alignment:Splign:2.1.0"
     exon            729..849
                     /gene="Prom1"
                     /gene_synonym="4932416E19Rik; AC133; CD133; Prom; Prom-1;
                     Proml1"
                     /inference="alignment:Splign:2.1.0"
     exon            850..913
                     /gene="Prom1"
                     /gene_synonym="4932416E19Rik; AC133; CD133; Prom; Prom-1;
                     Proml1"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1003
                     /gene="Prom1"
                     /gene_synonym="4932416E19Rik; AC133; CD133; Prom; Prom-1;
                     Proml1"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1221
                     /gene="Prom1"
                     /gene_synonym="4932416E19Rik; AC133; CD133; Prom; Prom-1;
                     Proml1"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1296
                     /gene="Prom1"
                     /gene_synonym="4932416E19Rik; AC133; CD133; Prom; Prom-1;
                     Proml1"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1360
                     /gene="Prom1"
                     /gene_synonym="4932416E19Rik; AC133; CD133; Prom; Prom-1;
                     Proml1"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1520
                     /gene="Prom1"
                     /gene_synonym="4932416E19Rik; AC133; CD133; Prom; Prom-1;
                     Proml1"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1673
                     /gene="Prom1"
                     /gene_synonym="4932416E19Rik; AC133; CD133; Prom; Prom-1;
                     Proml1"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1797
                     /gene="Prom1"
                     /gene_synonym="4932416E19Rik; AC133; CD133; Prom; Prom-1;
                     Proml1"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..1901
                     /gene="Prom1"
                     /gene_synonym="4932416E19Rik; AC133; CD133; Prom; Prom-1;
                     Proml1"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..1986
                     /gene="Prom1"
                     /gene_synonym="4932416E19Rik; AC133; CD133; Prom; Prom-1;
                     Proml1"
                     /inference="alignment:Splign:2.1.0"
     exon            1987..2133
                     /gene="Prom1"
                     /gene_synonym="4932416E19Rik; AC133; CD133; Prom; Prom-1;
                     Proml1"
                     /inference="alignment:Splign:2.1.0"
     exon            2134..2205
                     /gene="Prom1"
                     /gene_synonym="4932416E19Rik; AC133; CD133; Prom; Prom-1;
                     Proml1"
                     /inference="alignment:Splign:2.1.0"
     exon            2206..2298
                     /gene="Prom1"
                     /gene_synonym="4932416E19Rik; AC133; CD133; Prom; Prom-1;
                     Proml1"
                     /inference="alignment:Splign:2.1.0"
     exon            2299..2352
                     /gene="Prom1"
                     /gene_synonym="4932416E19Rik; AC133; CD133; Prom; Prom-1;
                     Proml1"
                     /inference="alignment:Splign:2.1.0"
     exon            2353..2433
                     /gene="Prom1"
                     /gene_synonym="4932416E19Rik; AC133; CD133; Prom; Prom-1;
                     Proml1"
                     /inference="alignment:Splign:2.1.0"
     exon            2434..2502
                     /gene="Prom1"
                     /gene_synonym="4932416E19Rik; AC133; CD133; Prom; Prom-1;
                     Proml1"
                     /inference="alignment:Splign:2.1.0"
     exon            2503..2595
                     /gene="Prom1"
                     /gene_synonym="4932416E19Rik; AC133; CD133; Prom; Prom-1;
                     Proml1"
                     /inference="alignment:Splign:2.1.0"
     exon            2596..2711
                     /gene="Prom1"
                     /gene_synonym="4932416E19Rik; AC133; CD133; Prom; Prom-1;
                     Proml1"
                     /inference="alignment:Splign:2.1.0"
     exon            2712..2735
                     /gene="Prom1"
                     /gene_synonym="4932416E19Rik; AC133; CD133; Prom; Prom-1;
                     Proml1"
                     /inference="alignment:Splign:2.1.0"
     exon            2736..2804
                     /gene="Prom1"
                     /gene_synonym="4932416E19Rik; AC133; CD133; Prom; Prom-1;
                     Proml1"
                     /inference="alignment:Splign:2.1.0"
     exon            2805..2844
                     /gene="Prom1"
                     /gene_synonym="4932416E19Rik; AC133; CD133; Prom; Prom-1;
                     Proml1"
                     /inference="alignment:Splign:2.1.0"
     exon            2845..3719
                     /gene="Prom1"
                     /gene_synonym="4932416E19Rik; AC133; CD133; Prom; Prom-1;
                     Proml1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2993..2998
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prom1"
                     /gene_synonym="4932416E19Rik; AC133; CD133; Prom; Prom-1;
                     Proml1"
                     /note="hexamer: AATGAA"
     polyA_site      3038
                     /gene="Prom1"
                     /gene_synonym="4932416E19Rik; AC133; CD133; Prom; Prom-1;
                     Proml1"
                     /note="major polyA site"
     regulatory      3699..3704
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prom1"
                     /gene_synonym="4932416E19Rik; AC133; CD133; Prom; Prom-1;
                     Proml1"
                     /note="hexamer: AATAAA"
     polyA_site      3719
                     /gene="Prom1"
                     /gene_synonym="4932416E19Rik; AC133; CD133; Prom; Prom-1;
                     Proml1"
                     /note="major polyA site"
ORIGIN      
        1 aaataattca tgaattaagt ggaaggagcc cagcttagag gcgaggggct ggagggttcc
       61 gagacccgga ggagagctgg accggagagg gatggtactt tgagtgaatg accaccttgg
      121 agaccgttct tctgtttccc ttgttaccag ccaggaggca gaagagtcca ccggtccagg
      181 aaagacccat ttcccttgag tttccagaaa gtacctcatg cttgagagat caggccaaca
      241 actatggctc tcgtcttcag tgccctgctg ttactggggc tgtgtggaaa gatctcttca
      301 gaaggtcagc ctgcattcca taacactcct ggggctatga attatgaatt gcctaccacc
      361 aaatatgaga cccaagatac cttcaatgct gggattgttg gccctctcta caaaatggtg
      421 cacatcttcc tcaacgtggt ccagccgaat gacttccctc tagatttgat caaaaaactc
      481 atacagaaca agaactttga catctcagtt gattccaagg agattgccct ctatgagatc
      541 ggagtcctta tctgcgccat cctgggactg ctgttcatta tcctcatgcc tctggtgggc
      601 tgcttctttt gtatgtgccg ttgctgcaac aaatgcggcg gagagatgca ccagcggcag
      661 aagcagaatg cgccatgcag gaggaagtgc ttgggcctct ccctcctggt gatttgtctg
      721 ctcatgagcc ttggcattat atatggcttt gtggctaacc agcagaccag gactcggatc
      781 aaagggaccc agaaactggc aaagagcaat ttcagagact ttcaaacact cctgactgaa
      841 acaccaaagc aaattgacta tgtagtggag cagtacacca acaccaagaa caaggcattc
      901 tcagacctgg atggcatcgg ctccgtgctg ggaggcagaa taaaggacca actaaaaccc
      961 aaagtaactc ctgtcctcga agagattaag gccatggcga cagccatcaa acagaccaag
     1021 gatgccctgc agaacatgag cagcagcctg aaaagtctcc aagatgcagc cacccagctc
     1081 aataccaacc tgagctctgt gagaaacagc atcgagaatt cgctcagcag cagtgactgt
     1141 acctcagatc cagccagcaa gatctgcgat agcatcagac caagcctaag cagtctgggg
     1201 agcagcctca attcaagtca gctcccatca gtggatagag aactcaacac tgttactgaa
     1261 gtcgacaaaa ctgatctgga gagcctcgtc aaaagggggt atacgacaat tgatgaaata
     1321 cccaatacaa tacaaaacca aactgtggat gtcatcaaag acgtcaaaaa taccttggac
     1381 tccattagct ccaacattaa ggacatgagc caaagtattc ctattgagga tatgctgtta
     1441 caggtctccc attaccttaa taacagcaac agatacttaa accaggagct gcccaagctg
     1501 gaagaatatg actcgtactg gtggctgggt ggcttgattg tctgctttct gctgactctc
     1561 attgtgacct tctttttcct gggcttgctg tgtggtgtgt ttggctatga caagcatgcc
     1621 accccaacta gaagaggctg tgtgtccaac actggaggca tcttcctcat ggctggggtt
     1681 ggattcggct tccttttttg ctggatattg atgatccttg tggttcttac gtttgttgtt
     1741 ggtgcaaatg tggaaaagtt gctctgcgaa ccttatgaaa acaagaaatt attacaggtt
     1801 ttggacactc cctatctgct caaggaacaa tggcaatttt atctttctgg catgctattc
     1861 aataacccag acattaacat gacctttgag caagtctaca gggattgcaa aagaggtcga
     1921 ggtatatatg ctgcttttca gcttgagaat gtcgtcaacg tcagtgatca tttcaacatt
     1981 gaccagattt ctgaaaacat aaatacggag ttggaaaacc tgaatgtgaa cattgatagc
     2041 attgaactgt tggataacac aggaaggaag agcctcgagg actttgcaca ttctgggata
     2101 gatacaatcg attattccac atacttgaag gagactgaga aatcccctac tgaagtgaat
     2161 ctgctgacat ttgcctctac cctggaagca aaagcaaacc agttgcctga aggaaagctg
     2221 aaacaggcct tcttactgga tgtacagaat ataagagcca tccaccagca tctcctccct
     2281 cctgtgcagc aatcactgaa tacgttaaga caaagtgtct ggaccctcca gcaaacaagc
     2341 aacaagttgc cggagaaagt gaagaagatc cttgcctctt tggactctgt tcagcatttc
     2401 ctcaccaata acgtttccct catcgttatc ggggaaacga agaagtttgg gaaaacaata
     2461 ctaggctact ttgaacatta tctgcactgg gtcttttatg ccatcacaga gaagatgaca
     2521 tcctgcaaac ccatggccac cgcgatggac tctgctgtta atggcattct gtgtggctat
     2581 gttgcggacc ctctgaattt gttctggttc ggcataggga aagccacggt gctcttactt
     2641 ccggctgtaa tcattgctat caagctggcc aagtactatc gcaggatgga ttcagaggat
     2701 gtatacgacg atgttgagac tgtgcccatg aaaaatttgg aaatcggtag taatggttat
     2761 cataaagatc atttatatgg tgttcacaat cctgttatga caagcccgtc tcgatactga
     2821 caactggagt tgaagctgct tgaacaacaa gatagtcaac atggaaagca tcacagattt
     2881 tggatagttt ctgagtcttc tagaacgttc caagtgcaga agaaacctgg tggagactca
     2941 ggcgggcact aggaacatgg catcagtggt cttagggtag cactttgtca ggaatgaaca
     3001 gtcatcatgg ttataatcca catatccatt gcaactcatg aatgattctc tcctgttttg
     3061 tttttaactt ttctttttac actgattttc tatttagaca ctaaaacata taggggtgct
     3121 tattccccct ggatacattt acctgtgaac cagctattcc ggtgtcatag ctgggtacct
     3181 aacttacttc catatgtgaa gtgtgctaaa cacaaaccag tttacagaag agatgtattt
     3241 tgtgtatagt aaactgtata tatacccttt taccacagtc agttttttaa acaaatgaat
     3301 actctagatt tttcttctaa atgaggttac tgttggggtg gttgtgacct agtgatgctg
     3361 tagaaaggag tctgcattca ctaaaagtgt gtcaacctag agcaggcaat gcccttcctt
     3421 gtggatttct gtctgctcgt tttggagcta cctgcggttt agaaatagaa ttcaagaaca
     3481 atcacggagt ttcccacttg atgccactgc caaagtcaga acaagggatc ttgagagaag
     3541 gaactgtcgc tcagctggga gcggaatcat tatcgcaatc acaggtcctg gttcacagtt
     3601 tagtggcact ctctggtttg taagaatggg cattacgttc agtgtcatct ggtcatctgt
     3661 gatgtgtgtc atcagcctgt cctgatgttg agatttaaaa taaagcatga atgaacagaa
     3721 aaaaaaaaaa aaaaaaaaa
//
