LOCUS       NM_144944               4533 bp    mRNA    linear   ROD 23-APR-2024
DEFINITION  Mus musculus prokineticin receptor 2 (Prokr2), mRNA.
ACCESSION   NM_144944
VERSION     NM_144944.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4533)
  AUTHORS   Amato,E. Jr., Taroc,E.Z.M. and Forni,P.E.
  TITLE     Illuminating the terminal nerve: Uncovering the link between GnRH-1
            neuron and olfactory development
  JOURNAL   J Comp Neurol 532 (3), e25599 (2024)
   PUBMED   38488687
REFERENCE   2  (bases 1 to 4533)
  AUTHORS   Cheffer,A., Garcia-Miralles,M., Maier,E., Akol,I., Franz,H.,
            Srinivasan,V.S.V. and Vogel,T.
  TITLE     DOT1L deletion impairs the development of cortical
            parvalbumin-expressing interneurons
  JOURNAL   Cereb Cortex 33 (19), 10272-10285 (2023)
   PUBMED   37566909
REFERENCE   3  (bases 1 to 4533)
  AUTHORS   Martinez-Mayer,J. and Perez-Millan,M.I.
  TITLE     Phenotypic and genotypic landscape of PROKR2 in neuroendocrine
            disorders
  JOURNAL   Front Endocrinol (Lausanne) 14, 1132787 (2023)
   PUBMED   36843573
  REMARK    GeneRIF: Phenotypic and genotypic landscape of PROKR2 in
            neuroendocrine disorders.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4533)
  AUTHORS   Prokopuk,L., Jarred,E.G., Blucher,R.O., McLaughlin,E.A.,
            Stringer,J.M. and Western,P.S.
  TITLE     An essential role for Polycomb Repressive Complex 2 in the mouse
            ovary
  JOURNAL   Reproduction 163 (3), 167-182 (2022)
   PUBMED   35084365
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4533)
  AUTHORS   Morris,E.L., Patton,A.P., Chesham,J.E., Crisp,A., Adamson,A. and
            Hastings,M.H.
  TITLE     Single-cell transcriptomics of suprachiasmatic nuclei reveal a
            Prokineticin-driven circadian network
  JOURNAL   EMBO J 40 (20), e108614 (2021)
   PUBMED   34487375
  REMARK    GeneRIF: Single-cell transcriptomics of suprachiasmatic nuclei
            reveal a Prokineticin-driven circadian network.
REFERENCE   6  (bases 1 to 4533)
  AUTHORS   Bouma,G.J., Hart,G.T., Washburn,L.L., Recknagel,A.K. and
            Eicher,E.M.
  TITLE     Using real time RT-PCR analysis to determine multiple gene
            expression patterns during XX and XY mouse fetal gonad development
  JOURNAL   Gene Expr Patterns 5 (1), 141-149 (2004)
   PUBMED   15533830
REFERENCE   7  (bases 1 to 4533)
  AUTHORS   LeCouter,J., Lin,R., Frantz,G., Zhang,Z., Hillan,K. and Ferrara,N.
  TITLE     Mouse endocrine gland-derived vascular endothelial growth factor: a
            distinct expression pattern from its human ortholog suggests
            different roles as a regulator of organ-specific angiogenesis
  JOURNAL   Endocrinology 144 (6), 2606-2616 (2003)
   PUBMED   12746324
REFERENCE   8  (bases 1 to 4533)
  AUTHORS   LeCouter,J., Lin,R., Tejada,M., Frantz,G., Peale,F., Hillan,K.J.
            and Ferrara,N.
  TITLE     The endocrine-gland-derived VEGF homologue Bv8 promotes
            angiogenesis in the testis: Localization of Bv8 receptors to
            endothelial cells
  JOURNAL   Proc Natl Acad Sci U S A 100 (5), 2685-2690 (2003)
   PUBMED   12604792
REFERENCE   9  (bases 1 to 4533)
  AUTHORS   Menke,D.B. and Page,D.C.
  TITLE     Sexually dimorphic gene expression in the developing mouse gonad
  JOURNAL   Gene Expr Patterns 2 (3-4), 359-367 (2002)
   PUBMED   12617826
REFERENCE   10 (bases 1 to 4533)
  AUTHORS   Cheng,M.Y., Bullock,C.M., Li,C., Lee,A.G., Bermak,J.C.,
            Belluzzi,J., Weaver,D.R., Leslie,F.M. and Zhou,Q.Y.
  TITLE     Prokineticin 2 transmits the behavioural circadian rhythm of the
            suprachiasmatic nucleus
  JOURNAL   Nature 417 (6887), 405-410 (2002)
   PUBMED   12024206
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB844646.1, BC043116.1 and AL807793.7.
            
            On Jul 25, 2009 this sequence version replaced NM_144944.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057557.1, AK041586.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                BB844646.1         2-48
            48-1051             BC043116.1         1-1004
            1052-4533           AL807793.7         127514-130995       c
FEATURES             Location/Qualifiers
     source          1..4533
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 64.15 cM"
     gene            1..4533
                     /gene="Prokr2"
                     /gene_synonym="B830005M06Rik; EG-VEGRF2; Gpcr73l1;
                     Gpr73l1; PKR2"
                     /note="prokineticin receptor 2"
                     /db_xref="GeneID:246313"
                     /db_xref="MGI:MGI:2181363"
     exon            1..192
                     /gene="Prokr2"
                     /gene_synonym="B830005M06Rik; EG-VEGRF2; Gpcr73l1;
                     Gpr73l1; PKR2"
                     /inference="alignment:Splign:2.1.0"
     exon            193..771
                     /gene="Prokr2"
                     /gene_synonym="B830005M06Rik; EG-VEGRF2; Gpcr73l1;
                     Gpr73l1; PKR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             323..1468
                     /gene="Prokr2"
                     /gene_synonym="B830005M06Rik; EG-VEGRF2; Gpcr73l1;
                     Gpr73l1; PKR2"
                     /note="PK-R2; G protein-coupled receptor 73-like 1"
                     /codon_start=1
                     /product="prokineticin receptor 2"
                     /protein_id="NP_659193.3"
                     /db_xref="CCDS:CCDS16773.1"
                     /db_xref="GeneID:246313"
                     /db_xref="MGI:MGI:2181363"
                     /translation="MGPQNRNTSFAPDLNPPQDHVSLNYSYGDYDLPLGEDEDVTKTQ
                     TFFAAKIVIGVALAGIMLVCGIGNFVFIAALARYKKLRNLTNLLIANLAISDFLVAIV
                     CCPFEMDYYVVRQLSWAHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLKP
                     RMNYQTASFLIALVWMVSILIAVPSAYFTTETILVIVKNQEKIFCGQIWSVDQQLYYK
                     SYFLFVFGLEFVGPVVTMTLCYARISQELWFKAVPGFQTEQIRKRLRCRRKTVLLLMG
                     ILTAYVLCWAPFYGFTIVRDFFPTVVVKEKHYLTAFYVVECIAMSNSMINTICFVTVK
                     NNTMKYFKKMLRLHWRPSHYGSKSSADLDLKTSGVPATEEVDCIRLK"
     exon            772..4533
                     /gene="Prokr2"
                     /gene_synonym="B830005M06Rik; EG-VEGRF2; Gpcr73l1;
                     Gpr73l1; PKR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4514..4519
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prokr2"
                     /gene_synonym="B830005M06Rik; EG-VEGRF2; Gpcr73l1;
                     Gpr73l1; PKR2"
                     /note="hexamer: AATATA"
     polyA_site      4533
                     /gene="Prokr2"
                     /gene_synonym="B830005M06Rik; EG-VEGRF2; Gpcr73l1;
                     Gpr73l1; PKR2"
                     /note="major polyA site"
ORIGIN      
        1 cggggctgtt ggatgagctg cagagcgaag cagcaactcc agaaagactg atgcgaggag
       61 agcaggacca agcgacacac gcccaccaag taggcaagcc tcaaccagag ctagtgttcc
      121 cagagcccgg gccgcgccca cctatggtgg cgccaccggc cagggagtgc gtccctgaaa
      181 gcaccgaggc aaatcctgga tggtatctgt tctccctaag gattctaaca gggacctgca
      241 ctcactgacc ccagcagaac tgctgaactc cacgtgagcg catctccctg atacacacca
      301 gcccacctgt agcatcatca acatgggacc ccagaacaga aacactagct ttgcaccaga
      361 cttgaatcca ccccaagacc atgtctcctt aaactacagt tatggtgatt atgacctccc
      421 cctgggtgag gatgaggatg tgaccaagac acagaccttc tttgcagcca aaattgtcat
      481 tggcgtggca ctggcaggca tcatgctggt ctgcggcatt ggcaactttg tcttcattgc
      541 tgccctcgcc cgctacaaga agctgcgcaa ccttaccaac ctcctcattg ctaacctggc
      601 catctctgac ttcctggtgg cgatcgtctg ctgccccttt gagatggact attatgtagt
      661 acggcagctt tcctgggcgc atggtcacgt gctttgtgcc tccgtcaact accttcgtac
      721 ggtctccctg tacgtctcca ccaacgctct gctggccatc gctattgaca gatacctcgc
      781 tattgtccac cctttgaaac cacggatgaa ttatcagacc gcttccttcc tgatcgcttt
      841 ggtctggatg gtctccatcc tcatcgctgt cccatctgcc tacttcacca cagaaaccat
      901 cctcgttatc gtcaagaatc aagaaaaaat cttctgtggt cagatctggt cggtggacca
      961 gcagctctac tacaaatcct acttcctctt cgtcttcggg cttgagttcg tgggtcccgt
     1021 ggtcactatg accctgtgct atgccaggat ctcccaagag ctctggttca aggctgtacc
     1081 tggcttccag acggagcaaa tccgcaagcg gctgcgttgc cgccgcaaga cagtgctact
     1141 gctcatgggc atcctcacag cctacgtgct gtgctgggcg ccgttctatg gctttaccat
     1201 agtgcgagac ttcttcccca cggtagttgt gaaggagaag cactacctca ccgccttcta
     1261 cgtcgtggag tgcattgcca tgagcaacag catgatcaat actatatgct tcgtgacggt
     1321 caagaacaac accatgaaat acttcaagaa gatgctgcgg ctccactggc ggccctctca
     1381 ctacgggagt aagtccagcg ctgacctcga cctcaaaacc agcggggtgc ctgccactga
     1441 agaggtggat tgtatcagac taaagtagcc ttcaggtgtt gcccaaggaa aaatttaaca
     1501 ttcggtactc agtaaatcac acaccatcaa ccactcacaa gctacatgga aagatacggc
     1561 tgtattcacg ttctcctgct ctaatgtatc aggacgcttc tatgtaataa catacagcac
     1621 aactgatgtc tgcataacat cttagaaggc agacacaaat agtaacaagt gatgtggact
     1681 gaatgcttct gtctgcaaac cacaccaacc aattattcaa ggacaagagc tgacatgtga
     1741 gaattacctg ctatgtgcaa aaacaagtta cccccccaaa aaatgataga agctatttgg
     1801 agttattcag ctctatctat ctatctatct atccatccat ccatccatcc atccaggtca
     1861 ctagaaagaa gtcacaaatg actagccaga gtcatgctac atattctttc attctgtatc
     1921 ttttctgcac agaactgtca aaggcaatag aataaagcac ctagacatac tagaaatgta
     1981 aggataactc catcaatagg gagaccaagg cctcatagga agagggtcca tatagtatac
     2041 tgactttccc cactccacac cagttatctc cttagatatt ctgtacttat ctgcaatgat
     2101 gtaatttcaa atgaggaaaa ataaggggac aggctttacc acagatgtat caaatctcat
     2161 caagcccata gggcaaagat gggaggctcc tgacacaaga aatgtatcca gttctggata
     2221 actttaatgc caagcatttc agggctctgg ggtcttggag gaagaggaca cagaaagagc
     2281 cgaggtttcc agtggcaatg agtataatct gtccatttgc tatgatttgg acaattttct
     2341 agaacatact ccgacttaca aaaggaactc tacttgagat ccaaagatcc gggtaaaagt
     2401 cctaacccca ggactcatct ctgtgtgtct ccactgtaat gaaatggaaa taatgaaaac
     2461 ggatcattag gaacatcagc ccggcgaagt catggtgtgg atgtgatttt cacctcttcc
     2521 tttgtgaaga atgaggtcgt gaaaagctca ttagagggag tttggaatgg agaaacagct
     2581 ccacactttt catccctctt ctttgaatca gagaccacta aactcatctt tgaagtagcg
     2641 tatctatagt gaggcataaa ggtctccctg tcacagagtg caatcaagaa gatagagtca
     2701 atgcccatac cctcagcatc cctgtggtct tagacagtct tcccaacaaa gcactggtgg
     2761 accccaggac tgaattcact tgtattatta tgtcatctac tgaatactag ggttgatcag
     2821 gttagctaga taggtatttt cttcctcctt cacagcccca tatgtatccc tcccttaaac
     2881 tcagttacta aggaagacct tcttaaacac aggagaacca ttattctgtc caggacacaa
     2941 ataacctctc cagtagacac tgtacccttc acatgtcaac agaatttgcc tccttcttgt
     3001 atttaaacat atcatcctcc tttcatttag atttaaccag aaaccattcc tgtaaatttc
     3061 aatgtgtttg tgatacccca ctgtaaaaag cgtatgctgt tatcatatgg aataattaac
     3121 atacagaatt gtaatcgtag ttcccaaaag gttccctact cgtgttgtat cttatgttta
     3181 tatgtttgat gtaaatggag ctgtgtagct gtctaagcag ctcaagcctg aaatgaggga
     3241 atgtccaatg gtgttcttag agcagggcca tctcaggcta gcagctggcc tcagtctgtg
     3301 ctctctcggg agtgtgttct taaatatgaa ttagcagcaa accattatcc tatgtgctcc
     3361 cttgtttata aacgattttt aaaatgcagg cttcttttca cttagcgaat atttgtgcgt
     3421 ctggctagaa ctaaggtaat aagttaatta catttttcag tcttcccaag actaattaag
     3481 ggtaagatta agacactctt aacacgtcaa gatacgtaca cacttatgcc tcctatttca
     3541 tggagaaagt taatatcact tagcaaagcc agatctattt tcttggccac attatgagaa
     3601 aagatggttc gacaatgaag ctgttacaga tttttgttat gcatccaaca tttaaaataa
     3661 gttacttcta aatttggaga aatcaaaaaa aaaaaaatgc ttcaggccct caggcatgac
     3721 aaacaactcc agacttcaca aggaacaatg tgacatttgg gaggtaatta gaaatcttaa
     3781 cacaagttct gtttctactt aaaaatggtg gctccaaaac ccatctttgc atccaaccat
     3841 atactccctt ggccacaaga acacacacac acacacacac acacacacac acatcactag
     3901 aacaccatac caagaaatgc cttgagaaca ttcagctcct ttctttggtg gatctgaatt
     3961 ccgagaaagg aaatcaccta taacagtaca cagttgattc tttctagagc taaagccttg
     4021 ccctaagatt ttctctctag gacaatgagc agctttcagt gactgcccat acttgagtcc
     4081 aaaggacctg gcacactgtg gtatcaggtt ccagagtatg tagaatctta agtctctagg
     4141 ttgctttgct tgttcattaa aaagaagtta gatccccatt ctggatacct tgtggtataa
     4201 ggtaagatca agagacaaag tgtgggttgt acacagggat tccttgtaga cggctgttgg
     4261 aggttcatgg tatccaactc tatccagaag atgttcaaaa cataacatcc agttcttata
     4321 aatgagcatt tctctaaaaa gttttccatc catagtgcat cttaatcaat tttaatttta
     4381 acatctactc ccttttctac atacagttga aaatattacg tatgtgtatc ctcatgagtt
     4441 gttatgatat atatgcatat gcacagtctc attgttgtag gattgcatgt ttgtagattt
     4501 gttcacaaac taaaatatat ttgtaatccc caa
//
