LOCUS       NM_015768               1955 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus prokineticin 2 (Prok2), transcript variant 1, mRNA.
ACCESSION   NM_015768
VERSION     NM_015768.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1955)
  AUTHORS   Yang,J., Shin,Y., Kim,H.J., Kim,H.E. and Chun,J.S.
  TITLE     Prokineticin 2 is a catabolic regulator of osteoarthritic cartilage
            destruction in mouse
  JOURNAL   Arthritis Res Ther 25 (1), 236 (2023)
   PUBMED   38057865
  REMARK    GeneRIF: Prokineticin 2 is a catabolic regulator of osteoarthritic
            cartilage destruction in mouse.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1955)
  AUTHORS   Onodera,K., Tsuno,Y., Hiraoka,Y., Tanaka,K., Maejima,T. and
            Mieda,M.
  TITLE     In vivo recording of the circadian calcium rhythm in Prokineticin 2
            neurons of the suprachiasmatic nucleus
  JOURNAL   Sci Rep 13 (1), 16974 (2023)
   PUBMED   37813987
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1955)
  AUTHORS   Liu,B., Qiao,L., Liu,K., Liu,J., Piccinni-Ash,T.J. and Chen,Z.F.
  TITLE     Molecular and neural basis of pleasant touch sensation
  JOURNAL   Science 376 (6592), 483-491 (2022)
   PUBMED   35482870
REFERENCE   4  (bases 1 to 1955)
  AUTHORS   Cheng,A.H., Fung,S.W., Hegazi,S., Abdalla,O.H.M.H. and Cheng,H.M.
  TITLE     SOX2 Regulates Neuronal Differentiation of the Suprachiasmatic
            Nucleus
  JOURNAL   Int J Mol Sci 23 (1), 229 (2021)
   PUBMED   35008655
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1955)
  AUTHORS   Morris,E.L., Patton,A.P., Chesham,J.E., Crisp,A., Adamson,A. and
            Hastings,M.H.
  TITLE     Single-cell transcriptomics of suprachiasmatic nuclei reveal a
            Prokineticin-driven circadian network
  JOURNAL   EMBO J 40 (20), e108614 (2021)
   PUBMED   34487375
  REMARK    GeneRIF: Single-cell transcriptomics of suprachiasmatic nuclei
            reveal a Prokineticin-driven circadian network.
REFERENCE   6  (bases 1 to 1955)
  AUTHORS   LeCouter,J., Lin,R., Frantz,G., Zhang,Z., Hillan,K. and Ferrara,N.
  TITLE     Mouse endocrine gland-derived vascular endothelial growth factor: a
            distinct expression pattern from its human ortholog suggests
            different roles as a regulator of organ-specific angiogenesis
  JOURNAL   Endocrinology 144 (6), 2606-2616 (2003)
   PUBMED   12746324
REFERENCE   7  (bases 1 to 1955)
  AUTHORS   LeCouter,J., Lin,R., Tejada,M., Frantz,G., Peale,F., Hillan,K.J.
            and Ferrara,N.
  TITLE     The endocrine-gland-derived VEGF homologue Bv8 promotes
            angiogenesis in the testis: Localization of Bv8 receptors to
            endothelial cells
  JOURNAL   Proc Natl Acad Sci U S A 100 (5), 2685-2690 (2003)
   PUBMED   12604792
  REMARK    GeneRIF: Bv8 and EG-VEGF, along with other factors such as VEGF-A,
            may maintain the integrity and also regulate proliferation of the
            blood vessels in the testis
REFERENCE   8  (bases 1 to 1955)
  AUTHORS   Cheng,M.Y., Bullock,C.M., Li,C., Lee,A.G., Bermak,J.C.,
            Belluzzi,J., Weaver,D.R., Leslie,F.M. and Zhou,Q.Y.
  TITLE     Prokineticin 2 transmits the behavioural circadian rhythm of the
            suprachiasmatic nucleus
  JOURNAL   Nature 417 (6887), 405-410 (2002)
   PUBMED   12024206
REFERENCE   9  (bases 1 to 1955)
  AUTHORS   Jilek,A., Engel,E., Beier,D. and Lepperdinger,G.
  TITLE     Murine Bv8 gene maps near a synteny breakpoint of mouse chromosome
            6 and human 3p21
  JOURNAL   Gene 256 (1-2), 189-195 (2000)
   PUBMED   11054548
REFERENCE   10 (bases 1 to 1955)
  AUTHORS   Wechselberger,C., Puglisi,R., Engel,E., Lepperdinger,G., Boitani,C.
            and Kreil,G.
  TITLE     The mammalian homologues of frog Bv8 are mainly expressed in
            spermatocytes
  JOURNAL   FEBS Lett 462 (1-2), 177-181 (1999)
   PUBMED   10580115
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122929.4.
            
            On Feb 14, 2022 this sequence version replaced NM_015768.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF182064.1, AK015462.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-180               AC122929.4         126803-126982
            181-306             AC122929.4         130576-130701
            307-369             AC122929.4         138729-138791
            370-1955            AC122929.4         140753-142338
FEATURES             Location/Qualifiers
     source          1..1955
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 46.29 cM"
     gene            1..1955
                     /gene="Prok2"
                     /gene_synonym="Bv8; PK2; Prok1"
                     /note="prokineticin 2"
                     /db_xref="GeneID:50501"
                     /db_xref="MGI:MGI:1354178"
     exon            1..180
                     /gene="Prok2"
                     /gene_synonym="Bv8; PK2; Prok1"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..474
                     /gene="Prok2"
                     /gene_synonym="Bv8; PK2; Prok1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; prokineticin 1; protein Bv8 homolog; Bombina
                     variegata 8kDa protein; Bombina variegata 8 kD protein; Bv
                     8 homolog (Bombina variegata)"
                     /codon_start=1
                     /product="prokineticin-2 isoform 1 precursor"
                     /protein_id="NP_056583.1"
                     /db_xref="CCDS:CCDS20389.1"
                     /db_xref="GeneID:50501"
                     /db_xref="MGI:MGI:1354178"
                     /translation="MGDPRCAPLLLLLLLPLLFTPPAGDAAVITGACDKDSQCGGGMC
                     CAVSIWVKSIRICTPMGQVGDSCHPLTRKSHVANGRQERRRAKRRKRKKEVPFWGRRM
                     HHTCPCLPGLACLRTSFNRFICLARK"
     exon            181..306
                     /gene="Prok2"
                     /gene_synonym="Bv8; PK2; Prok1"
                     /inference="alignment:Splign:2.1.0"
     exon            307..369
                     /gene="Prok2"
                     /gene_synonym="Bv8; PK2; Prok1"
                     /inference="alignment:Splign:2.1.0"
     exon            370..1955
                     /gene="Prok2"
                     /gene_synonym="Bv8; PK2; Prok1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1508..1513
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prok2"
                     /gene_synonym="Bv8; PK2; Prok1"
                     /note="hexamer: ATTATA"
     polyA_site      1528
                     /gene="Prok2"
                     /gene_synonym="Bv8; PK2; Prok1"
                     /note="major polyA site"
     regulatory      1935..1940
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prok2"
                     /gene_synonym="Bv8; PK2; Prok1"
                     /note="hexamer: AATAAA"
     polyA_site      1955
                     /gene="Prok2"
                     /gene_synonym="Bv8; PK2; Prok1"
ORIGIN      
        1 agagcagccc ggccacgcgt ccccaacgtc ccgggtccca acgccccgga acgcgtcccc
       61 taaccgccac cgcgtccccg ggacgccatg ggggacccgc gctgtgcccc gctactgcta
      121 cttctgctgc taccgctgct gttcacaccg cccgccgggg atgccgcggt catcaccggg
      181 gcttgcgaca aggactctca gtgcggagga ggcatgtgct gtgctgtcag tatctgggtt
      241 aagagcataa ggatctgcac acctatgggc caagtgggcg acagctgcca ccccctgact
      301 cggaaaagtc atgttgcaaa tggaaggcag gaaagaagaa gggcgaagag aagaaagagg
      361 aagaaggagg ttccattttg ggggcggagg atgcaccaca cctgcccctg cctgccaggc
      421 ttggcgtgtt taaggacttc tttcaaccgg tttatttgct tggcccggaa atgatcactc
      481 tgaagtagga acttgaaatg cgaccctccg ctgcacaatg tccgtcgagt ctcacttgta
      541 attgtggcaa acaaagaata ctccagaaag aaatgttctc ccccttcctt gactttccaa
      601 gtaacgtttc tatctttgat ttttgaagtg gctttttttt tttttttttt ttcctttcct
      661 tgaaggaaag ttttgatttt tggagagatt tatagaggac tttctgacat ggcttctcat
      721 ttccctgttt atgttttgcc ttgacatttt tgaatgccaa taacaactgt tttcacaaat
      781 aggagaataa gagggaacaa tctgttgcag aaacttcctt ttgccctttg ccccactcgc
      841 cccgccccgc cccgccccgc cctgcccatg cgcagacaga cacaccctta ctcttcaaag
      901 actctgatga tcctcacctt actgtagcat tgtgggtttc tacacttccc cgccttgctg
      961 gtggacccac tgaggaggct cagagagcta gcactgtaca ggtttgaacc agatccccca
     1021 agcagctcat ttggggcaga cgttgggagc gctccaggaa ctttcctgca cccatctggc
     1081 ccactggctt tcagttctgc tgtttaactg gtgggaggac aaaattaacg ggaccctgaa
     1141 ggaacctggc ccgtttatct agatttgttt aagtaaaaga cattttctcc ttgttgtgga
     1201 atattacatg tctttttctt ttttatctga agcttttttt ttttttcttt aagtcttctt
     1261 gttggagaca ttttaaagaa cgccactcga ggaagcattg attttcatct ggcatgacag
     1321 gagtcatcat tttaaaaaat cggtgttaag ttataattta aactttattt gtaacccaaa
     1381 ggtctaatgt aaatggattt cctgatatcc tgccatttgt actggtatca atatttctat
     1441 gtaaaaaaaa aaaaaaattc tgtatcagaa taatgacaat actgtatatc ctttgattta
     1501 ttttgatatt atatccttat ttttgtcacg gctgtcaaca gtttttatta cgagcggatt
     1561 tctatatagc cctcatccta aagtcggcag acaccccaaa gctggtgaat tcactctaac
     1621 gatacatgca ttttcatctc acatccagga gagctgtgtt tgtgtgaatt tcaaggtagc
     1681 acaaaaacga ataaataaac catgtgtatt caaaaaaaca aaagccaaaa caaaaaagct
     1741 ttggcaagtg aaggaaagca tggcacccgg aagcgattgt tagctggcat ggacccgtag
     1801 gcttgccctg cgagatccga tggggcatgt gtgatgcgtg gcgtgacatg ggttaggctc
     1861 gaactgcaca gtggtaccaa tgtggtctgg ccttgaacaa ctcactaagt gttgtcaacc
     1921 catattgtgt cacaaataaa catctgaacc ctcaa
//
