LOCUS       NM_001357885            3959 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus prokineticin 1 (Prok1), transcript variant 2, mRNA.
ACCESSION   NM_001357885 XM_017319584
VERSION     NM_001357885.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3959)
  AUTHORS   Reynaud,D., Sergent,F., Abi Nahed,R., Brouillet,S., Benharouga,M.
            and Alfaidy,N.
  TITLE     EG-VEGF Maintenance Over Early Gestation to Develop a
            Pregnancy-Induced Hypertensive Animal Model
  JOURNAL   Methods Mol Biol 1710, 317-324 (2018)
   PUBMED   29197014
  REMARK    GeneRIF: Clinical studies strongly suggested the potential
            involvement of the new angiogenic factor EG-VEGF in
            pregnancy-induced hypertension. Here is described the protocol that
            served to demonstrate that maintenance of EG-VEGF production over
            11.5 days post coitus (dpc) in the gravid mice caused the
            development of pregnancy-induced hypertension.
            Erratum:[Methods Mol Biol. 2018;1710:E1. doi:
            10.1007/978-1-4939-7498-6_29.. PMID: 29704221]
REFERENCE   2  (bases 1 to 3959)
  AUTHORS   Alfaidy,N.
  TITLE     Prokineticin1 and pregnancy
  JOURNAL   Ann Endocrinol (Paris) 77 (2), 101-104 (2016)
   PUBMED   27172869
  REMARK    Review article
REFERENCE   3  (bases 1 to 3959)
  AUTHORS   Garnier,V., Traboulsi,W., Salomon,A., Brouillet,S., Fournier,T.,
            Winkler,C., Desvergne,B., Hoffmann,P., Zhou,Q.Y., Congiu,C.,
            Onnis,V., Benharouga,M., Feige,J.J. and Alfaidy,N.
  TITLE     PPARgamma controls pregnancy outcome through activation of EG-VEGF:
            new insights into the mechanism of placental development
  JOURNAL   Am J Physiol Endocrinol Metab 309 (4), E357-E369 (2015)
   PUBMED   26081281
  REMARK    GeneRIF: EG-VEGF is a new mediator of PPARgamma effects during
            pregnancy and bring new insights into the fine mechanism of
            trophoblast invasion.
REFERENCE   4  (bases 1 to 3959)
  AUTHORS   Olivey,H.E. and Svensson,E.C.
  TITLE     Epicardial-myocardial signaling directing coronary vasculogenesis
  JOURNAL   Circ Res 106 (5), 818-832 (2010)
   PUBMED   20299672
  REMARK    Review article
REFERENCE   5  (bases 1 to 3959)
  AUTHORS   Long,J.E., Swan,C., Liang,W.S., Cobos,I., Potter,G.B. and
            Rubenstein,J.L.
  TITLE     Dlx1&2 and Mash1 transcription factors control striatal patterning
            and differentiation through parallel and overlapping pathways
  JOURNAL   J Comp Neurol 512 (4), 556-572 (2009)
   PUBMED   19030180
REFERENCE   6  (bases 1 to 3959)
  AUTHORS   Ngan,E.S., Lee,K.Y., Sit,F.Y., Poon,H.C., Chan,J.K., Sham,M.H.,
            Lui,V.C. and Tam,P.K.
  TITLE     Prokineticin-1 modulates proliferation and differentiation of
            enteric neural crest cells
  JOURNAL   Biochim Biophys Acta 1773 (4), 536-545 (2007)
   PUBMED   17324478
  REMARK    GeneRIF: This is the first report demonstrating that Prok-1 acts as
            a gut mucosa/mesenchyme-derived factor and maintains proliferation
            and differentiation of enteric neural crest cells.
REFERENCE   7  (bases 1 to 3959)
  AUTHORS   LeCouter,J., Lin,R., Frantz,G., Zhang,Z., Hillan,K. and Ferrara,N.
  TITLE     Mouse endocrine gland-derived vascular endothelial growth factor: a
            distinct expression pattern from its human ortholog suggests
            different roles as a regulator of organ-specific angiogenesis
  JOURNAL   Endocrinology 144 (6), 2606-2616 (2003)
   PUBMED   12746324
  REMARK    GeneRIF: plays a role in regulating the phenotype and growth
            properties of endothelial cells within distinct capillary beds
REFERENCE   8  (bases 1 to 3959)
  AUTHORS   LeCouter,J., Lin,R., Tejada,M., Frantz,G., Peale,F., Hillan,K.J.
            and Ferrara,N.
  TITLE     The endocrine-gland-derived VEGF homologue Bv8 promotes
            angiogenesis in the testis: Localization of Bv8 receptors to
            endothelial cells
  JOURNAL   Proc Natl Acad Sci U S A 100 (5), 2685-2690 (2003)
   PUBMED   12604792
  REMARK    GeneRIF: Bv8 and EG-VEGF, along with other factors such as VEGF-A,
            may maintain the integrity and also regulate proliferation of the
            blood vessels in the testis
REFERENCE   9  (bases 1 to 3959)
  AUTHORS   Vogler,C., Galvin,N., Levy,B., Grubb,J., Jiang,J., Zhou,X.Y. and
            Sly,W.S.
  TITLE     Transgene produces massive overexpression of human beta
            -glucuronidase in mice, lysosomal storage of enzyme, and
            strain-dependent tumors
  JOURNAL   Proc Natl Acad Sci U S A 100 (5), 2669-2673 (2003)
   PUBMED   12591953
REFERENCE   10 (bases 1 to 3959)
  AUTHORS   Cheng,M.Y., Bullock,C.M., Li,C., Lee,A.G., Bermak,J.C.,
            Belluzzi,J., Weaver,D.R., Leslie,F.M. and Zhou,Q.Y.
  TITLE     Prokineticin 2 transmits the behavioural circadian rhythm of the
            suprachiasmatic nucleus
  JOURNAL   Nature 417 (6887), 405-410 (2002)
   PUBMED   12024206
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132405.3 and AW123932.1.
            
            On Nov 10, 2017 this sequence version replaced XM_017319584.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC042707.1, BG973041.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                AC132405.3         143269-143313
            46-171              AC132405.3         144708-144833
            172-3943            AC132405.3         146233-150004
            3944-3959           AW123932.1         1-16                c
FEATURES             Location/Qualifiers
     source          1..3959
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 46.72 cM"
     gene            1..3959
                     /gene="Prok1"
                     /gene_synonym="EG-VEGF"
                     /note="prokineticin 1"
                     /db_xref="GeneID:246691"
                     /db_xref="MGI:MGI:2180370"
     exon            1..45
                     /gene="Prok1"
                     /gene_synonym="EG-VEGF"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..291
                     /gene="Prok1"
                     /gene_synonym="EG-VEGF"
                     /note="isoform 2 is encoded by transcript variant 2;
                     endocrine-gland-derived vascular endothelial growth
                     factor"
                     /codon_start=1
                     /product="prokineticin-1 isoform 2"
                     /protein_id="NP_001344814.1"
                     /db_xref="CCDS:CCDS89674.1"
                     /db_xref="GeneID:246691"
                     /db_xref="MGI:MGI:2180370"
                     /translation="MKAVVKTKACERDIQCGAGTCCAISLWLRGLRLCTPLGREGEEC
                     HPGSHKIPFLRKRQHHTCPCSPSLLCSRFPDGRYRCFRDLKNANF"
     exon            46..171
                     /gene="Prok1"
                     /gene_synonym="EG-VEGF"
                     /inference="alignment:Splign:2.1.0"
     exon            172..3944
                     /gene="Prok1"
                     /gene_synonym="EG-VEGF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3921..3926
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prok1"
                     /gene_synonym="EG-VEGF"
                     /note="hexamer: ATTAAA"
     polyA_site      3944
                     /gene="Prok1"
                     /gene_synonym="EG-VEGF"
                     /note="major polyA site"
ORIGIN      
        1 tgcatcgagc aggcatgact gatgaaagcc gtcgtgaaga ccaaggcctg tgaacgagat
       61 atccagtgtg gggccggcac ctgctgcgct atcagtctgt ggctgcgggg cctgcggttg
      121 tgtaccccac tggggcgtga aggagaggag tgccacccag gaagccacaa gatccccttc
      181 ttgaggaaac gccaacacca tacctgtccc tgctcaccca gcctgctgtg ctccaggttc
      241 ccggacggca ggtaccgctg cttccgggac ttgaagaatg ccaactttta gtttgtctgg
      301 actctgtctg gagcctgact gggtgacctc ttgctttaca cctgtgtgat ttagctccct
      361 gcaacttcgc cattccccat cttgtccgtg tatgtgcaga caggcagacc ttccgctatg
      421 gaatagttca ccagggtgca gagaggagtt cgtggccttg agaagttggc cagcccgacc
      481 ttcctggctc agactgcctg aagttgtgac agtgtgggcc tcctcagttg cctgcccctt
      541 cctgcatgtg cgcttcttcc taaaccacac ctttctgggc actggcccat ggatgcacca
      601 ctaaatcaca gggtctgtgg ggtggatgat caactttctc tccatttttc ttttattgac
      661 tggctcctta ttttaggact gttaagtcca aagtcagcac ttcttaggac actattctaa
      721 agcgagagga tttcagggtc tctttgagct agggtgagcg gcagcttaga gggctctggg
      781 gatgtgttcg tgcttgtggt ggtgcgagag gtcagctggg aaggatggga acatgcagaa
      841 actctatgga ggagactggc gtgggccact gcaactctca gagccaagca tcagtccctt
      901 tgggtttatg ccaaagtttc gacccacagg ccacgtgtgc tgtgtgatag taatttgtgt
      961 cagtgatgga gctggcaagg tccagagcct gaaccctcgc ctgggagctt tctctacagc
     1021 aggtttctgg tacagctgac tcttcccacc ccgattctta ttctagatac agggcgtcca
     1081 gcaacattgt gacaaaatgt tgccctctac aaagttcaga aaggagcaat tgagttgcaa
     1141 caaccaaatc tctttttcag taagcttaca ctttttgcct tgggccacat tgacagctat
     1201 ccaaagcaag caagcaagca agcaaacaaa caaacaaatg aacaaactaa tgaatgaaca
     1261 aacaccaaaa gaacctaaaa cgtgaaagga cagggtgctg cacccactct ggttctcagg
     1321 agccttaagg agagttcact gaggtttccg aggccctggg ttcctgccct ctaccggtct
     1381 ttgctcagtc cttaatccag ggcccactag cctgggcatt ggacagcaca gggatctttc
     1441 tgtgcttttg tcccctttag acagacattg tcacctgttc tgctgacctg tgcagctctt
     1501 ccctgaatgc agaccacagt ctctttcctt tcaggctcca ggcctggttc ctagatgtaa
     1561 agttcctttc taagtctgtg ggcccatgtc tgacagatct ccatgttcca ctaactgccc
     1621 tcgggtccca atccccagat tgtgtccctc ccagcacaca gagcaaccct gaatgcagtg
     1681 gcctacagcc agtgcctcaa tgctccatag ataagatact ggggtggcct atggagctcc
     1741 cctgcacagt cacactgcct gtccatccta gccttagggc aggccaccca cagaactata
     1801 gggtgaacca acaatttaat gtgactgtat tcattttcgt ttttaatgtc ataattttga
     1861 ggactgtcta atgagtctct accttctctg ctgtggcaaa agataggaca gtggagaggt
     1921 taggaggctt agaacatata ttcatgagta gtatttatat tcaggaatat gctcttcaga
     1981 aatatggata taaaaaacta cctatagggt tagtatgcaa ctaagaatat attttagaag
     2041 aattaggaga ggcaaagttg acattctttc aagatccatc cgcagcttaa gtgactgttc
     2101 ttaggcccaa cgcttccatc ttcaactatt ggtatctggc gccatctcgt ggacaatgtg
     2161 gaagtagcaa ggaacgtgaa ggcgaaaaga ggactgcatg atttcagaaa tagacgtggg
     2221 agttcttcct ggtttggact ccattggaga tcctgaacag tgcttgtcaa gaagccggcc
     2281 tcctgaagga ccacaaaaac aactctttat taacactctg tcctgctcca ccttacaagt
     2341 ggggaagcca cagtttcctt cctgtggggt ttaggttctc tagagcgaga gagcagatgt
     2401 gaataaggtc cccatcctcc accctctgca ccccaccccc ctctgtgaat caccaggatg
     2461 tagcaggctc tgcagggccg cttttgaagc taaatccctc ggactcctcc ccatctctgg
     2521 ttcattttga gtgacttgct ttcatcactc tctaggtagc caggacctag agataccccc
     2581 atcctcccag gacaaaaggg ccagacccag aaggccagag gccagaacag aggctgtgtg
     2641 gggaccccag aaggccagag gccagagcag aggctgtgtg gggaccaacg cttccagatc
     2701 tcctgccaga gcctcctctg tctgccgttc atcttcaaac tcccctcagt gtggctctta
     2761 gcattctgag taaggtccag ggaaactcga gttagctact atctatccag ttgttacctg
     2821 gtgatgaaag ggcttcttga agtccatgtc caggggtgag actggaccat ggaggagcaa
     2881 gaggctccta aggctgagga gaaagaccag agagggaaga aaggctgcag ggttggacgc
     2941 ggactcagag ctgaccctgc cgagtggacc caaatcattg acccaaggtc agctcagacc
     3001 agccaaaggg ccaacatcga ggctttgtgt gcagtttatt aaaaagcaaa aaaaaaaaaa
     3061 aaaaaatcat acctagccat gtaggtagag agaagcacat gctggcctag ggtacactaa
     3121 tggtgtcttc tgggatgttt tccctgacca gggctgggca ctgaaagcaa agaactgacc
     3181 tggtacgaaa agctcctttc cattccagat gaggacaata tgatgtccaa gcacggagta
     3241 tcactcagcg ctgagaagac ataaggcaca gatatgcttc atagcacgag gggcccttga
     3301 atcattagac agtgggagct agtcataaaa ggttacattg gtacaactcc acttatgtga
     3361 aaactccaca acaggcgaac ccacaggggc aggaagcaag tcatagttgg ttaggattgg
     3421 ggtggagtga aggcagaaaa atggcgaggc actgtaaagg gactcaggct tctttaaggg
     3481 tgacaagaac gttctaaaat taaattgtgg agatggccgt acaatctgtc agcatcggca
     3541 acattgctga agtgtatggt ttgtgagggc aaatggtgtg ctatatggat tacaccacaa
     3601 tgcagctatt ttgaaagtgt taaaatacac aaagttgaaa agaggaaggt tagcaaaagt
     3661 gtcttccccc tcccccgact tcaggatcct gaaggaagga ctgggtgcgg tgcggcaaga
     3721 agaccctcag agtctcctgt ggggaatggg tgcgctgggt gctgcgaagt ggcttgactt
     3781 cccttcaaac aggagggcga ggagaatgga taccttatta actaaagcta catatagcgt
     3841 cacgtgaccc aaaccgcata tagtcagccc tccggaccct ggggctcttc atgggaattc
     3901 caccaactgt ggatcaaaat attaaaaagt gcatctgcat tgaaaaaaaa aaaaaaaaa
//
