LOCUS       NM_019546               1820 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus proline dehydrogenase (oxidase) 2 (Prodh2), transcript
            variant 1, mRNA.
ACCESSION   NM_019546
VERSION     NM_019546.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1820)
  AUTHORS   Buchalski,B., Wood,K.D., Challa,A., Fargue,S., Holmes,R.P.,
            Lowther,W.T. and Knight,J.
  TITLE     The effects of the inactivation of Hydroxyproline dehydrogenase on
            urinary oxalate and glycolate excretion in mouse models of primary
            hyperoxaluria
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1866 (3), 165633 (2020)
   PUBMED   31821850
REFERENCE   2  (bases 1 to 1820)
  AUTHORS   Li,X., Knight,J., Fargue,S., Buchalski,B., Guan,Z., Inscho,E.W.,
            Liebow,A., Fitzgerald,K., Querbes,W., Todd Lowther,W. and
            Holmes,R.P.
  TITLE     Metabolism of (13)C5-hydroxyproline in mouse models of Primary
            Hyperoxaluria and its inhibition by RNAi therapeutics targeting
            liver glycolate oxidase and hydroxyproline dehydrogenase
  JOURNAL   Biochim Biophys Acta 1862 (2), 233-239 (2016)
   PUBMED   26655602
  REMARK    GeneRIF: Decreasing hepatic glycolate oxidase and HYPDH expression
            decreases oxalate excretion.
REFERENCE   3  (bases 1 to 1820)
  AUTHORS   Lettieri Barbato,D., Aquilano,K., Baldelli,S., Cannata,S.M.,
            Bernardini,S., Rotilio,G. and Ciriolo,M.R.
  TITLE     Proline oxidase-adipose triglyceride lipase pathway restrains
            adipose cell death and tissue inflammation
  JOURNAL   Cell Death Differ 21 (1), 113-123 (2014)
   PUBMED   24096872
  REMARK    GeneRIF: The nutrient starvation elicits increased activity of
            mitochondrial proline oxidase/dehydrogenase (POX/PRODH) that is
            causal in triggering a ROS-dependent induction of ATGL.
REFERENCE   4  (bases 1 to 1820)
  AUTHORS   Thiagarajan,R.D., Georgas,K.M., Rumballe,B.A., Lesieur,E.,
            Chiu,H.S., Taylor,D., Tang,D.T., Grimmond,S.M. and Little,M.H.
  TITLE     Identification of anchor genes during kidney development defines
            ontological relationships, molecular subcompartments and regulatory
            pathways
  JOURNAL   PLoS One 6 (2), e17286 (2011)
   PUBMED   21386911
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1820)
  AUTHORS   Brunskill,E.W., Aronow,B.J., Georgas,K., Rumballe,B.,
            Valerius,M.T., Aronow,J., Kaimal,V., Jegga,A.G., Yu,J.,
            Grimmond,S., McMahon,A.P., Patterson,L.T., Little,M.H. and
            Potter,S.S.
  TITLE     Atlas of gene expression in the developing kidney at microanatomic
            resolution
  JOURNAL   Dev Cell 15 (5), 781-791 (2008)
   PUBMED   19000842
  REMARK    Erratum:[Dev Cell. 2009 Mar;16(3):482. Yu, Jing [added]]
REFERENCE   6  (bases 1 to 1820)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   7  (bases 1 to 1820)
  AUTHORS   Kamiya,A., Inoue,Y., Kodama,T. and Gonzalez,F.J.
  TITLE     Hepatocyte nuclear factors 1alpha and 4alpha control expression of
            proline oxidase in adult liver
  JOURNAL   FEBS Lett 578 (1-2), 63-68 (2004)
   PUBMED   15581617
  REMARK    GeneRIF: study revealed that the expression of PO and PDH was
            regulated by HNF1alpha and HNF4alpha
REFERENCE   8  (bases 1 to 1820)
  AUTHORS   Maynard,T.M., Haskell,G.T., Peters,A.Z., Sikich,L., Lieberman,J.A.
            and LaMantia,A.S.
  TITLE     A comprehensive analysis of 22q11 gene expression in the developing
            and adult brain
  JOURNAL   Proc Natl Acad Sci U S A 100 (24), 14433-14438 (2003)
   PUBMED   14614146
REFERENCE   9  (bases 1 to 1820)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC167970.4.
            
            On Mar 21, 2023 this sequence version replaced NM_019546.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK050141.1, AF222851.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-200               AC167970.4         126434-126633       c
            201-397             AC167970.4         126163-126359       c
            398-536             AC167970.4         125941-126079       c
            537-623             AC167970.4         125767-125853       c
            624-704             AC167970.4         113990-114070       c
            705-860             AC167970.4         113759-113914       c
            861-1027            AC167970.4         113514-113680       c
            1028-1138           AC167970.4         110414-110524       c
            1139-1224           AC167970.4         109068-109153       c
            1225-1820           AC167970.4         106886-107481       c
FEATURES             Location/Qualifiers
     source          1..1820
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 18.36 cM"
     gene            1..1820
                     /gene="Prodh2"
                     /gene_synonym="2510028N04Rik; 2510038B11Rik; HYPDH; MmPOX;
                     MmPOX1; POX1"
                     /note="proline dehydrogenase (oxidase) 2"
                     /db_xref="GeneID:56189"
                     /db_xref="MGI:MGI:1929093"
     exon            1..200
                     /gene="Prodh2"
                     /gene_synonym="2510028N04Rik; 2510038B11Rik; HYPDH; MmPOX;
                     MmPOX1; POX1"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..1397
                     /gene="Prodh2"
                     /gene_synonym="2510028N04Rik; 2510038B11Rik; HYPDH; MmPOX;
                     MmPOX1; POX1"
                     /EC_number="1.5.5.2"
                     /EC_number="1.5.5.3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     proline oxidase 1; kidney and liver proline oxidase 1;
                     probable proline dehydrogenase 2; probable proline oxidase
                     2; hydroxyproline dehydrogenase; proline oxidase-like
                     protein; PO"
                     /codon_start=1
                     /product="hydroxyproline dehydrogenase isoform 1"
                     /protein_id="NP_062419.2"
                     /db_xref="CCDS:CCDS21093.1"
                     /db_xref="GeneID:56189"
                     /db_xref="MGI:MGI:1929093"
                     /translation="MIWTRLPLYGPSKPSTGGWQPLRFDGGAFHVKGTAELARALLVL
                     RLCAWPPLVTHGLAFQAWSQRLLGSRLSGALLRASIYGQFVAGETAEEVRNCVGQLQA
                     LGLQPLLAVPTEEEPDSTAKTSEVWYEENLSAMLRCVDLSRALVDAHGPARNSLMQLK
                     VTALASTRLCKELSAWIQRPRGSSELSPERLAEAMDSGRNLQLSCLSTEQNQHLQASL
                     SRLHRVAQHARAKCVRLLVDAEYTFINPALSLLVAALAVRWNSPEEGGPWVWNTYQAY
                     LKDTHQRLEQDAEAAHKAGLAFGVKLVRGAYLDKERSMTQLQGKEDCTQPDYEATSRS
                     YSRCLELMLRCVSNHGPPCHLMVASHNEESVRQATKRMWELGIPLDGPVCFGQLLGMC
                     DHVSLALGQAGYMVYKSIPYGCLEEVIPYLIRRAQENRSVLQGARREQALLSQELWRR
                     LLGRTA"
     exon            201..397
                     /gene="Prodh2"
                     /gene_synonym="2510028N04Rik; 2510038B11Rik; HYPDH; MmPOX;
                     MmPOX1; POX1"
                     /inference="alignment:Splign:2.1.0"
     exon            398..536
                     /gene="Prodh2"
                     /gene_synonym="2510028N04Rik; 2510038B11Rik; HYPDH; MmPOX;
                     MmPOX1; POX1"
                     /inference="alignment:Splign:2.1.0"
     exon            537..623
                     /gene="Prodh2"
                     /gene_synonym="2510028N04Rik; 2510038B11Rik; HYPDH; MmPOX;
                     MmPOX1; POX1"
                     /inference="alignment:Splign:2.1.0"
     exon            624..704
                     /gene="Prodh2"
                     /gene_synonym="2510028N04Rik; 2510038B11Rik; HYPDH; MmPOX;
                     MmPOX1; POX1"
                     /inference="alignment:Splign:2.1.0"
     exon            705..860
                     /gene="Prodh2"
                     /gene_synonym="2510028N04Rik; 2510038B11Rik; HYPDH; MmPOX;
                     MmPOX1; POX1"
                     /inference="alignment:Splign:2.1.0"
     exon            861..1027
                     /gene="Prodh2"
                     /gene_synonym="2510028N04Rik; 2510038B11Rik; HYPDH; MmPOX;
                     MmPOX1; POX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1138
                     /gene="Prodh2"
                     /gene_synonym="2510028N04Rik; 2510038B11Rik; HYPDH; MmPOX;
                     MmPOX1; POX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1224
                     /gene="Prodh2"
                     /gene_synonym="2510028N04Rik; 2510038B11Rik; HYPDH; MmPOX;
                     MmPOX1; POX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1820
                     /gene="Prodh2"
                     /gene_synonym="2510028N04Rik; 2510038B11Rik; HYPDH; MmPOX;
                     MmPOX1; POX1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1434..1439
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prodh2"
                     /gene_synonym="2510028N04Rik; 2510038B11Rik; HYPDH; MmPOX;
                     MmPOX1; POX1"
                     /note="hexamer: AATAAA"
     polyA_site      1461
                     /gene="Prodh2"
                     /gene_synonym="2510028N04Rik; 2510038B11Rik; HYPDH; MmPOX;
                     MmPOX1; POX1"
                     /note="major polyA site"
     regulatory      1795..1800
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prodh2"
                     /gene_synonym="2510028N04Rik; 2510038B11Rik; HYPDH; MmPOX;
                     MmPOX1; POX1"
                     /note="hexamer: AATAAA"
     polyA_site      1820
                     /gene="Prodh2"
                     /gene_synonym="2510028N04Rik; 2510038B11Rik; HYPDH; MmPOX;
                     MmPOX1; POX1"
                     /note="major polyA site"
ORIGIN      
        1 agtgtggtgg taaccaggca cttgcaatga tctggacgcg tctgccgctg tatggcccct
       61 ccaagccctc tacaggtggc tggcagcccc tgcgctttga tggtggggcc ttccatgtca
      121 agggaaccgc agaactggca cgggctttgc tagtgcttcg cctatgcgcc tggccccctt
      181 tggtcactca tggactagcg tttcaggcct ggtctcagcg actcctggga tcccggctct
      241 caggcgcact tcttcgagca tccatctacg ggcagtttgt ggccggggag acagcagagg
      301 aagtgaggaa ctgtgtcggg cagctgcagg ccctgggact ccagcccctg ttggcagtac
      361 ccaccgagga ggaaccagac tccactgcca agaccagtga ggtctggtat gaggagaacc
      421 ttagcgccat gctgcgctgt gtggacttat cccgagccct cgtggacgcc cacggcccag
      481 ccaggaacag cctcatgcag ctgaaggtga ccgcgctagc cagcactcgg ctttgtaaag
      541 agctgtcggc ttggatccaa agacccagag gctcctcgga gctgagccct gagaggctgg
      601 cagaagccat ggactcgggt cggaacctcc agctctcctg cctcagcaca gaacagaatc
      661 agcacctgca ggcctccctc agccgcttgc accgagtggc acagcacgcc cgggcgaagt
      721 gtgtgcggct gctggtagat gctgaatata ctttcattaa ccctgcactg tccctgctgg
      781 tggctgccct ggctgtgcgc tggaacagcc ctgaggaagg tggtccgtgg gtgtggaaca
      841 cttaccaggc ctatctaaag gacactcacc aacggctgga gcaggacgcc gaggcagcac
      901 acaaggctgg cctggcattt ggggtgaagt tggtgcgagg tgcctatctg gacaaggaga
      961 gatccatgac acagctccaa gggaaggaag actgtaccca gcctgactat gaggccacta
     1021 gtcggagtta cagccgctgt ctagagctga tgctgcgctg cgtgtcgaac cacggtcccc
     1081 cgtgtcacct catggtggct tcccacaatg aagaatccgt tcgccaggca actaagcgca
     1141 tgtgggagct gggcattcct ctggatgggc ctgtctgttt tggacaactt ctgggcatgt
     1201 gtgaccatgt ctccctggca ttagggcagg ctggatatat ggtgtacaag tctattccct
     1261 atggctgcct ggaggaggtg attccctacc tgatccgaag agcccaggag aacaggagtg
     1321 tgctgcaggg tgcccgcagg gagcaggcac tactcagcca ggaactgtgg cggagactgc
     1381 tgggaaggac ggcctaagat gtctccatca gcaccatcag gggccatgtg ctcaataaag
     1441 gtcccgagtc ctggccctgt ctgtacttct cagaagctgc ctccttgggg aaagggctga
     1501 ccctggtgtc tgctcggaca ggtggggcat gcctgagact caagagatct ttagtcctgt
     1561 gtggtggcac actcctgtta tcctagcact tgggaggctg agacaggagg gccatgtgtt
     1621 ccaagccagc ctggactaca gagtgagaag aaggaagagg aggagtggga gaggggaggg
     1681 gaggagaagt gctagcctag ggtggtagtg acttggtaac cgaagggtaa ttaatccttc
     1741 aatgtgctta gccagggatc tagtcaagaa ttctttccct ctcagaggat ttgtaataaa
     1801 caacacaggt gaatagcaga
//
