LOCUS       NM_011172               2283 bp    mRNA    linear   ROD 21-DEC-2022
DEFINITION  Mus musculus proline dehydrogenase (Prodh), mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_011172
VERSION     NM_011172.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2283)
  AUTHORS   Olivares O, Mayers JR, Gouirand V, Torrence ME, Gicquel T, Borge L,
            Lac S, Roques J, Lavaut MN, Berthezene P, Rubis M, Secq V, Garcia
            S, Moutardier V, Lombardo D, Iovanna JL, Tomasini R, Guillaumond F,
            Vander Heiden MG and Vasseur S.
  TITLE     Collagen-derived proline promotes pancreatic ductal adenocarcinoma
            cell survival under nutrient limited conditions
  JOURNAL   Nat Commun 8, 16031 (2017)
   PUBMED   28685754
  REMARK    GeneRIF: PRODH1-mediated proline metabolism promotes pancreatic
            ductal adenocarcinoma growth.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2283)
  AUTHORS   Crabtree GW, Park AJ, Gordon JA and Gogos JA.
  TITLE     Cytosolic Accumulation of L-Proline Disrupts GABA-Ergic
            Transmission through GAD Blockade
  JOURNAL   Cell Rep 17 (2), 570-582 (2016)
   PUBMED   27705802
  REMARK    GeneRIF: Here, we show that Prodh-deficient mice with elevated CNS
            L-proline display specific deficits in high-frequency GABA-ergic
            transmission and gamma-band oscillations. We find that L-proline is
            a GABA-mimetic and can act at multiple GABA-ergic targets
REFERENCE   3  (bases 1 to 2283)
  AUTHORS   Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK,
            Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L,
            Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre
            JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A,
            Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ,
            Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall
            S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA,
            Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR,
            Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana
            S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, MacArthur DG,
            Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC,
            Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL,
            de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown
            SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bucan M and Murray
            SA.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   4  (bases 1 to 2283)
  AUTHORS   Hancock CN, Liu W, Alvord WG and Phang JM.
  TITLE     Co-regulation of mitochondrial respiration by proline
            dehydrogenase/oxidase and succinate
  JOURNAL   Amino Acids 48 (3), 859-872 (2016)
   PUBMED   26660760
  REMARK    GeneRIF: PRODH/POX and succinate regulated mitochondrial
            respiration.
            Erratum:[Amino Acids. 2016 May;48(5):1337-8. PMID: 26874699]
REFERENCE   5  (bases 1 to 2283)
  AUTHORS   Paronett EM, Meechan DW, Karpinski BA, LaMantia AS and Maynard TM.
  TITLE     Ranbp1, Deleted in DiGeorge/22q11.2 Deletion Syndrome, is a
            Microcephaly Gene That Selectively Disrupts Layer 2/3 Cortical
            Projection Neuron Generation
  JOURNAL   Cereb Cortex 25 (10), 3977-3993 (2015)
   PUBMED   25452572
REFERENCE   6  (bases 1 to 2283)
  AUTHORS   Lund J, Roe B, Chen F, Budarf M, Galili N, Riblet R, Miller RD,
            Emanuel BS and Reeves RH.
  TITLE     Sequence-ready physical map of the mouse chromosome 16 region with
            conserved synteny to the human velocardiofacial syndrome region on
            22q11.2
  JOURNAL   Mamm Genome 10 (5), 438-443 (1999)
   PUBMED   10337614
REFERENCE   7  (bases 1 to 2283)
  AUTHORS   Gogos JA, Santha M, Takacs Z, Beck KD, Luine V, Lucas LR, Nadler JV
            and Karayiorgou M.
  TITLE     The gene encoding proline dehydrogenase modulates sensorimotor
            gating in mice
  JOURNAL   Nat Genet 21 (4), 434-439 (1999)
   PUBMED   10192398
REFERENCE   8  (bases 1 to 2283)
  AUTHORS   Blake,R.L., Hall,J.G. and Russell,E.S.
  TITLE     Mitochondrial proline dehydrogenase deficiency in hyperprolinemic
            PRO/Re mice: genetic and enzymatic analyses
  JOURNAL   Biochem Genet 14 (9-10), 739-757 (1976)
   PUBMED   1008803
REFERENCE   9  (bases 1 to 2283)
  AUTHORS   Scriver,C.R., McInnes,R.R. and Mohyuddin,F.
  TITLE     Role of epithelial architecture and intracellular metabolism in
            proline uptake and transtubular reclamation in PRO/re mouse kidney
  JOURNAL   Proc Natl Acad Sci U S A 72 (4), 1431-1435 (1975)
   PUBMED   1055415
REFERENCE   10 (bases 1 to 2283)
  AUTHORS   Blake,R.L. and Russell,E.S.
  TITLE     Hyperprolinemia and prolinuria in a new inbred strain of mice,
            PRO-Re
  JOURNAL   Science 176 (4036), 809-811 (1972)
   PUBMED   5031477
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY785647.1, AK144068.1, BB611875.1, AF120279.1 and AV225532.2.
            
            [WARNING] On Dec 12, 2023 this sequence was replaced by
            NM_011172.3.
            
            On Dec 2, 2006 this sequence version replaced NM_011172.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF120279.1, U80020.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                BY785647.1         6-35
            31-31               AK144068.1         1-1
            32-543              BB611875.1         31-542
            544-940             AK144068.1         514-910
            941-1145            AF120279.1         898-1102
            1146-1168           AK144068.1         1116-1138
            1169-1339           AF120279.1         1126-1296
            1340-2132           AK144068.1         1310-2102
            2133-2274           AV225532.2         481-622
            2275-2283           AF120279.1         2232-2240
FEATURES             Location/Qualifiers
     source          1..2283
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 11.19 cM"
     gene            1..2283
                     /gene="Prodh"
                     /gene_synonym="Pro-1; Pro1; Ym24d07"
                     /note="proline dehydrogenase"
                     /db_xref="GeneID:19125"
                     /db_xref="MGI:MGI:97770"
     exon            1..303
                     /gene="Prodh"
                     /gene_synonym="Pro-1; Pro1; Ym24d07"
                     /inference="alignment:Splign:2.1.0"
     exon            304..512
                     /gene="Prodh"
                     /gene_synonym="Pro-1; Pro1; Ym24d07"
                     /inference="alignment:Splign:2.1.0"
     exon            513..547
                     /gene="Prodh"
                     /gene_synonym="Pro-1; Pro1; Ym24d07"
                     /inference="alignment:Splign:2.1.0"
     exon            548..697
                     /gene="Prodh"
                     /gene_synonym="Pro-1; Pro1; Ym24d07"
                     /inference="alignment:Splign:2.1.0"
     exon            698..762
                     /gene="Prodh"
                     /gene_synonym="Pro-1; Pro1; Ym24d07"
                     /inference="alignment:Splign:2.1.0"
     exon            763..879
                     /gene="Prodh"
                     /gene_synonym="Pro-1; Pro1; Ym24d07"
                     /inference="alignment:Splign:2.1.0"
     exon            880..959
                     /gene="Prodh"
                     /gene_synonym="Pro-1; Pro1; Ym24d07"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1041
                     /gene="Prodh"
                     /gene_synonym="Pro-1; Pro1; Ym24d07"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1134
                     /gene="Prodh"
                     /gene_synonym="Pro-1; Pro1; Ym24d07"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1281
                     /gene="Prodh"
                     /gene_synonym="Pro-1; Pro1; Ym24d07"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1457
                     /gene="Prodh"
                     /gene_synonym="Pro-1; Pro1; Ym24d07"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1556
                     /gene="Prodh"
                     /gene_synonym="Pro-1; Pro1; Ym24d07"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1645
                     /gene="Prodh"
                     /gene_synonym="Pro-1; Pro1; Ym24d07"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..2283
                     /gene="Prodh"
                     /gene_synonym="Pro-1; Pro1; Ym24d07"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttaagcctcc tgagcgcgtg tatcggctcc gccatggctc tcaagcgcgt cttcttgctg
       61 cggtcggtgg caccacgcgt cgctgccctc tcaaccaaac cgcaagccca ggaacagcct
      121 cccgcgagcc ctgaggctct tcggggatgt ggggcggcca aggctgtgcg gccgcctgtg
      181 ccagccgtgg acttcaccaa cacgcaggag gcgtatcgca gccggcggag ttgggagttg
      241 gtgcgcaacc tgctagtgct gcggctgtgt gcgtcgccgg tgctgctagc gcaccacgag
      301 cagttgttcc aagttgccag gaagcttctg gggcaaagga tgttcgagag attgatgaag
      361 atgaccttct atggccattt tgtggctggc gaggaccagg agtctatcag gcctctgatc
      421 cggcacaaca aagcctttgg tgttggcttt atcctggact atggagtgga ggaagatctg
      481 agccctgagg aggcggagcg caaagagatg gagtcatgca cttctgaagc agagagagat
      541 ggcagtggag caaataagag ggagaagcag tatcaggtgc accccgcctt tggagaccgc
      601 agagatggtg tcatcagtgc ccgcacctac ttctatgcca atgaagccaa gtgtgacaac
      661 tacatggaga acttactgca gtgcatcaag gcctcaggtg gagccagtga tggtggtttc
      721 tcagccatta agctcactgc actggggaga ccacagtttc tgctgcagtt ctcagacgtg
      781 ctgaccaggt ggagacggtt cttccatcaa atggctgcag agcagggaca ggctgggcgt
      841 gctgctgtag acacaaagct ggaggtggcg gtgctccagg acagcatcgc aaagatgggc
      901 atcgcatcca gggctgagat tgaagggtgg ttcacgccag agacgctggg agtgtctggc
      961 accgtggact tgctggactg gaacagcctc attgacagca ggacccggct ctccaggcac
     1021 ttggtggtcc ccaatgtgca gactggccag ctggagcccc tgctgtcacg gttcactgag
     1081 gaggaagagc agcagatgaa aaggatgctg cagaggatgg atgtactggc caagaaagca
     1141 aaagaggcag gtgtgcgcct gatgattgat gctgagcaga gctacttcca accagccatc
     1201 agccgcctga ccctggagat gcagcgcagg ttcaatgtgg ataagccgtt catcttcaac
     1261 acattccagt gctacctcaa ggatgcctat gacaatgtga ccttggatat ggaactggct
     1321 cgccgtgagg gctggtgttt tggggccaag ctggtacgtg gtgcatacat ggcccaagag
     1381 cgtgtcaggg cagcagagat cggttatgag gaccccatca accctacata tgaagccacc
     1441 aatgctatgt accacaggtg ccttaactat gttctggagg agctgaagca cagcaccaag
     1501 gcagaggtga tggtggcttc ccacaacgag gacaccgtgc acttcacgtt gtgcaggatg
     1561 aaggagatag gcctgcatcc tgctgatggt caggtgtgct tcggacagct gctggggatg
     1621 tgtgaccaaa tcagcttccc actaggccag gcaggctttc ctgtgtacaa gtatgtgccc
     1681 tatggccctg tgatggaggt actcccttac ctgtcccgcc gtgccctgga gaacagcagc
     1741 atcatgaagg gtgctcagcg agagaggcag ctgctatggc aggagctccg caggcggctg
     1801 cgcactggca gcctcttcca ccatccggcc tagtcaccgc aggagccttg cccacccgct
     1861 cgtactccac tcaacccctt acctctgggg cttcaggcgg ggcacagctt gggattgggc
     1921 tggggttcct tagcccaacc tgcccagaca cagttcacct ttttatgccc aaggcttttt
     1981 atgcccaagg cgggatttca tcagtggaca gctcctgagg aacagtgccc aagatggtcg
     2041 tctggtcaca gaggctgccc tctgggactt cctgtacccc aaggaacaga cactcaggag
     2101 tggggtcagc tagagcccct gggagctgcc ccactaatct gagtaagcac tgaccacctc
     2161 tgcaggttac agagccctag tccaggatta accttctgcc agggtctaac ccatcttccc
     2221 tgcactgggc agaggacaga ctaggaagcc tgtttagtca ataaatcatc ctgtaacaga
     2281 gtc
//
