LOCUS       NM_011171               1504 bp    mRNA    linear   ROD 05-APR-2023
DEFINITION  Mus musculus protein C receptor, endothelial (Procr), mRNA.
ACCESSION   NM_011171
VERSION     NM_011171.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1504)
  AUTHORS   Yu QC, Geng A, Preusch CB, Chen Y, Peng G, Xu Y, Jia Y, Miao Y, Xue
            H, Gao D, Bao L, Pan W, Chen J, Garcia KC, Cheung TH and Zeng YA.
  TITLE     Activation of Wnt/beta-catenin signaling by Zeb1 in endothelial
            progenitors induces vascular quiescence entry
  JOURNAL   Cell Rep 41 (8), 111694 (2022)
   PUBMED   36417861
REFERENCE   2  (bases 1 to 1504)
  AUTHORS   Liu X, Huo Y, Zhao J, Wang G, Liu H, Yin F, Pang C, Wang Y and Bai
            L.
  TITLE     Endothelial cell protein C receptor regulates neutrophil
            extracellular trap-mediated rheumatoid arthritis disease
            progression
  JOURNAL   Int Immunopharmacol 112, 109249 (2022)
   PUBMED   36152537
  REMARK    GeneRIF: Endothelial cell protein C receptor regulates neutrophil
            extracellular trap-mediated rheumatoid arthritis disease
            progression.
REFERENCE   3  (bases 1 to 1504)
  AUTHORS   Bochenek ML, Gogiraju R, Grossmann S, Krug J, Orth J, Reyda S,
            Georgiadis GS, Spronk HM, Konstantinides S, Munzel T, Griffin JH,
            Wild P, Espinola-Klein C, Ruf W and Schafer K.
  TITLE     EPCR-PAR1 biased signaling regulates perfusion recovery and
            neovascularization in peripheral ischemia
  JOURNAL   JCI Insight 7 (14), e157701 (2022)
   PUBMED   35700057
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1504)
  AUTHORS   Cissy Yu Q, Bai L, Chen Y, Chen Y, Peng G, Wang D, Yang G, Cui G,
            Jing N and Arial Zeng Y.
  TITLE     Embryonic vascular establishment requires protein C
            receptor-expressing endothelial progenitors
  JOURNAL   Development 149 (12) (2022)
   PUBMED   35587592
REFERENCE   5  (bases 1 to 1504)
  AUTHORS   Liu C, Lin C, Wang D, Wang J, Tao Y, Li Y, Chen X, Bai L, Jia Y,
            Chen J and Zeng YA.
  TITLE     Procr functions as a signaling receptor and is essential for the
            maintenance and self-renewal of mammary stem cells
  JOURNAL   Cell Rep 38 (12), 110548 (2022)
   PUBMED   35320720
REFERENCE   6  (bases 1 to 1504)
  AUTHORS   Rothbarth K, Dabaghian AR, Stammer H and Werner D.
  TITLE     One single mRNA encodes the centrosomal protein CCD41 and the
            endothelial cell protein C receptor (EPCR)
  JOURNAL   FEBS Lett 458 (1), 77-80 (1999)
   PUBMED   10518938
REFERENCE   7  (bases 1 to 1504)
  AUTHORS   Liang Z, Rosen ED and Castellino FJ.
  TITLE     Nucleotide structure and characterization of the murine gene
            encoding the endothelial cell protein C receptor
  JOURNAL   Thromb Haemost 81 (4), 585-588 (1999)
   PUBMED   10235444
REFERENCE   8  (bases 1 to 1504)
  AUTHORS   Mincheva A, Rothbarth K, Werner D and Lichter P.
  TITLE     Assignment of the gene encoding centrosome-associated protein CCD41
            to mouse chromosome 2H
  JOURNAL   Mamm Genome 6 (6), 444 (1995)
   PUBMED   7647473
REFERENCE   9  (bases 1 to 1504)
  AUTHORS   Fukudome K and Esmon CT.
  TITLE     Molecular cloning and expression of murine and bovine endothelial
            cell protein C/activated protein C receptor (EPCR). The structural
            and functional conservation in human, bovine, and murine EPCR
  JOURNAL   J Biol Chem 270 (10), 5571-5577 (1995)
   PUBMED   7890676
REFERENCE   10 (bases 1 to 1504)
  AUTHORS   Rothbarth K, Petzelt C, Lu X, Todorov IT, Joswig G, Pepperkok R,
            Ansorge W and Werner D.
  TITLE     cDNA-derived molecular characteristics and antibodies to a new
            centrosome-associated and G2/M phase-prevalent protein
  JOURNAL   J Cell Sci 104 (Pt 1), 19-30 (1993)
   PUBMED   8449997
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL929233.9, AK167302.1 and BY393288.1.
            
            [WARNING] On May 5, 2023 this sequence was replaced by NM_011171.3.
            
            On Jul 8, 2009 this sequence version replaced NM_011171.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK167302.1, L39017.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                AL929233.9         60093-60153
            62-1444             AK167302.1         2-1384
            1445-1504           BY393288.1         338-397
FEATURES             Location/Qualifiers
     source          1..1504
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2"
     gene            1..1504
                     /gene="Procr"
                     /gene_synonym="Ccca; Ccd41; Epcr"
                     /note="protein C receptor, endothelial"
                     /db_xref="GeneID:19124"
                     /db_xref="MGI:MGI:104596"
     exon            1..248
                     /gene="Procr"
                     /gene_synonym="Ccca; Ccd41; Epcr"
                     /inference="alignment:Splign:2.1.0"
     CDS             182..910
                     /gene="Procr"
                     /gene_synonym="Ccca; Ccd41; Epcr"
                     /note="endothelial protein C receptor; activated protein C
                     receptor; centrocyclin; centrosomal protein CCD41; CD
                     antigen CD201; APC receptor; endothelial cell protein C
                     receptor"
                     /codon_start=1
                     /product="endothelial protein C receptor precursor"
                     /protein_id="NP_035301.2"
                     /db_xref="CCDS:CCDS16954.1"
                     /db_xref="GeneID:19124"
                     /db_xref="MGI:MGI:104596"
                     /translation="MLTKFLPLLLLLLPGCALCNSDGSQSLHMLQISYFQDNHHVRHQ
                     GNASLGKLLTHTLEGPSQNVTILQLQPWQDPESWERTESGLQIYLTQFESLVKLVYRE
                     RKENVFFPLTVSCSLGCELPEEEEEGSEPHVFFDVAVNGSAFVSFRPKTAVWVSGSQE
                     PSKAANFTLKQLNAYNRTRYELQEFLQDTCVEFLENHITTQNMKGSQTGRSYTSLVLG
                     ILMGCFIIAGVAVGIFMCTSGRRC"
     exon            249..506
                     /gene="Procr"
                     /gene_synonym="Ccca; Ccd41; Epcr"
                     /inference="alignment:Splign:2.1.0"
     exon            507..794
                     /gene="Procr"
                     /gene_synonym="Ccca; Ccd41; Epcr"
                     /inference="alignment:Splign:2.1.0"
     exon            795..1504
                     /gene="Procr"
                     /gene_synonym="Ccca; Ccd41; Epcr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtaggaaat gagacagatc caagtaacac tttaaaagcc tgactccctc ttcctgcacg
       61 cgttctcttt ccatcctccg ctctgctccg gcccctcccg gacagcctcc cttctctttc
      121 ctaatcagca gcctgaggaa cccgagcctg ccccgaccca ggtgggaccc agaactccag
      181 gatgttgacg aagtttctgc cgctactgct gctgctgctg cctggctgcg ccctttgtaa
      241 ctccgatggc tcccaaagcc tgcatatgct ccagatctcc tatttccaag acaaccatca
      301 tgtgaggcat cagggcaacg cctctctggg aaaactcctg acacacacgc tggaaggccc
      361 cagccaaaac gtcaccatcc tccagctaca gccctggcag gatccggaga gctgggagcg
      421 cacagagagt ggcctgcaga tctatctgac ccagttcgaa agcctggtga agctggtata
      481 tcgcgagcgc aaggagaacg tgttctttcc tctcactgtt agctgctccc tgggctgcga
      541 gctgccggag gaggaggagg agggctctga accccatgtc ttcttcgatg tggccgtgaa
      601 tggaagcgct tttgtaagtt tccggccaaa gactgccgtg tgggtgtcag gctcccagga
      661 gccctccaaa gcagccaact tcaccctgaa gcagctcaat gcctacaacc ggactcggta
      721 tgaactgcag gaatttcttc aggacacttg tgtggagttc ctggagaacc acatcaccac
      781 gcaaaacatg aaagggagcc aaacaggtcg ctcttacaca tcactggtcc tgggcatcct
      841 gatgggctgt ttcataatcg ctggtgtggc cgtgggcatc ttcatgtgca caagtggacg
      901 gcgttgctaa ttatctaatt attctccagg ccccttggag aaagggctgg actggtgggg
      961 gctggtaagg gaaggtcgta gctcatatga tgccaaacag actcccccag tgggccatca
     1021 catctcagga ggttaaaagc aacaactcca ggtctgtctg cctaagaagt gtgtgtgtgg
     1081 gagggggcag tatgtagaca acaaagtaac gggtttgcaa aggacttgag agcatttgtg
     1141 ctttgtgtag ctggtctgag aagtgggtgc ttaattgtgg aaatcagacc atagacttgg
     1201 ggggaggctg ggaggtctgt gatctccctg aataggcaga cttactgtag gcattcaaaa
     1261 catcttacta aataaaagaa gttgtctgta accaaaatca aacatagtta atgtgtccag
     1321 gtgtatccaa cttgggaagg gacactggaa tgacagggaa gaaagaacca cagaaatatc
     1381 accgttgtga ggttgaacaa tatgggagca gtgaattcat aaatattaaa tttcttattt
     1441 atgtaaaagg tgtacttata tcttctattt tattaaaact tctgaaaaaa aaaagtatag
     1501 ccca
//
