LOCUS       NM_001270646            4875 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus proline rich basic protein 1 (Prob1), mRNA.
ACCESSION   NM_001270646 XM_891736 XM_908264
VERSION     NM_001270646.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4875)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121821.3 and AK146021.1.
            
            On Jun 24, 2019 this sequence version replaced NM_001270646.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK146021.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                AC121821.3         145767-145799       c
            34-3301             AK146021.1         2-3269
            3302-3302           AC121821.3         142498-142498       c
            3303-4867           AK146021.1         3271-4835
            4868-4875           AC121821.3         140925-140932       c
FEATURES             Location/Qualifiers
     source          1..4875
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.2 cM"
     gene            1..4875
                     /gene="Prob1"
                     /gene_synonym="Gm1614"
                     /note="proline rich basic protein 1"
                     /db_xref="GeneID:381148"
                     /db_xref="MGI:MGI:2686460"
     exon            1..4875
                     /gene="Prob1"
                     /gene_synonym="Gm1614"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..3055
                     /gene="Prob1"
                     /gene_synonym="Gm1614"
                     /codon_start=1
                     /product="proline-rich basic protein 1"
                     /protein_id="NP_001257575.1"
                     /db_xref="CCDS:CCDS79611.1"
                     /db_xref="GeneID:381148"
                     /db_xref="MGI:MGI:2686460"
                     /translation="MLTALAPLALPGLSRRLPAPAGRQDSSGSSGSYHTAPGSPEPPD
                     VGPDTEGRGTWLWVAPGRGAGAQPVLSVSAQNSRQQHGSGSGFPRGPGSGPLPPRPQL
                     RMLPSGEMEVIFGAGPLFNRSDAEDLQEQQLMAPTFSSPQLPGPASPASVSSQPQVPD
                     GGSRWATYLELPPREPSPAVSGQYECVEVALEERSAPVRPRTVPKRQIELRPRPRSPS
                     QDSRAPRPRLLLRTGSLDESLSRLQAAAGIVQTALARKLGSAVPAPSNVTFKSTAKPE
                     STTNSQETTDSTRVLLEEAKSRPPRAHDNSSSARVPRPWPSLRERAIRRDKPAPGTEP
                     LGPVSSSIFLQSEEKPHQAYKQESKTQFPRETPDRTVPRARSPPFHSRGSRVVPSRVV
                     RPRSPSPPQQAPNGSPHNPPQPSKIVWRRSSPAFPGGTSSAWENRNASVEEVVSRRTP
                     SPPPLPQWTQGVARVGNPCPEAPLVWKVPNSRGGDAVGLSRDSSLPALLPREAPHPIE
                     TRTPSPGETWSPVVQGASTALHQEAMNGLTQELEPPTPSAPATPELTEALCLLSLENA
                     GIAVRGGQRSPDVDTPEQPRSHLTSTLDDDVCPEAVGSGEAASERPRVTIPRPRDVRK
                     MVKTTYAPSFPAGTPGSGLPAPPADTCGEDGDASKTHKLPALESPAPAHYTSIFLKDF
                     LPVVPHPYESPEPSLHATPKDASQSSGVPRRRAENSTAKPFARSEIRLPGALAFGQRR
                     EKTPSVQRRGPGGENPDAEAQRLVRDPEGRTSPLGGARTSTQCSPLESTGTRPPRPGS
                     PQACPNSSLRAAPELETPLVAPATAVQAPLLPDHPATAARAAAPFPRAASAPPTDRLP
                     PASSLGRRPPGAAPAGKVLVDPESGRYYFVEAPRQPRLRLLFDPESGQYVEVLLPPSP
                     SPSRQPRQPYAPLALGPGLYPPAYGPISGPSLSPLSPNLSALGSLQLPWAPEAGPLEG
                     MYYMPLSGTPSPAPPMLFCAPPSSSGPIQSSKGSVFPL"
     regulatory      4828..4833
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prob1"
                     /gene_synonym="Gm1614"
                     /note="hexamer: AATAAA"
     polyA_site      4871
                     /gene="Prob1"
                     /gene_synonym="Gm1614"
                     /note="major polyA site"
     polyA_site      4875
                     /gene="Prob1"
                     /gene_synonym="Gm1614"
ORIGIN      
        1 agtgctaggt gtcctgccca ccatgctgac tgcgctcgcc ccgctagccc ttcctgggct
       61 ctcaaggcgg ctgcctgccc cagcggggcg tcaggactcg tccggttcgt ccggctccta
      121 ccacacagct ccgggttctc cggagccccc ggacgttggg ccggacacag aaggccgggg
      181 gacttggctc tgggtggctc ctgggcgggg ggcgggcgcg cagcctgtcc tgtccgtcag
      241 cgcccagaat agccgccagc agcacggctc cggctcgggt ttcccgcgag gcccgggctc
      301 cggcccgctg ccgccccggc cccagctgcg catgctgccg tcgggggaga tggaagtcat
      361 cttcggcgcg gggcctctgt tcaaccgctc cgacgcggag gatctgcagg agcaacagct
      421 catggcgcct accttcagca gtccccagct gcccgggcca gcgtctcctg cctctgtctc
      481 atcgcagccg caggtccccg acggaggctc tcgctgggcc acctacctgg agctgccgcc
      541 ccgcgagccg agtcctgccg tctcaggcca gtacgagtgt gtggaggtgg ccctggagga
      601 gcgcagcgcg cccgttagac cccgcactgt gccgaaacgt cagatcgagc tgcgtccgcg
      661 gcctcggagt ccctcgcagg acagtcgcgc gccgcgtccc cgactgctcc tgcgcacggg
      721 ctccctggac gagtctctga gccgcttgca ggccgccgcg ggcatcgtgc agacggcgct
      781 ggctagaaaa ctaggctctg cggtcccagc ccccagcaac gtcactttta agtctaccgc
      841 caagccagaa tccacgacga actctcagga gacgacagac agcactcgtg tgctcctgga
      901 agaggctaag tctcggccac cccgcgcgca cgataattcc tcctctgcca gagtcccgcg
      961 gccttggcct agcctccgag agcgagcgat tcggcgggac aagccggcgc ccgggaccga
     1021 gcctctgggt ccagttagtt ccagcatctt tctgcagtca gaggagaaac ctcatcaggc
     1081 ttacaaacag gaatccaaga cccagtttcc ccgtgagact cctgatagaa ccgtgccgag
     1141 agcacggagt cctccttttc attctagagg ttcccgggtg gttcccagta gggttgtgag
     1201 gcccaggagc ccctctcctc cgcagcaggc tccaaacggg tctccccaca accccccaca
     1261 accttctaag attgtttgga gacggagcag cccggccttc cctggcggca catcctctgc
     1321 gtgggaaaat cggaatgctt ccgtcgagga agtcgtcagc agaaggaccc cttccccacc
     1381 accacttccc caatggactc agggtgtcgc tagagttggg aacccatgtc ctgaagctcc
     1441 tcttgtgtgg aaggttccga attcgagagg cggagatgca gtagggctga gtagggactc
     1501 gtcgctgcca gccctgctcc cgcgggaagc acctcatcct attgaaacgc gtaccccatc
     1561 tcccggagag acttggagtc ctgttgtgca gggtgcatcg acggcactgc atcaggaagc
     1621 tatgaacggt ctaacccagg agctggagcc gcctacacca tcagcacccg cgactccaga
     1681 gctcacagag gctctgtgtc tgctctcact ggaaaatgcg ggtatcgccg tcagaggcgg
     1741 tcaacggtct ccagatgtgg atacaccgga acagccccga agtcacctca caagcactct
     1801 ggacgacgat gtgtgcccag aagccgtggg ctcgggagaa gcggcttctg aacgcccgcg
     1861 cgtgaccatt ccgcggccgc gagacgtgcg caagatggtt aagactactt atgcaccaag
     1921 cttccctgca gggaccccag gctccgggct tcccgcgcct cctgcggaca cctgcgggga
     1981 ggacggtgat gcatccaaaa ctcacaagct ccccgcactt gagtcgcccg ccccggctca
     2041 ttacacttcc atttttctca aggactttct gcctgtggta cctcatccct acgagtcacc
     2101 agagccttca ctccatgcaa cccctaagga tgcctcccag tccagcgggg tcccgaggcg
     2161 gcgggcagag aacagcaccg cgaagccttt cgctcgaagt gagatccgct tgcctggcgc
     2221 tctagctttc ggccagcggc gggagaaaac cccgagtgtc caaagacgcg gtcctggagg
     2281 agaaaacccg gatgctgagg cccagcgcct ggtccgggac cctgagggtc ggaccagccc
     2341 tttaggaggc gctcgcacct caacccaatg ttccccttta gagtcgacag ggacgcgacc
     2401 acctcgcccc ggctccccgc aggcgtgtcc aaactcgagc cttagggcag cgccggaatt
     2461 ggagacaccg cttgtggctc ctgcaactgc ggtccaggcg cccctacttc ccgatcatcc
     2521 ggcgacggca gccagggccg ctgcaccctt cccgcgagct gcttctgcgc ctcccaccga
     2581 ccggctcccc cctgcatctt ccctggggcg gaggcctccg ggagccgccc ccgcggggaa
     2641 ggtccttgta gacccggaga gcggccggta ctactttgtg gaggcgccga ggcagccgag
     2701 gctgcgacta cttttcgatc ccgagagcgg gcagtacgtg gaagtactgc tgccaccctc
     2761 gccctctccc tcccggcagc cacgccagcc ctatgcccca ctggccctag ggcccggcct
     2821 ctacccgccc gcctatgggc ctatctctgg tccatcactg tcgccgctgt cccccaacct
     2881 gtcggccctt ggtagtctcc agctaccttg ggctcctgag gctggacccc tggagggaat
     2941 gtattacatg cccttgagcg ggacccctag tcccgcacca ccaatgctct tctgtgcccc
     3001 accctccagt tctggtccca tccagtccag caagggttct gtgtttcctt tgtgaagcct
     3061 cagcccttat tcccatggag ttgggttccc tagaaggcat tggaagttcc agatcccagt
     3121 ctctttaact ttttttctcc catcaattct ttggccagtt ccagccagtc accacaccag
     3181 aagtggcctt aagagagtgt atctgctacc tgggctaata gtgacagagt atcgttagca
     3241 aatggctgtc tgcctacccc tcagccccaa caaaaatatg tatccttttc ccagaccttc
     3301 ccagggtgtg gtgtatttgt gtatttgttt atgtaggcaa gcaagtctgt caaagtgaga
     3361 agccagtcta ggaggtgttg gggtttccca gaatagcagg tgtgggagca gcaggacccg
     3421 ggctgcctgg gtcaactgtt tgtatctccc taacactggg cccagttgag tggagcccga
     3481 cagtgggtgc tgctgagatg gaagggatag gtgacagcca tcacatctgg atgtgtgctt
     3541 tatcctggga gcctatggga gaacccagtg tggccctagg gcagcttggg gcagccaatg
     3601 agagctacga ggatagtagc tggagttgtg gtatggatgt cgtttaagga gatgtggagg
     3661 atcagcctgg attggaggtg agagaagagg atgaaatggc ccagggttgc tgtagagaca
     3721 gccaatggga caagcagctc ctggacagag aggcagcagg aggcactagg aaatgaggag
     3781 gggggaggaa gattacttgt ctttgggttt tctgtggcta ggggtgacta gggacaagta
     3841 gtgaattaaa gaatctcaag tggtcagcaa gtgtttctct tgtttgccca tttctggagt
     3901 tgagagggca gggagagcaa gaatctagaa aaacaagtta ctttagtttt gggaattgtt
     3961 gtttaaccaa aatggaggag cttcataaaa tggtgtgaca gctggccagt cctttgatcc
     4021 cagcactctg gaggcagcga caggtggatc tctgtgagtt caaggccagc ctacagagtg
     4081 agttccagga ctacccagag aaatcctgtc tcaaaaacaa caaacaaata aacaaagaca
     4141 ctgactaaaa ctaacagccc acagcaggga acccagctct ttcctcaagc cccaggcctg
     4201 tcttctgtag accctaggag ctgagctggc ttatcttgaa gccttcattg accccaagta
     4261 agttaaatca acaggaagac aatagagagg aaggctgtca tcacactagt gagttagaac
     4321 tggcaagagg aagggcgttc ctatatggag taggccaagg gtccctgacc ctttagctgg
     4381 ttccattctc catgttcctc caggagcaga ggcaacagag cccacacagg gactggccct
     4441 cccggctgct cacagcacag gaaagaccct aaacctgtgc tctgtctgct ctgagcctgg
     4501 ggtaaactga gggccagaga ccaatctctg tgaggtggga ggtgatctct gtcatttgga
     4561 gccttgctgg aggagtgttt gataggaggt gtttgggaag gataatccct atgagaagca
     4621 atgccgagta ggcatttgat agctttctgg ttccgagcct gtgtagctaa aatcccttgg
     4681 agcttctgtc aagctccttg ccctagactg gaaatcggct aaagtgcacc gtcaaaataa
     4741 cctcaacatc tctaccagag acactggtcc tagtgacatg gagagaccag gcccacccct
     4801 agagtgtatc atctcacctt cgtgtgcaat aaatggctga ccatggagag ccatggtggc
     4861 cgaaatgaca accaa
//
