LOCUS       NM_023043               3178 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus prion like protein doppel (Prnd), transcript variant
            1, mRNA.
ACCESSION   NM_023043
VERSION     NM_023043.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3178)
  AUTHORS   Chen,Z., Morales,J.E., Avci,N., Guerrero,P.A., Rao,G., Seo,J.H. and
            McCarty,J.H.
  TITLE     The vascular endothelial cell-expressed prion protein doppel
            promotes angiogenesis and blood-brain barrier development
  JOURNAL   Development 147 (18) (2020)
   PUBMED   32895288
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3178)
  AUTHORS   Raspa,M., Guan,M., Paoletti,R., Montoliu,L., Ayadi,A.,
            Marschall,S., Fray,M. and Scavizzi,F.
  CONSRTM   EMMA/Infrafrontier Technical Working Group
  TITLE     Dry ice is a reliable substrate for the distribution of frozen
            mouse spermatozoa: A multi-centric study
  JOURNAL   Theriogenology 96, 49-57 (2017)
   PUBMED   28532839
REFERENCE   3  (bases 1 to 3178)
  AUTHORS   Mays,C.E., Coomaraswamy,J., Watts,J.C., Yang,J., Ko,K.W.,
            Strome,B., Mercer,R.C., Wohlgemuth,S.L., Schmitt-Ulms,G. and
            Westaway,D.
  TITLE     Endoproteolytic processing of the mammalian prion glycoprotein
            family
  JOURNAL   FEBS J 281 (3), 862-876 (2014)
   PUBMED   24286250
  REMARK    GeneRIF: Data suggest that glycosylation status of the prion
            protein and yet-to-be-identified proteases modulate internal C1 and
            C2 endoproteolysis of Doppel (doppelganger prion) and Shadoo
            (shadow of prion protein) in mouse neurons.
REFERENCE   4  (bases 1 to 3178)
  AUTHORS   Mercer,R.C., Ma,L., Watts,J.C., Strome,R., Wohlgemuth,S., Yang,J.,
            Cashman,N.R., Coulthart,M.B., Schmitt-Ulms,G., Jhamandas,J.H. and
            Westaway,D.
  TITLE     The prion protein modulates A-type K+ currents mediated by Kv4.2
            complexes through dipeptidyl aminopeptidase-like protein 6
  JOURNAL   J Biol Chem 288 (52), 37241-37255 (2013)
   PUBMED   24225951
REFERENCE   5  (bases 1 to 3178)
  AUTHORS   Qin,K., Ding,T., Xiao,Y., Ma,W., Wang,Z., Gao,J. and Zhao,L.
  TITLE     Differential responses of neuronal and spermatogenic cells to the
            doppel cytotoxicity
  JOURNAL   PLoS One 8 (12), e82130 (2013)
   PUBMED   24339999
  REMARK    GeneRIF: in GC-1 spg cells, phosphorylation of p21 and N-terminal
            truncated PrP may play roles in the control of Dpl-induced
            apoptosis, which may benefit the physiological function of Dpl in
            the male reproduction system.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3178)
  AUTHORS   Li,A., Sakaguchi,S., Atarashi,R., Roy,B.C., Nakaoke,R., Arima,K.,
            Okimura,N., Kopacek,J. and Shigematsu,K.
  TITLE     Identification of a novel gene encoding a PrP-like protein
            expressed as chimeric transcripts fused to PrP exon 1/2 in ataxic
            mouse line with a disrupted PrP gene
  JOURNAL   Cell Mol Neurobiol 20 (5), 553-567 (2000)
   PUBMED   10930132
REFERENCE   7  (bases 1 to 3178)
  AUTHORS   Silverman,G.L., Qin,K., Moore,R.C., Yang,Y., Mastrangelo,P.,
            Tremblay,P., Prusiner,S.B., Cohen,F.E. and Westaway,D.
  TITLE     Doppel is an N-glycosylated, glycosylphosphatidylinositol-anchored
            protein. Expression in testis and ectopic production in the brains
            of Prnp(0/0) mice predisposed to Purkinje cell loss
  JOURNAL   J Biol Chem 275 (35), 26834-26841 (2000)
   PUBMED   10842180
REFERENCE   8  (bases 1 to 3178)
  AUTHORS   Moore,R.C., Lee,I.Y., Silverman,G.L., Harrison,P.M., Strome,R.,
            Heinrich,C., Karunaratne,A., Pasternak,S.H., Chishti,M.A.,
            Liang,Y., Mastrangelo,P., Wang,K., Smit,A.F., Katamine,S.,
            Carlson,G.A., Cohen,F.E., Prusiner,S.B., Melton,D.W., Tremblay,P.,
            Hood,L.E. and Westaway,D.
  TITLE     Ataxia in prion protein (PrP)-deficient mice is associated with
            upregulation of the novel PrP-like protein doppel
  JOURNAL   J Mol Biol 292 (4), 797-817 (1999)
   PUBMED   10525406
REFERENCE   9  (bases 1 to 3178)
  AUTHORS   Lee,I.Y., Westaway,D., Smit,A.F., Wang,K., Seto,J., Chen,L.,
            Acharya,C., Ankener,M., Baskin,D., Cooper,C., Yao,H., Prusiner,S.B.
            and Hood,L.E.
  TITLE     Complete genomic sequence and analysis of the prion protein gene
            region from three mammalian species
  JOURNAL   Genome Res 8 (10), 1022-1037 (1998)
   PUBMED   9799790
REFERENCE   10 (bases 1 to 3178)
  AUTHORS   Westaway,D., Cooper,C., Turner,S., Da Costa,M., Carlson,G.A. and
            Prusiner,S.B.
  TITLE     Structure and polymorphism of the mouse prion protein gene
  JOURNAL   Proc Natl Acad Sci U S A 91 (14), 6418-6422 (1994)
   PUBMED   7912827
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK161043.1, AF192384.1, AK043023.1 and BY450477.1.
            
            On May 21, 2013 this sequence version replaced NM_023043.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2, 3 and 4 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF192384.1, AK161043.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1648              AK161043.1         2-1649
            1649-2389           AF192384.1         1647-2387
            2390-3152           AK043023.1         1183-1945
            3153-3178           BY450477.1         410-435
FEATURES             Location/Qualifiers
     source          1..3178
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 64.07 cM"
     gene            1..3178
                     /gene="Prnd"
                     /gene_synonym="doppel; Dpl; PrPLP"
                     /note="prion like protein doppel"
                     /db_xref="GeneID:26434"
                     /db_xref="MGI:MGI:1346999"
     exon            1..55
                     /gene="Prnd"
                     /gene_synonym="doppel; Dpl; PrPLP"
                     /inference="alignment:Splign:2.1.0"
     exon            56..3178
                     /gene="Prnd"
                     /gene_synonym="doppel; Dpl; PrPLP"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..602
                     /gene="Prnd"
                     /gene_synonym="doppel; Dpl; PrPLP"
                     /note="doppelganger; prion protein-like protein; prion
                     protein dublet"
                     /codon_start=1
                     /product="prion-like protein doppel precursor"
                     /protein_id="NP_075530.1"
                     /db_xref="CCDS:CCDS16767.1"
                     /db_xref="GeneID:26434"
                     /db_xref="MGI:MGI:1346999"
                     /translation="MKNRLGTWWVAILCMLLASHLSTVKARGIKHRFKWNRKVLPSSG
                     GQITEARVAENRPGAFIKQGRKLDIDFGAEGNRYYAANYWQFPDGIYYEGCSEANVTK
                     EMLVTSCVNATQAANQAEFSREKQDSKLHQRVLWRLIKEICSAKHCDFWLERGAALRV
                     AVDQPAMVCLLGFVWFIVK"
     regulatory      3152..3157
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prnd"
                     /gene_synonym="doppel; Dpl; PrPLP"
                     /note="hexamer: AATAAA"
     polyA_site      3177
                     /gene="Prnd"
                     /gene_synonym="doppel; Dpl; PrPLP"
                     /note="major polyA site"
ORIGIN      
        1 gttccggaga agtgagggct ccaagcttca gaggccacag tagcagagaa ccgagattca
       61 ccatgaagaa ccggctgggt acatggtggg tggccatcct ctgcatgctg cttgccagcc
      121 acctctccac ggtcaaggca aggggcataa agcacaggtt caagtggaac cggaaggtcc
      181 tgcccagcag cggcggccag atcaccgaag ctcgggtagc tgagaaccgc ccaggagcct
      241 tcatcaagca aggccggaag ctggacatcg actttggagc agagggcaac aggtactacg
      301 cggctaacta ttggcagttc cctgatggga tctactacga aggctgctct gaagccaacg
      361 tgaccaagga gatgctggtg accagctgcg tcaacgccac ccaggcggcc aaccaggctg
      421 agttctcccg ggagaagcag gatagcaagc tccaccagcg agtcctgtgg cggctgatca
      481 aagagatctg ctccgccaag cactgcgatt tctggctgga aaggggagct gcgcttcggg
      541 tcgccgtgga ccaaccggcg atggtctgcc tgctgggttt cgtttggttc attgtgaagt
      601 aaaaatcaat gaagctggca gccacagagg tgagctggtg ggcaaaggta gacagaggta
      661 gcccagttct ctctatctag cccccgagtg ttctgaaagt acaacgtgta gcgtttcagg
      721 gcatttcaaa agtccctccc aagtactccc cctactccat gtgtttgata atgtgtttca
      781 gtgcccctat gctccacccc tgtgagacct ggcctgttcc tgcctttgca gctacactag
      841 gtgagaaacc agccaaagga tacaagaatt gtcctgtgca ctccacctga ttttccaact
      901 ccaggaaact gaggctcaca ttgcaggagt ccctgtccag cacagttaga aaacagaaga
      961 gctggggttc ccctgctctg tcttccctca ggttttctgc tctgtgtagc ctagagctgc
     1021 ctcctgatcc ctccaagact caggtccaag tgcagtcccg aatgtggact gaaatgtgga
     1081 agtcacaccc tgaactaagt gggaagccct gagcgacaac cgtgcacctt gacaccttac
     1141 gtgagacaat ataacaaaaa ttaagctaaa gtagacatga cactagacaa cggctcagaa
     1201 atcagattgt agggaaattt gctatgcacc tcccggagag cagcttcagg gcaggatgtg
     1261 tttgtggtgt ctagatgcgt cttcacaagg actggtgttt gctggttggg cccctgcaat
     1321 gtctgcaaag ttaagaaaac ctttttaagt gacacattgt gcgtgcgtgt gcatgcctgt
     1381 gtgtgtgtgt gtgtgtgtgt gtgtgtgttt atttgttttc tagatagaaa tttttctatg
     1441 tagcccaggt tgaccccata atcatgatct tctggcctct gcctcctgaa tgctgggatt
     1501 gcagacatgc caccaagccc aatatgtgtt tacttctgat gtcccctggc cctatgtgca
     1561 tgtgtgttct taggcatctt aagatgctca ctgcgcacag agctctctgc aaacactgtc
     1621 tgtttttaaa acccactttg gtaaaagcta atctccgtga atcatttaac actcccaaaa
     1681 tataattatt agccaaaaag cctaagagaa atgtcatctt taggaagacc caataaagaa
     1741 gtggtgtcta ccatcataag aactgatatg ccactttgtg aacttaaata tatattaaaa
     1801 atatgaatgt tacctaaatg tttaaaaatc ttttaagatt cttccacagg ttttcctcac
     1861 ctttcaggac tccaggagtt gctgagcggg atctggaaat aactgctact gggtgtagtc
     1921 tcttgtaaac ggagtatctg ccaggggggt cgggtattgt caaaggattc atctgcaaca
     1981 ttccagaaca cgagtgctga tagcagtact tcgagtgctg agttcccagt gcaatcggtt
     2041 cttctcaagg acacctctgg caggtgtcac atggtaaagg gacatgaagc agggcggaac
     2101 ctttaccact ggacagacag cccagagaaa ccagcctgct gcagtacgcc actgctgcca
     2161 agacacacct cctcagtcta ctgatcctaa accagagagc aggcccagat cacacagttt
     2221 accccttgca cgccatttta aatatcagac aataaagaag gaatagttag ttcttagatg
     2281 gtgatgttgg tgtttcagct ccaagcttaa ggcttagtta cccgggtgca caaagctgta
     2341 gacaaccaac ttccttccag cgtgaaaatg tgtaggctgg acagagtccc gtgctccacg
     2401 atcgctgagt tctttcagac cattggttgt cacacccaca agcctaactg tgacagccaa
     2461 tgagtgtcca tgtgattttg actgcaaatt tcgcttattt gatttttagc ggagacgtcc
     2521 ttgctcttac ttgtggatca ggagaggttt tcttagccct tctaagtgtt cccaacccgt
     2581 gcgctgtaga acagattgcg caaactgaca gcagagtaaa agggggcggg gcttcacttc
     2641 cggcatccca ccagtccacg cccgccgttt tcacctctcc agactcgcca ctcctttatt
     2701 catttgcaac tgcaaatgta gcaatttgca atcctaatac agggccaggg cggtggatac
     2761 cttaaagttt tatttgactt catttagtgc tttctgtcca tttttaatga cttttgtttt
     2821 tttgtttttg tttctccagc cccatctcct ccctctgccc tagtatgaaa cttgtacccc
     2881 tttactgtgt ttaaatataa agaagagggg ttttgttttg ttacattaca acccttaaaa
     2941 tacaacgatc acttgtataa tatttgtttc tctgcggttt gtattcctga tttagtggaa
     3001 tgccattaaa ctctctgggt cagtatctaa ctagttaaca tctaactagt ccttttagat
     3061 gaccatgaag tattccacag tacagatgtg ctgcaagtga cttgataact tccttgttga
     3121 cagatcttca gattgttctt atcttgcaaa caataaacac ccatacatat acagacag
//
