LOCUS       NM_001278258            3400 bp    mRNA    linear   ROD 18-APR-2023
DEFINITION  Mus musculus prion protein readthrough transcript (Prn), transcript
            variant 1, mRNA.
ACCESSION   NM_001278258
VERSION     NM_001278258.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3400)
  AUTHORS   Slapsak U, Salzano G, Amin L, Abskharon RN, Ilc G, Zupancic B,
            Biljan I, Plavec J, Giachin G and Legname G.
  TITLE     The N Terminus of the Prion Protein Mediates Functional
            Interactions with the Neuronal Cell Adhesion Molecule (NCAM)
            Fibronectin Domain
  JOURNAL   J Biol Chem 291 (42), 21857-21868 (2016)
   PUBMED   27535221
REFERENCE   2  (bases 1 to 3400)
  AUTHORS   Jones CE, Abdelraheim SR, Brown DR and Viles JH.
  TITLE     Preferential Cu2+ coordination by His96 and His111 induces
            beta-sheet formation in the unstructured amyloidogenic region of
            the prion protein
  JOURNAL   J Biol Chem 279 (31), 32018-32027 (2004)
   PUBMED   15145944
  REMARK    GeneRIF: Preferential Cu2+ coordination by His96 and His111 induces
            beta-sheet formation in the unstructured amyloidogenic region of
            the prion protein
REFERENCE   3  (bases 1 to 3400)
  AUTHORS   Kim C and Morre DJ.
  TITLE     Prion proteins and ECTO-NOX proteins exhibit similar oscillating
            redox activities
  JOURNAL   Biochem Biophys Res Commun 315 (4), 1140-1146 (2004)
   PUBMED   14985132
REFERENCE   4  (bases 1 to 3400)
  AUTHORS   Li A, Sakaguchi S, Atarashi R, Roy BC, Nakaoke R, Arima K, Okimura
            N, Kopacek J and Shigematsu K.
  TITLE     Identification of a novel gene encoding a PrP-like protein
            expressed as chimeric transcripts fused to PrP exon 1/2 in ataxic
            mouse line with a disrupted PrP gene
  JOURNAL   Cell Mol Neurobiol 20 (5), 553-567 (2000)
   PUBMED   10930132
REFERENCE   5  (bases 1 to 3400)
  AUTHORS   Baybutt H and Manson J.
  TITLE     Characterisation of two promoters for prion protein (PrP) gene
            expression in neuronal cells
  JOURNAL   Gene 184 (1), 125-131 (1997)
   PUBMED   9016962
REFERENCE   6  (bases 1 to 3400)
  AUTHORS   Hunter N, Dann JC, Bennett AD, Somerville RA, McConnell I and Hope
            J.
  TITLE     Are Sinc and the PrP gene congruent? Evidence from PrP gene
            analysis in Sinc congenic mice
  JOURNAL   J Gen Virol 73 (Pt 10), 2751-2755 (1992)
   PUBMED   1357080
REFERENCE   7  (bases 1 to 3400)
  AUTHORS   Manson J, West JD, Thomson V, McBride P, Kaufman MH and Hope J.
  TITLE     The prion protein gene: a role in mouse embryogenesis?
  JOURNAL   Development 115 (1), 117-122 (1992)
   PUBMED   1353438
REFERENCE   8  (bases 1 to 3400)
  AUTHORS   Carlson GA.
  TITLE     Genetics of prion diversity and host susceptibility
  JOURNAL   Curr Top Microbiol Immunol 172, 153-164 (1991)
   PUBMED   1687380
  REMARK    Review article
REFERENCE   9  (bases 1 to 3400)
  AUTHORS   Oesch B, Westaway D and Prusiner SB.
  TITLE     Prion protein genes: evolutionary and functional aspects
  JOURNAL   Curr Top Microbiol Immunol 172, 109-124 (1991)
   PUBMED   1687379
  REMARK    Review article
REFERENCE   10 (bases 1 to 3400)
  AUTHORS   Prusiner SB.
  TITLE     Prion biology and diseases
  JOURNAL   Harvey Lect 87, 85-114 (1991)
   PUBMED   1670551
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL833794.9.
            
            Summary: This locus represents naturally occurring readthrough
            transcription between the neighboring Prnp (major prion protein)
            and Prnd (prion-like protein doppel) genes on chromosome 2. The
            readthrough transcript encodes a protein that shares sequence
            identity with the downstream gene product but its N-terminal region
            is distinct due to the presence of an in-frame, upstream AUG
            compared to the downstream gene. [provided by RefSeq, May 2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Sequence Note: The RefSeq transcript was derived from the reference
            genome assembly. The genomic coordinates were determined from
            alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF192382.1, SRR17253012.4772961.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 19122, 26434
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                AL833794.9         108021-108096
            77-174              AL833794.9         110288-110385
            175-277             AL833794.9         144464-144566
            278-3400            AL833794.9         151102-154224
FEATURES             Location/Qualifiers
     source          1..3400
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2"
     gene            1..3400
                     /gene="Prn"
                     /gene_synonym="Gm28045; Gm44637; Prnp-Prnd"
                     /note="prion protein readthrough transcript"
                     /db_xref="GeneID:111368"
                     /db_xref="MGI:MGI:97767"
     exon            1..76
                     /gene="Prn"
                     /gene_synonym="Gm28045; Gm44637; Prnp-Prnd"
                     /inference="alignment:Splign:2.1.0"
     exon            77..174
                     /gene="Prn"
                     /gene_synonym="Gm28045; Gm44637; Prnp-Prnd"
                     /inference="alignment:Splign:2.1.0"
     exon            175..277
                     /gene="Prn"
                     /gene_synonym="Gm28045; Gm44637; Prnp-Prnd"
                     /inference="alignment:Splign:2.1.0"
     CDS             231..824
                     /gene="Prn"
                     /gene_synonym="Gm28045; Gm44637; Prnp-Prnd"
                     /note="Prnp-Prnd readthrough"
                     /codon_start=1
                     /product="prion protein gene complex"
                     /protein_id="NP_001265187.1"
                     /db_xref="GeneID:111368"
                     /db_xref="MGI:MGI:97767"
                     /translation="MMEWRSLRVEVASRTGFTMKNRLGTWWVAILCMLLASHLSTVKA
                     RGIKHRFKWNRKVLPSSGGQITEARVAENRPGAFIKQGRKLDIDFGAEGNRYYAANYW
                     QFPDGIYYEGCSEANVTKEMLVTSCVNATQAANQAEFSREKQDSKLHQRVLWRLIKEI
                     CSAKHCDFWLERGAALRVAVDQPAMVCLLGFVWFIVK"
     exon            278..3400
                     /gene="Prn"
                     /gene_synonym="Gm28045; Gm44637; Prnp-Prnd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccctttcca ctcccggctc ccccgcgttg tcggatcagc agaccgattc tgggcgctgc
       61 gtcgcatcgg tggcaggact cctgagtata tttcagaact gaaccatttc aaccgagctg
      121 aagcattctg ccttcctagt ggtaccagtc caatttagga gagccaagca gactactaaa
      181 agttaactca gaatcaagcg aaggcttttc tggaggtcga gttctggatc atgatggagt
      241 ggaggtcgct tcgagtggag gtcgcttcgc gcaccggatt caccatgaag aaccggctgg
      301 gtacatggtg ggtggccatc ctctgcatgc tgcttgccag ccacctctcc acggtcaagg
      361 caaggggcat aaagcacagg ttcaagtgga accggaaggt cctgcccagc agcggcggcc
      421 agatcaccga agctcgggta gctgagaacc gcccaggagc cttcatcaag caaggccgga
      481 agctggacat cgactttgga gcagagggca acaggtacta cgcggctaac tattggcagt
      541 tccctgatgg gatctactac gaaggctgct ctgaagccaa cgtgaccaag gagatgctgg
      601 tgaccagctg cgtcaacgcc acccaggcgg ccaaccaggc tgagttctcc cgggagaagc
      661 aggatagcaa gctccaccag cgagtcctgt ggcggctgat caaagagatc tgctccgcca
      721 agcactgcga tttctggctg gaaaggggag ctgcgcttcg ggtcgccgtg gaccaaccgg
      781 cgatggtctg cctgctgggt ttcgtttggt tcattgtgaa gtaaaaatca atgaagctgg
      841 cagccacaga ggtgagctgg tgggcaaagg tagacagagg tagcccagtt ctctctatct
      901 agcccccgag tgttctgaaa gtacaacgtg tagcgtttca gggcatttca aaagtccctc
      961 ccaagtactc cccctactcc atgtgtttga taatgtgttt cagtgcccct atgctccacc
     1021 cctgtgagac ctggcctgtt cctgcctttg cagctacact aggtgagaaa ccagccaaag
     1081 gatacaagaa ttgtcctgtg cactccacct gattttccaa ctccaggaaa ctgaggctca
     1141 cattgcagga gtccctgtcc agcacagtta gaaaacagaa gagctggggt tcccctgctc
     1201 tgtcttccct caggttttct gctctgtgta gcctagagct gcctcctgat ccctccaaga
     1261 ctcaggtcca agtgcagtcc cgaatgtgga ctgaaatgtg gaagtcacac cctgaactaa
     1321 gtgggaagcc ctgagcgaca accgtgcacc ttgacacctt acgtgagaca atataacaaa
     1381 aattaagcta aagtagacat gacactagac aacggctcag aaatcagatt gtagggaaat
     1441 ttgctatgca cctcccggag agcagcttca gggcaggatg tgtttgtggt gtctagatgc
     1501 gtcttcacaa ggactggtgt ttgctggttg ggcccctgca atgtctgcaa agttaagaaa
     1561 acctttttaa gtgacacatt gtgcgtgcgt gtgcatgcct gtgtgtgtgt gtgtgtgtgt
     1621 gtgtgtgtgt ttatttgttt tctagataga aatttttcta tgtagcccag gttgacccca
     1681 taatcatgat cttctggcct ctgcctcctg aatgctggga ttgcagacat gccaccaagc
     1741 ccaatatgtg tttacttctg atgtcccctg gccctatgtg catgtgtgtt cttaggcatc
     1801 ttaagatgct cactgcgcac agagctctct gcaaacactg tctgttttta aaacccactt
     1861 tggtaaaagc taatctccgt gaatcattta acactcccaa aatataatta ttagccaaaa
     1921 agcctaagag aaatgtcatc tttaggaaga cccaataaag aagtggtgtc taccatcata
     1981 agaactgata tgccactttg tgaacttaaa tatatattaa aaatatgaat gttacctaaa
     2041 tgtttaaaaa tcttttaaga ttcttccaca ggttttcctc acctttcagg actccaggag
     2101 ttgctgagcg ggatctggaa ataactgcta ctgggtgtag tctcttgtaa acggagtatc
     2161 tgccaggggg gtcgggtatt gtcaaaggat tcatctgcaa cattccagaa cacgagtgct
     2221 gatagcagta cttcgagtgc tgagttccca gtgcaatcgg ttcttctcaa ggacacctct
     2281 ggcaggtgtc acatggtaaa gggacatgaa gcagggcgga acctttacca ctggacagac
     2341 agcccagaga aaccagcctg ctgcagtacg ccactgctgc caagacacac ctcctcagtc
     2401 tactgatcct aaaccagaga gcaggcccag atcacacagt ttaccccttg cacgccattt
     2461 taaatatcag acaataaaga aggaatagtt agttcttaga tggtgatgtt ggtgtttcag
     2521 ctccaagctt aaggcttagt tacccgggtg cacaaagctg tagacaacca acttccttcc
     2581 agcgtgaaaa tgtgtaggct ggacagagtc ccgtgctcca cgatcgctga gttctttcag
     2641 accattggtt gtcacaccca caagcctaac tgtgacagcc aatgagtgtc catgtgattt
     2701 tgactgcaaa tttcgcttat ttgattttta gcggagacgt ccttgctctt acttgtggat
     2761 caggagaggt tttcttagcc cttctaagtg ttcccaaccc gtgcgctgta gaacagattg
     2821 cgcaaactga cagcagagta aaagggggcg gggcttcact tccggcatcc caccagtcca
     2881 cgcccgccgt tttcacctct ccagactcgc cactccttta ttcatttgca actgcaaatg
     2941 tagcaatttg caatcctaat acagggccag ggcggtggat accttaaagt tttatttgac
     3001 ttcatttagt gctttctgtc catttttaat gacttttgtt tttttgtttt tgtttctcca
     3061 gccccatctc ctccctctgc cctagtatga aacttgtacc cctttactgt gtttaaatat
     3121 aaagaagagg ggttttgttt tgttacatta caacccttaa aatacaacga tcacttgtat
     3181 aatatttgtt tctctgcggt ttgtattcct gatttagtgg aatgccatta aactctctgg
     3241 gtcagtatct aactagttaa catctaacta gtccttttag atgaccatga agtattccac
     3301 agtacagatg tgctgcaagt gacttgataa cttccttgtt gacagatctt cagattgttc
     3361 ttatcttgca aacaataaac acccatacat atacagacag
//
