LOCUS       NM_201371               2413 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus protein arginine N-methyltransferase 8 (Prmt8),
            transcript variant 1, mRNA.
ACCESSION   NM_201371 XM_355815
VERSION     NM_201371.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2413)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2413)
  AUTHORS   Ishii,A., Matsuba,Y., Mihira,N., Kamano,N., Saito,T.,
            Muramatsu,S.I., Yokosuka,M., Saido,T.C. and Hashimoto,S.
  TITLE     Tau-binding protein PRMT8 facilitates vacuole degeneration in the
            brain
  JOURNAL   J Biochem 172 (4), 233-243 (2022)
   PUBMED   35818334
  REMARK    GeneRIF: Tau-binding protein PRMT8 facilitates vacuole degeneration
            in the brain.
REFERENCE   3  (bases 1 to 2413)
  AUTHORS   Zheng,K., Zhang,Y., Zhang,C., Ye,W., Ye,C., Tan,X. and Xiong,Y.
  TITLE     PRMT8 Attenuates Cerebral Ischemia/Reperfusion Injury via
            Modulating Microglia Activation and Polarization to Suppress
            Neuroinflammation by Upregulating Lin28a
  JOURNAL   ACS Chem Neurosci 13 (7), 1096-1104 (2022)
   PUBMED   35275616
  REMARK    GeneRIF: PRMT8 Attenuates Cerebral Ischemia/Reperfusion Injury via
            Modulating Microglia Activation and Polarization to Suppress
            Neuroinflammation by Upregulating Lin28a.
REFERENCE   4  (bases 1 to 2413)
  AUTHORS   Couto E Silva,A., Wu,C.Y., Clemons,G.A., Acosta,C.H., Chen,C.T.,
            Possoit,H.E., Citadin,C.T., Lee,R.H., Brown,J.I., Frankel,A. and
            Lin,H.W.
  TITLE     Protein arginine methyltransferase 8 modulates mitochondrial
            bioenergetics and neuroinflammation after hypoxic stress
  JOURNAL   J Neurochem 159 (4), 742-761 (2021)
   PUBMED   34216036
REFERENCE   5  (bases 1 to 2413)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2413)
  AUTHORS   Li,M.Z., Wang,J.S., Jiang,D.J., Xiang,C.X., Wang,F.Y., Zhang,K.H.,
            Williams,P.R. and Chen,Z.F.
  TITLE     Molecular mapping of developing dorsal horn-enriched genes by
            microarray and dorsal/ventral subtractive screening
  JOURNAL   Dev Biol 292 (2), 555-564 (2006)
   PUBMED   16516881
REFERENCE   7  (bases 1 to 2413)
  AUTHORS   Lee,J., Sayegh,J., Daniel,J., Clarke,S. and Bedford,M.T.
  TITLE     PRMT8, a new membrane-bound tissue-specific member of the protein
            arginine methyltransferase family
  JOURNAL   J Biol Chem 280 (38), 32890-32896 (2005)
   PUBMED   16051612
REFERENCE   8  (bases 1 to 2413)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2413)
  AUTHORS   Aubert,J., Stavridis,M.P., Tweedie,S., O'Reilly,M., Vierlinger,K.,
            Li,M., Ghazal,P., Pratt,T., Mason,J.O., Roy,D. and Smith,A.
  TITLE     Screening for mammalian neural genes via fluorescence-activated
            cell sorter purification of neural precursors from Sox1-gfp
            knock-in mice
  JOURNAL   Proc Natl Acad Sci U S A 100 Suppl 1 (Suppl 1), 11836-11841 (2003)
   PUBMED   12923295
REFERENCE   10 (bases 1 to 2413)
  AUTHORS   Alappat,S.R., Zhang,M., Zhao,X., Alliegro,M.A., Alliegro,M.C. and
            Burdsal,C.A.
  TITLE     Mouse pigpen encodes a nuclear protein whose expression is
            developmentally regulated during craniofacial morphogenesis
  JOURNAL   Dev Dyn 228 (1), 59-71 (2003)
   PUBMED   12950080
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127373.3 and BC060250.1.
            
            On Nov 18, 2011 this sequence version replaced NM_201371.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK001349.1, BC060250.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-430               AC127373.3         207268-207697       c
            431-2411            BC060250.1         1-1981
            2412-2413           AC127373.3         127547-127548       c
FEATURES             Location/Qualifiers
     source          1..2413
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 62.49 cM"
     gene            1..2413
                     /gene="Prmt8"
                     /gene_synonym="Hrmt1l3; Hrmt1l4"
                     /note="protein arginine N-methyltransferase 8"
                     /db_xref="GeneID:381813"
                     /db_xref="MGI:MGI:3043083"
     exon            1..487
                     /gene="Prmt8"
                     /gene_synonym="Hrmt1l3; Hrmt1l4"
                     /inference="alignment:Splign:2.1.0"
     CDS             413..1597
                     /gene="Prmt8"
                     /gene_synonym="Hrmt1l3; Hrmt1l4"
                     /EC_number="2.1.1.319"
                     /note="protein arginine N-methyltransferase 4; HMT1 hnRNP
                     methyltransferase-like 3; heterogeneous nuclear
                     ribonucleoprotein methyltransferase-like 4; heterogeneous
                     nuclear ribonucleoprotein methyltransferase-like protein
                     4"
                     /codon_start=1
                     /product="protein arginine N-methyltransferase 8"
                     /protein_id="NP_958759.2"
                     /db_xref="CCDS:CCDS57449.1"
                     /db_xref="GeneID:381813"
                     /db_xref="MGI:MGI:3043083"
                     /translation="MGMKHSSRCLLLRRKMAENAVESTEVSSAPPQPPQPVIPAKPVQ
                     CVHHVSTQPSCPGRGKMSKLLNPEEMTSRDYYFDSYAHFGIHEEMLKDEVRTLTYRNS
                     MYHNKHVFKDKVVLDVGSGTGILSMFAAKAGAKKVFGIECSSISDYSEKIIKANHLDN
                     VITIFKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVIFARDKWLKPGGLMFPDR
                     AALYVVAIEDRQYKDFKIHWWENVYGFDMTCIRDVAMKEPLVDIVDPKQVVTNACLIK
                     EVDIYTVKTEELSFTSAFCLQIQRNDYVHALVTYFNIEFTKCHKKMGFSTAPDAPYTH
                     WKQTVFYLEDYLTVRRGEEIYGTISMKPNAKNVRDLDFTVDLDFKGQLCETSVSNDYK
                     MR"
     exon            488..673
                     /gene="Prmt8"
                     /gene_synonym="Hrmt1l3; Hrmt1l4"
                     /inference="alignment:Splign:2.1.0"
     exon            674..829
                     /gene="Prmt8"
                     /gene_synonym="Hrmt1l3; Hrmt1l4"
                     /inference="alignment:Splign:2.1.0"
     exon            830..893
                     /gene="Prmt8"
                     /gene_synonym="Hrmt1l3; Hrmt1l4"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1036
                     /gene="Prmt8"
                     /gene_synonym="Hrmt1l3; Hrmt1l4"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1124
                     /gene="Prmt8"
                     /gene_synonym="Hrmt1l3; Hrmt1l4"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1240
                     /gene="Prmt8"
                     /gene_synonym="Hrmt1l3; Hrmt1l4"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1391
                     /gene="Prmt8"
                     /gene_synonym="Hrmt1l3; Hrmt1l4"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1513
                     /gene="Prmt8"
                     /gene_synonym="Hrmt1l3; Hrmt1l4"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..2413
                     /gene="Prmt8"
                     /gene_synonym="Hrmt1l3; Hrmt1l4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2390..2395
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prmt8"
                     /gene_synonym="Hrmt1l3; Hrmt1l4"
                     /note="hexamer: AATAAA"
     polyA_site      2411
                     /gene="Prmt8"
                     /gene_synonym="Hrmt1l3; Hrmt1l4"
                     /note="major polyA site"
ORIGIN      
        1 ggacgcgtgt tgcttcgccc agcgatcggc agaagttggg agagttgccg tccgcctccc
       61 gcctgccgga cttcggagcc gctgcctctg ccggcgagcc cgcggggccg cctccctccc
      121 tcccgcccag cccgccgcgc aggggagagg ggcgcggagg gggtcgtgag cgcgaccaga
      181 acttgcaagt gtgcgaaggg atgcgaggca gatgaagagc gaggaaacgt gaacaaagtg
      241 gcgaccgcag gagggactcc acagagctcg attgtcgcgg aggacgctcc gggagagggg
      301 ctggctggga ttttttcccc cctcctcttg cattcttagg ctctctttta aagccacatc
      361 agccgtctct cgttctttac tatctcgaat ccccaaaccc ttgttggctc ttatgggcat
      421 gaaacactcc tcccgctgcc tgctcctccg gaggaaaatg gcggagaatg cagtcgaaag
      481 caccgaggtg agcagcgccc cccctcagcc ccctcagcct gtcattccag ccaagcctgt
      541 gcaatgtgtc caccatgtat ccacacagcc cagctgccct ggacggggca agatgtccaa
      601 gctgctgaac cccgaggaga tgacatcgag agattactat ttcgactcat acgctcactt
      661 tgggatccac gaggaaatgt tgaaagacga ggtgaggaca ctcacgtacc ggaactccat
      721 gtaccataat aagcatgtgt tcaaggacaa agtggtactg gatgttggga gtggcacagg
      781 gatcctttcc atgtttgccg ccaaagcagg ggccaagaag gtgtttggga ttgaatgttc
      841 cagtatttct gactactcgg agaagatcat taaggccaat cacctggaca atgtcatcac
      901 catatttaag ggcaaagtgg aggaggtgga gctgcctgtg gagaaggtgg acatcatcat
      961 cagcgagtgg atgggctact gtctgttcta cgagtccatg ctcaacaccg tgatctttgc
     1021 cagggacaag tggttgaaac ctggagggct tatgtttcca gaccgggcag ctttgtacgt
     1081 ggtagcaatc gaagacagac agtacaagga cttcaaaatc cactggtggg agaatgtcta
     1141 tggctttgac atgacctgca tccgggatgt tgccatgaag gagcccctgg tggacatcgt
     1201 ggacccaaag caagtggtga ccaatgcctg tttaataaag gaagtggaca tttacactgt
     1261 gaagacggaa gagctgtcct tcacgtctgc cttctgcctg cagatccagc gcaacgacta
     1321 tgtccatgcc ctcgtcacct attttaatat tgaatttacc aagtgccaca agaaaatggg
     1381 tttttctaca gcccctgatg ccccctacac ccactggaag cagactgtct tctacttaga
     1441 agactacctc actgtccgga gaggggagga aatctacggg accatatcca tgaagccaaa
     1501 tgccaaaaat gtgcgagacc tcgatttcac agtagacttg gattttaagg gacagctgtg
     1561 tgaaacatct gtatctaatg actacaaaat gcgttagcat acgtgggaag ctgcggagag
     1621 cgagcaagaa gaggcactca cttcagtctg ccacgctgcc ccaaggaata ctgttaggag
     1681 gaccacacca accagagctt tccactctgc cttgaagatt ggcgaacttg cccagggctc
     1741 tcctgggccc ccgccatcac agggagcctc caggtcctct gctctgcccc tggagccctt
     1801 cacaaaggct ttgttgttgc cttccgtgct atggctgggg ctctgaggat ggaagcatac
     1861 ccatgtgccc ccattgttct cctaaactga ctctctggat ctttcaagtt ttgcatgctg
     1921 cagacatcta ggacaggtta cttccgctag aacctggaga catagtgtct ttgatagcat
     1981 aagccagatt ttctgtctgt gtggtggttt gtgtgagagt gtatgtgtgt gcgtgtgcca
     2041 gtgtgtgtgt gtacagcata tatattaatt tacttgccca ccaacatctg tatatgcatg
     2101 catatacaac taagtgggca tagttgggtg ttcattctga gggtgtgtgt gtgtgtgtgt
     2161 gtgtgtgtgt gtgtgtgtgg tgagtatgtg tgcctagaat ctatattact ctcagaggag
     2221 gttctgttgc ttttgaatag gaatttgttt cgtgattagt tttccccatc ctgatcccgt
     2281 aacagatgtt acacagctat gaaacattct gtggactagc tctggtctcg ttctgactag
     2341 actgtggctc tgaatcctga gcacagtacc acgggctctg tcggcgctca ataaacacac
     2401 atgagaaaga agc
//
