LOCUS       NM_145404               2269 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus protein arginine N-methyltransferase 7 (Prmt7), mRNA.
ACCESSION   NM_145404
VERSION     NM_145404.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2269)
  AUTHORS   Su,M., Chen,F., Han,D., Song,M. and Wang,Y.
  TITLE     PRMT7-Dependent Transcriptional Activation of Hmgb2 Aggravates
            Severe Acute Pancreatitis by Promoting Acsl1-Induced Ferroptosis
  JOURNAL   J Proteome Res 23 (3), 1075-1087 (2024)
   PUBMED   38376246
  REMARK    GeneRIF: PRMT7-Dependent Transcriptional Activation of Hmgb2
            Aggravates Severe Acute Pancreatitis by Promoting Acsl1-Induced
            Ferroptosis.
REFERENCE   2  (bases 1 to 2269)
  AUTHORS   Ahn,B.Y., Zhang,Y., Wei,S., Jeong,Y., Park,D.H., Lee,S.J.,
            Leem,Y.E. and Kang,J.S.
  TITLE     Prmt7 regulates the JAK/STAT/Socs3 signaling pathway in
            postmenopausal cardiomyopathy
  JOURNAL   Exp Mol Med 56 (3), 711-720 (2024)
   PUBMED   38486105
  REMARK    GeneRIF: Prmt7 regulates the JAK/STAT/Socs3 signaling pathway in
            postmenopausal cardiomyopathy.
REFERENCE   3  (bases 1 to 2269)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2269)
  AUTHORS   Li,Q., Jiao,J., Heng,Y., Lu,Q., Zheng,Y., Li,H., Cai,J., Mei,M. and
            Bao,S.
  TITLE     Prmt5 promotes ciliated cell specification of airway epithelial
            progenitors via transcriptional inhibition of Tp63
  JOURNAL   J Biol Chem 299 (8), 104964 (2023)
   PUBMED   37364687
REFERENCE   5  (bases 1 to 2269)
  AUTHORS   Acosta,C.H., Clemons,G.A., Citadin,C.T., Carr,W.C., Udo,M.S.B.,
            Tesic,V., Sanicola,H.W., Freelin,A.H., Toms,J.B., Jordan,J.D.,
            Guthikonda,B., Wu,C.Y., Lee,R.H. and Lin,H.W.
  TITLE     A role for protein arginine methyltransferase 7 in repetitive and
            mild traumatic brain injury
  JOURNAL   Neurochem Int 166, 105524 (2023)
   PUBMED   37030326
  REMARK    GeneRIF: A role for protein arginine methyltransferase 7 in
            repetitive and mild traumatic brain injury.
REFERENCE   6  (bases 1 to 2269)
  AUTHORS   Jelinic,P., Stehle,J.C. and Shaw,P.
  TITLE     The testis-specific factor CTCFL cooperates with the protein
            methyltransferase PRMT7 in H19 imprinting control region
            methylation
  JOURNAL   PLoS Biol 4 (11), e355 (2006)
   PUBMED   17048991
  REMARK    GeneRIF: CTCFL and PRMT7 may play a role in male germline imprinted
            gene methylation.
REFERENCE   7  (bases 1 to 2269)
  AUTHORS   Yildirim,A.O., Bulau,P., Zakrzewicz,D., Kitowska,K.E.,
            Weissmann,N., Grimminger,F., Morty,R.E. and Eickelberg,O.
  TITLE     Increased protein arginine methylation in chronic hypoxia: role of
            protein arginine methyltransferases
  JOURNAL   Am J Respir Cell Mol Biol 35 (4), 436-443 (2006)
   PUBMED   16690984
REFERENCE   8  (bases 1 to 2269)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   9  (bases 1 to 2269)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   10 (bases 1 to 2269)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC006705.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006705.1, BC057177.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2269
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.11 cM"
     gene            1..2269
                     /gene="Prmt7"
                     /gene_synonym="4933402B05Rik"
                     /note="protein arginine N-methyltransferase 7"
                     /db_xref="GeneID:214572"
                     /db_xref="MGI:MGI:2384879"
     exon            1..29
                     /gene="Prmt7"
                     /gene_synonym="4933402B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            30..225
                     /gene="Prmt7"
                     /gene_synonym="4933402B05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..2209
                     /gene="Prmt7"
                     /gene_synonym="4933402B05Rik"
                     /EC_number="2.1.1.321"
                     /note="histone-arginine N-methyltransferase PRMT7; [Myelin
                     basic protein]-arginine N-methyltransferase PRMT7"
                     /codon_start=1
                     /product="protein arginine N-methyltransferase 7"
                     /protein_id="NP_663379.1"
                     /db_xref="CCDS:CCDS22633.1"
                     /db_xref="GeneID:214572"
                     /db_xref="MGI:MGI:2384879"
                     /translation="MKVFCGRANPTTGSLEWLEEDEHYDYHQEIARSSYADMLHDKDR
                     NIKYYQGIRAAVSRVKDRGQKALVLDIGTGTGLLSMMAVTAGADFCYAIEVFKPMAEA
                     AVKIVERNGFSDKIKVINKHSTEVTVGPDGDLPCRANILITELFDTELIGEGALPSYE
                     HAHKHLVQEDCEAVPHRATVYAQLVESRRMWSWNKLFPVRVRTSLGEQVIVPPSELER
                     CPGAPSVCDIQLNQVSPADFTVLSDVLPMFSVDFSKQVSSSAACHSRQFVPLASGQAQ
                     VVLSWWDIEMDPEGKIKCTMAPFWAQTDPQELQWRDHWMQCVYFLPQEEPVVQGSPRC
                     LVAHHDDYCVWYSLQRTSPDENDSAYQVRPVCDCQAHLLWNRPRFGEINDQDRTDHYA
                     QALRTVLLPGSVCLCVSDGSLLSMLAHHLGAEQVFTVESSVASYRLMKRIFKVNHLED
                     KISVINKRPELLTAADLEGKKVSLLLGEPFFTTSLLPWHNLYFWYVRTSVDQHLAPGA
                     VVMPQAASLHAVIVEFRDLWRIRSPCGDCEGFDVHIMDDMIKHSLDFRESREAEPHPL
                     WEYPCRSLSKPQEILTFDFQQPIPQQPMQSKGTMELTRPGKSHGAVLWMEYQLTPDST
                     ISTGLINPAEDKGDCCWNPHCKQAVYFLSTTLDLRVPLNGPRSVSYVVEFHPLTGDIT
                     MEFRLADTLS"
     exon            226..262
                     /gene="Prmt7"
                     /gene_synonym="4933402B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            263..412
                     /gene="Prmt7"
                     /gene_synonym="4933402B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            413..521
                     /gene="Prmt7"
                     /gene_synonym="4933402B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            522..634
                     /gene="Prmt7"
                     /gene_synonym="4933402B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            635..876
                     /gene="Prmt7"
                     /gene_synonym="4933402B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1057
                     /gene="Prmt7"
                     /gene_synonym="4933402B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1185
                     /gene="Prmt7"
                     /gene_synonym="4933402B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1321
                     /gene="Prmt7"
                     /gene_synonym="4933402B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1405
                     /gene="Prmt7"
                     /gene_synonym="4933402B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1453
                     /gene="Prmt7"
                     /gene_synonym="4933402B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1543
                     /gene="Prmt7"
                     /gene_synonym="4933402B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1705
                     /gene="Prmt7"
                     /gene_synonym="4933402B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1780
                     /gene="Prmt7"
                     /gene_synonym="4933402B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..1941
                     /gene="Prmt7"
                     /gene_synonym="4933402B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..2038
                     /gene="Prmt7"
                     /gene_synonym="4933402B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2039..2254
                     /gene="Prmt7"
                     /gene_synonym="4933402B05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2223..2228
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prmt7"
                     /gene_synonym="4933402B05Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2254
                     /gene="Prmt7"
                     /gene_synonym="4933402B05Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggcggcgagt ggatcgcttc ccacagcggg cattataatt gattaggttt ctgatatcaa
       61 gatatcttcc taagaagtaa attaacaagc ctcacgtttc tgtgcaaaca ctgaggagcc
      121 agttggcacc atgaaggtct tctgtggccg tgccaatcct accacgggat ccctggagtg
      181 gctggaggag gatgaacact atgattacca ccaggagatt gccaggtcat cctatgccga
      241 catgctacat gacaaagaca gaaatataaa atactaccag ggtatccggg cagctgtgag
      301 cagggtgaaa gacagaggac agaaggcctt ggttcttgac attggcactg gcacaggcct
      361 cttgtcaatg atggcagtta ctgcaggggc tgacttctgc tatgctatcg aggtttttaa
      421 gcctatggct gaggctgctg tgaagattgt ggagaggaat ggcttcagtg ataagattaa
      481 agtcattaac aagcactcca ctgaggtgac agtcggacca gatggtgact tgccgtgtcg
      541 tgctaacatt ctgatcacgg agctgtttga cacagagctg attggggagg gagcgctgcc
      601 ctcttatgag catgcacaca agcatcttgt ccaggaagac tgcgaggcag tgccacacag
      661 ggcaactgtc tatgcccagc tggtggagtc ccgaaggatg tggtcctgga acaagctgtt
      721 tcccgtccgt gtccggacga gtctaggcga gcaggtcatc gtccccccct cagaattgga
      781 gaggtgtcct ggtgcgcctt cagtctgtga cattcagctg aaccaggtgt cgcctgctga
      841 cttcactgtc ctcagtgatg tgctgccaat gttcagcgtg gacttcagca agcaagtcag
      901 cagctcggca gcgtgccata gcaggcagtt tgtacctttg gcgtctggcc aagcacaggt
      961 ggttctgtcc tggtgggaca ttgaaatgga ccctgagggc aagatcaagt gcaccatggc
     1021 acccttttgg gcacagacag atccgcagga gcttcagtgg cgggaccact ggatgcagtg
     1081 tgtgtacttc ctgccgcagg aggagcctgt tgtgcagggc tcaccccggt gcctggtagc
     1141 ccaccatgat gactactgtg tgtggtacag ccttcagaga accagccctg atgagaacga
     1201 cagcgcctac caagtgcgac ctgtgtgtga ctgtcaggct cacttgctct ggaaccggcc
     1261 tcggtttgga gaaatcaatg atcaggacag aactgatcac tatgcccagg ccctgaggac
     1321 tgtgctgctg ccaggtagcg tctgcctttg tgtgagtgat ggcagtctcc tctccatgct
     1381 ggcccatcac ctcggagcgg agcaggtgtt tacagttgag agttcagtag cttcctatag
     1441 actgatgaaa aggatcttca aggttaacca cttggaagat aaaatcagtg tcatcaataa
     1501 acggcctgag ttgctgacag ctgcagacct ggagggcaag aaggtctccc tcctcctggg
     1561 tgaacccttt ttcaccacca gcctgctgcc atggcacaac ctgtacttct ggtatgtccg
     1621 tacctctgtg gaccagcacc tagcacctgg agctgtggtg atgcctcagg ctgcctcact
     1681 gcatgccgtg attgtggagt tcagggacct gtggcggatc cggagtcctt gcggtgactg
     1741 cgaaggtttt gatgtgcaca tcatggatga tatgatcaag cactccctgg atttccgaga
     1801 gagcagagag gcagagccac acccactgtg ggaatacccc tgcagaagcc tctccaagcc
     1861 tcaagagatc ctgacttttg atttccagca gcccatcccc caacagccta tgcaatccaa
     1921 gggcacaatg gagctgacaa gacccgggaa gagccatggg gctgtcctgt ggatggagta
     1981 tcagctcact ccagacagca cgatcagcac tggcctcata aaccctgcag aagacaaggg
     2041 ggactgctgc tggaaccccc actgcaagca agctgtgtac ttcctcagca ccacgctgga
     2101 tctcagagtg cctctgaatg gccctcggtc agtcagctat gttgtggagt ttcaccccct
     2161 cactggagac atcaccatgg agtttaggct tgcagacacc ttgagctgat ctcttattga
     2221 gaaataaaat ggccagcagg ctgcagactc tgaaaaaaaa aaaaaaaaa
//
