LOCUS       NM_013768               2641 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus protein arginine N-methyltransferase 5 (Prmt5),
            transcript variant 1, mRNA.
ACCESSION   NM_013768
VERSION     NM_013768.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2641)
  AUTHORS   Muro,R., Nitta,T., Nitta,S., Tsukasaki,M., Asano,T., Nakano,K.,
            Okamura,T., Nakashima,T., Okamoto,K. and Takayanagi,H.
  TITLE     Transcript splicing optimizes the thymic self-antigen repertoire to
            suppress autoimmunity
  JOURNAL   J Clin Invest 134 (20), e179612 (2024)
   PUBMED   39403924
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2641)
  AUTHORS   Hou,A., Xu,X., Zhang,Y., He,H., Feng,Y., Fan,W., Tan,R., Gong,L.
            and Chen,J.
  TITLE     Excessive fatty acids activate PRMT5/MDM2/Drosha pathway to
            regulate miRNA biogenesis and lipid metabolism
  JOURNAL   Liver Int 44 (7), 1634-1650 (2024)
   PUBMED   38517158
  REMARK    GeneRIF: Excessive fatty acids activate PRMT5/MDM2/Drosha pathway
            to regulate miRNA biogenesis and lipid metabolism.
REFERENCE   3  (bases 1 to 2641)
  AUTHORS   Read,K.A., Amici,S.A., Farsi,S., Cutcliffe,M., Lee,B., Lio,C.J.,
            Wu,H.J., Guerau-de-Arellano,M. and Oestreich,K.J.
  TITLE     PRMT5 Promotes T follicular helper Cell Differentiation and
            Germinal Center Responses during Influenza Virus Infection
  JOURNAL   J Immunol 212 (9), 1442-1449 (2024)
   PUBMED   38436421
  REMARK    GeneRIF: PRMT5 Promotes T follicular helper Cell Differentiation
            and Germinal Center Responses during Influenza Virus Infection.
REFERENCE   4  (bases 1 to 2641)
  AUTHORS   Katanasaka,Y., Yabe,H., Murata,N., Sobukawa,M., Sugiyama,Y.,
            Sato,H., Honda,H., Sunagawa,Y., Funamoto,M., Shimizu,S.,
            Shimizu,K., Hamabe-Horiike,T., Hawke,P., Komiyama,M., Mori,K.,
            Hasegawa,K. and Morimoto,T.
  TITLE     Fibroblast-specific PRMT5 deficiency suppresses cardiac fibrosis
            and left ventricular dysfunction in male mice
  JOURNAL   Nat Commun 15 (1), 2472 (2024)
   PUBMED   38503742
  REMARK    GeneRIF: Fibroblast-specific PRMT5 deficiency suppresses cardiac
            fibrosis and left ventricular dysfunction in male mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2641)
  AUTHORS   Wang,Y.J., Cao,J.B., Yang,J., Liu,T., Yu,H.L., He,Z.X., Bao,S.L.,
            He,X.X. and Zhu,X.J.
  TITLE     PRMT5-mediated homologous recombination repair is essential to
            maintain genomic integrity of neural progenitor cells
  JOURNAL   Cell Mol Life Sci 81 (1), 123 (2024)
   PUBMED   38459149
  REMARK    GeneRIF: PRMT5-mediated homologous recombination repair is
            essential to maintain genomic integrity of neural progenitor cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2641)
  AUTHORS   Miranda,T.B., Khusial,P., Cook,J.R., Lee,J.H., Gunderson,S.I.,
            Pestka,S., Zieve,G.W. and Clarke,S.
  TITLE     Spliceosome Sm proteins D1, D3, and B/B' are asymmetrically
            dimethylated at arginine residues in the nucleus
  JOURNAL   Biochem Biophys Res Commun 323 (2), 382-387 (2004)
   PUBMED   15369763
REFERENCE   7  (bases 1 to 2641)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   8  (bases 1 to 2641)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 2641)
  AUTHORS   Friesen,W.J., Wyce,A., Paushkin,S., Abel,L., Rappsilber,J., Mann,M.
            and Dreyfuss,G.
  TITLE     A novel WD repeat protein component of the methylosome binds Sm
            proteins
  JOURNAL   J Biol Chem 277 (10), 8243-8247 (2002)
   PUBMED   11756452
REFERENCE   10 (bases 1 to 2641)
  AUTHORS   Pollack,B.P., Kotenko,S.V., He,W., Izotova,L.S., Barnoski,B.L. and
            Pestka,S.
  TITLE     The human homologue of the yeast proteins Skb1 and Hsl7p interacts
            with Jak kinases and contains protein methyltransferase activity
  JOURNAL   J Biol Chem 274 (44), 31531-31542 (1999)
   PUBMED   10531356
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY064945.1, AK165165.1 and
            AK076346.1.
            
            On May 17, 2008 this sequence version replaced NM_013768.2.
            
            Summary: This gene encodes an enzyme that belongs to the
            methyltransferase family. The encoded protein catalyzes the
            transfer of methyl groups to the amino acid arginine, in target
            proteins that include histones, transcriptional elongation factors
            and the tumor suppressor p53. This gene plays a role in several
            cellular processes, including transcriptional regulation and the
            assembly of small nuclear ribonucleoproteins. Alternative splicing
            results in multiple transcript variants encoding different
            isoforms. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK076346.1, AK132414.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                BY064945.1         57-138
            83-2357             AK165165.1         1-2275
            2358-2641           AK076346.1         2249-2532
FEATURES             Location/Qualifiers
     source          1..2641
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 27.82 cM"
     gene            1..2641
                     /gene="Prmt5"
                     /gene_synonym="Jbp1; Skb1"
                     /note="protein arginine N-methyltransferase 5"
                     /db_xref="GeneID:27374"
                     /db_xref="MGI:MGI:1351645"
     exon            1..224
                     /gene="Prmt5"
                     /gene_synonym="Jbp1; Skb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..2028
                     /gene="Prmt5"
                     /gene_synonym="Jbp1; Skb1"
                     /EC_number="2.1.1.320"
                     /note="isoform 1 is encoded by transcript variant 1; shk1
                     kinase-binding protein 1 homolog; histone-arginine
                     N-methyltransferase PRMT5; Jak-binding protein 1; SKB1
                     homolog"
                     /codon_start=1
                     /product="protein arginine N-methyltransferase 5 isoform
                     1"
                     /protein_id="NP_038796.2"
                     /db_xref="CCDS:CCDS27091.1"
                     /db_xref="GeneID:27374"
                     /db_xref="MGI:MGI:1351645"
                     /translation="MAAMAVGGAGGSRVSSGRDLNCVPEIADTLGAVAKQGFDFLCMP
                     VFHPRFKREFIQEPAKNRPGPQTRSDLLLSGRDWNTLIVGKLSPWIHPDSKVEKIRRN
                     SEAAMLQELNFGAYLGLPAFLLPLNQEDNTNLARVLTNHIHTGHHSSMFWMRVPLVAP
                     EDLRDDVIENAPTTHTEEYSGEEKTWMWWHNFRTLCDYSKRIAVALEIGADLPSNHVI
                     DRWLGEPIKAAILPTSIFLTNKKGFPVLSKVQQRLIFRLLKLEVQFIITGTNHHSEKE
                     FCSYLQYLEYLSQNRPPPNAYELFAKGYEDYLQSPLQPLMDNLESQTYEVFEKDPIKY
                     SQYQQAIYKCLLDRVPEEEKETNVQVLMVLGAGRGPLVNASLRAAKQAERRIRLYAVE
                     KNPNAVVTLENWQFEEWGSQVTVVSSDMREWVAPEKADIIVSELLGSFADNELSPECL
                     DGAQHFLKDDGVSIPGEYTSFLAPISSSKLYNEVRACREKDRDPEAQFEMPYVVRLHN
                     FHQLSAPKPCFTFSHPNRDPMIDNNRYCTLEFPVEVNTVLHGFAGYFETVLYRDITLS
                     IRPETHSPGMFSWFPIFFPIKQPITVHEGQNICVRFWRCSNSKKVWYEWAVTAPVCSS
                     IHNPTGRSYTIGL"
     exon            225..343
                     /gene="Prmt5"
                     /gene_synonym="Jbp1; Skb1"
                     /inference="alignment:Splign:2.1.0"
     exon            344..429
                     /gene="Prmt5"
                     /gene_synonym="Jbp1; Skb1"
                     /inference="alignment:Splign:2.1.0"
     exon            430..564
                     /gene="Prmt5"
                     /gene_synonym="Jbp1; Skb1"
                     /inference="alignment:Splign:2.1.0"
     exon            565..677
                     /gene="Prmt5"
                     /gene_synonym="Jbp1; Skb1"
                     /inference="alignment:Splign:2.1.0"
     exon            678..727
                     /gene="Prmt5"
                     /gene_synonym="Jbp1; Skb1"
                     /inference="alignment:Splign:2.1.0"
     exon            728..891
                     /gene="Prmt5"
                     /gene_synonym="Jbp1; Skb1"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1053
                     /gene="Prmt5"
                     /gene_synonym="Jbp1; Skb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1131
                     /gene="Prmt5"
                     /gene_synonym="Jbp1; Skb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1190
                     /gene="Prmt5"
                     /gene_synonym="Jbp1; Skb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1313
                     /gene="Prmt5"
                     /gene_synonym="Jbp1; Skb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1489
                     /gene="Prmt5"
                     /gene_synonym="Jbp1; Skb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1599
                     /gene="Prmt5"
                     /gene_synonym="Jbp1; Skb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1693
                     /gene="Prmt5"
                     /gene_synonym="Jbp1; Skb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1810
                     /gene="Prmt5"
                     /gene_synonym="Jbp1; Skb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1811..1875
                     /gene="Prmt5"
                     /gene_synonym="Jbp1; Skb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..2641
                     /gene="Prmt5"
                     /gene_synonym="Jbp1; Skb1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2607..2612
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prmt5"
                     /gene_synonym="Jbp1; Skb1"
                     /note="hexamer: AATAAA"
     polyA_site      2626
                     /gene="Prmt5"
                     /gene_synonym="Jbp1; Skb1"
                     /note="major polyA site"
ORIGIN      
        1 gtaaagacgc tctggttgtt aaggcgactt gtcccgcctc ctggggactc ttcaccgctt
       61 cgtgattgga ctctagtatc aaggaatccc ggcgtgggcc gcgcgaggga aaagatggcg
      121 gcgatggcag tcggaggtgc tggtggcagc cgcgtgtcca gcgggaggga cctgaattgc
      181 gtccccgaaa tagctgacac actgggtgct gtggccaagc aggggtttga tttcctctgc
      241 atgcctgtct tccacccgcg tttcaagagg gagttcattc aggaacctgc taagaatcgg
      301 cctggccccc agacacgatc agacctactg ctgtcaggaa gggactggaa tacgctaatt
      361 gtgggaaagc tttctccatg gattcatcca gactcaaaag tggagaagat ccgaaggaac
      421 tctgaagcgg ctatgttaca ggagttgaat tttggggcat atctgggtct tccagctttc
      481 ctattgcccc ttaatcagga agataacacg aatctggcca gagttctgac caaccacatc
      541 cacactggcc accactcttc catgttctgg atgagggtac ccttggtggc cccagaggac
      601 ctgagagatg atgtaattga gaatgccccg actacacaca cagaggagta cagtggagaa
      661 gagaaaacat ggatgtggtg gcataacttt cggactctgt gtgactatag caagagaatt
      721 gcagtagctc ttgaaattgg agctgacctc ccgtctaatc acgtcattga ccgctggctt
      781 ggagagccca tcaaagcagc cattctcccc accagcattt tcctaaccaa caagaaagga
      841 tttcctgttc tttctaaggt gcagcagagg ctgatcttcc ggctcctcaa gttggaagtg
      901 cagtttatca tcacgggaac caaccaccac tcagagaagg agttctgttc ctacctccag
      961 tacttggaat acttaagcca aaatcgccct ccacccaatg cctatgagct ctttgccaaa
     1021 ggctatgaag actatctgca gtccccactc cagcctctga tggacaatct ggaatctcag
     1081 acatatgaag tgtttgaaaa ggaccccatc aaatactctc aatatcagca ggctatttat
     1141 aaatgtttgc tagaccgagt accagaagaa gaaaaggaga ccaatgtcca ggtacttatg
     1201 gtgctgggtg caggccgggg tcctcttgtg aatgcgtctc ttcgggcagc caaacaggcc
     1261 gagcggcgga tcaggctgta tgctgtggag aagaacccca atgctgtggt gacgctagag
     1321 aactggcagt ttgaagaatg ggggagccag gtgacagttg tctcatcaga catgcgggaa
     1381 tgggtggctc cggagaaagc tgacatcatt gtcagtgagc ttctgggttc ctttgccgac
     1441 aacgagctgt cacctgagtg tctggatgga gcacagcact tcctgaaaga tgatggcgtg
     1501 agcatccctg gagaatacac ctccttcctg gctcccattt cttcctctaa gctgtacaat
     1561 gaggtccgtg cctgtcggga aaaggaccgc gatcctgagg cacagtttga gatgccttat
     1621 gtggttcggt tgcacaactt ccaccagctc tctgctccta agccctgctt taccttcagc
     1681 catcccaacc gagatcctat gattgacaac aaccgctact gtaccttgga gtttcctgtg
     1741 gaggtgaaca cagtgcttca tggcttcgca ggctactttg agactgtgct ttaccgggac
     1801 atcactctga gtatccgccc agagactcac tctcctggga tgttctcatg gttccccatc
     1861 ttcttcccca ttaagcagcc catcacggtg cacgaaggcc agaacatctg tgtgcgtttc
     1921 tggcgatgca gcaattccaa gaaagtgtgg tacgagtggg cggtgacggc ccccgtctgt
     1981 tcttctattc acaaccctac cggccgctcc tataccattg gcctctagcc ctgcacacag
     2041 tgtcaaaacc ttggaagcag ctctgagttc tcttcctaca gcacagaagg tgtagaacat
     2101 ctgctggttc agttcctcag tgagaccctc agccgccaga gaggagcggt tccggctgct
     2161 ttcctaccta atgtcatggt ggccaacggg taggcattcc cggactgcca ggcatggtgg
     2221 tgcatactct ttatcccagc actccagagg cagaggcaga ggcagatgga tctctttaag
     2281 ttcaaggcta gcccggtcta cctagcaagt ttcaggccac ctagggctac atagtgagac
     2341 cctgtctcca aaaaacgaaa aaaaaaaaaa aaaagaacta gaggacacaa gccagcagca
     2401 gtcttcagag cctctggctt gggcatgaga actcagcagc tctggatgaa gcaacctcag
     2461 cagatgctca gccgccagag ctccccaggg gtcaggagag aaagcgaagg ctgtggaaga
     2521 gcccgggctg cgtgcatgaa cacttgacct gcgctcttct tgccctactc tgttgttgtt
     2581 tgggtggttt gtgtctgaag gaaacaaata aagtgaagtt acggcctctg ctgctttacc
     2641 c
//
