LOCUS       NM_133740               2495 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus protein arginine N-methyltransferase 3 (Prmt3), mRNA.
ACCESSION   NM_133740
VERSION     NM_133740.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2495)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2495)
  AUTHORS   Zhou,G., Zhang,C., Peng,H., Su,X., Huang,Q., Zhao,Z. and Zhao,G.
  TITLE     PRMT3 methylates HIF-1alpha to enhance the vascular calcification
            induced by chronic kidney disease
  JOURNAL   Mol Med 30 (1), 8 (2024)
   PUBMED   38200452
  REMARK    GeneRIF: PRMT3 methylates HIF-1alpha to enhance the vascular
            calcification induced by chronic kidney disease.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2495)
  AUTHORS   Zhu,J., Li,X., Cai,X., Zhou,Z., Liao,Q., Liu,X., Wang,J. and
            Xiao,W.
  TITLE     Asymmetric arginine dimethylation of cytosolic RNA and DNA sensors
            by PRMT3 attenuates antiviral innate immunity
  JOURNAL   Proc Natl Acad Sci U S A 120 (36), e2214956120 (2023)
   PUBMED   37639603
  REMARK    GeneRIF: Asymmetric arginine dimethylation of cytosolic RNA and DNA
            sensors by PRMT3 attenuates antiviral innate immunity.
REFERENCE   4  (bases 1 to 2495)
  AUTHORS   Wang,Y., Wu,M., Yang,F., Lin,J., Zhang,L., Yuan,M., Chen,D.,
            Tan,B., Huang,D. and Ye,C.
  TITLE     Protein arginine methyltransferase 3 inhibits renal
            tubulointerstitial fibrosis through asymmetric dimethylarginine
  JOURNAL   Front Med (Lausanne) 9, 995917 (2022)
   PUBMED   36177327
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2495)
  AUTHORS   Min,Z., Xiaomeng,L., Zheng,L., Yangge,D., Xuejiao,L., Longwei,L.,
            Xiao,Z., Yunsong,L., Ping,Z. and Yongsheng,Z.
  TITLE     Asymmetrical methyltransferase PRMT3 regulates human mesenchymal
            stem cell osteogenesis via miR-3648
  JOURNAL   Cell Death Dis 10 (8), 581 (2019)
   PUBMED   31378783
  REMARK    GeneRIF: PRMT3 is an essential regulator of mesenchymal stem
            cell-mediated osteogenesis and bone homeostasis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2495)
  AUTHORS   Yildirim,A.O., Bulau,P., Zakrzewicz,D., Kitowska,K.E.,
            Weissmann,N., Grimminger,F., Morty,R.E. and Eickelberg,O.
  TITLE     Increased protein arginine methylation in chronic hypoxia: role of
            protein arginine methyltransferases
  JOURNAL   Am J Respir Cell Mol Biol 35 (4), 436-443 (2006)
   PUBMED   16690984
REFERENCE   7  (bases 1 to 2495)
  AUTHORS   Stefan,M., Claiborn,K.C., Stasiek,E., Chai,J.H., Ohta,T.,
            Longnecker,R., Greally,J.M. and Nicholls,R.D.
  TITLE     Genetic mapping of putative Chrna7 and Luzp2 neuronal
            transcriptional enhancers due to impact of a transgene-insertion
            and 6.8 Mb deletion in a mouse model of Prader-Willi and Angelman
            syndromes
  JOURNAL   BMC Genomics 6, 157 (2005)
   PUBMED   16280085
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2495)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2495)
  AUTHORS   Swiercz,R., Person,M.D. and Bedford,M.T.
  TITLE     Ribosomal protein S2 is a substrate for mammalian PRMT3 (protein
            arginine methyltransferase 3)
  JOURNAL   Biochem J 386 (Pt 1), 85-91 (2005)
   PUBMED   15473865
  REMARK    GeneRIF: The zinc-finger domain of mouse PRMT3 is necessary &
            sufficient for binding to human rpS2. rpS2 is methylated by PRMT3,
            implicating PRMT3 in ribosomal function & in the regulation of
            protein synthesis.
REFERENCE   10 (bases 1 to 2495)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK031738.1.
            
            On Apr 6, 2007 this sequence version replaced NM_133740.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK031738.1, AK010534.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2495              AK031738.1         2-2496
FEATURES             Location/Qualifiers
     source          1..2495
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 31.44 cM"
     gene            1..2495
                     /gene="Prmt3"
                     /gene_synonym="2010005E20Rik; 2410018A17Rik; Hrmt1l3"
                     /note="protein arginine N-methyltransferase 3"
                     /db_xref="GeneID:71974"
                     /db_xref="MGI:MGI:1919224"
     exon            1..144
                     /gene="Prmt3"
                     /gene_synonym="2010005E20Rik; 2410018A17Rik; Hrmt1l3"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..1706
                     /gene="Prmt3"
                     /gene_synonym="2010005E20Rik; 2410018A17Rik; Hrmt1l3"
                     /EC_number="2.1.1.319"
                     /note="protein arginine methyltransferase 3; heterogeneous
                     nuclear ribonucleoprotein methyltransferase-like protein
                     3; heterogeneous nuclear ribonucleoprotein
                     methyltransferase-like 3"
                     /codon_start=1
                     /product="protein arginine N-methyltransferase 3"
                     /protein_id="NP_598501.1"
                     /db_xref="CCDS:CCDS21307.1"
                     /db_xref="GeneID:71974"
                     /db_xref="MGI:MGI:1919224"
                     /translation="MCSLAAGNGRGAELGPEPLELSDSGDDAGWEDEDADTEPAHGRQ
                     HTPCLFCDRLFASAEETFSHCKLEHQFNIDSMVHKHGLEFYGYIKLINFIRLKNPTVE
                     YMNSIYNPVPWEKDEYLKPVLEDDLLLQFDVEDLYEPVSTPFSYPNGLSESASVVEKL
                     KHMEARALSAEAALARAREDLQKMKQFAQDFVMNVDVRTCSSTTTIADLQEDEDGVYF
                     SSYGHYGIHEEMLKDKVRTESYRDFIYQNPHIFKDKVVLDVGCGTGILSMFAAKVGAK
                     KVIAVDQSEILYQAMDIIRLNKLEDTIVLIKGKIEEVSLPVEKVDVIISEWMGYFLLF
                     ESMLDSVLYAKSKYLAKGGSVYPDICTISLVAVSDVSKHADRIAFWDDVYGFNMSCMK
                     KAVIPEAVVEVVDHKTLISDPCDIKHIDCHTTSISDLEFSSDFTLRTTKTAMCTAVAG
                     YFDIYFEKNCHNRVVFSTGPQSTKTHWKQTVFLLEKPFPVKAGEALKGKITVHKNKKD
                     PRSLIVTLTLNSSTQTYSLQ"
     exon            145..277
                     /gene="Prmt3"
                     /gene_synonym="2010005E20Rik; 2410018A17Rik; Hrmt1l3"
                     /inference="alignment:Splign:2.1.0"
     exon            278..360
                     /gene="Prmt3"
                     /gene_synonym="2010005E20Rik; 2410018A17Rik; Hrmt1l3"
                     /inference="alignment:Splign:2.1.0"
     exon            361..410
                     /gene="Prmt3"
                     /gene_synonym="2010005E20Rik; 2410018A17Rik; Hrmt1l3"
                     /inference="alignment:Splign:2.1.0"
     exon            411..513
                     /gene="Prmt3"
                     /gene_synonym="2010005E20Rik; 2410018A17Rik; Hrmt1l3"
                     /inference="alignment:Splign:2.1.0"
     exon            514..673
                     /gene="Prmt3"
                     /gene_synonym="2010005E20Rik; 2410018A17Rik; Hrmt1l3"
                     /inference="alignment:Splign:2.1.0"
     exon            674..815
                     /gene="Prmt3"
                     /gene_synonym="2010005E20Rik; 2410018A17Rik; Hrmt1l3"
                     /inference="alignment:Splign:2.1.0"
     exon            816..881
                     /gene="Prmt3"
                     /gene_synonym="2010005E20Rik; 2410018A17Rik; Hrmt1l3"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1003
                     /gene="Prmt3"
                     /gene_synonym="2010005E20Rik; 2410018A17Rik; Hrmt1l3"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1103
                     /gene="Prmt3"
                     /gene_synonym="2010005E20Rik; 2410018A17Rik; Hrmt1l3"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1182
                     /gene="Prmt3"
                     /gene_synonym="2010005E20Rik; 2410018A17Rik; Hrmt1l3"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1370
                     /gene="Prmt3"
                     /gene_synonym="2010005E20Rik; 2410018A17Rik; Hrmt1l3"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1457
                     /gene="Prmt3"
                     /gene_synonym="2010005E20Rik; 2410018A17Rik; Hrmt1l3"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1508
                     /gene="Prmt3"
                     /gene_synonym="2010005E20Rik; 2410018A17Rik; Hrmt1l3"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1596
                     /gene="Prmt3"
                     /gene_synonym="2010005E20Rik; 2410018A17Rik; Hrmt1l3"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..2495
                     /gene="Prmt3"
                     /gene_synonym="2010005E20Rik; 2410018A17Rik; Hrmt1l3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2463..2468
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prmt3"
                     /gene_synonym="2010005E20Rik; 2410018A17Rik; Hrmt1l3"
                     /note="hexamer: AATAAA"
     polyA_site      2484
                     /gene="Prmt3"
                     /gene_synonym="2010005E20Rik; 2410018A17Rik; Hrmt1l3"
                     /note="major polyA site"
ORIGIN      
        1 agcgctctcc ggacggttca cgctccgcgt gtggatcgct ttgggggctc ccgcgcaccc
       61 gcgccgctcg ttcccggctc cggtgccgcg ctgtgcggcc gcgcgcttgg tcggcggcca
      121 tgtgttcgct agcggcgggg aacggccgtg gcgccgagct ggggccggag cccctggaac
      181 tgtcggacag cggagacgac gcgggctggg aggacgagga cgcggacact gagcccgcgc
      241 acggccggca gcacacaccc tgcctgttct gtgacaggtt gttcgcctct gctgaggaaa
      301 cgttttcaca ctgtaagttg gagcatcaat ttaatattga tagtatggtc cataaacatg
      361 gacttgaatt ttatggatac attaaactaa taaattttat tagacttaag aatcctacgg
      421 ttgaatatat gaattccata tataaccctg tgccttggga aaaagatgag tacctgaagc
      481 cagtgttgga agatgacctt ttgcttcagt ttgatgtaga agatctttat gagcctgtgt
      541 ctactccatt ctcatacccc aatggactca gtgaaagcgc atctgttgtt gagaagttga
      601 agcacatgga agcgcgggcg ctgtctgctg aggctgcctt ggctcgggcg cgtgaggatc
      661 tgcagaagat gaaacaattt gctcaggact ttgtgatgaa cgtagatgtc agaacctgct
      721 cctccacgac gaccattgca gacctgcagg aggatgagga tggcgtctac ttcagctcct
      781 atgggcatta tgggatacat gaagaaatgc taaaggacaa agtacgcaca gaaagttaca
      841 gagatttcat ataccaaaat ccacacatct tcaaagataa ggttgttctg gatgttgggt
      901 gtggaactgg aattctctcc atgtttgctg ccaaagttgg ggcaaagaaa gtgattgcag
      961 tcgaccagtc tgaaatcctc taccaggcta tggatatcat aagactaaat aaacttgaag
     1021 ataccattgt actaattaaa ggaaagattg aagaagtgag tcttcctgtg gaaaaggtgg
     1081 atgttattat atcagagtgg atgggctatt ttcttctttt tgagtcgatg ttggattctg
     1141 tcctttatgc taagagtaaa tacttggcaa aagggggatc ggtctaccct gacatttgca
     1201 ccatcagcct tgtagctgtg agtgatgtga gcaagcacgc cgatagaatt gccttctggg
     1261 atgacgtcta tggcttcaac atgtcctgca tgaagaaagc agttataccg gaagctgttg
     1321 tggaagttgt ggatcacaag actcttattt cagacccttg tgatatcaag cacatagact
     1381 gccacaccac gtctatctca gacttggagt tttcttcaga ttttaccctg agaaccacaa
     1441 agacggccat gtgcacggca gttgctgggt actttgatat atattttgag aagaattgcc
     1501 acaacagggt cgtgttctct actggccccc agagcaccaa aacacactgg aaacagacag
     1561 tatttctgct ggaaaaacct tttccggtta aagcaggtga agctctgaaa ggaaagatca
     1621 cagttcacaa gaataagaag gatcctcgtt ccctcattgt gaccctgact ttgaacagtt
     1681 caacccagac ttacagtctc cagtgacagt catggcctcc agctgccaca aagtctgaag
     1741 cacatccagc tgtctgtctt taaagcggaa tagggcagtg accgggatgg gcaggctcca
     1801 tgggactgta gcacagctga tcctggccct gcaactactg ggtagtaagc ctagataaag
     1861 cagagctcag cggaggatcc cgccctcctc cctcctcctg cttctgctcc tagagatcct
     1921 agtcacagaa gcctgcctgg ccaggttagc tgaggagact tcctctcctg ctagactgag
     1981 agtcatttga attggcttac ttttggaaca gtaataatcc tgtttttttt taatatagat
     2041 atacgtttct tactataaat tttgttttta ataatgagca gcacaaagca gtgttttact
     2101 gtagatttcc tttctagagg aacaattttt agttacactt tttgctgaaa tatcaggata
     2161 tctcaagact agagagccag tggacaaaca tcctgtttgc agaggctgtg ctgcggtccc
     2221 ctctacccac ctgcagctct ctctcagctg ggcctcttca gtgttcttca gccatggcct
     2281 agcattgtgg ggaagtctaa cttcaggatg tagcctatgt gtgacagact gctctccagg
     2341 atggggtaga tgttgcctct ctaaaatgct gccttttcag atcaggtttg caccaaggtc
     2401 atgtatccgt ctgctaattc tagaaaatca tgttattcgg gtcgaaagaa tgaaaaatat
     2461 ccaataaata tgcaactatt gaaagcttct gcatc
//
