LOCUS       NM_133182               2056 bp    mRNA    linear   ROD 15-JUL-2024
DEFINITION  Mus musculus protein arginine N-methyltransferase 2 (Prmt2),
            transcript variant 1, mRNA.
ACCESSION   NM_133182
VERSION     NM_133182.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2056)
  AUTHORS   Sauter,C., Morin,T., Guidez,F., Simonet,J., Fournier,C., Row,C.,
            Masnikov,D., Pernon,B., Largeot,A., Aznague,A., Herault,Y.,
            Sauvageau,G., Maynadie,M., Callanan,M., Bastie,J.N., Aucagne,R. and
            Delva,L.
  TITLE     Protein arginine methyltransferase 2 controls inflammatory
            signaling in acute myeloid leukemia
  JOURNAL   Commun Biol 7 (1), 753 (2024)
   PUBMED   38902349
  REMARK    GeneRIF: Protein arginine methyltransferase 2 controls inflammatory
            signaling in acute myeloid leukemia.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2056)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2056)
  AUTHORS   Liu,T., Li,Y., Xu,M., Huang,H. and Luo,Y.
  TITLE     PRMT2 silencing regulates macrophage polarization through
            activation of STAT1 or inhibition of STAT6
  JOURNAL   BMC Immunol 25 (1), 1 (2024)
   PUBMED   38172698
  REMARK    GeneRIF: PRMT2 silencing regulates macrophage polarization through
            activation of STAT1 or inhibition of STAT6.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2056)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2056)
  AUTHORS   Sato,A., Kim,J.D., Mizukami,H., Nakashima,M., Kako,K., Ishida,J.,
            Itakura,A., Takeda,S. and Fukamizu,A.
  TITLE     Gestational changes in PRMT1 expression of murine placentas
  JOURNAL   Placenta 65, 47-54 (2018)
   PUBMED   29908641
REFERENCE   6  (bases 1 to 2056)
  AUTHORS   Reymond,A., Marigo,V., Yaylaoglu,M.B., Leoni,A., Ucla,C.,
            Scamuffa,N., Caccioppoli,C., Dermitzakis,E.T., Lyle,R., Banfi,S.,
            Eichele,G., Antonarakis,S.E. and Ballabio,A.
  TITLE     Human chromosome 21 gene expression atlas in the mouse
  JOURNAL   Nature 420 (6915), 582-586 (2002)
   PUBMED   12466854
REFERENCE   7  (bases 1 to 2056)
  AUTHORS   Pletcher,M.T., Roe,B.A., Chen,F., Do,T., Do,A., Malaj,E. and
            Reeves,R.H.
  TITLE     Chromosome evolution: the junction of mammalian chromosomes in the
            formation of mouse chromosome 10
  JOURNAL   Genome Res 10 (10), 1463-1467 (2000)
   PUBMED   11042146
REFERENCE   8  (bases 1 to 2056)
  AUTHORS   Wiltshire,T., Pletcher,M., Cole,S.E., Villanueva,M., Birren,B.,
            Lehoczky,J., Dewar,K. and Reeves,R.H.
  TITLE     Perfect conserved linkage across the entire mouse chromosome 10
            region homologous to human chromosome 21
  JOURNAL   Genome Res 9 (12), 1214-1222 (1999)
   PUBMED   10613844
REFERENCE   9  (bases 1 to 2056)
  AUTHORS   Cole,S.E., Wiltshire,T., Rue,E.E., Morrow,D., Hieter,P., Brahe,C.,
            Fisher,E.M., Katsanis,N. and Reeves,R.H.
  TITLE     High-resolution comparative physical mapping of mouse chromosome 10
            in the region of homology with human chromosome 21
  JOURNAL   Mamm Genome 10 (3), 229-234 (1999)
   PUBMED   10051316
REFERENCE   10 (bases 1 to 2056)
  AUTHORS   Cole,S.E., Wiltshire,T. and Reeves,R.H.
  TITLE     Physical mapping of the evolutionary boundary between human
            chromosomes 21 and 22 on mouse chromosome 10
  JOURNAL   Genomics 50 (1), 109-111 (1998)
   PUBMED   9628829
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY288156.1, BY727303.1, AK159186.1 and AI504737.1.
            
            On Dec 11, 2014 this sequence version replaced NM_133182.2.
            
            Transcript Variant: This variant (1) uses an alternate in-frame
            splice site in the 3' coding region, compared to variant 3. This
            results in isoform 2, which is shorter than isoform 1. Variants 1
            and 2 encode the same isoform (2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164131,
                              SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-99                BY288156.1         2-100
            100-593             BY727303.1         93-586
            594-2039            AK159186.1         567-2012
            2040-2056           AI504737.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..2056
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 38.74 cM"
     gene            1..2056
                     /gene="Prmt2"
                     /gene_synonym="Hrmt1l1"
                     /note="protein arginine N-methyltransferase 2"
                     /db_xref="GeneID:15468"
                     /db_xref="MGI:MGI:1316652"
     exon            1..116
                     /gene="Prmt2"
                     /gene_synonym="Hrmt1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            117..226
                     /gene="Prmt2"
                     /gene_synonym="Hrmt1l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..1510
                     /gene="Prmt2"
                     /gene_synonym="Hrmt1l1"
                     /EC_number="2.1.1.319"
                     /note="isoform 2 is encoded by transcript variant 1;
                     histone-arginine N-methyltransferase PRMT2; heterogeneous
                     nuclear ribonucleoprotein methyltransferase-like 1"
                     /codon_start=1
                     /product="protein arginine N-methyltransferase 2 isoform
                     2"
                     /protein_id="NP_573445.2"
                     /db_xref="CCDS:CCDS35942.1"
                     /db_xref="GeneID:15468"
                     /db_xref="MGI:MGI:1316652"
                     /translation="MEAPGEGPCSESQVIPVLEEDPVDYGCEMQLLQDGAQLQLQLQP
                     EEFVAIADYTATDETQLSFLRGEKILILRQTTADWWWGERAGCCGYIPANHLGKQLEE
                     YDPEDTWQDEEYFDSYGTLKLHLEMLADQPRTTKYHSVILQNKESLKDKVILDVGCGT
                     GIISLFCAHHARPKAVYAVEASDMAQHTSQLVLQNGFADTITVFQQKVEDVVLPEKVD
                     VLVSEWMGTCLLFEFMIESILYARDTWLKGDGIIWPTTAALHLVPCSAEKDYHSKVLF
                     WDNAYEFNLSALKSLAIKEFFSRPKSNHILKPEDCLSEPCTILQLDMRTVQVPDLETM
                     RGELRFDIQKAGTLHGFTAWFSVYFQSLEEGQPQQVLSTGPLHPTTHWKQTLFMMDDP
                     VPVHTGDVVTGSVVLQRNPVWRRHMSVSLSWVVTSALDPTSQRVGEKVFPIWR"
     exon            227..352
                     /gene="Prmt2"
                     /gene_synonym="Hrmt1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            353..535
                     /gene="Prmt2"
                     /gene_synonym="Hrmt1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            536..697
                     /gene="Prmt2"
                     /gene_synonym="Hrmt1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            698..862
                     /gene="Prmt2"
                     /gene_synonym="Hrmt1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            863..1038
                     /gene="Prmt2"
                     /gene_synonym="Hrmt1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1168
                     /gene="Prmt2"
                     /gene_synonym="Hrmt1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1305
                     /gene="Prmt2"
                     /gene_synonym="Hrmt1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1477
                     /gene="Prmt2"
                     /gene_synonym="Hrmt1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..2045
                     /gene="Prmt2"
                     /gene_synonym="Hrmt1l1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2022..2027
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prmt2"
                     /gene_synonym="Hrmt1l1"
                     /note="hexamer: AATAAA"
     polyA_site      2045
                     /gene="Prmt2"
                     /gene_synonym="Hrmt1l1"
                     /note="major polyA site"
ORIGIN      
        1 ggccagctgg agtgctccgc gcttgcgcag gtccagggcg gcggctcagg cttcgggtgg
       61 gcatcgtctg ttcctttctg gtatagccta gaattcagcg gagaaacgcg gctgaggcat
      121 gggagagaaa ctgaagtaaa gccccagtta tgagacatga tcatattgaa ctatggaggc
      181 accaggagaa ggtccctgca gcgagtcaca ggtcatcccg gttctggagg aagaccccgt
      241 ggactatggc tgtgagatgc agctcctgca ggatggggca cagttacagc tgcagctgca
      301 acctgaggag ttcgtggcca ttgcagacta tacggccacc gatgagacac agctcagctt
      361 tttgagagga gaaaaaattc ttatcctgag acaaaccacg gcggactggt ggtggggcga
      421 gcgcgcaggc tgctgtggtt acatccctgc gaaccacctc ggcaagcaac tggaggaata
      481 cgacccggag gacacctggc aggacgagga gtacttcgac agctatggaa ctctgaaact
      541 tcacctggaa atgttggctg accagcctcg gaccaccaag taccacagcg tcatcctgca
      601 gaacaaggag tccctgaagg acaaggtcat cctggatgtg ggctgcggca ccggcatcat
      661 cagcctcttc tgcgcacacc atgcccggcc caaggcggtc tacgcagtgg aggccagtga
      721 catggcccag cacaccagcc agctggtcct gcagaatggc tttgctgaca caatcactgt
      781 gttccagcag aaggtggagg acgtggtgct gcccgagaag gtggacgtgc tggtgtctga
      841 gtggatgggg acctgtctgc tgtttgagtt catgatcgag tccatcctgt atgcccggga
      901 cacatggtta aagggggacg gcatcatctg gccaaccacg gccgcactgc atctggtgcc
      961 ctgcagcgcc gagaaagact accacagcaa ggtgctcttc tgggacaacg cgtacgagtt
     1021 caacctcagt gcactcaagt ctttagcaat caaggagttc ttttcaaggc caaagtcgaa
     1081 tcatatcttg aagccagaag actgtctctc tgagccatgc acaatcttgc agctggacat
     1141 gagaactgtg caggtccctg acctggagac catgcgtggc gaactgcgat ttgacatcca
     1201 gaaggctggg accctgcacg gcttcacagc ttggttcagt gtgtacttcc agagcctgga
     1261 ggagggccag cctcagcagg tgctcagcac aggcccgctg caccccacca cacactggaa
     1321 gcagaccttg ttcatgatgg acgacccagt cccggtccac acgggagatg tggtcacggg
     1381 ttctgttgtg ttacaaagaa atccggtatg gagaaggcac atgtctgtct ctctgagctg
     1441 ggttgtcacg tccgcactcg atcccacgtc tcaaagagtt ggagagaagg tctttccgat
     1501 ctggaggtga cagttaaaca gggcgtggga gctgtggtca cggcatgcat ctcagtgaaa
     1561 gaagatgcac ctggccaccc actgtgacat ccacactcac ccgttccatg ctgacccctt
     1621 cccacctatc agctgacctt tggcccctca cagctcaccc gaagtgtcat gtctctcgta
     1681 ggctgtgtat ataggtgttc atcctgtggt gcctgtcggc tgccagtggt gaccgtgttc
     1741 ccagctggga gtagttgtag attcccccag acacacattt cagcctgtgt acctgtgact
     1801 gtgatgtccg catcttgtgt cagtggtgtc cttgatgccc ttggctagct gctgtatacc
     1861 tgtggactgt gacttgcaga gctgtgctcc aatatgagag atggccatgc acccgtgtct
     1921 cggtgcaagg actggaggtg gcagtgtgcc cagtggactc tgcatgggta gccgcgtgta
     1981 atgtctatgg gtaaattata tgtgggactt agtacatgct caataaatat tttttaacga
     2041 acaaaaaaaa aaaaaa
//
