LOCUS       NM_001252476            1325 bp    mRNA    linear   ROD 06-AUG-2024
DEFINITION  Mus musculus protein arginine N-methyltransferase 1 (Prmt1),
            transcript variant 2, mRNA.
ACCESSION   NM_001252476
VERSION     NM_001252476.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1325)
  AUTHORS   Cao,N., Zhang,F., Yin,J., Zhang,J., Bian,X., Zheng,G., Li,N.,
            Lin,Y. and Luo,L.
  TITLE     LPCAT2 inhibits colorectal cancer progression via the PRMT1/SLC7A11
            axis
  JOURNAL   Oncogene 43 (22), 1714-1725 (2024)
   PUBMED   38605214
  REMARK    GeneRIF: LPCAT2 inhibits colorectal cancer progression via the
            PRMT1/SLC7A11 axis.
REFERENCE   2  (bases 1 to 1325)
  AUTHORS   Peng,L., Sun,X., Yi,X., Wang,Z. and Chen,K.
  TITLE     EGR3 reduces podocyte inflammatory damage in obesity related
            glomerulopathy by inhibiting the PRMT1/p-STAT3 pathway
  JOURNAL   Zhong Nan Da Xue Xue Bao Yi Xue Ban 49 (3), 349-358 (2024)
   PUBMED   38970508
  REMARK    GeneRIF: EGR3 reduces podocyte inflammatory damage in obesity
            related glomerulopathy by inhibiting the PRMT1/p-STAT3 pathway.
REFERENCE   3  (bases 1 to 1325)
  AUTHORS   Ku,B., Eisenbarth,D., Baek,S., Jeong,T.K., Kang,J.G., Hwang,D.,
            Noh,M.G., Choi,C., Choi,S., Seol,T., Kim,H., Kim,Y.H., Woo,S.M.,
            Kong,S.Y. and Lim,D.S.
  TITLE     PRMT1 promotes pancreatic cancer development and resistance to
            chemotherapy
  JOURNAL   Cell Rep Med 5 (3), 101461 (2024)
   PUBMED   38460517
  REMARK    GeneRIF: PRMT1 promotes pancreatic cancer development and
            resistance to chemotherapy.
REFERENCE   4  (bases 1 to 1325)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 1325)
  AUTHORS   Peng,Z., Bao,L., Shi,B. and Shi,Y.B.
  TITLE     Protein arginine methyltransferase 1 is required for the
            maintenance of adult small intestinal and colonic epithelial cell
            homeostasis
  JOURNAL   Int J Biol Sci 20 (2), 554-568 (2024)
   PUBMED   38169732
  REMARK    GeneRIF: Protein arginine methyltransferase 1 is required for the
            maintenance of adult small intestinal and colonic epithelial cell
            homeostasis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1325)
  AUTHORS   Cimato,T.R., Tang,J., Xu,Y., Guarnaccia,C., Herschman,H.R.,
            Pongor,S. and Aletta,J.M.
  TITLE     Nerve growth factor-mediated increases in protein methylation occur
            predominantly at type I arginine methylation sites and involve
            protein arginine methyltransferase 1
  JOURNAL   J Neurosci Res 67 (4), 435-442 (2002)
   PUBMED   11835310
  REMARK    GeneRIF: Type I protein arginine methyltransferase (PRMT) activity
            produces asymmetric dimethylation of the terminal guanidinonitrogen
            of arginines in substrate proteins, particularly glycine and
            arginine-rich (GAR) segments of proteins
REFERENCE   7  (bases 1 to 1325)
  AUTHORS   Pawlak,M.R., Scherer,C.A., Chen,J., Roshon,M.J. and Ruley,H.E.
  TITLE     Arginine N-methyltransferase 1 is required for early
            postimplantation mouse development, but cells deficient in the
            enzyme are viable
  JOURNAL   Mol Cell Biol 20 (13), 4859-4869 (2000)
   PUBMED   10848611
REFERENCE   8  (bases 1 to 1325)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   9  (bases 1 to 1325)
  AUTHORS   Scherer,C.A., Chen,J., Nachabeh,A., Hopkins,N. and Ruley,H.E.
  TITLE     Transcriptional specificity of the pluripotent embryonic stem cell
  JOURNAL   Cell Growth Differ 7 (10), 1393-1401 (1996)
   PUBMED   8891343
REFERENCE   10 (bases 1 to 1325)
  AUTHORS   Lin,W.J., Gary,J.D., Yang,M.C., Clarke,S. and Herschman,H.R.
  TITLE     The mammalian immediate-early TIS21 protein and the
            leukemia-associated BTG1 protein interact with a protein-arginine
            N-methyltransferase
  JOURNAL   J Biol Chem 271 (25), 15034-15044 (1996)
   PUBMED   8663146
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU524421.1, AK152342.1, BY760714.1 and AI846916.1.
            
            Transcript Variant: This variant (2) lacks an alternate exon in the
            5' coding region, compared to variant 1. The resulting protein
            (isoform 2) is shorter when it is compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK152342.1, AK146927.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                BU524421.1         1-67
            68-970              AK152342.1         14-916
            971-1300            BY760714.1         396-725
            1301-1325           AI846916.1         1-25                c
FEATURES             Location/Qualifiers
     source          1..1325
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.07 cM"
     gene            1..1325
                     /gene="Prmt1"
                     /gene_synonym="6720434D09Rik; Hrmt1l2; Mrmt1"
                     /note="protein arginine N-methyltransferase 1"
                     /db_xref="GeneID:15469"
                     /db_xref="MGI:MGI:107846"
     exon            1..138
                     /gene="Prmt1"
                     /gene_synonym="6720434D09Rik; Hrmt1l2; Mrmt1"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1164
                     /gene="Prmt1"
                     /gene_synonym="6720434D09Rik; Hrmt1l2; Mrmt1"
                     /EC_number="2.1.1.319"
                     /note="isoform 2 is encoded by transcript variant 2;
                     arginine N-methyltransferase 1; histone-arginine
                     N-methyltransferase PRMT1; heterogeneous nuclear
                     ribonucleoproteins methyltransferase-like 2"
                     /codon_start=1
                     /product="protein arginine N-methyltransferase 1 isoform
                     2"
                     /protein_id="NP_001239405.1"
                     /db_xref="CCDS:CCDS57547.1"
                     /db_xref="GeneID:15469"
                     /db_xref="MGI:MGI:107846"
                     /translation="MAAAEAANCIMEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGI
                     HEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECS
                     SISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVL
                     HARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPL
                     VDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTR
                     CHKRTGFSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTID
                     LDFKGQLCELSCSTDYRMR"
     exon            139..240
                     /gene="Prmt1"
                     /gene_synonym="6720434D09Rik; Hrmt1l2; Mrmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            241..396
                     /gene="Prmt1"
                     /gene_synonym="6720434D09Rik; Hrmt1l2; Mrmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            397..460
                     /gene="Prmt1"
                     /gene_synonym="6720434D09Rik; Hrmt1l2; Mrmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            461..603
                     /gene="Prmt1"
                     /gene_synonym="6720434D09Rik; Hrmt1l2; Mrmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            604..691
                     /gene="Prmt1"
                     /gene_synonym="6720434D09Rik; Hrmt1l2; Mrmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            692..807
                     /gene="Prmt1"
                     /gene_synonym="6720434D09Rik; Hrmt1l2; Mrmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            808..958
                     /gene="Prmt1"
                     /gene_synonym="6720434D09Rik; Hrmt1l2; Mrmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1080
                     /gene="Prmt1"
                     /gene_synonym="6720434D09Rik; Hrmt1l2; Mrmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1309
                     /gene="Prmt1"
                     /gene_synonym="6720434D09Rik; Hrmt1l2; Mrmt1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1285..1290
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prmt1"
                     /gene_synonym="6720434D09Rik; Hrmt1l2; Mrmt1"
                     /note="hexamer: AATAAA"
     polyA_site      1309
                     /gene="Prmt1"
                     /gene_synonym="6720434D09Rik; Hrmt1l2; Mrmt1"
                     /note="major polyA site"
ORIGIN      
        1 ggggctgggc tgaggaccct ctggtaaaag gcggtccccg gtcgagccgg ggggagaaaa
       61 gagagagggg ggggtctcgg aggccggagg actcgggtga agatggcggc agccgaggcc
      121 gcgaactgca tcatggaggt ttcctgtggc caagcagaaa gtagtgagaa gcccaacgct
      181 gaggacatga catccaaaga ctactacttt gactcctatg cccactttgg catccacgag
      241 gagatgctga aggatgaggt gcgcaccctc acataccgca actccatgtt tcacaatcgg
      301 catctcttca aagacaaggt ggtgctggat gtgggctcag gcactggcat cctctgcatg
      361 tttgctgcca aggcgggggc ccgcaaggtt attgggattg agtgttccag tatctccgat
      421 tatgctgtga agattgtcaa agccaacaag ttagaccatg tggtgaccat catcaagggc
      481 aaggtggagg aggtggagct gcccgtggag aaggtggaca tcatcatcag cgagtggatg
      541 ggttactgcc tcttctacga gtccatgctc aacaccgtgc tgcacgctcg ggacaagtgg
      601 ctggcacccg atggcctcat cttcccagac cgggccacct tgtatgtgac agccattgag
      661 gaccgacaat ataaagacta caagatccac tggtgggaga acgtgtatgg ctttgatatg
      721 tcctgcatta aagacgtggc catcaaggag cccctggtgg acgtggtgga cccaaagcag
      781 ctggtcacca atgcctgcct cataaaggag gtggacatct acacagtcaa ggtggaggac
      841 ctgaccttca cctccccctt ctgcctgcaa gtgaagagga acgactacgt gcacgcgctg
      901 gtggcttact tcaacatcga gttcacccga tgccacaaga ggaccggctt ctccaccagt
      961 cctgagtccc cgtacacaca ctggaagcag actgtgttct acatggagga ctacctaaca
     1021 gtgaagactg gcgaggagat ctttggcacc attggaatga ggcccaatgc caaaaacaat
     1081 cgtgacttgg actttaccat cgacctggac ttcaagggtc agctgtgtga gctctcttgt
     1141 tccaccgact accggatgcg ctgaggaggt gccaggctgg ccctcctgca gaagggggct
     1201 cggggggatg ggcttggggg atgggggggt acatcgtgac tgtgtttttc ataacttatg
     1261 tttttatatg gttgcgttta tgccaataaa tcctcagctg accatgccaa aaaaaaaaaa
     1321 aaaaa
//
