LOCUS       NM_013638                407 bp    mRNA    linear   ROD 01-FEB-2024
DEFINITION  Mus musculus protamine 3 (Prm3), mRNA.
ACCESSION   NM_013638
VERSION     NM_013638.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 407)
  AUTHORS   Cantu,C., Valenta,T., Hausmann,G., Vilain,N., Aguet,M. and
            Basler,K.
  TITLE     The Pygo2-H3K4me2/3 interaction is dispensable for mouse
            development and Wnt signaling-dependent transcription
  JOURNAL   Development 140 (11), 2377-2386 (2013)
   PUBMED   23637336
REFERENCE   2  (bases 1 to 407)
  AUTHORS   Martin-Coello,J., Gomendio,M. and Roldan,E.R.
  TITLE     Protamine 3 shows evidence of weak, positive selection in mouse
            species (genus Mus)--but it is not a protamine
  JOURNAL   Biol Reprod 84 (2), 320-326 (2011)
   PUBMED   20944085
  REMARK    GeneRIF: PRM3 shows several clear differences from other
            protamines, and it cannot be regarded as a true protamine.  Among
            10 mouse species, PRM3 showed weak evidence of positive selection
            in two species but no clear association with levels of sperm
            competition.
REFERENCE   3  (bases 1 to 407)
  AUTHORS   Grzmil,P., Boinska,D., Kleene,K.C., Adham,I., Schluter,G.,
            Kamper,M., Buyandelger,B., Meinhardt,A., Wolf,S. and Engel,W.
  TITLE     Prm3, the fourth gene in the mouse protamine gene cluster, encodes
            a conserved acidic protein that affects sperm motility
  JOURNAL   Biol Reprod 78 (6), 958-967 (2008)
   PUBMED   18256328
  REMARK    GeneRIF: PRM3 is an acidic protein that is localized in the
            cytoplasm of elongated spermatids. Sperm from Prm3(-/-) males
            exhibited reductions in motility.
REFERENCE   4  (bases 1 to 407)
  AUTHORS   Schluter,G., Celik,A., Obata,R., Schlicker,M., Hofferbert,S.,
            Schlung,A., Adham,I.M. and Engel,W.
  TITLE     Sequence analysis of the conserved protamine gene cluster shows
            that it contains a fourth expressed gene
  JOURNAL   Mol Reprod Dev 43 (1), 1-6 (1996)
   PUBMED   8720108
REFERENCE   5  (bases 1 to 407)
  AUTHORS   Schluter,G. and Engel,W.
  TITLE     The rat Prm3 gene is an intronless member of the protamine gene
            cluster and is expressed in haploid male germ cells
  JOURNAL   Cytogenet Cell Genet 71 (4), 352-355 (1995)
   PUBMED   8521723
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK132894.1.
            
            On Sep 14, 2006 this sequence version replaced NM_013638.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK132894.1, CJ047148.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-407               AK132894.1         2-408
FEATURES             Location/Qualifiers
     source          1..407
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 5.84 cM"
     gene            1..407
                     /gene="Prm3"
                     /gene_synonym="PX; Pxg"
                     /note="protamine 3"
                     /db_xref="GeneID:19120"
                     /db_xref="MGI:MGI:106601"
     exon            1..407
                     /gene="Prm3"
                     /gene_synonym="PX; Pxg"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..331
                     /gene="Prm3"
                     /gene_synonym="PX; Pxg"
                     /note="sperm protamine P3"
                     /codon_start=1
                     /product="protamine-3"
                     /protein_id="NP_038666.2"
                     /db_xref="CCDS:CCDS27954.1"
                     /db_xref="GeneID:19120"
                     /db_xref="MGI:MGI:106601"
                     /translation="MGSRCAKLSTGHGPAQNTGHSRGHESSMKKLVACVSQDNFSLSS
                     EGEEEEEDEEEEEEEEEEEEEEQIPVKGKLLLLEPEKQESAEDGEAQPSPEPKQTHS"
     regulatory      391..396
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prm3"
                     /gene_synonym="PX; Pxg"
                     /note="putative"
ORIGIN      
        1 tagtccagag agacaggagt gggcgatggg ttcccgctgt gccaagctca gcactggcca
       61 tggcccagcc cagaacactg gtcacagccg tggccacgag tcctccatga agaagctcgt
      121 ggcctgtgtg agtcaagaca acttttccct gtcatcagag ggcgaggaag aggaggagga
      181 cgaggaagag gaggaggagg aagaagaaga agaggaagag gagcaaatcc cggtgaaggg
      241 caagctgctg ctgctggagc ccgaaaagca agagagcgcc gaggatgggg aggcccagcc
      301 aagccccgag cccaagcaga cacactcctg agccacaagg cctgcctggc aatgggtgcc
      361 cattgccacg ccagaggaca ttcagaaaag aataaagagt ctccatg
//
