LOCUS       NM_011169              10328 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus prolactin receptor (Prlr), transcript variant 1, mRNA.
ACCESSION   NM_011169 NM_008932 NM_178921
VERSION     NM_011169.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 10328)
  AUTHORS   Vazquez-Carrillo,D.I., Ocampo-Ruiz,A.L., Baez-Meza,A.,
            Ramirez-Hernandez,G., Adan-Castro,E., Garcia-Rodrigo,J.F.,
            Dena-Beltran,J.L., de Los Rios,E.A., Sanchez-Martinez,M.K.,
            Ortiz,M.G., Martinez de la Escalera,G., Clapp,C. and Macotela,Y.
  TITLE     Dopamine D2 receptor antagonist counteracts hyperglycemia and
            insulin resistance in diet-induced obese male mice
  JOURNAL   PLoS One 19 (4), e0301496 (2024)
   PUBMED   38635745
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10328)
  AUTHORS   Wang,X., Zhang,Y., Yu,J., Ma,Y., Xu,Y., Shi,J., Qi,Z. and Liu,X.
  TITLE     Identification and analysis of key circRNAs in the mouse embryonic
            ovary provides insight into primordial follicle development
  JOURNAL   BMC Genomics 25 (1), 139 (2024)
   PUBMED   38310234
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 10328)
  AUTHORS   de Castro Moreira,A.R., Trarbach,E., Bueno,C.B.F., Monteiro,A.L.S.,
            Grande,I.P.P., Padula,M., Maciel,G.A.R. and Glezer,A.
  TITLE     PRL-R Variants Are Not Only Associated With Prolactinomas But Also
            With Dopamine Agonist Resistance
  JOURNAL   J Clin Endocrinol Metab 108 (7), e450-e457 (2023)
   PUBMED   36638053
  REMARK    GeneRIF: PRL-R Variants Are Not Only Associated With Prolactinomas
            But Also With Dopamine Agonist Resistance.
REFERENCE   4  (bases 1 to 10328)
  AUTHORS   Lopez-Tello,J. and Sferruzzi-Perri,A.N.
  TITLE     Characterization of placental endocrine function and fetal brain
            development in a mouse model of small for gestational age
  JOURNAL   Front Endocrinol (Lausanne) 14, 1116770 (2023)
   PUBMED   36843585
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 10328)
  AUTHORS   Begon,E. and Bernard,V.
  TITLE     [Prolactin and its receptor: From animal models to pituitary
            pathophysiology]
  JOURNAL   Biol Aujourdhui 216 (3-4), 105-110 (2022)
   PUBMED   36744975
  REMARK    GeneRIF: [Prolactin and its receptor: From animal models to
            pituitary pathophysiology].
REFERENCE   6  (bases 1 to 10328)
  AUTHORS   Gala,R.R.
  TITLE     Influence of thyroxine and thyroxine with growth hormone and
            prolactin on splenocyte subsets and on the expression of
            interleukin-2 and prolactin receptors on splenocyte subsets of
            Snell dwarf mice
  JOURNAL   Proc Soc Exp Biol Med 210 (2), 117-125 (1995)
   PUBMED   7568281
REFERENCE   7  (bases 1 to 10328)
  AUTHORS   Barker,C.S., Bear,S.E., Keler,T., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A., Yeung,R.S. and Tsichlis,P.N.
  TITLE     Activation of the prolactin receptor gene by promoter insertion in
            a Moloney murine leukemia virus-induced rat thymoma
  JOURNAL   J Virol 66 (11), 6763-6768 (1992)
   PUBMED   1404614
REFERENCE   8  (bases 1 to 10328)
  AUTHORS   Davis,J.A. and Linzer,D.I.
  TITLE     Mutational analysis of mouse placental lactogen II, and molecular
            characterization of the mouse prolactin receptor
  JOURNAL   Prog Clin Biol Res 342, 127-132 (1990)
   PUBMED   2381944
REFERENCE   9  (bases 1 to 10328)
  AUTHORS   Davis,J.A. and Linzer,D.I.
  TITLE     Expression of multiple forms of the prolactin receptor in mouse
            liver
  JOURNAL   Mol Endocrinol 3 (4), 674-680 (1989)
   PUBMED   2725531
REFERENCE   10 (bases 1 to 10328)
  AUTHORS   Herington,A.C., Harrison,D. and Graystone,J.
  TITLE     Hepatic binding of human and bovine growth hormones and ovine
            prolactin in the dwarf 'little' mouse
  JOURNAL   Endocrinology 112 (6), 2032-2038 (1983)
   PUBMED   6303755
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK054551.1, AK052679.1, AK077980.1, BG087509.2, DV053280.1,
            AK087727.1, AK165113.1, AK087749.1, AK083198.1 and AI527408.1.
            
            On Jul 24, 2009 this sequence version replaced NM_011169.4.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005555.1, SRR7652917.607410.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1362              AK054551.1         2-1363
            1363-1588           AK052679.1         818-1043
            1589-2696           AK054551.1         2100-3207
            2697-4797           AK077980.1         338-2438
            4798-5080           BG087509.2         270-552
            5081-5697           DV053280.1         139-755
            5698-6936           AK087727.1         562-1800
            6937-9056           AK165113.1         412-2531
            9057-9837           AK087749.1         1364-2144
            9838-10319          AK083198.1         3009-3490
            10320-10328         AI527408.1         1-9                 c
FEATURES             Location/Qualifiers
     source          1..10328
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 5.23 cM"
     gene            1..10328
                     /gene="Prlr"
                     /gene_synonym="Pr-1; Pr-3; Prlr-rs1"
                     /note="prolactin receptor"
                     /db_xref="GeneID:19116"
                     /db_xref="MGI:MGI:97763"
     exon            1..634
                     /gene="Prlr"
                     /gene_synonym="Pr-1; Pr-3; Prlr-rs1"
                     /inference="alignment:Splign:2.1.0"
     exon            635..694
                     /gene="Prlr"
                     /gene_synonym="Pr-1; Pr-3; Prlr-rs1"
                     /inference="alignment:Splign:2.1.0"
     exon            695..803
                     /gene="Prlr"
                     /gene_synonym="Pr-1; Pr-3; Prlr-rs1"
                     /inference="alignment:Splign:2.1.0"
     CDS             749..2575
                     /gene="Prlr"
                     /gene_synonym="Pr-1; Pr-3; Prlr-rs1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; prolactin receptor related sequence 1; PRL-R"
                     /codon_start=1
                     /product="prolactin receptor isoform 1 precursor"
                     /protein_id="NP_035299.4"
                     /db_xref="CCDS:CCDS27377.1"
                     /db_xref="GeneID:19116"
                     /db_xref="MGI:MGI:97763"
                     /translation="MSSALAYMLLVLSISLLNGQSPPGKPEIHKCRSPDKETFTCWWN
                     PGSDGGLPTNYSLTYSKEGEKNTYECPDYKTSGPNSCFFSKQYTSIWKIYIITVNATN
                     EMGSSTSDPLYVDVTYIVEPEPPRNLTLEVKQLKDKKTYLWVKWLPPTITDVKTGWFT
                     MEYEIRLKSEEADEWEIHFTGHQTQFKVFDLYPGQKYLVQTRCKPDHGYWSRWGQEKS
                     IEIPNDFTLKDTTVWIIVAVLSAVICLIMVWAVALKGYSMMTCIFPPVPGPKIKGFDT
                     HLLEKGKSEELLSALGCQDFPPTSDCEDLLVEFLEVDDNEDERLMPSHSKEYPGQGVK
                     PTHLDPDSDSGHGSYDSHSLLSEKCEEPQAYPPAFHIPEITEKPENPEANIPPTPNPQ
                     NNTPNCHTDTSKSTTWPLPPGQHTRRSPYHSIADVCKLAGSPGDTLDSFLDKAEENVL
                     KLSEDAGEEEVAVQEGAKSFPSDKQNTSWPPLQEKGPIVYAKPPDYVEIHKVNKDGVL
                     SLLPKQRENHQTENPGVPETSKEYAKVSGVTDNNILVLVPDSRAQNTALLEESAKKVP
                     PSLEQNQSEKDLASFTATSSNCRLQLGRLDYLDPTCFMHSFH"
     exon            804..936
                     /gene="Prlr"
                     /gene_synonym="Pr-1; Pr-3; Prlr-rs1"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1106
                     /gene="Prlr"
                     /gene_synonym="Pr-1; Pr-3; Prlr-rs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1276
                     /gene="Prlr"
                     /gene_synonym="Pr-1; Pr-3; Prlr-rs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1418
                     /gene="Prlr"
                     /gene_synonym="Pr-1; Pr-3; Prlr-rs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1518
                     /gene="Prlr"
                     /gene_synonym="Pr-1; Pr-3; Prlr-rs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1588
                     /gene="Prlr"
                     /gene_synonym="Pr-1; Pr-3; Prlr-rs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..10328
                     /gene="Prlr"
                     /gene_synonym="Pr-1; Pr-3; Prlr-rs1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9030..9035
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prlr"
                     /gene_synonym="Pr-1; Pr-3; Prlr-rs1"
                     /note="hexamer: AATAAA"
     polyA_site      9057
                     /gene="Prlr"
                     /gene_synonym="Pr-1; Pr-3; Prlr-rs1"
                     /note="major polyA site"
     regulatory      10298..10303
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prlr"
                     /gene_synonym="Pr-1; Pr-3; Prlr-rs1"
                     /note="hexamer: AATAAA"
     polyA_site      10318
                     /gene="Prlr"
                     /gene_synonym="Pr-1; Pr-3; Prlr-rs1"
                     /note="major polyA site"
ORIGIN      
        1 attgtcaagc ggctggctgc tgggtgttgc ttgctgggaa gtacggaaag aaatttgaca
       61 ccgaatctca tcttggctac tgggagaaat accatctttg aggtcacagg acttaaagga
      121 catttctatt attgttttgt ctctttactg gtagtcttga tggaagaagg tcccctgatc
      181 atgcgaaacg gatccgggag aaatcagaca ttaccttgtc caccttttct ctgcattctg
      241 attcccccaa ctatctccgt caccttataa aactggcagg ctctggacct tttgcacgct
      301 ggagaaaaat cactgttttg cctccagcaa ggaacatgca tgttgcaaca ctgactcctc
      361 ctctagtgaa gaaagagtga acaagtgcac cgagttgagc ttcttctcag agacacgcgg
      421 ctggcgacgg cagagcagag gctaaaatcc ccagactgcc gggtcttctg agctgggctt
      481 tccccgcctt cctgctctgt ctcactcact cctctcctgc gttctggatt ttacacgggg
      541 ctcaggaaac agctttacct gtcactgaaa aagctcgcgt tctttgcaag aagtgctcaa
      601 tccctggtat ggcagacttt tctctccagc agaactaaag aacgcttctc tgtggaggtg
      661 agcatcgcag atgttttgca catgaaccct gaagggagcc tctgatctat tgcctgtagc
      721 aagaagaagg gccagcctga agcaaaacat gtcatctgca cttgcttaca tgctgcttgt
      781 cctcagcatc agcctcctga atggacagtc accacctgga aaacctgaaa tccacaaatg
      841 tcgttcccct gacaaggaaa cattcacctg ctggtggaat cctgggtcag atggaggact
      901 ccccaccaat tattcattga catacagcaa agaaggagag aaaaacacct atgaatgtcc
      961 agactacaaa accagtggcc ccaattcctg tttctttagc aagcagtaca cttccatatg
     1021 gaaaatatac atcatcacag taaatgccac gaacgaaatg ggaagcagta cctcggatcc
     1081 actttatgtg gatgtgactt acattgttga accagagcct cctcggaacc tgactttaga
     1141 agtgaaacaa ctaaaagaca aaaaaacata tctgtgggta aaatggttgc cacctaccat
     1201 aactgatgta aaaactggtt ggtttacaat ggaatatgaa attcgattaa agtctgaaga
     1261 agcagatgag tgggagatcc acttcacagg tcatcaaaca caatttaagg tttttgactt
     1321 atatccagga caaaagtatc ttgtccagac tcgctgcaag ccagaccatg gatactggag
     1381 tagatggggc caggagaaat ctattgaaat accaaatgac ttcaccttga aagacacaac
     1441 tgtgtggatc attgtggccg ttctctctgc tgtcatctgt ttgattatgg tctgggcagt
     1501 ggctttgaag ggttatagca tgatgacctg catctttcca ccagttccgg ggccaaaaat
     1561 aaaaggattt gatactcatc tgctagagaa gggcaagtct gaagaactgc tgagtgcctt
     1621 ggggtgccaa gactttcccc ccacttctga ctgtgaggac ttgctggtgg agttcttgga
     1681 agtggatgac aatgaggacg agcggctaat gccatcccat tccaaagagt atccgggtca
     1741 aggtgttaaa cccacacacc tagatcctga cagtgactct ggtcatggaa gctatgacag
     1801 ccattctctt ttgtctgaaa agtgtgagga gccccaggcc tacccccctg ccttccacat
     1861 ccctgagatc actgagaagc cagagaatcc tgaggcaaat attcctccca ccccaaatcc
     1921 ccaaaataac acccccaatt gtcatacaga tacatccaaa tctacaacat ggcctttacc
     1981 acctggccaa cacacgcgca gatctcctta ccacagcatt gccgatgtgt gcaagctagc
     2041 tggaagtcct ggagatacac tggactcttt cttggacaaa gcagaggaaa atgttctaaa
     2101 gttgtctgaa gatgctggag aggaagaagt ggctgtgcaa gaaggggcca aaagcttccc
     2161 ttctgacaaa caaaacacat cttggccacc actccaggag aaaggcccca ttgtctatgc
     2221 taaaccccca gattacgtgg agattcacaa agtcaacaaa gacggagtgc tatcattact
     2281 ccccaagcag agagaaaacc accagacaga aaaccctggg gttcctgaaa ccagtaagga
     2341 gtatgccaag gtatctgggg tcacggataa caacatcctg gtgttagtgc cagactcacg
     2401 agcccagaac acagctttgc ttgaggaatc agccaagaag gttccaccat cgcttgaaca
     2461 gaaccaatct gagaaagatc tggccagctt tactgcaacc tcaagcaact gcagactcca
     2521 actgggcagg ctggattacc tggatcctac gtgcttcatg cactcctttc actgagagct
     2581 agacttatgg acagattgac taaaatgtga tttctcttca ggttaacact acagagtcat
     2641 gaagtaatgt ggtctgctaa cagatgttac aggatgtggg tataaaaaaa aaaaacaaaa
     2701 agaaaaaaaa aacaaaaaga aaaacactac ttcactcctc cacacgcttg tgttcagcat
     2761 ttgcctcttt ccaacagctg atttccagaa caaatcaact tgtttcctgt gatttgtaca
     2821 tttgctcttt gctaccatat atatgtgtgt gcatatatat gcatatatac atgcgcatat
     2881 atatatattc aatgaaataa aagcacatcg cttactattc ttgagggatg gtgccaacag
     2941 gtacagcctc tgcaatagat ttgtcatcag acagaaggca tgaaatagtc aaaatggcct
     3001 agcacaagaa gatgacggac aggctggaaa tgccatgaaa atggctctta agaactgatg
     3061 gctaagcctt tacactcctc tttcattttc atgatgatgg tcccaatatt gcacattttg
     3121 gaaagaatac attccaggac accagccaaa ttgtttacat ccgtccctgt accttaatga
     3181 cccattgcct gtatgcaaat ggtatcatgc ccccagtgtt ttcttaaggt gatttgaata
     3241 tgttaagcct gggttattct gctgaaactt tattttattc taaggcttct taagtgtgta
     3301 gtttgaggaa gtaaaatttt catacaaaat aaggccaatg aattccacgc agtgaacctt
     3361 ttcaaacgtg ttccttgctt catttgagca agagatggtt tgttataaac cctagtgttt
     3421 tcttagtaga aaaaagcgat tcccccaaga ctaacgatct aaaaggtaat cattgcagga
     3481 tgctaataga agtgttgcct tactgtacat acgattctac tttaatacaa acccgtaagt
     3541 ttagcaatgt atttttgaag actatttttc tatcgcttaa gtaaagacta ttttctaact
     3601 tcccagtact gctgtttacg tagtcaagtg agtagagtga tttctgctgc aacgttacag
     3661 tgagtattca aagtttatca gtatatgcag tccctgttag actgaagtgc caggcaaccc
     3721 attgcccact gaggaatgca aagtagatga aaacctcaat tgagtacaat agagtaaggt
     3781 ttatctgatt atttttatcc ctaggatacg ttaaacagca accatcactg actttgggtt
     3841 ttagggcttt ctatagaccc ataacacatt tctcccatga gtttagggca tctgcccacc
     3901 tatggaagag tctcccaaac caccatgaac aagggcagtg atttctatgg agggtttcca
     3961 agacagagat ctgactttgt tttgtttcct tttatctgag caatcctgaa cacaaaagga
     4021 ttttaagtat aacgaacgtc agcatctcct tggaattcat gcatttgcaa gatcttggca
     4081 caggctgtgc tcacgtcaca gatgtccaga taaaagtttt aggaaagcaa gcatctgccc
     4141 agtgataaca gttttaaagg tcaggggatg gtagaatctg caagccaact ccaagggcag
     4201 gcttcctggg aaagttcaaa gcaaagcctt gggtctccat tggaccatag catctatgac
     4261 tcactctccc tctgctttgc aaatcagttc tctctttcac caactggata tagagactct
     4321 gaaatcacct cttgtgagtt cagcattcca cccaacatgc acatgccctc agagattctc
     4381 cgacgaagga aaagaaacaa aggaaacgct tccagaacta caaatgcaag cagccaaagc
     4441 ttatattcct aatatataag acatcttgtg aacaacagaa gtatttggga aagttgtcca
     4501 agctcatgca ataccctgaa tcctccatac agaatgtctg agaaacaact gcatcttcaa
     4561 agacacagag aattggagtc tgaatcgtac tgcattcact aagctcccag gcatgcgcaa
     4621 gctgaagaag aagcagtttt ctctatgacc attttcataa aaagttattt ttctctccct
     4681 ctcttggaaa gtatggagaa aagtttatta tcttgaaatg agcaacaatg tatgtaaata
     4741 gaaaacaaga tcaaaactct tagtgattta aagttcacgt agcaatgttg cttatataaa
     4801 gtcacacaag accatgacat gcaaaataca cacaacctcc aagagggtca gtgaatctaa
     4861 ttcacctgga aagctaccaa caaaaaaata aataaataaa caccaaagcc aatgcaagct
     4921 aaaccttctt tgccaagaca ttctatcctt ctccaggaga caaataaatg catttattta
     4981 caaatcacca ctataaaatt gatgctgcat atatggctca tagtatgaaa tttctaaaaa
     5041 ttggctttag atatgtaatt ttgaaaatgt ggaaaatatg gctatctaaa gtcaagttac
     5101 attccacaaa aataagttag cattcatgag ataaaaacaa atctatacag ttctatacat
     5161 ttattaaatt cttgtggtca aatattttct attgaaagac agctgcttga ataaaagaag
     5221 gcacactagg agttgagaca cctgggttct agttctgttt tgccttggaa agaagaatta
     5281 cctattctag ttttctttgt attggaccca ataatctcta cagccttttg gaattcagtc
     5341 ttcttgattc tgtggcttga tgaataatca aaaccaatcc cttgcatctc agtgaggttt
     5401 tcaggcaatt ataaaaatgc agagccaccc acattcctgt gctcatcctg tttcactctt
     5461 taaagtctca gcacccattt gtctctacat actgaacatg tatttcatat tatatggaca
     5521 ccatgtaagt cagactctag gatcatatgg tgatatgggt gctgaggtaa gatatagcgc
     5581 taagaaagac acaggagatg agacacaagt ctttagccat gctcattcct acatggagcc
     5641 aacagcctca aacttctgtt cttgtatttg gttgttgcct gttttctcat catcctgttt
     5701 aatgaataac cattgcccat atagattaaa gaatcttttg cgctgaatca tttcaaaatg
     5761 tatagttttc taagcaactc tctgaaaaat ttcaagttat gaagtacatg gaaactaaat
     5821 atattcattt ggatggctga tggaacttta ggacacaaat ggcagaatgt tctctgataa
     5881 gttttaacaa gtacatagaa ggaacttcat atgagcacaa cttaccatca gcaatgccac
     5941 tgacttttaa tagatgatac attctcctaa gtgcctgaga ctaatcatgg tggtcagtta
     6001 taggtcaatg attcactgta aaccagtttg gtggaaaaca gtcaagccca tgttgcatgt
     6061 gtaaaattaa agccggggga ctctttactt gatccaaggt gaatcctcag tcaatgaaca
     6121 accaaaggac ctgaactcca ggttaaagtt tgtcctgatg gaaaactagc tcctccattt
     6181 tcattctgct ttagctgctc atcatttgta aaatgaccca gcctgccctt agcaacttca
     6241 atttagcata gacaagggag aaagagatct gtatatgttt tacaaagtgc ctttctttgc
     6301 ttctaaaagg tttcattttg gaagaaaagt gcattaattg gaaagcaaat tttatcttaa
     6361 atggatttct tttaaataaa tggagagatg accaaaaaaa ggaggggaga tgacaaaatg
     6421 ttctaaagac taacgaacaa aatgtgcagg gatttttgtg tatagtttaa ctgaatcatc
     6481 agagaactga agtgaatagt atcaatcatt ttgcctgagt ctgggcgtga ttggagatga
     6541 acccaggagc ctgtaattca agactttcca ttctgaaaac aatgttgatt cattcttgaa
     6601 tgacactgaa ttgtatgcct ggccccgaag aggccaatgt gtgcactttg aagctcttca
     6661 cccagatgga aaagtagtaa tgaccttgaa tatctatcct gtgacttgtt atggatgaaa
     6721 gctttatata tacatcatca aacaaggttt cttttgtgac tttttttggc tcaagcacaa
     6781 tactgattct ggtaggagag tctctgagcc ctcagtgtcc agctctgggc atgttactgc
     6841 tactaaatag gctgcaagac cttgattttt ttttttaatt ctgaccactt gtttcccctc
     6901 ttgtaggtta accctccaaa aaaaaaaaaa aaaaaaaagc ttctacaatt tcttctaggt
     6961 ctgtctttaa tcctcatgag ttaagtaaaa tctaagattg tagttgaaag gcccaggggc
     7021 catggccaac acgcccctaa cttagacagt aaatgcctga aactgtgtaa agacatgctt
     7081 aacagaaacc tgagatccag atctccaaat cagttagacc agaactcttg tattctgcct
     7141 ccttaccatt tctacattct tagagccttt tcagcccctc tttccagggc ctgctattct
     7201 ccctaaagat taattatgca gaatagtaaa gttggggtct gcgggaaaga aattacctac
     7261 aaacaatgat ttgactctgc ataagatgaa ccaattgtta actctccaca cagacacaaa
     7321 cctaaattat ggtcataaat aatgcttcgt tttgatatgt atgtgtttaa agattcaagc
     7381 cagcaactta ttttctaata agtctgggat gtcttgatga gtagatgttg actgccttaa
     7441 aaagaaactt taaaaaagta tactgttttc ttcagagttt atgattcaac aaaagaatct
     7501 acttataatt acagtccttt cctatgagta ttaggtgtta tctgtgaatc acatgcagat
     7561 tttcctcttg gagttttttt tcccaaaaag ataactttag gtttgagctc tgccggtatc
     7621 aatttccagt ggaggggaaa ggtaaaaaac agaatgttcc aaaatgtagg gcatatcaga
     7681 actccaccaa atggggtatt cattcactca aatcttacca gaaatggtaa atctacatgt
     7741 aattgtgagt gaattgcaga gaggtaaaca taacttctaa gaccataggc taacagcagt
     7801 tctgttcacg ccaattcctt ctatctcgag ttataaagca ttgagacaca tagagtagaa
     7861 aggcaaccat ctatacagtc tggtcaatga gtaaagggac tcacagataa tcttagcatg
     7921 ttgattagta tttacctact gttgtttaaa aagagaagaa gaaattctaa aaaaaaaaat
     7981 ttgtaacaga aacaggacta tcaaacataa accttatcag ttatggtcaa attatgcccc
     8041 cctggataca cttcaaaata caggcttggt ttttctgtgc acattttgca aatggggggt
     8101 tgtcttttat cacatcctct aaaatacaaa caataaaaaa gaaattttaa gagaaaaaca
     8161 cctctgaaaa tcatttgttt tactaaattc tgagaaacag attttgaatt tttaaaacta
     8221 cctcccttcc acatcctaat ggccttcctt caaagctgct tatagttaga aatgaaagat
     8281 accacatttt tatgtttgga ctggtgttga tggaatattt gatatacttt tcatgtgaca
     8341 ctcctaactc taaagtatgt tattttactg taaagaatgt tattttacac tattttgctt
     8401 ttttgtgatt caaaaccctt atatgccata ttgaagtata taatcctctt attgtaaaat
     8461 ttatcatgta atacaagtga taatcattat ttaatgactt atgatctaat catatctaat
     8521 ttcaatataa ttatgtcaat gtctgtaaag caaagctaaa tctatataat catgtatgta
     8581 atcatatttc tgttgaaact gtgaatgttg tgactttccc tttaatcttt gtctacaagt
     8641 gatagtgtat gtcattgtat aactgacttg ggatgctagt gtgtttacag tacaattcac
     8701 cagtggttga aatgtcaacc ctttggcttg gcttcttgtg atccccgagt gttctctgca
     8761 ccttgagact tgcttttgtg ctttgtgctc tgtcattaat tttaaacaat gtaagagtct
     8821 cttgtataaa ccaaagtaat cagcccactg agtgatcatg ccttctgtaa agccatattg
     8881 aagtaaagac tccgctgtag cataaggtcc cctgtctcca gagctgccac tacctcgctc
     8941 ctgctctttc cctacaaaat gccaaacaaa gtttaaccct taagtggaat attagatgtg
     9001 cttgctatta ttgtcatttt taacctgata ataaaccttc taattcatta ctttgcagat
     9061 gtatgctagg ttttatgaat aaccattttc acattttgat attttgtaga cattgcctga
     9121 tgagcaaagt tcaaaaagag tacacactca gtcatcagat ttaaaaaaat aatcacagag
     9181 tgcaggtgtt tttcctgtca gtgagtcacc tcaagttggg tggccaaagc aactataacc
     9241 ttggtcacta tagctgaaat acccaactca gtgcctggct caaagatgtt tatccccttg
     9301 gtctcccttg gttctcattt ttttttaatt aggtatttat ttcatttaca tttccaatgc
     9361 tatcccaaag tcccacacat ggtcctccac ctactccctc aaccacccac tctcacttct
     9421 tggccctgga gttcccctgt actgaggcat ataaagtttg cacaatcaat gggcctctct
     9481 ttccactgat ggcagactag gccatcttct gatacatatg cagctagaga caaaagctcc
     9541 gggggtattt agttcatatt gttgttccac ctatagggtt gcagatctcc ccagctcctt
     9601 gggtattttc tctagctcct ccattggggg ccctgtgatc cgtccaatag ttgacttctg
     9661 tgtttgctag gccccagcat agtctcacaa gagacagcta tatcttggtc cttttttgtt
     9721 gctgttgttt gaaatgcaaa tgaacagaat cacttggatg tggatgaagt gagttttcta
     9781 atttttggct gtcagatctg taatcataaa tttgcaattt catttcccca aactcccaaa
     9841 aaataaatat cctctttact tgattttaat catcaaatat ctagtggtat tgaaagagtc
     9901 agccatttat cagaaacaat cttgttttga acttaaagac tcatttctat gtctcactac
     9961 tgtgatatcg actttttctt tagtattaaa gggtgatatg atgctaaact cttatgattt
    10021 atcctcctac attttttact ctgcaaatct tgggttattg cacattgtac ttcctagttt
    10081 ttatgaattt attcacttgt ctccatccac tttgtaggga caacatggac agttaaatct
    10141 ttgtcagtta tatgaacata atgctaattt ctctcatatt tttattgcat gctaaaaata
    10201 atgcttgcca aatggaatct tagacatccc agaataatat ggtcactata tttctatttc
    10261 tgtcattatt gaaaataccc agctcagtgc ctggctcaat aaatgtttgt tttcctggct
    10321 tgtccttc
//
