LOCUS       NM_201615               1572 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus prolactin releasing hormone receptor (Prlhr), mRNA.
ACCESSION   NM_201615 XM_140765
VERSION     NM_201615.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1572)
  AUTHORS   Talbot,F., Feetham,C.H., Mokrosinski,J., Lawler,K., Keogh,J.M.,
            Henning,E., Mendes de Oliveira,E., Ayinampudi,V., Saeed,S.,
            Bonnefond,A., Arslan,M., Yeo,G.S.H., Froguel,P., Bechtold,D.A.,
            Adamson,A., Humphreys,N., Barroso,I., Luckman,S.M. and Farooqi,I.S.
  TITLE     A rare human variant that disrupts GPR10 signalling causes weight
            gain in mice
  JOURNAL   Nat Commun 14 (1), 1450 (2023)
   PUBMED   36922513
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1572)
  AUTHORS   Prazienkova,V., Funda,J., Pirnik,Z., Karnosova,A., Hruba,L.,
            Korinkova,L., Neprasova,B., Janovska,P., Benzce,M., Kadlecova,M.,
            Blahos,J., Kopecky,J., Zelezna,B., Kunes,J., Bardova,K. and
            Maletinska,L.
  TITLE     GPR10 gene deletion in mice increases basal neuronal activity,
            disturbs insulin sensitivity and alters lipid homeostasis
  JOURNAL   Gene 774, 145427 (2021)
   PUBMED   33450349
  REMARK    GeneRIF: GPR10 gene deletion in mice increases basal neuronal
            activity, disturbs insulin sensitivity and alters lipid
            homeostasis.
REFERENCE   3  (bases 1 to 1572)
  AUTHORS   Badgandi,H.B., Hwang,S.H., Shimada,I.S., Loriot,E. and
            Mukhopadhyay,S.
  TITLE     Tubby family proteins are adapters for ciliary trafficking of
            integral membrane proteins
  JOURNAL   J Cell Biol 216 (3), 743-760 (2017)
   PUBMED   28154160
REFERENCE   4  (bases 1 to 1572)
  AUTHORS   Omori,Y., Chaya,T., Yoshida,S., Irie,S., Tsujii,T. and Furukawa,T.
  TITLE     Identification of G Protein-Coupled Receptors (GPCRs) in Primary
            Cilia and Their Possible Involvement in Body Weight Control
  JOURNAL   PLoS One 10 (6), e0128422 (2015)
   PUBMED   26053317
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1572)
  AUTHORS   Bjursell,M., Lenneras,M., Goransson,M., Elmgren,A. and
            Bohlooly-Y,M.
  TITLE     GPR10 deficiency in mice results in altered energy expenditure and
            obesity
  JOURNAL   Biochem Biophys Res Commun 363 (3), 633-638 (2007)
   PUBMED   17904108
  REMARK    GeneRIF: Female mice deficient of the gene encoding GPR10 develop
            higher body weight and obesity due to lower energy expenditure.
REFERENCE   6  (bases 1 to 1572)
  AUTHORS   Bechtold,D.A. and Luckman,S.M.
  TITLE     Prolactin-releasing Peptide mediates cholecystokinin-induced
            satiety in mice
  JOURNAL   Endocrinology 147 (10), 4723-4729 (2006)
   PUBMED   16794001
REFERENCE   7  (bases 1 to 1572)
  AUTHORS   Laurent,P., Becker,J.A., Valverde,O., Ledent,C., de Kerchove
            d'Exaerde,A., Schiffmann,S.N., Maldonado,R., Vassart,G. and
            Parmentier,M.
  TITLE     The prolactin-releasing peptide antagonizes the opioid system
            through its receptor GPR10
  JOURNAL   Nat Neurosci 8 (12), 1735-1741 (2005)
   PUBMED   16299503
  REMARK    GeneRIF: Altogether, our data identify the PrRP-GPR10 system as a
            new and potent negative modulator of the opioid system.
REFERENCE   8  (bases 1 to 1572)
  AUTHORS   Gu,W., Geddes,B.J., Zhang,C., Foley,K.P. and Stricker-Krongrad,A.
  TITLE     The prolactin-releasing peptide receptor (GPR10) regulates body
            weight homeostasis in mice
  JOURNAL   J Mol Neurosci 22 (1-2), 93-103 (2004)
   PUBMED   14742914
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC167713.2.
            
            On Aug 28, 2009 this sequence version replaced NM_201615.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC125651.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1572              AC167713.2         34837-36408         c
FEATURES             Location/Qualifiers
     source          1..1572
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 56.52 cM"
     gene            1..1572
                     /gene="Prlhr"
                     /gene_synonym="Gm339; Gpr10; Gr3; Prrpr"
                     /note="prolactin releasing hormone receptor"
                     /db_xref="GeneID:226278"
                     /db_xref="MGI:MGI:2135956"
     exon            1..1572
                     /gene="Prlhr"
                     /gene_synonym="Gm339; Gpr10; Gr3; Prrpr"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..1291
                     /gene="Prlhr"
                     /gene_synonym="Gm339; Gpr10; Gr3; Prrpr"
                     /note="PrRP receptor; G-protein coupled receptor 10"
                     /codon_start=1
                     /product="prolactin-releasing peptide receptor"
                     /protein_id="NP_963909.2"
                     /db_xref="CCDS:CCDS29940.1"
                     /db_xref="GeneID:226278"
                     /db_xref="MGI:MGI:2135956"
                     /translation="MTSLSTETTGDPDLSSGLLPASSTPANQSAEASEGNLSATVPRA
                     AAVTPFQSLQLVHQLKGLIVMLYSIVVVVGLVGNCLLVLVIARVRRLHNVTNFLIGNL
                     ALSDVLMCAACVPLTLAYAFEPRGWVFGGGLCHLVFFLQPVTVYVSVFTLTTIALDRY
                     VVLVHPLRRRISLRLSAYAVLGIWALSAVLALPAAVHTYHVELKPHDVSLCEEFWGSQ
                     ERQRQIYAWGLLLGTYLLPLLAILLSYVRVSVKLRNRVVPGSVTQSQADWDRARRRRT
                     FCLLVVVVVVFAVCWLPLHIFNLLRDLDPRAIDPYAFGLVQLLCHWLAMSSACYNPFI
                     YAWLHDSFREELRKMLLSWPRKIVPHGQNMTVSVVI"
ORIGIN      
        1 cacgaatagg agctgtttaa agaacctgtg ttaggcttat ttttatagaa ctggaaggac
       61 aacattcatt gcgcttgatg ttctgggtct tgtgtccaag agaggagttg ggtggtggga
      121 aaaggtacac gagggaagat ggaaagtgac aactttgatt acctttgaac aggtagccat
      181 gacctcactg tccactgaga ccactggaga ccccgatttg tcttctgggc tgttgccagc
      241 tagctcgact ccagccaacc agagcgcaga ggcctcggag ggcaacctgt ctgcaacggt
      301 tccccgagct gcagcagtca cgccgttcca gagcctgcag ctggtgcacc agctgaaggg
      361 gttgatcgtg atgctgtaca gcatcgtggt ggtcgtgggt ctggtgggca actgcctgct
      421 tgtgctggtg atcgcgcgcg tgcgccggct gcacaacgtg accaacttcc tcattggcaa
      481 cctggccttg tccgacgtgc tcatgtgtgc cgcctgtgtg cctctcacgc tagcttatgc
      541 ctttgaacct cggggctggg tgttcggtgg aggcctgtgt catctggttt tcttcctgca
      601 gccggtcacc gtctatgtat cggtgttcac actcaccaca atcgccttgg accgctatgt
      661 ggttctggtg cacccgctac gtcggcgcat ttcactgagg ctcagcgcct acgcggtgct
      721 gggcatctgg gctctatctg cagtgctggc gctgccggcc gcggtgcaca cctaccatgt
      781 ggagctcaag ccccacgacg tgagcctctg cgaggagttc tggggctcgc aggagcgcca
      841 acgccagatc tacgcctggg ggctgcttct gggcacctat ttgctccccc tgctggccat
      901 cctcctgtct tacgtacggg tgtcagtgaa gctgaggaac cgcgtggtgc ctggcagcgt
      961 gacccagagt caagctgact gggaccgagc gcgtcgccgc cgcactttct gtctgctggt
     1021 ggtggtggtg gtagtgttcg cggtctgctg gctgccgctg cacattttca acctattgcg
     1081 agacctggac ccgcgtgcca tcgaccccta cgccttcggg ctggtgcagc tactctgcca
     1141 ctggcttgct atgagctccg cctgctacaa ccccttcatc tatgcatggc tgcacgacag
     1201 ctttcgagag gagctgcgca agatgctgct gtcctggccc cgcaagattg tgcctcatgg
     1261 ccagaacatg actgtcagcg tggtcatctg atgtcgctct gccaggtccg agctggggaa
     1321 attcatatcc cttagcccca gaggtcgtcg tgagatctta ttcccagcac caaagttaag
     1381 ccaacacatg cgaattccca cccagccctt ttgatttgtc tggtttttgt gtttctgtga
     1441 aatgttaggt gggctttgga gcagaagagc ctggggagag agagagaagc agatttatca
     1501 ggtctacccc tgaaagcaaa acagctattt ttctgggttc agaaaaataa atcagtagca
     1561 ggtctttctt tc
//
