LOCUS       NM_001101647             469 bp    mRNA    linear   ROD 08-AUG-2023
DEFINITION  Mus musculus prolactin releasing hormone (Prlh), mRNA.
ACCESSION   NM_001101647 XM_006529772 XM_887970 XM_907371
VERSION     NM_001101647.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cheng W, Ndoka E, Maung JN, Pan W, Rupp AC, Rhodes CJ, Olson DP and
            Myers MG Jr.
  TITLE     NTS Prlh overcomes orexigenic stimuli and ameliorates dietary and
            genetic forms of obesity
  JOURNAL   Nat Commun 12 (1), 5175 (2021)
   PUBMED   34462445
  REMARK    GeneRIF: NTS Prlh overcomes orexigenic stimuli and ameliorates
            dietary and genetic forms of obesity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Worth AA, Shoop R, Tye K, Feetham CH, D'Agostino G, Dodd GT,
            Reimann F, Gribble FM, Beebe EC, Dunbar JD, Alexander-Chacko JT,
            Sindelar DK, Coskun T, Emmerson PJ and Luckman SM.
  TITLE     The cytokine GDF15 signals through a population of brainstem
            cholecystokinin neurons to mediate anorectic signalling
  JOURNAL   Elife 9, e55164 (2020)
   PUBMED   32723474
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 469)
  AUTHORS   Dodd GT, Worth AA, Nunn N, Korpal AK, Bechtold DA, Allison MB,
            Myers MG Jr, Statnick MA and Luckman SM.
  TITLE     The thermogenic effect of leptin is dependent on a distinct
            population of prolactin-releasing peptide neurons in the
            dorsomedial hypothalamus
  JOURNAL   Cell Metab 20 (4), 639-649 (2014)
   PUBMED   25176149
REFERENCE   4  (bases 1 to 469)
  AUTHORS   Yoshida M, Takayanagi Y and Onaka T.
  TITLE     The medial amygdala-medullary PrRP-synthesizing neuron pathway
            mediates neuroendocrine responses to contextual conditioned fear in
            male rodents
  JOURNAL   Endocrinology 155 (8), 2996-3004 (2014)
   PUBMED   24877622
  REMARK    GeneRIF: The medial amygdala-medullary PrRP-synthesizing neuron
            pathway plays an important role in neuroendocrine responses to
            contextual conditioned fear
REFERENCE   5  (bases 1 to 469)
  AUTHORS   Sasaki K, Suzuki A, Kagatsume S, Ono M, Matsuzawa K, Taguchi Y and
            Kurihara Y.
  TITLE     Acetylation of Prrp K150 regulates the subcellular localization
  JOURNAL   Gene 491 (1), 13-19 (2012)
   PUBMED   22001406
REFERENCE   6  (bases 1 to 469)
  AUTHORS   Sun B, Mochiduki A, Nakamura K, Yokoyama K, Adachi S, Fujiwara K,
            Matsumoto H and Inoue K.
  TITLE     Blockade of PrRP attenuates MPTP-induced toxicity in mice
  JOURNAL   Peptides 30 (7), 1267-1275 (2009)
   PUBMED   19540425
  REMARK    GeneRIF: Data report that PrRP and its receptor, GPR10, were found
            in the mouse substantia nigra pars compacta (SNpc), the main
            location of dopaminergic (DA) neurons of the nigrostriatal system.
REFERENCE   7  (bases 1 to 469)
  AUTHORS   De Santo C, Salio M, Masri SH, Lee LY, Dong T, Speak AO, Porubsky
            S, Booth S, Veerapen N, Besra GS, Grone HJ, Platt FM, Zambon M and
            Cerundolo V.
  TITLE     Invariant NKT cells reduce the immunosuppressive activity of
            influenza A virus-induced myeloid-derived suppressor cells in mice
            and humans
  JOURNAL   J Clin Invest 118 (12), 4036-4048 (2008)
   PUBMED   19033672
REFERENCE   8  (bases 1 to 469)
  AUTHORS   Takayanagi Y, Matsumoto H, Nakata M, Mera T, Fukusumi S, Hinuma S,
            Ueta Y, Yada T, Leng G and Onaka T.
  TITLE     Endogenous prolactin-releasing peptide regulates food intake in
            rodents
  JOURNAL   J Clin Invest 118 (12), 4014-4024 (2008)
   PUBMED   19033670
  REMARK    Erratum:[J Clin Invest. 2009 Feb;119(2):422]
REFERENCE   9  (bases 1 to 469)
  AUTHORS   Komatsu D, Abe T, Sano Y, Shimazaki K, Tomita M, Kanayama N and
            Takahashi K.
  TITLE     Increase of the trophoblast giant cells with prolactin-releasing
            peptide (PrRP) receptor expression in p53-null mice
  JOURNAL   Mol Reprod Dev 74 (9), 1089-1094 (2007)
   PUBMED   17410546
  REMARK    GeneRIF: These results suggest that p53 may regulate the
            differentiation of trophoblast giant cells, and may control the
            physiological PrRP stimuli in mouse placentas.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC118682.8.
            
            On or before Oct 12, 2022 this sequence version replaced
            XM_006529772.3, NM_001101647.1.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            CDS exon combination :: FJ424613.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849374, SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                AC118682.8         69885-69933         c
            50-191              AC118682.8         68552-68693         c
            192-469             AC118682.8         67630-67907         c
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 45.81 cM"
     gene            1..469
                     /gene="Prlh"
                     /gene_synonym="EG623503"
                     /note="prolactin releasing hormone"
                     /db_xref="GeneID:623503"
                     /db_xref="MGI:MGI:3644668"
     exon            1..49
                     /gene="Prlh"
                     /gene_synonym="EG623503"
                     /inference="alignment:Splign:2.1.0"
     exon            50..191
                     /gene="Prlh"
                     /gene_synonym="EG623503"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..355
                     /gene="Prlh"
                     /gene_synonym="EG623503"
                     /note="prolactin-releasing peptide"
                     /codon_start=1
                     /product="prolactin-releasing peptide precursor"
                     /protein_id="NP_001095117.1"
                     /db_xref="CCDS:CCDS48318.1"
                     /db_xref="GeneID:623503"
                     /db_xref="MGI:MGI:3644668"
                     /translation="MAPRTWLLCLLLLGLVLPGASSRAHQHSMETRTPDINPAWYTGR
                     GIRPVGRFGRRRAALRDVTGPGLRCRLSCFPLDGSAKFSHSS"
     exon            192..469
                     /gene="Prlh"
                     /gene_synonym="EG623503"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acctcacgcc caggcagcct tatcgccaca ctcaagggac agagagaggg cttcaggatc
       61 caatctccag ggcatcatcc aggaagccgg aagcatggca ccgaggacct ggcttctgtg
      121 cttgctgctg ctaggcttag tcctcccagg agcttccagc cgagcccacc agcactccat
      181 ggagacccgc acccctgaca tcaatcctgc ctggtacacg ggtcgtggga tcaggcctgt
      241 gggccgcttc gggaggagga gggcagccct gagggatgtc accggacctg gcctgcggtg
      301 ccggctaagc tgcttcccac tggatggaag tgccaagttc tctcacagct catgaagaca
      361 gtgatgctga gcccaagccc accctccctg tccccccgca gagcctcctc caccctccct
      421 ttccggtttt ccctctgatc taataaaagt gctggctttg tttattgta
//
