LOCUS       NM_011120                997 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus prolactin family 7, subfamily d, member 1 (Prl7d1),
            transcript variant 1, mRNA.
ACCESSION   NM_011120
VERSION     NM_011120.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 997)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 997)
  AUTHORS   Roberts,G.A.G. and Tunster,S.J.
  TITLE     Characterising the dynamics of placental glycogen stores in the
            mouse
  JOURNAL   Placenta 99, 131-140 (2020)
   PUBMED   32798765
REFERENCE   3  (bases 1 to 997)
  AUTHORS   Zhang,Q., Hao,J. and Li,G.
  TITLE     Deletion of Prl7d1 causes placental defects at mid-pregnancy in
            mice
  JOURNAL   Mol Reprod Dev 86 (6), 696-713 (2019)
   PUBMED   31012985
  REMARK    GeneRIF: Together, this study demonstrates that Prl7d1 possesses
            antiangiogenic properties in deciduas and inhibits the development
            of junctional zone, which potentially alters the functional
            capacity of the placenta to support optimal fetal growth.
REFERENCE   4  (bases 1 to 997)
  AUTHORS   Liu,Y., Su,X., Hao,J., Chen,M., Liu,W., Liao,X. and Li,G.
  TITLE     Overexpression of PRL7D1 in Leydig Cells Causes Male Reproductive
            Dysfunction in Mice
  JOURNAL   Int J Mol Sci 17 (1), 96 (2016)
   PUBMED   26771609
  REMARK    GeneRIF: PRL7D1 overexpression could lead to increased germ cell
            apoptosis and exert an inhibitory effect on testosterone production
            in Leydig cells by reducing the expression of certain
            steroidogenic-related genes.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 997)
  AUTHORS   Premzl,M.
  TITLE     Curated eutherian third party data gene data sets
  JOURNAL   Data Brief 6, 208-213 (2015)
   PUBMED   26862561
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 997)
  AUTHORS   Yamaguchi,M., Imai,T., Maeda,T., Sakata,M., Miyake,A. and
            Linzer,D.I.
  TITLE     Cyclic adenosine 3',5'-monophosphate stimulation of placental
            proliferin and proliferin-related protein secretion
  JOURNAL   Endocrinology 136 (5), 2040-2046 (1995)
   PUBMED   7720652
REFERENCE   7  (bases 1 to 997)
  AUTHORS   Jackson,D., Volpert,O.V., Bouck,N. and Linzer,D.I.
  TITLE     Stimulation and inhibition of angiogenesis by placental proliferin
            and proliferin-related protein
  JOURNAL   Science 266 (5190), 1581-1584 (1994)
   PUBMED   7527157
REFERENCE   8  (bases 1 to 997)
  AUTHORS   Colosi,P., Swiergiel,J.J., Wilder,E.L., Oviedo,A. and Linzer,D.I.
  TITLE     Characterization of proliferin-related protein
  JOURNAL   Mol Endocrinol 2 (6), 579-586 (1988)
   PUBMED   3047555
REFERENCE   9  (bases 1 to 997)
  AUTHORS   Jackson-Grusby,L.L., Pravtcheva,D., Ruddle,F.H. and Linzer,D.I.
  TITLE     Chromosomal mapping of the prolactin/growth hormone gene family in
            the mouse
  JOURNAL   Endocrinology 122 (6), 2462-2466 (1988)
   PUBMED   2836164
REFERENCE   10 (bases 1 to 997)
  AUTHORS   Linzer,D.I. and Nathans,D.
  TITLE     A new member of the prolactin-growth hormone gene family expressed
            in mouse placenta
  JOURNAL   EMBO J 4 (6), 1419-1423 (1985)
   PUBMED   4029117
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            X02594.1 and AK005421.1.
            
            On Mar 27, 2010 this sequence version replaced NM_011120.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X02594.1, AK005557.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-972               X02594.1           1-972
            973-997             AK005421.1         970-994
FEATURES             Location/Qualifiers
     source          1..997
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 12.6 cM"
     gene            1..997
                     /gene="Prl7d1"
                     /gene_synonym="Ghd19; PLF-RP; Plfr; PRP"
                     /note="prolactin family 7, subfamily d, member 1"
                     /db_xref="GeneID:18814"
                     /db_xref="MGI:MGI:97619"
     exon            1..99
                     /gene="Prl7d1"
                     /gene_synonym="Ghd19; PLF-RP; Plfr; PRP"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..803
                     /gene="Prl7d1"
                     /gene_synonym="Ghd19; PLF-RP; Plfr; PRP"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; prolactin-7D1; proliferin-related protein;
                     growth hormone d19"
                     /codon_start=1
                     /product="prolactin-7D1 isoform 1 precursor"
                     /protein_id="NP_035250.1"
                     /db_xref="CCDS:CCDS26405.1"
                     /db_xref="GeneID:18814"
                     /db_xref="MGI:MGI:97619"
                     /translation="MLPSLIQPCSSGTLLMLLMSNLFLWEKVSSAPINASEAVLSDLK
                     DLFDNATVLSGEMSKLGVIMRKEFFMNSFSSETFNKIILDLHKSTENITKAFNSCHTV
                     PINVPETVEDVRKTSFEEFLKMVLHMLLAWKEPLKHLVTELSALPECPYRILSKAEAI
                     EAKNKDLLEYIIRIISKVNPAIKENEDYPTWSDLDSLKSADKETQFFALYMFSFCLRI
                     DLETVDFLVNFLKCLLLYDDVCYSEF"
     exon            100..272
                     /gene="Prl7d1"
                     /gene_synonym="Ghd19; PLF-RP; Plfr; PRP"
                     /inference="alignment:Splign:2.1.0"
     exon            273..311
                     /gene="Prl7d1"
                     /gene_synonym="Ghd19; PLF-RP; Plfr; PRP"
                     /inference="alignment:Splign:2.1.0"
     exon            312..419
                     /gene="Prl7d1"
                     /gene_synonym="Ghd19; PLF-RP; Plfr; PRP"
                     /inference="alignment:Splign:2.1.0"
     exon            420..599
                     /gene="Prl7d1"
                     /gene_synonym="Ghd19; PLF-RP; Plfr; PRP"
                     /inference="alignment:Splign:2.1.0"
     exon            600..997
                     /gene="Prl7d1"
                     /gene_synonym="Ghd19; PLF-RP; Plfr; PRP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      954..959
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prl7d1"
                     /gene_synonym="Ghd19; PLF-RP; Plfr; PRP"
                     /note="hexamer: AATAAA"
     polyA_site      976
                     /gene="Prl7d1"
                     /gene_synonym="Ghd19; PLF-RP; Plfr; PRP"
                     /note="major polyA site"
ORIGIN      
        1 aaggcttcca actccagtga agcatctccc cggaatccac agctaagcct ggctaggact
       61 ctgcagagat gctcccttct ttgatccaac cgtgctcctc agggactctc ctgatgctgt
      121 tgatgtcaaa tctcttcctg tgggagaagg tgtcctctgc acccataaat gccagtgagg
      181 ctgttctcag tgatctgaag gacttgtttg ataatgccac tgtactttct ggagagatgt
      241 ctaagcttgg tgtaatcatg cgcaaagaat ttttcatgaa ctcattctct tcagagacgt
      301 tcaataagat tatattagat ttgcacaaga gtacggagaa tataaccaag gctttcaaca
      361 gctgccacac tgttcccatc aacgttcctg aaacagttga ggatgtccga aagacatcgt
      421 ttgaagagtt tttgaaaatg gtgctccata tgctgctagc ctggaaagag cctctgaaac
      481 atctagtgac agaactcagt gctttgccag aatgccctta taggatccta tcaaaggccg
      541 aagccattga ggcaaaaaac aaagaccttc tagagtacat cataagaata atatctaagg
      601 ttaatcctgc aatcaaagaa aatgaagact acccgacctg gtcagatttg gactccctga
      661 agtcagctga taaagaaact caattttttg ctctttatat gttttccttc tgcctgcgta
      721 ttgacctaga aacagttgat tttctagtca atttcctaaa atgtctgctt ctttatgatg
      781 atgtctgcta ctctgaattt tgagatatta catgatccat cttttggaat cttcttctag
      841 tctttgcact ttgaatatat gattaaatct aatgtaaatc tattagtaaa aagagacaac
      901 agatatgtct agttgttaag aaagttttaa atttaaattg cagaatatgt atcaataaag
      961 tggtataaac ataaaagaac tctctttttc tcaactc
//
