LOCUS       NM_181852                845 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus prolactin family 2, subfamily c, member 5 (Prl2c5),
            transcript variant 2, mRNA.
ACCESSION   NM_181852 XM_195807
VERSION     NM_181852.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 845)
  AUTHORS   Sallais,J., Park,C., Alahari,S., Porter,T., Liu,R., Kurt,M.,
            Farrell,A., Post,M. and Caniggia,I.
  TITLE     HIF1 inhibitor acriflavine rescues early-onset preeclampsia
            phenotype in mice lacking placental prolyl hydroxylase domain
            protein 2
  JOURNAL   JCI Insight 7 (23), e158908 (2022)
   PUBMED   36227697
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 845)
  AUTHORS   Premzl,M.
  TITLE     Curated eutherian third party data gene data sets
  JOURNAL   Data Brief 6, 208-213 (2015)
   PUBMED   26862561
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 845)
  AUTHORS   Premzl,M.
  TITLE     Third party data gene data set of eutherian growth hormone genes
  JOURNAL   Genom Data 6, 166-169 (2015)
   PUBMED   26697363
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 845)
  AUTHORS   Hayakawa,K., Nakanishi,M.O., Ohgane,J., Tanaka,S., Hirosawa,M.,
            Soares,M.J., Yagi,S. and Shiota,K.
  TITLE     Bridging sequence diversity and tissue-specific expression by DNA
            methylation in genes of the mouse prolactin superfamily
  JOURNAL   Mamm Genome 23 (5-6), 336-345 (2012)
   PUBMED   22193412
REFERENCE   5  (bases 1 to 845)
  AUTHORS   Simmons,D.G., Rawn,S., Davies,A., Hughes,M. and Cross,J.C.
  TITLE     Spatial and temporal expression of the 23 murine
            Prolactin/Placental Lactogen-related genes is not associated with
            their position in the locus
  JOURNAL   BMC Genomics 9, 352 (2008)
   PUBMED   18662396
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 845)
  AUTHORS   Soares,M.J., Alam,S.M., Duckworth,M.L., Horseman,N.D., Konno,T.,
            Linzer,D.I., Maltais,L.J., Nilsen-Hamilton,M., Shiota,K.,
            Smith,J.R. and Wallis,M.
  TITLE     A standardized nomenclature for the mouse and rat prolactin
            superfamilies
  JOURNAL   Mamm Genome 18 (3), 154-156 (2007)
   PUBMED   17476555
REFERENCE   7  (bases 1 to 845)
  AUTHORS   Wang,J.W., Jiang,Y.N., Huang,C.Y., Huang,P.Y., Huang,M.C.,
            Cheng,W.T., Shen,C.K. and Ju,Y.T.
  TITLE     Proliferin enhances microvilli formation and cell growth of
            neuroblastoma cells
  JOURNAL   Neurosci Res 56 (1), 80-90 (2006)
   PUBMED   16876275
REFERENCE   8  (bases 1 to 845)
  AUTHORS   Wiemers,D.O., Shao,L.J., Ain,R., Dai,G. and Soares,M.J.
  TITLE     The mouse prolactin gene family locus
  JOURNAL   Endocrinology 144 (1), 313-325 (2003)
   PUBMED   12488360
REFERENCE   9  (bases 1 to 845)
  AUTHORS   Fassett,J.T., Hamilton,R.T. and Nilsen-Hamilton,M.
  TITLE     Mrp4, a new mitogen-regulated protein/proliferin gene; unique in
            this gene family for its expression in the adult mouse tail and ear
  JOURNAL   Endocrinology 141 (5), 1863-1871 (2000)
   PUBMED   10803597
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT030187.7.
            
            On Jul 24, 2015 this sequence version replaced NM_181852.1.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the 5' coding region and uses an upstream start codon
            compared to variant 1. The encoded isoform (2) has a shorter and
            distinct N-terminus compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CK020843.1, CF618100.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                CT030187.7         159063-159159
            98-273              CT030187.7         162137-162312
            274-381             CT030187.7         165715-165822
            382-564             CT030187.7         166933-167115
            565-845             CT030187.7         167992-168272
FEATURES             Location/Qualifiers
     source          1..845
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 5.21 cM"
     gene            1..845
                     /gene="Prl2c5"
                     /gene_synonym="Ghd3; MRP-4; Mrpplf4; PLF-4"
                     /note="prolactin family 2, subfamily c, member 5"
                     /db_xref="GeneID:107849"
                     /db_xref="MGI:MGI:1858413"
     exon            1..97
                     /gene="Prl2c5"
                     /gene_synonym="Ghd3; MRP-4; Mrpplf4; PLF-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..735
                     /gene="Prl2c5"
                     /gene_synonym="Ghd3; MRP-4; Mrpplf4; PLF-4"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; mitogen regulated protein, proliferin 4; growth
                     hormone d3; mitogen-regulated protein 4; prolactin-2C5"
                     /codon_start=1
                     /product="prolactin-2C5 isoform 2 precursor"
                     /protein_id="NP_862900.1"
                     /db_xref="CCDS:CCDS26242.1"
                     /db_xref="GeneID:107849"
                     /db_xref="MGI:MGI:1858413"
                     /translation="MLPSLIQPCSWILLLLLVNSSLLWKNVASLPMCAMRNDRCFMFF
                     EDTFELAGSLSHNISIEVSELFTEFEKHYSNVPGLRDKSPMRCHTSFLPTPENKEQAR
                     HIRYEALLKSGDMILDAWENPLDYLVSELSTIKNVPDIIISKATDIKKKINAVQNGVN
                     ALMSTMNGDEENKNPAWFLQSDNEDARIRSSYGMISCLDNDFKKVDIYLNILKCYMLK
                     IDNC"
     exon            98..273
                     /gene="Prl2c5"
                     /gene_synonym="Ghd3; MRP-4; Mrpplf4; PLF-4"
                     /inference="alignment:Splign:2.1.0"
     exon            274..381
                     /gene="Prl2c5"
                     /gene_synonym="Ghd3; MRP-4; Mrpplf4; PLF-4"
                     /inference="alignment:Splign:2.1.0"
     exon            382..564
                     /gene="Prl2c5"
                     /gene_synonym="Ghd3; MRP-4; Mrpplf4; PLF-4"
                     /inference="alignment:Splign:2.1.0"
     exon            565..845
                     /gene="Prl2c5"
                     /gene_synonym="Ghd3; MRP-4; Mrpplf4; PLF-4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      822..827
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prl2c5"
                     /gene_synonym="Ghd3; MRP-4; Mrpplf4; PLF-4"
                     /note="hexamer: AATAAA"
     polyA_site      845
                     /gene="Prl2c5"
                     /gene_synonym="Ghd3; MRP-4; Mrpplf4; PLF-4"
                     /note="major polyA site"
ORIGIN      
        1 ggcttccaac tccagtgaag aatctttctg gaatccacag ctaagcctgg gtaggactct
       61 gcagagatgc tcccttcttt gattcaacca tgctcctgga tactgctcct actactggtg
      121 aacagctcgt tattgtggaa gaatgttgca tcattgccca tgtgtgcaat gaggaatgat
      181 cgttgcttta tgttctttga agacacattt gaattagccg gcagtttgtc tcataatatc
      241 agtatagaag tttcagaact gttcactgag tttgaaaaac attattctaa cgtgcctggg
      301 ctcagagaca aaagccccat gagatgccat acttctttcc ttccaactcc agaaaacaag
      361 gaacaagcca ggcacatacg ctatgaagct cttctgaaat caggagacat gattttggat
      421 gcctgggaaa accctctgga ctatctagtg agtgaattat ctaccataaa aaatgtccct
      481 gatataatca tctccaaagc cacagacata aagaaaaaga tcaacgcagt ccagaacggg
      541 gttaatgccc tcatgagcac catgaatgga gatgaagaaa ataagaaccc tgcctggttc
      601 ttgcaatctg acaatgaaga tgctcgcatt cgttcttcat atggcatgat cagctgccta
      661 gacaatgact ttaagaaggt tgatatttat ctcaacatcc tgaagtgtta catgttaaaa
      721 atagataact gctgatactt ctttcatgtg ctctgcttct gaaatatcat gtagcatcct
      781 ttaaatttgt atcttttgaa tttgttgttg actcatttaa aaataaaaag tggctctcag
      841 aaaca
//
