LOCUS       NM_031191                852 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus prolactin family 2, subfamily c, member 2 (Prl2c2),
            mRNA.
ACCESSION   NM_031191 XM_001006498
VERSION     NM_031191.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 852)
  AUTHORS   Zhu,Z., Zou,Q., Wang,C., Li,D., Yang,Y., Xiao,Y., Jin,Y., Yan,J.,
            Luo,L., Sun,Y. and Liang,X.
  TITLE     Isl Identifies the Extraembryonic Mesodermal/Allantois Progenitors
            and is Required for Placenta Morphogenesis and Vasculature
            Formation
  JOURNAL   Adv Sci (Weinh) 11 (32), e2400238 (2024)
   PUBMED   38923264
REFERENCE   2  (bases 1 to 852)
  AUTHORS   Zheng,W., Zhang,Y., Xu,P., Wang,Z., Shao,X., Chen,C., Cai,H.,
            Wang,Y., Sun,M.A., Deng,W., Liu,F., Lu,J., Zhang,X., Cheng,D.,
            Mysorekar,I.U., Wang,H., Wang,Y.L., Hu,X. and Cao,B.
  TITLE     TFEB safeguards trophoblast syncytialization in humans and mice
  JOURNAL   Proc Natl Acad Sci U S A 121 (28), e2404062121 (2024)
   PUBMED   38968109
REFERENCE   3  (bases 1 to 852)
  AUTHORS   Lee,J.G., Yon,J.M., Kim,G., Lee,S.G., Kim,C.Y., Cheong,S.A.,
            Kim,H.Y., Yu,J., Kim,K., Sung,Y.H., Yoo,H.J., Woo,D.C., Rho,J.K.,
            Ha,C.H., Pack,C.G., Oh,S.H., Lim,J.S., Han,Y.M., Hong,E.J.,
            Seong,J.K., Lee,H.W., Lee,S.W., Lee,K.U., Kim,C.J., Nam,S.Y.,
            Cho,Y.S. and Baek,I.J.
  TITLE     PIBF1 regulates trophoblast syncytialization and promotes
            cardiovascular development
  JOURNAL   Nat Commun 15 (1), 1487 (2024)
   PUBMED   38374152
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 852)
  AUTHORS   Singh,V.P., Hassan,H., Deng,F., Tsuchiya,D., McKinney,S., Ferro,K.
            and Gerton,J.L.
  TITLE     Myc promotes polyploidy in murine trophoblast cells and suppresses
            senescence
  JOURNAL   Development 150 (11) (2023)
   PUBMED   37278344
REFERENCE   5  (bases 1 to 852)
  AUTHORS   Rusidze,M., Faure,M.C., Sicard,P., Raymond-Letron,I., Giton,F.,
            Vessieres,E., Prevot,V., Henrion,D., Arnal,J.F., Cornil,C.A. and
            Lenfant,F.
  TITLE     Loss of function of the maternal membrane oestrogen receptor
            ERalpha alters expansion of trophoblast cells and impacts mouse
            fertility
  JOURNAL   Development 149 (19) (2022)
   PUBMED   36239412
REFERENCE   6  (bases 1 to 852)
  AUTHORS   Wilder,E.L. and Linzer,D.I.
  TITLE     Participation of multiple factors, including proliferin, in the
            inhibition of myogenic differentiation
  JOURNAL   Mol Cell Biol 9 (2), 430-441 (1989)
   PUBMED   2469001
REFERENCE   7  (bases 1 to 852)
  AUTHORS   Jackson-Grusby,L.L., Pravtcheva,D., Ruddle,F.H. and Linzer,D.I.
  TITLE     Chromosomal mapping of the prolactin/growth hormone gene family in
            the mouse
  JOURNAL   Endocrinology 122 (6), 2462-2466 (1988)
   PUBMED   2836164
REFERENCE   8  (bases 1 to 852)
  AUTHORS   Lee,S.J. and Nathans,D.
  TITLE     Proliferin secreted by cultured cells binds to mannose 6-phosphate
            receptors
  JOURNAL   J Biol Chem 263 (7), 3521-3527 (1988)
   PUBMED   2963825
REFERENCE   9  (bases 1 to 852)
  AUTHORS   Linzer,D.I. and Mordacq,J.C.
  TITLE     Transcriptional regulation of proliferin gene expression in
            response to serum in transfected mouse cells
  JOURNAL   EMBO J 6 (8), 2281-2288 (1987)
   PUBMED   3478191
REFERENCE   10 (bases 1 to 852)
  AUTHORS   Lee,S.J. and Nathans,D.
  TITLE     Secretion of proliferin
  JOURNAL   Endocrinology 120 (1), 208-213 (1987)
   PUBMED   3780559
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT033774.17 and BC080826.1.
            
            On Feb 6, 2019 this sequence version replaced NM_031191.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC080826.1, CK022150.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                CT033774.17        132588-132597       c
            11-852              BC080826.1         13-854
FEATURES             Location/Qualifiers
     source          1..852
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 5.18 cM"
     gene            1..852
                     /gene="Prl2c2"
                     /gene_synonym="Ghd2; MRP-1; Plf; PLF-1; Plf1"
                     /note="prolactin family 2, subfamily c, member 2"
                     /db_xref="GeneID:18811"
                     /db_xref="MGI:MGI:97618"
     exon            1..98
                     /gene="Prl2c2"
                     /gene_synonym="Ghd2; MRP-1; Plf; PLF-1; Plf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..742
                     /gene="Prl2c2"
                     /gene_synonym="Ghd2; MRP-1; Plf; PLF-1; Plf1"
                     /note="prolactin-2C2; proliferin-1; mitogen-regulated
                     protein 1; growth hormone d2"
                     /codon_start=1
                     /product="prolactin-2C2 precursor"
                     /protein_id="NP_112468.1"
                     /db_xref="CCDS:CCDS36596.1"
                     /db_xref="GeneID:18811"
                     /db_xref="MGI:MGI:97618"
                     /translation="MLPSLIQPCSWILLLLLVNSSLLWKNVASFPMCAMRNGRCFMSF
                     EDTFELAGSLSHNISIEVSELFTEFEKHYSNVSGLRDKSPMRCNTSFLPTPENKEQAR
                     LTHYSALLKSGAMILDAWESPLDDLVSELSTIKNVPDIIISKATDIKKKINAVRNGVN
                     ALMSTMLQNGDEEKKNPAWFLQSDNEDARIHSLYGMISCLDNDFKKVDIYLNVLKCYM
                     LKIDNC"
     exon            99..274
                     /gene="Prl2c2"
                     /gene_synonym="Ghd2; MRP-1; Plf; PLF-1; Plf1"
                     /inference="alignment:Splign:2.1.0"
     exon            275..382
                     /gene="Prl2c2"
                     /gene_synonym="Ghd2; MRP-1; Plf; PLF-1; Plf1"
                     /inference="alignment:Splign:2.1.0"
     exon            383..565
                     /gene="Prl2c2"
                     /gene_synonym="Ghd2; MRP-1; Plf; PLF-1; Plf1"
                     /inference="alignment:Splign:2.1.0"
     exon            566..852
                     /gene="Prl2c2"
                     /gene_synonym="Ghd2; MRP-1; Plf; PLF-1; Plf1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggcttccaa ctccagtgaa gcatcttccc ggaatccaca gctaagcctg ggtaggactc
       61 tgcagagatg ctcccttctt tgattcaacc atgctcctgg atactgctcc tactactggt
      121 gaacagctcg ttattgtgga agaatgttgc ctcatttccc atgtgtgcaa tgaggaatgg
      181 tcgttgcttt atgtcctttg aagacacatt tgaattagcc ggcagtttgt ctcataatat
      241 cagtatagaa gtttcagaac tgttcactga atttgaaaaa cattattcta acgtgtctgg
      301 gctcagagac aaaagcccca tgagatgcaa tacttctttc cttccaactc cagaaaacaa
      361 ggaacaagcc aggctcacac actattcagc tcttctgaaa tcaggagcca tgattttgga
      421 tgcctgggaa agccctctgg acgatctagt gagtgaatta tctaccataa aaaatgtccc
      481 tgatataatc atctccaaag ccacagacat aaagaaaaag atcaacgcag tccggaacgg
      541 ggttaatgcc ctcatgagca ccatgcttca gaatggagat gaagaaaaga agaaccctgc
      601 ctggttcttg caatctgaca atgaagatgc tcgcattcat tctttatatg gcatgatcag
      661 ctgcctagac aatgacttta agaaggttga tatttatctc aacgtcctga agtgttacat
      721 gttaaaaata gataactgct gatatttctt tcatgtgctc tgcttctgaa atatcatgta
      781 atatcctttc aatttgtatc ttttgaattt gttgttgact catttaaaaa taaaaagtag
      841 ctctcagaaa ta
//
