LOCUS       NM_019991                886 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus prolactin family 2, subfamily a, member 1 (Prl2a1),
            mRNA.
ACCESSION   NM_019991
VERSION     NM_019991.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 886)
  AUTHORS   Zhu,Z., Zou,Q., Wang,C., Li,D., Yang,Y., Xiao,Y., Jin,Y., Yan,J.,
            Luo,L., Sun,Y. and Liang,X.
  TITLE     Isl Identifies the Extraembryonic Mesodermal/Allantois Progenitors
            and is Required for Placenta Morphogenesis and Vasculature
            Formation
  JOURNAL   Adv Sci (Weinh) 11 (32), e2400238 (2024)
   PUBMED   38923264
REFERENCE   2  (bases 1 to 886)
  AUTHORS   Roberts,G.A.G. and Tunster,S.J.
  TITLE     Characterising the dynamics of placental glycogen stores in the
            mouse
  JOURNAL   Placenta 99, 131-140 (2020)
   PUBMED   32798765
REFERENCE   3  (bases 1 to 886)
  AUTHORS   Tunster,S.J., McNamara,G.I., Creeth,H.D.J. and John,R.M.
  TITLE     Increased dosage of the imprinted Ascl2 gene restrains two key
            endocrine lineages of the mouse Placenta
  JOURNAL   Dev Biol 418 (1), 55-65 (2016)
   PUBMED   27542691
REFERENCE   4  (bases 1 to 886)
  AUTHORS   Premzl,M.
  TITLE     Curated eutherian third party data gene data sets
  JOURNAL   Data Brief 6, 208-213 (2015)
   PUBMED   26862561
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 886)
  AUTHORS   Premzl,M.
  TITLE     Third party data gene data set of eutherian growth hormone genes
  JOURNAL   Genom Data 6, 166-169 (2015)
   PUBMED   26697363
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 886)
  AUTHORS   Soares,M.J., Alam,S.M., Duckworth,M.L., Horseman,N.D., Konno,T.,
            Linzer,D.I., Maltais,L.J., Nilsen-Hamilton,M., Shiota,K.,
            Smith,J.R. and Wallis,M.
  TITLE     A standardized nomenclature for the mouse and rat prolactin
            superfamilies
  JOURNAL   Mamm Genome 18 (3), 154-156 (2007)
   PUBMED   17476555
REFERENCE   7  (bases 1 to 886)
  AUTHORS   Ain,R., Canham,L.N. and Soares,M.J.
  TITLE     Gestation stage-dependent intrauterine trophoblast cell invasion in
            the rat and mouse: novel endocrine phenotype and regulation
  JOURNAL   Dev Biol 260 (1), 176-190 (2003)
   PUBMED   12885563
  REMARK    GeneRIF: Invading mouse trophoblast cells possess endocrine
            activities, including the expression of PLP-M.
REFERENCE   8  (bases 1 to 886)
  AUTHORS   Toft,D.J. and Linzer,D.I.
  TITLE     Identification of three prolactin-related hormones as markers of
            invasive trophoblasts in the rat
  JOURNAL   Biol Reprod 63 (2), 519-525 (2000)
   PUBMED   10906059
REFERENCE   9  (bases 1 to 886)
  AUTHORS   Dai,G., Wang,D., Liu,B., Kasik,J.W., Muller,H., White,R.A.,
            Hummel,G.S. and Soares,M.J.
  TITLE     Three novel paralogs of the rodent prolactin gene family
  JOURNAL   J Endocrinol 166 (1), 63-75 (2000)
   PUBMED   10856884
REFERENCE   10 (bases 1 to 886)
  AUTHORS   Ishibashi,K. and Imai,M.
  TITLE     Identification of four new members of the rat prolactin/growth
            hormone gene family
  JOURNAL   Biochem Biophys Res Commun 262 (3), 575-578 (1999)
   PUBMED   10471365
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF234636.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF234636.1, AB032428.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..886
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 12.62 cM"
     gene            1..886
                     /gene="Prl2a1"
                     /gene_synonym="Ghd21; PLP-M; Prlpm"
                     /note="prolactin family 2, subfamily a, member 1"
                     /db_xref="GeneID:56635"
                     /db_xref="MGI:MGI:1861446"
     exon            1..79
                     /gene="Prl2a1"
                     /gene_synonym="Ghd21; PLP-M; Prlpm"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..735
                     /gene="Prl2a1"
                     /gene_synonym="Ghd21; PLP-M; Prlpm"
                     /note="prolactin-2A1; PRL-like protein M; placental
                     prolactin-like protein M; growth hormone d21"
                     /codon_start=1
                     /product="prolactin-2A1 precursor"
                     /protein_id="NP_064375.1"
                     /db_xref="CCDS:CCDS26407.1"
                     /db_xref="GeneID:56635"
                     /db_xref="MGI:MGI:1861446"
                     /translation="MQLSVTHPCCRTLILLLVSNLLLWESEAVLPICSVRNGRCFGSF
                     EELLERAVSLSEEISKKAFELFTAFDSQYAQSHQLIVKSLKKCHTSSLDLPKPGSQAM
                     QTHPVTLLKLASKLLRAWQVPLNHLVNNLPSLKNVSPSILSKAKEIEEKSNGLLEGVK
                     SILIQMQNGDTEDENYPGWSGLASLKSETEDIRLFAYYNMIRCEGRDTQKVETALKMV
                     KCKISNENNC"
     exon            80..255
                     /gene="Prl2a1"
                     /gene_synonym="Ghd21; PLP-M; Prlpm"
                     /inference="alignment:Splign:2.1.0"
     exon            256..363
                     /gene="Prl2a1"
                     /gene_synonym="Ghd21; PLP-M; Prlpm"
                     /inference="alignment:Splign:2.1.0"
     exon            364..543
                     /gene="Prl2a1"
                     /gene_synonym="Ghd21; PLP-M; Prlpm"
                     /inference="alignment:Splign:2.1.0"
     exon            544..870
                     /gene="Prl2a1"
                     /gene_synonym="Ghd21; PLP-M; Prlpm"
                     /inference="alignment:Splign:2.1.0"
     regulatory      850..855
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prl2a1"
                     /gene_synonym="Ghd21; PLP-M; Prlpm"
                     /note="hexamer: AATAAA"
     polyA_site      870
                     /gene="Prl2a1"
                     /gene_synonym="Ghd21; PLP-M; Prlpm"
                     /note="major polyA site"
ORIGIN      
        1 ggaagaattc ctgacgctgt agtcagcctg ctgtggaact cctcagagat gcagctatct
       61 gtaactcatc cttgctgcag gaccctgatt ctgctcctgg tgtctaacct gcttctgtgg
      121 gaaagtgagg ccgtgctgcc catatgctca gtaaggaatg gacgctgctt tggttccttt
      181 gaagaactgc ttgaaagagc tgtcagtttg tctgaagaga taagtaaaaa agcctttgaa
      241 ctcttcactg catttgatag tcagtatgcc cagagccacc agctcattgt caagagcctc
      301 aaaaaatgtc acacatcttc tctcgacctt ccaaaaccag ggagtcaagc catgcagaca
      361 catcctgtaa ccctactgaa attagcaagc aaattattga gagcctggca agtccctctg
      421 aaccatctag tgaacaacct gccatccttg aaaaacgtct ctccttctat cctctctaaa
      481 gccaaagaga ttgaggaaaa gagcaatgga ctcctggagg gagttaagag cattctcatc
      541 caaatgcaaa atggagatac agaagatgag aactaccctg gctggtctgg actggcatcc
      601 ttgaagtcag agactgaaga tattcgcctc tttgcatatt ataacatgat ccgctgtgag
      661 ggcagagaca ctcagaaggt tgaaactgct ctcaagatgg tgaaatgcaa aatttcaaat
      721 gaaaacaact gctaagccct tttcatcata tcttcgtctg agccactgct tgatgatata
      781 ttgctgtgaa acttccttga atttttttct ctgttaaatg catgcccagt ggtgtttatc
      841 ttctttcaca ataaaaattg accccatgta aaaaaaaaaa aaaaaa
//
