LOCUS       NM_001163530             892 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus prolactin (Prl), transcript variant 2, mRNA.
ACCESSION   NM_001163530
VERSION     NM_001163530.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 892)
  AUTHORS   Yoshida,S., Tsuneoka,Y., Tsukada,T., Nakakura,T., Kawamura,A.,
            Kai,W. and Yoshida,K.
  TITLE     Primary Cilia are Required for Cell-Type Determination and
            Angiogenesis in Pituitary Development
  JOURNAL   Endocrinology 165 (8) (2024)
   PUBMED   39001875
REFERENCE   2  (bases 1 to 892)
  AUTHORS   Cerbantez-Bueno,V., Vinuela-Berni,V., Munoz-Mayorga,D.E.,
            Morales,T. and Corona,R.
  TITLE     Prolactin promotes the recruitment of main olfactory bulb cells and
            enhances the behavioral exploration toward a socio-sexual stimulus
            in female mice
  JOURNAL   Horm Behav 162, 105527 (2024)
   PUBMED   38492348
  REMARK    GeneRIF: Prolactin promotes the recruitment of main olfactory bulb
            cells and enhances the behavioral exploration toward a socio-sexual
            stimulus in female mice.
REFERENCE   3  (bases 1 to 892)
  AUTHORS   Wall,E.G., Desai,R., Khant Aung,Z., Yeo,S.H., Grattan,D.R.,
            Handelsman,D.J. and Herbison,A.E.
  TITLE     Unexpected Plasma Gonadal Steroid and Prolactin Levels Across the
            Mouse Estrous Cycle
  JOURNAL   Endocrinology 164 (6) (2023)
   PUBMED   37165692
  REMARK    GeneRIF: Unexpected Plasma Gonadal Steroid and Prolactin Levels
            Across the Mouse Estrous Cycle.
REFERENCE   4  (bases 1 to 892)
  AUTHORS   Gonzalez-Meljem,J.M., Ivins,S., Andoniadou,C.L., Le Tissier,P.,
            Scambler,P. and Martinez-Barbera,J.P.
  TITLE     An expression and function analysis of the CXCR4/SDF-1 signalling
            axis during pituitary gland development
  JOURNAL   PLoS One 18 (2), e0280001 (2023)
   PUBMED   36800350
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 892)
  AUTHORS   Maciuba,S., Bowden,G.D., Stratton,H.J., Wisniewski,K.,
            Schteingart,C.D., Almagro,J.C., Valadon,P., Lowitz,J., Glaser,S.M.,
            Lee,G., Dolatyari,M., Navratilova,E., Porreca,F. and Riviere,P.J.M.
  TITLE     Discovery and characterization of prolactin neutralizing monoclonal
            antibodies for the treatment of female-prevalent pain disorders
  JOURNAL   MAbs 15 (1), 2254676 (2023)
   PUBMED   37698877
REFERENCE   6  (bases 1 to 892)
  AUTHORS   Serikawa,T., Kuramoto,T., Hilbert,P., Mori,M., Yamada,J.,
            Dubay,C.J., Lindpainter,K., Ganten,D., Guenet,J.L., Lathrop,G.M. et
            al.
  TITLE     Rat gene mapping using PCR-analyzed microsatellites
  JOURNAL   Genetics 131 (3), 701-721 (1992)
   PUBMED   1628813
REFERENCE   7  (bases 1 to 892)
  AUTHORS   Deb,S., Roby,K.F., Faria,T.N., Szpirer,C., Levan,G., Kwok,S.C. and
            Soares,M.J.
  TITLE     Molecular cloning and characterization of prolactin-like protein C
            complementary deoxyribonucleic acid
  JOURNAL   J Biol Chem 266 (34), 23027-23032 (1991)
   PUBMED   1744098
REFERENCE   8  (bases 1 to 892)
  AUTHORS   Jackson-Grusby,L.L., Pravtcheva,D., Ruddle,F.H. and Linzer,D.I.
  TITLE     Chromosomal mapping of the prolactin/growth hormone gene family in
            the mouse
  JOURNAL   Endocrinology 122 (6), 2462-2466 (1988)
   PUBMED   2836164
REFERENCE   9  (bases 1 to 892)
  AUTHORS   Lee,S.J. and Nathans,D.
  TITLE     Proliferin secreted by cultured cells binds to mannose 6-phosphate
            receptors
  JOURNAL   J Biol Chem 263 (7), 3521-3527 (1988)
   PUBMED   2963825
REFERENCE   10 (bases 1 to 892)
  AUTHORS   Linzer,D.I. and Talamantes,F.
  TITLE     Nucleotide sequence of mouse prolactin and growth hormone mRNAs and
            expression of these mRNAs during pregnancy
  JOURNAL   J Biol Chem 260 (17), 9574-9579 (1985)
   PUBMED   2991252
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591843.14 and AK133645.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the coding region, compared to variant 1. This
            results in a shorter protein (isoform 2), compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB238156.1, AK133645.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849383,
                                           SAMN00849384 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 AL591843.14        51601-51607
            8-870               AK133645.1         2-864
            871-892             AL591843.14        59214-59235
FEATURES             Location/Qualifiers
     source          1..892
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 12.25 cM"
     gene            1..892
                     /gene="Prl"
                     /gene_synonym="Gha1; Prl1a1"
                     /note="prolactin"
                     /db_xref="GeneID:19109"
                     /db_xref="MGI:MGI:97762"
     exon            1..88
                     /gene="Prl"
                     /gene_synonym="Gha1; Prl1a1"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..738
                     /gene="Prl"
                     /gene_synonym="Gha1; Prl1a1"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; growth hormone a1"
                     /codon_start=1
                     /product="prolactin isoform 2 precursor"
                     /protein_id="NP_001157002.1"
                     /db_xref="GeneID:19109"
                     /db_xref="MGI:MGI:97762"
                     /translation="MTMNSQGSAQKGTLLLLLISNLLFCQNVQPLPICSAGDCQTSLR
                     ELFDRVVILSHYIHTLYTDMFIEFDKQYVQDREFMVKVINDCPTSSLATPEDKEQALK
                     VPPEVLLNLILSLVQSSSDPLFQLITGVGGIQEAPEYILSRAKEIEEQNKQLLEGVEK
                     IISQAYPEAKGNGIYFVWSQLPSLQGVDEESKILSLRNTIRCLRRDSHKVDNFLKVLR
                     CQIAHQNNC"
     exon            89..258
                     /gene="Prl"
                     /gene_synonym="Gha1; Prl1a1"
                     /inference="alignment:Splign:2.1.0"
     exon            259..366
                     /gene="Prl"
                     /gene_synonym="Gha1; Prl1a1"
                     /inference="alignment:Splign:2.1.0"
     exon            367..546
                     /gene="Prl"
                     /gene_synonym="Gha1; Prl1a1"
                     /inference="alignment:Splign:2.1.0"
     exon            547..892
                     /gene="Prl"
                     /gene_synonym="Gha1; Prl1a1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaagctgtg gttctctcag gccatcttgg agaagtgtgt tcccagcagt caccatgacc
       61 atgaacagcc aggggtcagc ccagaaaggg acactcctcc tgttgctgat atcaaacctg
      121 ctgttctgcc aaaatgttca gcctctgcca atctgttccg ctggtgactg ccagacttct
      181 ctccgagagc tgtttgaccg tgtggtcata ctttctcact acatccatac cctgtataca
      241 gatatgttca ttgaattcga taaacagtat gtgcaagacc gtgagtttat ggtcaaggtc
      301 atcaatgact gccccacttc ttccctggct acacctgaag acaaggaaca agccctgaaa
      361 gtccctccgg aagttcttct gaacctgatc ctcagtttgg tgcagtcctc gagtgaccct
      421 ctgtttcaac taataactgg agtaggtggt attcaagaag cccccgaata catcctatca
      481 agagccaaag agattgagga acaaaacaag cagcttcttg agggagttga gaagataatt
      541 agccaggcct atcctgaagc caaaggaaat gggatctact ttgtttggtc acaacttcca
      601 tccctacagg gagttgatga agaatccaaa atcttgtctt tgcgcaacac cattcgctgc
      661 ctgcgcaggg attcccacaa ggttgacaat tttctcaagg tcctgaggtg ccaaattgcc
      721 catcaaaaca actgctaaac ccacattcag tccatctctt tctgagatga tccttaaaag
      781 tccacttctt caaaagtttt atttgcttta tagttttcag tgcatgcttg ggtgcaattg
      841 gtctcctctt aaataataaa aacaaacttt aaaaaaatgt caaagtctga aa
//
