LOCUS       NM_001411701            3982 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus protein kinase, X-linked (Prkx), transcript variant 7,
            mRNA.
ACCESSION   NM_001411701
VERSION     NM_001411701.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3982)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3982)
  AUTHORS   Piazzon,N., Maisonneuve,C., Guilleret,I., Rotman,S. and
            Constam,D.B.
  TITLE     Bicc1 links the regulation of cAMP signaling in polycystic kidneys
            to microRNA-induced gene silencing
  JOURNAL   J Mol Cell Biol 4 (6), 398-408 (2012)
   PUBMED   22641646
REFERENCE   3  (bases 1 to 3982)
  AUTHORS   Li,X., Iomini,C., Hyink,D. and Wilson,P.D.
  TITLE     PRKX critically regulates endothelial cell proliferation,
            migration, and vascular-like structure formation
  JOURNAL   Dev Biol 356 (2), 475-485 (2011)
   PUBMED   21684272
  REMARK    GeneRIF: The interaction of PRKX with Pin-1, Magi-1 and Bag-3 could
            contribute to the stimulating role of PRKX in angiogenesis.
            Erratum:[Dev Biol. 2013 Sep 15;381(2):502]
REFERENCE   4  (bases 1 to 3982)
  AUTHORS   Li,X., Burrow,C.R., Polgar,K., Hyink,D.P., Gusella,G.L. and
            Wilson,P.D.
  TITLE     Protein kinase X (PRKX) can rescue the effects of polycystic kidney
            disease-1 gene (PKD1) deficiency
  JOURNAL   Biochim Biophys Acta 1782 (1), 1-9 (2008)
   PUBMED   17980165
REFERENCE   5  (bases 1 to 3982)
  AUTHORS   Li,W., Yu,Z.X. and Kotin,R.M.
  TITLE     Profiles of PrKX expression in developmental mouse embryo and human
            tissues
  JOURNAL   J Histochem Cytochem 53 (8), 1003-1009 (2005)
   PUBMED   15879576
REFERENCE   6  (bases 1 to 3982)
  AUTHORS   Blaschke,R.J., Monaghan,A.P., Bock,D. and Rappold,G.A.
  TITLE     A novel murine PKA-related protein kinase involved in neuronal
            differentiation
  JOURNAL   Genomics 64 (2), 187-194 (2000)
   PUBMED   10729225
REFERENCE   7  (bases 1 to 3982)
  AUTHORS   Blaschke,R.J. and Rappold,G.A.
  TITLE     Man to mouse--lessons learned from the distal end of the human X
            chromosome
  JOURNAL   Genome Res 7 (12), 1114-1117 (1997)
   PUBMED   9414316
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL714017.11.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784650.461808.1,
                                           SRR17784644.1093866.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-392               AL714017.11        157241-157632       c
            393-561             AL714017.11        147821-147989       c
            562-681             AL714017.11        134809-134928       c
            682-777             AL714017.11        132940-133035       c
            778-835             AL714017.11        127042-127099       c
            836-913             AL714017.11        126266-126343       c
            914-1062            AL714017.11        125799-125947       c
            1063-3982           AL714017.11        122665-125584       c
FEATURES             Location/Qualifiers
     source          1..3982
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 38.32 cM"
     gene            1..3982
                     /gene="Prkx"
                     /gene_synonym="Pkare; PKX1"
                     /note="protein kinase, X-linked"
                     /db_xref="GeneID:19108"
                     /db_xref="MGI:MGI:1309999"
     exon            1..392
                     /gene="Prkx"
                     /gene_synonym="Pkare; PKX1"
                     /inference="alignment:Splign:2.1.0"
     CDS             236..1039
                     /gene="Prkx"
                     /gene_synonym="Pkare; PKX1"
                     /EC_number="2.7.11.1"
                     /note="isoform 7 is encoded by transcript variant 7;
                     putative serine/threonine kinase; serine/threonine-protein
                     kinase PRKX; PKA-related protein kinase; cAMP-dependent
                     protein kinase catalytic subunit PRKX"
                     /codon_start=1
                     /product="cAMP-dependent protein kinase catalytic subunit
                     PRKX isoform 7"
                     /protein_id="NP_001398630.1"
                     /db_xref="GeneID:19108"
                     /db_xref="MGI:MGI:1309999"
                     /translation="MEPPAGAAATVKDPDHDPVKTKVSAPAADPKPRTSSQKAGHSLQ
                     DWDTIATVGTGTFGRVNLVKEKTGRQYCALKIMSIPDVIRLKQEQHVQNEKAVLKEIN
                     HPFLIKLTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFG
                     IYQKILACKIDFPRQLDFTSKDLIKKLLVVDRTRRLGNMKNGAEDIKRHRWFRGVEWE
                     SVPQRKLKPPIVPKLSGDGDISNFETYPESELDKTPSVSDKDLETFKNF"
     exon            393..561
                     /gene="Prkx"
                     /gene_synonym="Pkare; PKX1"
                     /inference="alignment:Splign:2.1.0"
     exon            562..681
                     /gene="Prkx"
                     /gene_synonym="Pkare; PKX1"
                     /inference="alignment:Splign:2.1.0"
     exon            682..777
                     /gene="Prkx"
                     /gene_synonym="Pkare; PKX1"
                     /inference="alignment:Splign:2.1.0"
     exon            778..835
                     /gene="Prkx"
                     /gene_synonym="Pkare; PKX1"
                     /inference="alignment:Splign:2.1.0"
     exon            836..913
                     /gene="Prkx"
                     /gene_synonym="Pkare; PKX1"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1062
                     /gene="Prkx"
                     /gene_synonym="Pkare; PKX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..3982
                     /gene="Prkx"
                     /gene_synonym="Pkare; PKX1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3957..3962
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prkx"
                     /gene_synonym="Pkare; PKX1"
                     /note="hexamer: AATAAA"
     polyA_site      3982
                     /gene="Prkx"
                     /gene_synonym="Pkare; PKX1"
                     /note="major polyA site"
ORIGIN      
        1 gcccagccgg cttccgccgg gaatgaagag ggttgcggtt ggctccggtc ccgcggaccc
       61 cacgcgcgtc cgtggagccc tcgggcgact tccatgagcc cctcccatcg ctctgagacc
      121 cgctgagttt gcttccattg tcctctcggc cgcgggctcc ggaacacccg tgcgagccca
      181 ctgctgatgc acagactgcc attgcgccgc tgtcacaccg tgcgtccccc gccccatgga
      241 gccgcccgct ggtgccgcgg cgaccgtaaa agatccagac catgaccccg tgaagaccaa
      301 ggtctcggcg cccgccgcgg accccaaacc caggacatcg tcacagaagg cggggcactc
      361 gttacaagat tgggacacca tagccaccgt gggcactggg acctttggcc gtgtaaacct
      421 ggtgaaggag aagacaggca ggcaatactg tgccttgaag attatgagta tcccagatgt
      481 catccgcctg aaacaggaac agcatgtgca gaatgagaaa gcagtcctga aggaaataaa
      541 ccatcccttc ctcattaaac tgacatggac tctctgtggg acaccagaat atctcgcccc
      601 agaagtcatt cagagcaaag gtcatggaag ggctgtggac tggtgggcac tgggcattct
      661 tatattcgag atgctgtctg ggtttccccc atttttcgat gacaacccgt ttgggattta
      721 ccagaaaatc cttgcatgca aaatagattt ccccagacaa ttggatttca cctctaagga
      781 cctcatcaag aagctgctgg tggtggacag gacccgacgc ctaggcaaca tgaagaatgg
      841 ggcagaagac atcaagcggc accggtggtt ccgaggtgtg gagtgggaat ctgtgccaca
      901 aagaaaactg aagccaccca ttgtgcccaa gttatcgggt gatggtgaca tctccaactt
      961 tgagacttat ccagagagtg aattggacaa gacaccttct gtatctgaca aagacctgga
     1021 aacattcaaa aatttctgag gatgagaact catgtctgaa agatgtatgt gaagacatcg
     1081 ataccacacc ataccacacc acagcacaac ataccacacc aatggccaga accttttttg
     1141 tcgtacgttt ccatttccta ctatgaaact agaaggtttg gtgtgtgtat tccagttcct
     1201 gaaagatcaa tacaatcatc acccttggaa cccagcctca tttcaacaac tggaaacctg
     1261 cccaatgaga attcgcaaaa cctgttaaat tgtaggtttt ctccttcttc atgagtcttg
     1321 tgtttgtgct gtgaattttg tttctttttt tgtttgtttg tctttctact gaacttttta
     1381 agtttgaatt tgacccattt ggttttatgg ctgtcagtgt atatgtgcac agaaattgtg
     1441 caaactggaa attttggcac tttgtgcttg tgacatgttc attttttaaa gctttctgaa
     1501 aaatctttca ccctacaggc aaaaaaaaaa agggtgagat atatgctttt taaaaatgcc
     1561 tttctatgca ttttgcaatc atttgtgtac attgtttatt tagttactgt ttgtttattt
     1621 agttcctttc tggtcacttt aaacttggaa gtcaggaagc cacatgccct gcagaccctt
     1681 attcagatat agcacaaatg tgtggctttc ctccaatctt ccagtttaga tgttttcagt
     1741 aaaatatccc ttcctaaagt taagccagaa ctctgcatac agcatggcac ctgggtgcaa
     1801 agattgcctt tttatgataa tacaaatgta cccacatccc cacaagggaa ctttaaggat
     1861 ccacccctta agcccctccc tcctctgttg taaatggcat tttcttctca ccatcttaac
     1921 tttgttctcc cagccatgtc cgtccgtgaa aactcaggtt ccaggccggg aacttctatg
     1981 aaagtttgta cagagctgta tttttggtga gctttctcag tgctttccaa tatgcaaact
     2041 aactgggtta tgtacctcaa acaaacaaac acatacagga gatagaatgc aggattataa
     2101 tcaagtcctg tcagtagatg tttgctatta agtaggaaat aacatgaaat tagcatagga
     2161 aatattgcct taattctaaa cacacatggg gagatcacac atgcgcacat gcaccctctg
     2221 tgtgctccta aagcaccttg caatctgact ccaatcctaa aaatcaaata aaaaaccctt
     2281 aatcaggctg taaatcaaat gacactatgc gatgtcacta cagtgacatc agacatcata
     2341 taggaatcat aattttctat tttaagattt ttaattctgt gtgtacatgt gactgcagta
     2401 cacacagcca acaagtgcac cagagaccct acagctggac ttataggcag ttctatgccg
     2461 ccctgcggat gctgagaacc aacccaacct cgatcctctg cagtccatgt agttaacatg
     2521 caagaagggg tggtaaggca aaagcagcca tgaaaaaggg tgagggaaat atgtcctgtt
     2581 cttaactctg agtccaggga gagttgtgca cccaacacct tctcatgaaa caatggaata
     2641 gttaataaat ttcaaatttc tctggtggta gcttgattcg aaccaaagta taaaagataa
     2701 tcactagcaa ataaaaattt aaaaacaaat ttctgggctg gagagatggc tcagcggtta
     2761 agagcagtga ctgctcttcc ggaggtcctg agttcaaatc ccagcatcaa cctggtggct
     2821 cacaactatc tgtaatggga tccgatgccc ttttctgatg tgtctaaaga cagctacaat
     2881 gtacttacat ataataaata aataaatctt aaaaagcaaa aaaaaaaaaa aggaaatccc
     2941 ctcttttaaa aaaaaaaaaa acaaatctct atgctcttca actaagactg actttaatgt
     3001 ttagtacaga taaagtacta cgtgctgtgg attggtgctt gtctcactaa actagctgtt
     3061 acatgttaca ctgtagaatg tgatttgatg gcttaatact gttcacagga ccctctggct
     3121 gtgcaaatat cccaacattg gaccaaaaca taccaatcac cactgtgttg ctaggtgaac
     3181 cctagtgaaa atttagcatt gtgtgggtct tgatgttgag gtgaaaatca cagaaagggt
     3241 ctcacttctg actgtagatt tgaaatatgt tgatttcctg ggatttgttt gtttgttttt
     3301 gttattgttt tggatgaagc tccgtaggaa gcatttgatg aacattcaac acctgtcatt
     3361 cttatttgtc agaacactgt aaaccacctg aaacttataa tgcaaagtca aggtttatgt
     3421 gtgagttggt gcccccatta ggttgtgttt gttcccatca gtttaggggg aggatctgct
     3481 tcccaactgt taaatgttac tatcaaatct gcctttgagt ctcacaccct tgcatctggc
     3541 ctcacagtta tttgggagag ggaggttgct ccagttggtt atgtaataga catcatgaca
     3601 tcattatctg tgtgacttag agaaagtgag caccccagcg ctcctggtcc tcacatgtca
     3661 gactaaaacc ccttgtcacc tccgttcttc tcagagtgtg gggctcatca cttgacctgc
     3721 tataacacag gtcccacgtg cactgttcag gtgcaccccc ccccctgctg ccgagcaacc
     3781 gtcagcttgc ctgaaattat gcagaatgaa aaagcctgtt tctttttcct tttttatcct
     3841 gatgcatatt aaaaaaaatc actgtgattt gtgtgtatat ctctctatat atttgcccca
     3901 ggaaaacttt ctgctgtcta atttataaaa tactattact gagtccaggt ttgtttaata
     3961 aaagtttgta tgttttaaga aa
//
