LOCUS       NM_001411692            4072 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus protein kinase, X-linked (Prkx), transcript variant 5,
            mRNA.
ACCESSION   NM_001411692
VERSION     NM_001411692.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4072)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4072)
  AUTHORS   Piazzon,N., Maisonneuve,C., Guilleret,I., Rotman,S. and
            Constam,D.B.
  TITLE     Bicc1 links the regulation of cAMP signaling in polycystic kidneys
            to microRNA-induced gene silencing
  JOURNAL   J Mol Cell Biol 4 (6), 398-408 (2012)
   PUBMED   22641646
REFERENCE   3  (bases 1 to 4072)
  AUTHORS   Li,X., Iomini,C., Hyink,D. and Wilson,P.D.
  TITLE     PRKX critically regulates endothelial cell proliferation,
            migration, and vascular-like structure formation
  JOURNAL   Dev Biol 356 (2), 475-485 (2011)
   PUBMED   21684272
  REMARK    GeneRIF: The interaction of PRKX with Pin-1, Magi-1 and Bag-3 could
            contribute to the stimulating role of PRKX in angiogenesis.
            Erratum:[Dev Biol. 2013 Sep 15;381(2):502]
REFERENCE   4  (bases 1 to 4072)
  AUTHORS   Li,X., Burrow,C.R., Polgar,K., Hyink,D.P., Gusella,G.L. and
            Wilson,P.D.
  TITLE     Protein kinase X (PRKX) can rescue the effects of polycystic kidney
            disease-1 gene (PKD1) deficiency
  JOURNAL   Biochim Biophys Acta 1782 (1), 1-9 (2008)
   PUBMED   17980165
REFERENCE   5  (bases 1 to 4072)
  AUTHORS   Li,W., Yu,Z.X. and Kotin,R.M.
  TITLE     Profiles of PrKX expression in developmental mouse embryo and human
            tissues
  JOURNAL   J Histochem Cytochem 53 (8), 1003-1009 (2005)
   PUBMED   15879576
REFERENCE   6  (bases 1 to 4072)
  AUTHORS   Blaschke,R.J., Monaghan,A.P., Bock,D. and Rappold,G.A.
  TITLE     A novel murine PKA-related protein kinase involved in neuronal
            differentiation
  JOURNAL   Genomics 64 (2), 187-194 (2000)
   PUBMED   10729225
REFERENCE   7  (bases 1 to 4072)
  AUTHORS   Blaschke,R.J. and Rappold,G.A.
  TITLE     Man to mouse--lessons learned from the distal end of the human X
            chromosome
  JOURNAL   Genome Res 7 (12), 1114-1117 (1997)
   PUBMED   9414316
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL714017.11.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR2680377.658079.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-392               AL714017.11        157241-157632       c
            393-561             AL714017.11        147821-147989       c
            562-825             AL714017.11        143731-143994       c
            826-945             AL714017.11        134809-134928       c
            946-1003            AL714017.11        127042-127099       c
            1004-1152           AL714017.11        125799-125947       c
            1153-4072           AL714017.11        122665-125584       c
FEATURES             Location/Qualifiers
     source          1..4072
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 38.32 cM"
     gene            1..4072
                     /gene="Prkx"
                     /gene_synonym="Pkare; PKX1"
                     /note="protein kinase, X-linked"
                     /db_xref="GeneID:19108"
                     /db_xref="MGI:MGI:1309999"
     exon            1..392
                     /gene="Prkx"
                     /gene_synonym="Pkare; PKX1"
                     /inference="alignment:Splign:2.1.0"
     CDS             236..1129
                     /gene="Prkx"
                     /gene_synonym="Pkare; PKX1"
                     /EC_number="2.7.11.1"
                     /note="isoform 5 is encoded by transcript variant 5;
                     putative serine/threonine kinase; serine/threonine-protein
                     kinase PRKX; PKA-related protein kinase; cAMP-dependent
                     protein kinase catalytic subunit PRKX"
                     /codon_start=1
                     /product="cAMP-dependent protein kinase catalytic subunit
                     PRKX isoform 5"
                     /protein_id="NP_001398621.1"
                     /db_xref="GeneID:19108"
                     /db_xref="MGI:MGI:1309999"
                     /translation="MEPPAGAAATVKDPDHDPVKTKVSAPAADPKPRTSSQKAGHSLQ
                     DWDTIATVGTGTFGRVNLVKEKTGRQYCALKIMSIPDVIRLKQEQHVQNEKAVLKEIN
                     HPFLIKLLWTGHDNRFLYMLMEFVPGGELFTYLRNRGRFSSVASVFYATEIVCAIEYL
                     HSKEIVYRDLKPENILLDREGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSKGH
                     GRAVDWWALGILIFEMLSGDLIKKLLVVDRTRRLGNMKPPIVPKLSGDGDISNFETYP
                     ESELDKTPSVSDKDLETFKNF"
     exon            393..561
                     /gene="Prkx"
                     /gene_synonym="Pkare; PKX1"
                     /inference="alignment:Splign:2.1.0"
     exon            562..825
                     /gene="Prkx"
                     /gene_synonym="Pkare; PKX1"
                     /inference="alignment:Splign:2.1.0"
     exon            826..945
                     /gene="Prkx"
                     /gene_synonym="Pkare; PKX1"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1003
                     /gene="Prkx"
                     /gene_synonym="Pkare; PKX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1152
                     /gene="Prkx"
                     /gene_synonym="Pkare; PKX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..4072
                     /gene="Prkx"
                     /gene_synonym="Pkare; PKX1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4047..4052
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prkx"
                     /gene_synonym="Pkare; PKX1"
                     /note="hexamer: AATAAA"
     polyA_site      4072
                     /gene="Prkx"
                     /gene_synonym="Pkare; PKX1"
                     /note="major polyA site"
ORIGIN      
        1 gcccagccgg cttccgccgg gaatgaagag ggttgcggtt ggctccggtc ccgcggaccc
       61 cacgcgcgtc cgtggagccc tcgggcgact tccatgagcc cctcccatcg ctctgagacc
      121 cgctgagttt gcttccattg tcctctcggc cgcgggctcc ggaacacccg tgcgagccca
      181 ctgctgatgc acagactgcc attgcgccgc tgtcacaccg tgcgtccccc gccccatgga
      241 gccgcccgct ggtgccgcgg cgaccgtaaa agatccagac catgaccccg tgaagaccaa
      301 ggtctcggcg cccgccgcgg accccaaacc caggacatcg tcacagaagg cggggcactc
      361 gttacaagat tgggacacca tagccaccgt gggcactggg acctttggcc gtgtaaacct
      421 ggtgaaggag aagacaggca ggcaatactg tgccttgaag attatgagta tcccagatgt
      481 catccgcctg aaacaggaac agcatgtgca gaatgagaaa gcagtcctga aggaaataaa
      541 ccatcccttc ctcattaaac tgctttggac aggccatgac aaccgcttcc tatacatgtt
      601 gatggagttc gtgcctggtg gtgagctctt cacctacctg cgtaatcgtg gccgattctc
      661 ctcagttgct tcagtcttct acgccacaga gattgtgtgt gccatagaat atctacactc
      721 aaaggaaatc gtatacaggg acctgaagcc tgaaaacatc cttctagaca gggaaggaca
      781 tattaaactg acagacttcg gcttcgccaa gaaactggtg gataggacat ggactctctg
      841 tgggacacca gaatatctcg ccccagaagt cattcagagc aaaggtcatg gaagggctgt
      901 ggactggtgg gcactgggca ttcttatatt cgagatgctg tctggggacc tcatcaagaa
      961 gctgctggtg gtggacagga cccgacgcct aggcaacatg aagccaccca ttgtgcccaa
     1021 gttatcgggt gatggtgaca tctccaactt tgagacttat ccagagagtg aattggacaa
     1081 gacaccttct gtatctgaca aagacctgga aacattcaaa aatttctgag gatgagaact
     1141 catgtctgaa agatgtatgt gaagacatcg ataccacacc ataccacacc acagcacaac
     1201 ataccacacc aatggccaga accttttttg tcgtacgttt ccatttccta ctatgaaact
     1261 agaaggtttg gtgtgtgtat tccagttcct gaaagatcaa tacaatcatc acccttggaa
     1321 cccagcctca tttcaacaac tggaaacctg cccaatgaga attcgcaaaa cctgttaaat
     1381 tgtaggtttt ctccttcttc atgagtcttg tgtttgtgct gtgaattttg tttctttttt
     1441 tgtttgtttg tctttctact gaacttttta agtttgaatt tgacccattt ggttttatgg
     1501 ctgtcagtgt atatgtgcac agaaattgtg caaactggaa attttggcac tttgtgcttg
     1561 tgacatgttc attttttaaa gctttctgaa aaatctttca ccctacaggc aaaaaaaaaa
     1621 agggtgagat atatgctttt taaaaatgcc tttctatgca ttttgcaatc atttgtgtac
     1681 attgtttatt tagttactgt ttgtttattt agttcctttc tggtcacttt aaacttggaa
     1741 gtcaggaagc cacatgccct gcagaccctt attcagatat agcacaaatg tgtggctttc
     1801 ctccaatctt ccagtttaga tgttttcagt aaaatatccc ttcctaaagt taagccagaa
     1861 ctctgcatac agcatggcac ctgggtgcaa agattgcctt tttatgataa tacaaatgta
     1921 cccacatccc cacaagggaa ctttaaggat ccacccctta agcccctccc tcctctgttg
     1981 taaatggcat tttcttctca ccatcttaac tttgttctcc cagccatgtc cgtccgtgaa
     2041 aactcaggtt ccaggccggg aacttctatg aaagtttgta cagagctgta tttttggtga
     2101 gctttctcag tgctttccaa tatgcaaact aactgggtta tgtacctcaa acaaacaaac
     2161 acatacagga gatagaatgc aggattataa tcaagtcctg tcagtagatg tttgctatta
     2221 agtaggaaat aacatgaaat tagcatagga aatattgcct taattctaaa cacacatggg
     2281 gagatcacac atgcgcacat gcaccctctg tgtgctccta aagcaccttg caatctgact
     2341 ccaatcctaa aaatcaaata aaaaaccctt aatcaggctg taaatcaaat gacactatgc
     2401 gatgtcacta cagtgacatc agacatcata taggaatcat aattttctat tttaagattt
     2461 ttaattctgt gtgtacatgt gactgcagta cacacagcca acaagtgcac cagagaccct
     2521 acagctggac ttataggcag ttctatgccg ccctgcggat gctgagaacc aacccaacct
     2581 cgatcctctg cagtccatgt agttaacatg caagaagggg tggtaaggca aaagcagcca
     2641 tgaaaaaggg tgagggaaat atgtcctgtt cttaactctg agtccaggga gagttgtgca
     2701 cccaacacct tctcatgaaa caatggaata gttaataaat ttcaaatttc tctggtggta
     2761 gcttgattcg aaccaaagta taaaagataa tcactagcaa ataaaaattt aaaaacaaat
     2821 ttctgggctg gagagatggc tcagcggtta agagcagtga ctgctcttcc ggaggtcctg
     2881 agttcaaatc ccagcatcaa cctggtggct cacaactatc tgtaatggga tccgatgccc
     2941 ttttctgatg tgtctaaaga cagctacaat gtacttacat ataataaata aataaatctt
     3001 aaaaagcaaa aaaaaaaaaa aggaaatccc ctcttttaaa aaaaaaaaaa acaaatctct
     3061 atgctcttca actaagactg actttaatgt ttagtacaga taaagtacta cgtgctgtgg
     3121 attggtgctt gtctcactaa actagctgtt acatgttaca ctgtagaatg tgatttgatg
     3181 gcttaatact gttcacagga ccctctggct gtgcaaatat cccaacattg gaccaaaaca
     3241 taccaatcac cactgtgttg ctaggtgaac cctagtgaaa atttagcatt gtgtgggtct
     3301 tgatgttgag gtgaaaatca cagaaagggt ctcacttctg actgtagatt tgaaatatgt
     3361 tgatttcctg ggatttgttt gtttgttttt gttattgttt tggatgaagc tccgtaggaa
     3421 gcatttgatg aacattcaac acctgtcatt cttatttgtc agaacactgt aaaccacctg
     3481 aaacttataa tgcaaagtca aggtttatgt gtgagttggt gcccccatta ggttgtgttt
     3541 gttcccatca gtttaggggg aggatctgct tcccaactgt taaatgttac tatcaaatct
     3601 gcctttgagt ctcacaccct tgcatctggc ctcacagtta tttgggagag ggaggttgct
     3661 ccagttggtt atgtaataga catcatgaca tcattatctg tgtgacttag agaaagtgag
     3721 caccccagcg ctcctggtcc tcacatgtca gactaaaacc ccttgtcacc tccgttcttc
     3781 tcagagtgtg gggctcatca cttgacctgc tataacacag gtcccacgtg cactgttcag
     3841 gtgcaccccc ccccctgctg ccgagcaacc gtcagcttgc ctgaaattat gcagaatgaa
     3901 aaagcctgtt tctttttcct tttttatcct gatgcatatt aaaaaaaatc actgtgattt
     3961 gtgtgtatat ctctctatat atttgcccca ggaaaacttt ctgctgtcta atttataaaa
     4021 tactattact gagtccaggt ttgtttaata aaagtttgta tgttttaaga aa
//
