LOCUS       NM_025774               1654 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus Prkr interacting protein 1 (IL11 inducible) (Prkrip1),
            mRNA.
ACCESSION   NM_025774
VERSION     NM_025774.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1654)
  AUTHORS   Butte,A.J., Sigdel,T.K., Wadia,P.P., Miklos,D.B. and Sarwal,M.M.
  TITLE     Protein microarrays discover angiotensinogen and PRKRIP1 as novel
            targets for autoantibodies in chronic renal disease
  JOURNAL   Mol Cell Proteomics 10 (3), M110.000497 (2011)
   PUBMED   21183621
  REMARK    GeneRIF: Significant elevations in the titer of novel auto-Ab were
            noted against angiotensinogen and PRKRIP1 in renal insufficiency.
REFERENCE   2  (bases 1 to 1654)
  AUTHORS   Yin,Z., Haynie,J., Williams,B.R. and Yang,Y.C.
  TITLE     C114 is a novel IL-11-inducible nuclear double-stranded RNA-binding
            protein that inhibits protein kinase R
  JOURNAL   J Biol Chem 278 (25), 22838-22845 (2003)
   PUBMED   12679338
  REMARK    GeneRIF: C114 binds to protein kinase R (PKR), via dsRNA-binding
            domains of PKR and the N-terminal region of the C114 protein
REFERENCE   3  (bases 1 to 1654)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK010961.1 and AK020280.1.
            
            On May 7, 2009 this sequence version replaced NM_025774.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660821.26326.1,
                                           SRR1660817.475517.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-759               AK010961.1         2-760
            760-1654            AK020280.1         59-953
FEATURES             Location/Qualifiers
     source          1..1654
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 75.88 cM"
     gene            1..1654
                     /gene="Prkrip1"
                     /gene_synonym="8430424D23Rik; C114"
                     /note="Prkr interacting protein 1 (IL11 inducible)"
                     /db_xref="GeneID:66801"
                     /db_xref="MGI:MGI:1914051"
     exon            1..180
                     /gene="Prkrip1"
                     /gene_synonym="8430424D23Rik; C114"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..615
                     /gene="Prkrip1"
                     /gene_synonym="8430424D23Rik; C114"
                     /codon_start=1
                     /product="PRKR-interacting protein 1"
                     /protein_id="NP_080050.1"
                     /db_xref="CCDS:CCDS19754.1"
                     /db_xref="GeneID:66801"
                     /db_xref="MGI:MGI:1914051"
                     /translation="MASPAAASVRPPRPKKEPQTLVIPKNAAEEQKLKLERLMKNPDK
                     AVPIPEKMNEWAPRAPPEFVRDVMGSSAGAGSGEFHVYRHLRRREYQRQDYMDAMAEK
                     QKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMKLEQKKQKEEPSQCQE
                     QHASSSDEASETEEEEEEPSVVIMGR"
     exon            181..259
                     /gene="Prkrip1"
                     /gene_synonym="8430424D23Rik; C114"
                     /inference="alignment:Splign:2.1.0"
     exon            260..360
                     /gene="Prkrip1"
                     /gene_synonym="8430424D23Rik; C114"
                     /inference="alignment:Splign:2.1.0"
     exon            361..446
                     /gene="Prkrip1"
                     /gene_synonym="8430424D23Rik; C114"
                     /inference="alignment:Splign:2.1.0"
     exon            447..514
                     /gene="Prkrip1"
                     /gene_synonym="8430424D23Rik; C114"
                     /inference="alignment:Splign:2.1.0"
     exon            515..1654
                     /gene="Prkrip1"
                     /gene_synonym="8430424D23Rik; C114"
                     /inference="alignment:Splign:2.1.0"
     regulatory      907..912
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prkrip1"
                     /gene_synonym="8430424D23Rik; C114"
                     /note="hexamer: AGTAAA"
     polyA_site      928
                     /gene="Prkrip1"
                     /gene_synonym="8430424D23Rik; C114"
                     /note="major polyA site"
ORIGIN      
        1 gtcatcaata cgagcggccg ccggcagctt tcgtaaagga gtaggagagc ggctatggcg
       61 agtcctgctg ccgcttctgt gagaccgccc aggcccaaga aagagccgca gacgctggtc
      121 atccccaaga atgcggccga ggagcagaag ctcaagctgg agcggctcat gaagaacccg
      181 gacaaagcag ttccaattcc agagaaaatg aatgaatggg ctcctcgagc gcctccagaa
      241 tttgtccgag atgtcatggg ttccagtgct ggggctggca gtggagagtt ccacgtgtat
      301 aggcacctac ggcggagaga gtaccagcgg caggactaca tggatgccat ggctgagaag
      361 caaaaactgg atgcagagtt tcagaagaga ctagaaaaga ataaaattgc tgcagaggag
      421 cagactgcaa agcgccggaa aaagcgccag aagttaaaag agaagaagtt actggcaaag
      481 aagatgaaac ttgaacagaa gaaacagaag gaagaaccca gtcagtgcca ggaacagcat
      541 gccagcagct ctgacgaggc atctgaaaca gaggaggagg aagaggagcc cagcgtcgtc
      601 atcatggggc gatgaggagt ttcagcagtc gtgagcccag ctcattctgt gaccagcctc
      661 agaagagaaa tggctgtgtg tgaccagctg ctagactggc tgtgttggga gaaggcaggc
      721 acctcctgca gccctgcctg cctggggagc agagggagca gaccttagac atttgcagat
      781 tgcattctgt atcctgccct gctcttgctg aaggggagtg agtgcttcac cttccccggg
      841 tgccgttccc ttctgcttga acagcagtga gctctgcgct ggtttctgtg aagggaatat
      901 ttatttagta aagaacagaa aacctgtagg tcttgtccac acgtgcgaga tgttgattac
      961 caaagcctca gcgaagccat caaatgacag acactgggcc ttgaaatgtg gcaggtcctg
     1021 ttgtgcttca ctctgggaaa ggcttgcact tgaggtacac agccctgcca tttacggacc
     1081 aggagaattc agagctgcag atttgtgccc acccaaccgt tctcaaaacg agtatgagcc
     1141 aatggggcct tcagcaggca gaaggagagc ggtcccaggg aaatgcaagt gatgaaagaa
     1201 agcaggagtg tcccagagtg ggaggcggac actgatactg gccaaagcct tagacagggg
     1261 agaggaactg gaaagagtgg aactcttagg tgtggaaagt cctcctgtca ccaggatttg
     1321 gaggcagcca gtcttgcact tagtgtcctt gagtgactgg ttcaagcctg ctgtgtgtag
     1381 tggcccagag ggcaagcaac acccacagaa tactgaggac caggcatcat gccagggaga
     1441 agaaaggtga cccaggactg ccttggtcct cagagccatc gtgtcagtgg ggcggcaggc
     1501 agtttctagt ttgggggtct ggagtgtctc cagcttccaa gtgcgttgtg tgtcttttag
     1561 ggatgttggt agcattttga gtgaaaggaa agctaagaat atatcttttt aagttttgtg
     1621 ggttttttcg acagctcata aatgtttaca gtgt
//
