LOCUS       NM_011871               1626 bp    mRNA    linear   ROD 15-MAR-2023
DEFINITION  Mus musculus protein kinase, interferon inducible double stranded
            RNA dependent activator (Prkra), mRNA.
ACCESSION   NM_011871
VERSION     NM_011871.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1626)
  AUTHORS   Liu W, Jin S, Lin L, Yang Q and Jiang H.
  TITLE     Prkra Mutation Alters Long Noncoding RNA Expression During
            Embryonic External Ear Development
  JOURNAL   J Craniofac Surg 34 (2), e156-e161 (2023)
   PUBMED   35968982
  REMARK    GeneRIF: Prkra Mutation Alters Long Noncoding RNA Expression During
            Embryonic External Ear Development.
REFERENCE   2  (bases 1 to 1626)
  AUTHORS   Liu W, Lin L, Yang Q, Jin S and Jiang H.
  TITLE     Point Mutation in Prkra Alters miRNA Expression During Embryonic
            External Ear Development
  JOURNAL   J Craniofac Surg 34 (2), 777-784 (2023)
   PUBMED   35968958
  REMARK    GeneRIF: Point Mutation in Prkra Alters miRNA Expression During
            Embryonic External Ear Development.
REFERENCE   3  (bases 1 to 1626)
  AUTHORS   Dogan AE, Hamid SM, Yildirim AD, Yildirim Z, Sen G, Riera CE,
            Gottlieb RA and Erbay E.
  TITLE     PACT establishes a posttranscriptional brake on mitochondrial
            biogenesis by promoting the maturation of miR-181c
  JOURNAL   J Biol Chem 298 (7), 102050 (2022)
   PUBMED   35598827
  REMARK    GeneRIF: PACT establishes a posttranscriptional brake on
            mitochondrial biogenesis by promoting the maturation of miR-181c.
REFERENCE   4  (bases 1 to 1626)
  AUTHORS   Murakami K, Terakado Y, Saito K, Jomen Y, Takeda H, Oshima M and
            Barker N.
  TITLE     A genome-scale CRISPR screen reveals factors regulating
            Wnt-dependent renewal of mouse gastric epithelial cells
  JOURNAL   Proc Natl Acad Sci U S A 118 (4) (2021)
   PUBMED   33479180
  REMARK    GeneRIF: A genome-scale CRISPR screen reveals factors regulating
            Wnt-dependent renewal of mouse gastric epithelial cells.
REFERENCE   5  (bases 1 to 1626)
  AUTHORS   Gurung C, Fendereski M, Sapkota K, Guo J, Huang F and Guo YL.
  TITLE     Dicer represses the interferon response and the double-stranded
            RNA-activated protein kinase pathway in mouse embryonic stem cells
  JOURNAL   J Biol Chem 296, 100264 (2021)
   PUBMED   33837743
  REMARK    GeneRIF: Dicer represses the interferon response and the
            double-stranded RNA-activated protein kinase pathway in mouse
            embryonic stem cells.
REFERENCE   6  (bases 1 to 1626)
  AUTHORS   Rowe TM, Rizzi M, Hirose K, Peters GA and Sen GC.
  TITLE     A role of the double-stranded RNA-binding protein PACT in mouse ear
            development and hearing
  JOURNAL   Proc Natl Acad Sci U S A 103 (15), 5823-5828 (2006)
   PUBMED   16571658
  REMARK    GeneRIF: Study demonstrated an essential role of PACT in mammalian
            ear development and produced the first animal model.
REFERENCE   7  (bases 1 to 1626)
  AUTHORS   Bennett RL, Blalock WL and May WS.
  TITLE     Serine 18 phosphorylation of RAX, the PKR activator, is required
            for PKR activation and consequent translation inhibition
  JOURNAL   J Biol Chem 279 (41), 42687-42693 (2004)
   PUBMED   15299031
  REMARK    GeneRIF: RAX phosphorylation at serine 18 is required for PKR
            activation and consequent translation inhibition
REFERENCE   8  (bases 1 to 1626)
  AUTHORS   Gupta V and Patel RC.
  TITLE     Proapoptotic protein PACT is expressed at high levels in colonic
            epithelial cells in mice
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 283 (3), G801-G808 (2002)
   PUBMED   12181197
REFERENCE   9  (bases 1 to 1626)
  AUTHORS   Rowe TM and Sen GC.
  TITLE     Organizations and promoter analyses of the human and the mouse
            genes for PACT, the protein-activator of the interferon-induced
            protein kinase, PKR
  JOURNAL   Gene 273 (2), 215-225 (2001)
   PUBMED   11595168
REFERENCE   10 (bases 1 to 1626)
  AUTHORS   Ito T, Yang M and May WS.
  TITLE     RAX, a cellular activator for double-stranded RNA-dependent protein
            kinase during stress signaling
  JOURNAL   J Biol Chem 274 (22), 15427-15432 (1999)
   PUBMED   10336432
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928867.9.
            
            [WARNING] On May 13, 2023 this sequence was replaced by
            NM_011871.4.
            
            On Apr 24, 2018 this sequence version replaced NM_011871.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011311.1, AF083032.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-236               AL928867.9         69213-69448         c
            237-406             AL928867.9         68546-68715         c
            407-488             AL928867.9         64644-64725         c
            489-567             AL928867.9         61662-61740         c
            568-685             AL928867.9         60621-60738         c
            686-780             AL928867.9         58216-58310         c
            781-955             AL928867.9         54954-55128         c
            956-1626            AL928867.9         51319-51989         c
FEATURES             Location/Qualifiers
     source          1..1626
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2"
     gene            1..1626
                     /gene="Prkra"
                     /gene_synonym="lear; Pact; PRK; RAX"
                     /note="protein kinase, interferon inducible double
                     stranded RNA dependent activator"
                     /db_xref="GeneID:23992"
                     /db_xref="MGI:MGI:1344375"
     exon            1..236
                     /gene="Prkra"
                     /gene_synonym="lear; Pact; PRK; RAX"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..1113
                     /gene="Prkra"
                     /gene_synonym="lear; Pact; PRK; RAX"
                     /note="PKR-associated protein X; PKR-associating protein
                     X; protein activator of the interferon-induced protein
                     kinase"
                     /codon_start=1
                     /product="interferon-inducible double-stranded
                     RNA-dependent protein kinase activator A"
                     /protein_id="NP_036001.1"
                     /db_xref="CCDS:CCDS16159.1"
                     /db_xref="GeneID:23992"
                     /db_xref="MGI:MGI:1344375"
                     /translation="MSHSRHRAEAPPLQREDSGTFSLGKMITAKPGKTPIQVLHEYGM
                     KTKNIPVYECERSDVQVHVPTFTFRVTVGDITCTGEGTSKKLAKHRAAEAAINILKAN
                     ASICFAVPDPLMPDPSKQPKNQLNPIGSLQELAIHHGWRLPEYTLSQEGGPAHKREYT
                     TICRLESFMETGKGASKKQAKRNAAEKFLAKFSNISPENHISLTNVVGHSLGCTWHSL
                     RNSPGEKINLLKRSLLSLPNTDYIQLLSEIASEQGFNITYLDIEELSANGQYQCLAEL
                     STSPITVCHGSGISCGNAQSDAAHNALQYLKIIAERK"
     exon            237..406
                     /gene="Prkra"
                     /gene_synonym="lear; Pact; PRK; RAX"
                     /inference="alignment:Splign:2.1.0"
     exon            407..488
                     /gene="Prkra"
                     /gene_synonym="lear; Pact; PRK; RAX"
                     /inference="alignment:Splign:2.1.0"
     exon            489..567
                     /gene="Prkra"
                     /gene_synonym="lear; Pact; PRK; RAX"
                     /inference="alignment:Splign:2.1.0"
     exon            568..685
                     /gene="Prkra"
                     /gene_synonym="lear; Pact; PRK; RAX"
                     /inference="alignment:Splign:2.1.0"
     exon            686..780
                     /gene="Prkra"
                     /gene_synonym="lear; Pact; PRK; RAX"
                     /inference="alignment:Splign:2.1.0"
     exon            781..955
                     /gene="Prkra"
                     /gene_synonym="lear; Pact; PRK; RAX"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1626
                     /gene="Prkra"
                     /gene_synonym="lear; Pact; PRK; RAX"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctctcctt ccttctcctc ctgtccctta gctggaggga ggcaggcagc gattcgaggg
       61 gcgtccaagc ggcagcgcgg gcacgctcct ctcgggaact ggccgacgtg gagagggagg
      121 acccagatcc acacttctct tgattgctgt ggccagccgt cccttctcgc catgtcccat
      181 agcaggcatc gtgccgaggc cccgccgctg cagcgcgagg acagcgggac cttcagtttg
      241 ggcaagatga taacagctaa gcctgggaaa acaccgattc aggtattgca cgagtacggc
      301 atgaagacca agaacattcc agtttatgaa tgtgaaagat ccgatgtgca agtacacgtg
      361 cccactttca ccttcagagt aaccgttggt gacataactt gcacaggtga aggtacaagt
      421 aagaagctgg cgaagcacag agctgcggag gccgccataa acattttgaa agccaatgca
      481 agtatttgct ttgcagttcc tgacccctta atgcctgatc catccaaaca gccgaagaac
      541 cagctgaatc caattggctc attacaggaa ttagcaattc accatggctg gcgacttcct
      601 gaatataccc tttcccagga aggaggaccg gctcataaga gggaatacac cacgatctgc
      661 aggcttgaat cattcatgga aactggaaag ggggcatcaa aaaaacaagc caagagaaat
      721 gctgctgaga aatttctcgc caagtttagt aatatttctc cagagaacca catttctcta
      781 acgaacgtgg ttggacattc cctaggatgc acttggcact ccttgaggaa ttcccctggt
      841 gagaagatca acctcctgaa aaggagcctc ctcagtctcc cgaacacaga ctacatccag
      901 ctgcttagtg agattgccag cgagcaaggc tttaacataa cgtatttgga tatagaggag
      961 ctgagtgcca acggacagta tcagtgtctc gcagagctgt ccaccagtcc tatcaccgtg
     1021 tgtcacggct caggcatctc ctgtggcaat gcacagagtg acgctgctca caatgctctg
     1081 cagtatttaa agataatagc agaaagaaag taggcttgga gcgacttagg aaatctttct
     1141 gcggcgcaaa gaagtttccc tcgcccttct ttccaagcaa aatgtttact gtaatgtatg
     1201 tctgtgtgtc ctttccaaat ctcttcagat tccgtcaact ttccagattt aaatgtctcc
     1261 tggtaggtta ttaagctctt tttaatggct tcaactttgt attggtatat cgtgtttata
     1321 aactttgtac cacaaggctg agtgtggttt tcattttaca gggtcagacg cataggttga
     1381 acatgcatgt ttgactgtaa cggtaaagag ataaaacagc cttactggtg ctgaaactct
     1441 tttgtgcaaa gctttgtgga gtggattctg aagagcccct ttagactaga gtgttgaggc
     1501 ttgtgatgaa tgtcattgct aaatttcagg gaacgtggtt ggtttgctat gtatttgaaa
     1561 ccatggaata aagagctgtt cttataatgg gagctctgct cattttatta cacagctact
     1621 cacttg
//
