LOCUS       NM_001403470            3219 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus parkin RBR E3 ubiquitin protein ligase (Prkn),
            transcript variant 3, mRNA.
ACCESSION   NM_001403470 XM_006523336
VERSION     NM_001403470.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3219)
  AUTHORS   Wang,A., Zhong,G., Ying,M., Fang,Z., Chen,Y., Wang,H., Wang,C.,
            Liu,C. and Guo,Y.
  TITLE     Inhibition of NLRP3 inflammasome ameliorates LPS-induced
            neuroinflammatory injury in mice via PINK1/Parkin pathway
  JOURNAL   Neuropharmacology 257, 110063 (2024)
   PUBMED   38972372
  REMARK    GeneRIF: Inhibition of NLRP3 inflammasome ameliorates LPS-induced
            neuroinflammatory injury in mice via PINK1/Parkin pathway.
REFERENCE   2  (bases 1 to 3219)
  AUTHORS   Qiu,Y., Xu,J., Chen,Y., Wu,Y., Lin,Y.N., Liu,W., Wang,Z., Wu,Y.,
            Qian,X. and Li,Y.C.
  TITLE     Parkin plays a crucial role in acute viral myocarditis by
            regulating mitophagy activity
  JOURNAL   Theranostics 14 (13), 5303-5315 (2024)
   PUBMED   39267792
  REMARK    GeneRIF: Parkin plays a crucial role in acute viral myocarditis by
            regulating mitophagy activity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3219)
  AUTHORS   Trease,A.J., Totusek,S., Lichter,E.Z., Stauch,K.L. and Fox,H.S.
  TITLE     Mitochondrial DNA Instability Supersedes Parkin Mutations in
            Driving Mitochondrial Proteomic Alterations and Functional Deficits
            in Polg Mutator Mice
  JOURNAL   Int J Mol Sci 25 (12), 6441 (2024)
   PUBMED   38928146
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3219)
  AUTHORS   Zhou,L., Liu,R., Pathak,H., Wang,X., Jeong,G.H., Kumari,P.,
            Kumar,M. and Yin,J.
  TITLE     Ubiquitin Ligase Parkin Regulates the Stability of SARS-CoV-2 Main
            Protease and Suppresses Viral Replication
  JOURNAL   ACS Infect Dis 10 (3), 879-889 (2024)
   PUBMED   38386664
  REMARK    GeneRIF: Ubiquitin Ligase Parkin Regulates the Stability of
            SARS-CoV-2 Main Protease and Suppresses Viral Replication.
REFERENCE   5  (bases 1 to 3219)
  AUTHORS   Ward,A., Jessop,F., Faris,R., Hollister,J., Shoup,D., Race,B.,
            Bosio,C.M. and Priola,S.A.
  TITLE     The PINK1/Parkin pathway of mitophagy exerts a protective effect
            during prion disease
  JOURNAL   PLoS One 19 (2), e0298095 (2024)
   PUBMED   38394123
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3219)
  AUTHORS   Huynh,D.P., Dy,M., Nguyen,D., Kiehl,T.R. and Pulst,S.M.
  TITLE     Differential expression and tissue distribution of parkin isoforms
            during mouse development
  JOURNAL   Brain Res Dev Brain Res 130 (2), 173-181 (2001)
   PUBMED   11675120
REFERENCE   7  (bases 1 to 3219)
  AUTHORS   Stichel,C.C., Augustin,M., Kuhn,K., Zhu,X.R., Engels,P., Ullmer,C.
            and Lubbert,H.
  TITLE     Parkin expression in the adult mouse brain
  JOURNAL   Eur J Neurosci 12 (12), 4181-4194 (2000)
   PUBMED   11122330
REFERENCE   8  (bases 1 to 3219)
  AUTHORS   Kitada,T., Asakawa,S., Minoshima,S., Mizuno,Y. and Shimizu,N.
  TITLE     Molecular cloning, gene expression, and identification of a
            splicing variant of the mouse parkin gene
  JOURNAL   Mamm Genome 11 (6), 417-421 (2000)
   PUBMED   10818204
REFERENCE   9  (bases 1 to 3219)
  AUTHORS   Gu,W.J., Abbas,N., Lagunes,M.Z., Parent,A., Pradier,L., Bohme,G.A.,
            Agid,Y., Hirsch,E.C., Raisman-Vozari,R. and Brice,A.
  TITLE     Cloning of rat parkin cDNA and distribution of parkin in rat brain
  JOURNAL   J Neurochem 74 (4), 1773-1776 (2000)
   PUBMED   10737637
REFERENCE   10 (bases 1 to 3219)
  AUTHORS   Kitada,T., Asakawa,S., Hattori,N., Matsumine,H., Yamamura,Y.,
            Minoshima,S., Yokochi,M., Mizuno,Y. and Shimizu,N.
  TITLE     Mutations in the parkin gene cause autosomal recessive juvenile
            parkinsonism
  JOURNAL   Nature 392 (6676), 605-608 (1998)
   PUBMED   9560156
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC105305.8, AC091254.77, AC091484.8, AC091777.26, AC093450.20,
            AC122259.2, CT009575.8 and AC163687.5.
            
            On Mar 30, 2022 this sequence version replaced XM_006523336.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784643.1011033.1,
                                           SRR7345562.2890109.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               AC105305.8         84580-84696         c
            118-281             AC091254.77        136222-136385
            282-522             AC091484.8         9669-9909           c
            523-644             AC091777.26        151025-151146       c
            645-728             AC091777.26        20103-20186         c
            729-844             AC093450.20        83852-83967         c
            845-981             AC122259.2         73614-73750
            982-1043            CT009575.8         143324-143385       c
            1044-1193           CT009575.8         127111-127260       c
            1194-1277           AC163687.5         123137-123220
            1278-1395           AC163687.5         169718-169835
            1396-3219           AC163687.5         180633-182456
FEATURES             Location/Qualifiers
     source          1..3219
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 7.8 cM"
     gene            1..3219
                     /gene="Prkn"
                     /gene_synonym="Park2"
                     /note="parkin RBR E3 ubiquitin protein ligase"
                     /db_xref="GeneID:50873"
                     /db_xref="MGI:MGI:1355296"
     exon            1..117
                     /gene="Prkn"
                     /gene_synonym="Park2"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..1508
                     /gene="Prkn"
                     /gene_synonym="Park2"
                     /EC_number="2.3.2.31"
                     /note="isoform 3 is encoded by transcript variant 3; E3
                     ubiquitin-protein ligase parkin; parkin protein; Parkinson
                     disease (autosomal recessive, juvenile) 2, parkin"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase parkin isoform 3"
                     /protein_id="NP_001390399.1"
                     /db_xref="GeneID:50873"
                     /db_xref="MGI:MGI:1355296"
                     /translation="MIVFVRFNSSYGFPVEVDSDTSILQLKEVVAKRQGVPADQLRVI
                     FAGKELPNHLTVQNCDLEQQSIVHIVQRPRRRSHETNASGGDEPQSTSEGSIWESRSL
                     TRVDLSSHTLPVDSVGLAVILDTDSKRDSEAARGPAVKPTYNSFFIYCKGPCHKVQPG
                     KLRVQCGTCKQATLTLAQGPSCWDDVLIPNRMSGECQSPDCPGTRAEFFFKCGAHPTS
                     DKDTSVALNLITSNRRSIPCIACTDVRSPVLVFQCNHRHVICLDCFHLYCVTRLNDRQ
                     FVHDAQLGYSLPCVAGCPNSLIKELHHFRILGEEQYTRYQQYGAEECVLQMGGVLCPR
                     PGCGAGLLPEQGQRKVTCEGGNGLGCGFVFCRDCKEAYHEGDCDSLLEPSGATSQAYR
                     VDKRAAEQARWEEASKETIKKTTKPCPRCNVPIEKNGGCMHMKCPQPQCKLEWCWNCG
                     CEWNRACMGDHWFDV"
     exon            118..281
                     /gene="Prkn"
                     /gene_synonym="Park2"
                     /inference="alignment:Splign:2.1.0"
     exon            282..522
                     /gene="Prkn"
                     /gene_synonym="Park2"
                     /inference="alignment:Splign:2.1.0"
     exon            523..644
                     /gene="Prkn"
                     /gene_synonym="Park2"
                     /inference="alignment:Splign:2.1.0"
     exon            645..728
                     /gene="Prkn"
                     /gene_synonym="Park2"
                     /inference="alignment:Splign:2.1.0"
     exon            729..844
                     /gene="Prkn"
                     /gene_synonym="Park2"
                     /inference="alignment:Splign:2.1.0"
     exon            845..981
                     /gene="Prkn"
                     /gene_synonym="Park2"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1043
                     /gene="Prkn"
                     /gene_synonym="Park2"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1193
                     /gene="Prkn"
                     /gene_synonym="Park2"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1277
                     /gene="Prkn"
                     /gene_synonym="Park2"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1395
                     /gene="Prkn"
                     /gene_synonym="Park2"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..3219
                     /gene="Prkn"
                     /gene_synonym="Park2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3191..3196
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prkn"
                     /gene_synonym="Park2"
                     /note="hexamer: AATAAA"
     polyA_site      3219
                     /gene="Prkn"
                     /gene_synonym="Park2"
                     /note="major polyA site"
ORIGIN      
        1 gaggaggcct ggatgactaa acctgacaga aacgctggtg ggaggctcgg gcgggcgcca
       61 gtgcccgcgt aggtccttct cgacccgcag ccaccacccg cccggtgacc atgatagtgt
      121 ttgtcaggtt caactccagc tatggcttcc cagtggaggt cgattctgac accagcatct
      181 tgcagctcaa ggaagtggtt gctaagcgac agggggttcc agctgaccag ctgcgtgtga
      241 tttttgccgg gaaggagctt ccgaatcacc tgacggttca aaactgtgac ctggaacaac
      301 agagtattgt acacatagta cagagaccac ggaggagaag tcatgaaaca aatgcatctg
      361 gaggggacga accccagagc acctcagagg gctccatatg ggagtccagg agcttgacac
      421 gagtggacct gagcagccat accctgccgg tggactctgt ggggctggcg gtcattctgg
      481 acacagacag taagagggat tcagaagcag ccagaggtcc agcagttaaa cccacctaca
      541 acagcttttt catctactgc aaaggcccct gccacaaggt ccagcctgga aagctccgag
      601 ttcagtgtgg cacctgcaaa caagcaaccc tcaccttggc ccagggccca tcttgctggg
      661 acgatgtctt aattccaaac cggatgagtg gtgagtgcca gtctccagac tgccctggaa
      721 ccagagctga atttttcttt aaatgtggag cacacccaac ctcagacaag gacacgtcgg
      781 tagctttgaa cctgatcacc agcaacaggc gcagcatccc ttgcatagcg tgcacagatg
      841 tcaggagccc tgtcctggtc ttccagtgta accaccgtca cgtgatctgt ttggactgtt
      901 tccacttgta ttgtgtcaca agactcaacg atcggcagtt tgtccacgat gctcaacttg
      961 gctactccct gccgtgtgta gctggctgtc ccaactccct gattaaagag ctccatcact
     1021 tcaggatcct tggagaagag cagtacacta ggtaccagca gtatggggcc gaggaatgcg
     1081 tgctgcaaat gggaggtgtg ctgtgccccc gtcctggctg tggagctgga ctgctacctg
     1141 aacagggcca gaggaaagtc acctgcgaag ggggcaacgg cctgggctgc gggtttgttt
     1201 tctgccggga ctgtaaggaa gcataccatg aaggggattg cgactcactg ctcgaaccct
     1261 caggagccac ttctcaggcc tacagggtgg acaaaagagc cgctgagcaa gctcgctggg
     1321 aggaggcctc caaggaaacc atcaagaaga ccaccaagcc ttgtcctcgc tgcaacgtgc
     1381 caattgaaaa aaacggagga tgtatgcaca tgaagtgtcc tcagccccag tgcaagctgg
     1441 agtggtgctg gaactgtggc tgtgagtgga accgagcctg catgggagat cactggtttg
     1501 acgtgtagag agagatgtca cttggccctg gacgcacaac ctcaagggaa actccgaaga
     1561 ttcctacctt ccttagccat ttcttcttct cgatgcatat aagcacataa atgcgcacac
     1621 acaaacacag gctgcagatt acagaagcag cccctagatc ctttccaggg cacccacaga
     1681 aaaccacagc acccgctggc cccaggggga ggaggcactt tcagcctctg gctcactcga
     1741 atgtcagagc ttagatgagg gtgcaccttt ggtttggatt ctgtagaagc catgagtgag
     1801 gtgggaagtg ttttccaggg ttgttgccac gccctgggta agtaacacct ctgaggattc
     1861 tcagaagcac acttgagatc tgaggaacgc tgctctcatg tagtaatcat ctattcccaa
     1921 agggccccct gcagtagtca aaactatttg tttatccccc caaatcctat ctttacaaat
     1981 ggtgctgatg agattacaac ccctctgtgt actaatcagc ttatcaacca agtgagaacc
     2041 taggaaagct aattggatgg cagactgctt aaatcgcagg gaggactcag aagccaaacc
     2101 tacttccgtt cgtttcatta tctgcaactt tagaaagaaa tgatcttttt ttccccctga
     2161 aaagataaca aagtctgcaa tttggtttgg agtattccta ctgcagcctg gaagtttagc
     2221 ttcactgtga atttaacaga gaaagtgcct ataaaggggg cgtttttaag agacaatccc
     2281 atgatgctgc gccaatgcta acaacagggt caagaaacac aatgtttata gaaggagcat
     2341 ccctcgacca tctgaatgag agtatgcctg accccttcca ccacaagtgg ggacacctct
     2401 gcatatctgc tccctcctct gctgttaagc cccagggagc cccatccacc cagtggtcct
     2461 acagacaggg caatacacac acaccaagat agccttcaga tcaacatgca tcacactcaa
     2521 gtgttaatct ttcaaggttt tcttttcttt ttcctgtttt ttatttgttt tgcttttgct
     2581 tttttttttt tttttttttt ggtggtggtg gggctaccaa acttgaggcc tagagctaaa
     2641 aatcatatag aaatgatgtt atcttgtggt gtgaggaaag gccagctggc ctaagttcac
     2701 acttttgtcc cagtggccct agactccacc cagccagctc ccaaaatgaa aagaccacct
     2761 gtcaagcagc agtcaggagt ctgatgtcac ccatcactat tttttttcca tcattgtgct
     2821 tgcctctgcc tccttccaca cccgtgtgac gtaatcgcat tgggaagcca ggacaatgtt
     2881 tgctgttctg ctttgggtaa agggactccc tgaagctctg tggctctcca gtatggtccc
     2941 ttttccttcc taacagatgc atatgttttc ttcagaatac aatagtgatt cttaaaataa
     3001 cccaaaagac aggcatccac agtgtgtgag catgaatcac agcctgcatt gtgtgagtgt
     3061 gaatagtggg ataaaagtgg atgtcagaag agtggaaatc aaacctctgc aaagcaatct
     3121 ttctctttct gtgaagtgta ttaagaaata cctgaagtct gtgtgtgtgg tggtacccag
     3181 actgtcaatc aataaagacc cagactgtca atgaaagaa
//
