LOCUS       NM_011159              12674 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus protein kinase, DNA activated, catalytic polypeptide
            (Prkdc), mRNA.
ACCESSION   NM_011159
VERSION     NM_011159.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 12674)
  AUTHORS   Zhang,Z., Schaefer,C., Jiang,W., Lu,Z., Lee,J., Sziraki,A.,
            Abdulraouf,A., Wick,B., Haeussler,M., Li,Z., Molla,G., Satija,R.,
            Zhou,W. and Cao,J.
  TITLE     A panoramic view of cell population dynamics in mammalian aging
  JOURNAL   Science 387 (6731), eadn3949 (2025)
   PUBMED   39607904
REFERENCE   2  (bases 1 to 12674)
  AUTHORS   Xia,M., Lu,J., Lan,J., Teng,T., Shiao,R., Sun,H., Jin,Z., Liu,X.,
            Wang,J., Wu,H., Wang,C., Yi,H., Qi,Q., Li,J., Schneeberger,M.,
            Shen,W., Lu,B., Chen,L., Ilanges,A., Zhou,X. and Yu,X.
  TITLE     Elevated IL-22 as a result of stress-induced gut leakage suppresses
            septal neuron activation to ameliorate anxiety-like behavior
  JOURNAL   Immunity 58 (1), 218-231 (2025)
   PUBMED   39644894
REFERENCE   3  (bases 1 to 12674)
  AUTHORS   Isshiki,Y., Chen,X., Teater,M., Karagiannidis,I., Nam,H., Cai,W.,
            Meydan,C., Xia,M., Shen,H., Gutierrez,J., Easwar Kumar,V.,
            Carrasco,S.E., Ouseph,M.M., Yamshon,S., Martin,P., Griess,O.,
            Shema,E., Porazzi,P., Ruella,M., Brentjens,R.J., Inghirami,G.,
            Zappasodi,R., Chadburn,A., Melnick,A.M. and Beguelin,W.
  TITLE     EZH2 inhibition enhances T cell immunotherapies by inducing
            lymphoma immunogenicity and improving T cell function
  JOURNAL   Cancer Cell 43 (1), 49-68 (2025)
   PUBMED   39642889
REFERENCE   4  (bases 1 to 12674)
  AUTHORS   Ursch,L.T., Muschen,J.S., Ritter,J., Klermund,J., Bernard,B.E.,
            Kolb,S., Warmuth,L., Andrieux,G., Miller,G., Jimenez-Munoz,M.,
            Theis,F.J., Boerries,M., Busch,D.H., Cathomen,T. and Schumann,K.
  TITLE     Modulation of TCR stimulation and pifithrin-alpha improve the
            genomic safety profile of CRISPR-engineered human T cells
  JOURNAL   Cell Rep Med 5 (12), 101846 (2024)
   PUBMED   39637860
REFERENCE   5  (bases 1 to 12674)
  AUTHORS   Portale,F., Carriero,R., Iovino,M., Kunderfranco,P., Pandini,M.,
            Marelli,G., Morina,N., Lazzeri,M., Casale,P., Colombo,P., De
            Simone,G., Camisaschi,C., Lugli,E., Basso,G., Cibella,J.,
            Marchini,S., Bordi,M., Meregalli,G., Garbin,A., Dambra,M.,
            Magrini,E., Rackwitz,W., Cecconi,F., Corbelli,A., Fiordaliso,F.,
            Eitler,J., Tonn,T. and Di Mitri,D.
  TITLE     C/EBPbeta-dependent autophagy inhibition hinders NK cell function
            in cancer
  JOURNAL   Nat Commun 15 (1), 10343 (2024)
   PUBMED   39609420
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 12674)
  AUTHORS   Valyi-Nagy,T., Deshmane,S.L., Raengsakulrach,B., Nicosia,M.,
            Gesser,R.M., Wysocka,M., Dillner,A. and Fraser,N.W.
  TITLE     Herpes simplex virus type 1 mutant strain in1814 establishes a
            unique, slowly progressing infection in SCID mice
  JOURNAL   J Virol 66 (12), 7336-7345 (1992)
   PUBMED   1331523
REFERENCE   7  (bases 1 to 12674)
  AUTHORS   Rudolphi,A., Claesson,M.H. and Reimann,J.
  TITLE     CD3+ T cells in severe combined immunodeficiency (scid) mice. VI.
            Rescue of scid-derived, IgM-producing B cells by transfer of CD4+
            CD8- T cells from various lymphoid organs
  JOURNAL   Immunology 77 (2), 157-164 (1992)
   PUBMED   1358814
REFERENCE   8  (bases 1 to 12674)
  AUTHORS   Prochazka,M., Gaskins,H.R., Shultz,L.D. and Leiter,E.H.
  TITLE     The nonobese diabetic scid mouse: model for spontaneous
            thymomagenesis associated with immunodeficiency
  JOURNAL   Proc Natl Acad Sci U S A 89 (8), 3290-3294 (1992)
   PUBMED   1373493
REFERENCE   9  (bases 1 to 12674)
  AUTHORS   Osmond,D.G., Kim,N., Manoukian,R., Phillips,R.A., Rico-Vargas,S.A.
            and Jacobsen,K.
  TITLE     Dynamics and localization of early B-lymphocyte precursor cells
            (pro-B cells) in the bone marrow of scid mice
  JOURNAL   Blood 79 (7), 1695-1703 (1992)
   PUBMED   1373084
REFERENCE   10 (bases 1 to 12674)
  AUTHORS   Gershwin,M.E., Merchant,B., Gelfand,M.C., Vickers,J.,
            Steinberg,A.D. and Hansen,C.T.
  TITLE     The natural history and immunopathology of outbred athymic (nude)
            mice
  JOURNAL   Clin Immunol Immunopathol 4 (3), 324-340 (1975)
   PUBMED   1104226
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK084827.1, AB007544.1, AB011543.1, CT030649.7, AK137732.1 and
            AU019811.2.
            
            On Feb 7, 2007 this sequence version replaced NM_011159.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D87521.1, AB011543.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2546              AK084827.1         2-2547
            2547-9594           AB007544.1         2524-9571
            9595-9921           AB011543.1         9584-9910
            9922-9923           CT030649.7         19046-19047         c
            9924-12460          AB007544.1         9901-12437
            12461-12672         AK137732.1         1895-2106
            12673-12674         AU019811.2         1-2                 c
FEATURES             Location/Qualifiers
     source          1..12674
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 10.09 cM"
     gene            1..12674
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /note="protein kinase, DNA activated, catalytic
                     polypeptide"
                     /db_xref="GeneID:19090"
                     /db_xref="MGI:MGI:104779"
     exon            1..177
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..12410
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /EC_number="2.7.11.1"
                     /note="severe combined immunodeficiency; DNA-PK catalytic
                     subunit; doxorubicin nephropathy"
                     /codon_start=1
                     /product="DNA-dependent protein kinase catalytic subunit"
                     /protein_id="NP_035289.2"
                     /db_xref="CCDS:CCDS27978.1"
                     /db_xref="GeneID:19090"
                     /db_xref="MGI:MGI:104779"
                     /translation="MAEEGTGVRCWLLQLQEFLSAADRCSAAGASYQLIRSLGQECVL
                     STSSAVQALQISLVFSRDFGLLVFIRKSLSIEDFRDCREEALKFLCVFLEKIDQKVMH
                     YSLDIKNTCTSVYTKDRTAKCKIPALDLLIKLLQILRSTRLMDEFKIGELFNKFYGEL
                     ASKSKLPDTVLEKVYELLGVLGEVHPSEMINHSENLFRAFLGELKTQMTSTVREPKFP
                     VLAGCLKGLSSLLCNFTKSMEEDPQTSKEIFGFTFKAIRPQIEMKRYAVPLAGLRLLT
                     LHASQFTACLLDNYITLFEVLSKWCSHTNVELKKAAHSALESFLRQISFTVAEDAELH
                     KSRLKYFMEQFYGIIRNTDSNNKELAIAIRGYGLFAGPCKVINAKDVDFMYVELIQRC
                     KQMFLTHADASEDHVYQMPSFLQSIASVLLYLDTVPEVYTPVLEHLMVVQIDSFPQYS
                     PKMQLVCCKAIIKLFLALSEKGPVHWNCISAVVHQGLIRICSKPVVLQKDVESRSDNR
                     SASEEVRTGRWKVPTYKDYVDLFQHLLGCDQMEDFILGDETFLFVNSSLKSLNHLLYD
                     EFIRSVLKIVEKLDLTLEKQTVGEQEDGSTADVWVIPTSDPAANLHPAKPSDFSALIN
                     LVEFCREILPRKHVGFFEPWVYSFAYELILQSTRLPLISGFYKLLSIAVKNARKIKYF
                     EGISPKSLKHSPEDTEKYSCFALFAKFGKEVSVKMKQYKDELLASCLTFVLSLPHDII
                     ELDVRAYVPALQMAFKLGLSHMPLAEIGLHALKEWSVHIDKSILQPYYKDILPCLDGY
                     LNTSTLSDETKSHWGLSALSRAAQKGFNRHVVKHLKRTRNSSPDEALSLEEIRIKVVQ
                     ILGSLGGQINKSLVTATSGERMKKYVAWDAERRLSFAVPFREMKPVIYLDVFLPRVTE
                     LALSASDRQTKVAACELLHSMVMFMLGRATQMPEGQGLPPMYQLYKHTFPVLLQLACD
                     VDQVTRQLYEPLVMQLIHWLTNNKKFESQDTVALLEAILDGIVDPVDSTLRDFCGRCV
                     QEFLKWSIKQTTPQQQEKSPVNSKSLFKRLYSLALHPNAFKRLGAALAFNHIYKEFRE
                     EGSLVEQFVFEALVTYMESLALAHEDEKSLGTVQQCCDAIDHLRRIIEKKHVSLNKAK
                     KRRLPQGFPPLTSLCLLDLVEWLLAHCGRPQTECRHKSMELFYKFVPLLPGNKSPSLW
                     LKDLIKKKGISFLINTFEGGASSSDQPAGILAQPTLVYLQGPISLRGVLQWLDLLLAA
                     LECYNTFIEKETVQGQEVLGAEVQSSLLKSVAFFLESIATHSARAVEQRFGSGAPGPP
                     SLHEEEKYNYSKCTVLVRIMEFTTTLLIASPEDCKLLEKDLCNTNLMQVLVKMICEPM
                     SLGFNIGDVQVMNHLPSICVNLLKALRKSPYRDMLETHLKEKVTVQSVEELCSINLCS
                     SGARQERSKLLSILSACKQLHKAGFSHVISPSQSTALNHSVGMRLLSLVYKGIVPAEE
                     RQCLQSLDPSCKSLANGLLELAFGFGGLCDHLVSLLLNSAMLSTQYLGSSQRNISFSH
                     GEYFYSLFSEVINSELLKNLDIAVSRLMESSSDNPKMVSTVLNGMLDTSFRDRAVQKH
                     QGLKLATAILQNWRKCDSWWAPDSAPESKTTVLSLLAKMLQIDSALSFDTNHSSFSEI
                     FTTYASLLADTKLGLHLKGQAIILLPFFTSLREGSLENLKHILEKLIVCNFPMKSDEF
                     PPDSLKYNNYVDCMKKFLDALELSQSPMLFQLMTDILCREQRHIMEELFQTTFKRIAR
                     QSPCVTQLNLLESVYTMFRKADLPSNVTRQAFVDRSLLTLLWHCDLDTLKEFFSRIVV
                     DAIDVLKSRFTKLNEFTFDTQITKKMCYYKMLAVMYSRLLKDDVHSKEAKINQAFHGS
                     RVAEGNELTKTLLKLCHDAFTENMVGESQLLEKRRLYHCAAYNCAISLISCVFNELKF
                     YQGFLFNEKPEKNLFIFENLIDLKRCYTFPIEVEVPMERKKKYIEIRKEARDAANGAS
                     GSPHYMSSLSYLTDSSLSEEMSQFDFSTGVQSYSYSSQDRKPTTGHFQRREHQDSMTQ
                     DDIMELEMDELNQHECMAPMIALIKHMQRNVIAPKGEEGSIPKDLPPWMKFLHDKLGN
                     ASVSLNIRLFLAKLVINTEEVFRPYAKHWLSPLLQLAVCENNREGIHYMMVEIVATIL
                     SWTGLATPTGVPKDEVLANRLLRFLMKHVFHPKRAVFRHNLEIIKTLVECWKECLSIP
                     YRLIFEKFSHKDPNSKDNSVGIQLLGIVIANNLPPYDPNCDITSAMYFEALVNNMSFV
                     KYKEVYAAAAEVLGLILQYITERKHVIAELVCELVIKQLKQHQNTMEDKFIVCLNKIA
                     KGFPPLADRFLNALFFLLPKFHGVMKTLCLEVVLCRAEEITGLYLQLKSKDFLQVMRH
                     RDDERQKVCLDIVYKMVAKLKPIELRELLNPVVEFVSHPSPTCREQMYNILMWIHDNY
                     RDQESQNDEDSQEIFKLAKDVLIQGLIDENVGLQLIIRNFWSHETRLPSNTLDRLLAL
                     NSLYSPKIEVHFLSLATNFLLEMTRMSPDYLNPIFEHPLSECEFQEYTIDPDWRFRST
                     VLTPMFIETQASPSILHTQTQEGPLSDQRQKPGQVRATQQQYDFTPTQASVERSSFDW
                     LTGSSIDLLADHTVFSSETLSSSLLFSHKRTEKSQRMSCKSVGPDFGTKKLGLPDDEV
                     DNQVKSGTPSQADILRLRRRFLKDREKLSLLYAKRGLMEQKLEKDIKSEFKMKQDAQV
                     VLYRSYRHGDLPDIQIQHSGLITPLQAVAQKDPIIAKQLFSSLFSGILKEMNKFKTTS
                     EKNIITQNLLQDFNRFLNTTFLFFPPFVSCIQEISCQHPDFLTLDPASVRVGCLASLQ
                     QPGGIRLLEEALLRLMPKEPPTKRVRGKTCLPPDVLRWMELAKLYRSIGEYDVLRGIF
                     SSELGTTQDTQNALLAEARSDYCQAAKLYDEALNKLEWVDGEPTEAEKEFWELASLDC
                     YNNLSKWKELEYCSTVNIVSENSLDLSKMWSEPFYQETYLPYVIRSKLKLLLQGEGNQ
                     SLLTFVDEAMNKELQKTVLELQYSQELSLLYILQDDIDRATYYIKNGIQIFMQNYSSI
                     DVLLYRSRLAKLQSVQTLAEIEEFLSFICKHGDLSSLGPLRRLLKTWTSRYPDVVTDP
                     MHIWDDIITNRCFFLSKIEERLTAPSGDHSMSVDEDEESIDREVYEPKEDVRCMLQSC
                     RFTMKMKMIESAWKQSNFSLSMKLLKEMHKESKTREIWRVQWLHSYSQLNHCRSHTQS
                     PREQVLNMLKTITLLDESDISNYLNKNIQASCDQSILLGTTCRIMADALSREPACLSD
                     LEENKVNSILTLSGSNAENTETVITGLYQRAFHHLSKAVQSAEEETQLSCWGHEAAAE
                     RAHAYMTLVGFCDQQLRKVEESASQKTSAEMEAYPALVVEKMLRALKLNSSEARLKFP
                     RLLQIIEQYSEETLNIMTKEISSIPCWQFIGWISHMMALLDKEEAIAVQHTVEEIADN
                     YPQAIIYPFIISSESYSFKNTSSGHNNKAFVERIKSKLDHGEVIHSFINALDQLSNPD
                     LLFKDWVSDTKDELGKNPVNKKNIEKLYERMYAALGDLRAPGLGPFRRRFIQAFGKEF
                     VKSFGNGGSKLLTMKVDDFCKITGSLLVRMKKDSKLPGNLKEYSPWMSEFKAQFLKNE
                     LEIPGQYDGKSKPLPEYHVRISGFDERVKVMLSLRKPKRIVIRGHDEKEYPFLVKGGE
                     DLRQDQRIEQIFEVMNAILSQDAACSQRNMQLRTYRVVPMTSRLGLIEWIENTMTLKD
                     LLLSNMSQEEKVANNSDPKAPIRDYKDWLMKVSGKSDAGAYVLMYSRANRTETVVAFR
                     RRESQVPPDLLKRAFVKMSTSPEAFLALRSHFASSHALLCISHWLLGIGDRHLNNFMV
                     AMETGSVIGIDFGHAFGSATQFLPVPELMPFRLTRQFVSLMLPMKETGLMCTVMVHAL
                     RAFRSCAGLLTDTMEIFVKEPSFDWKSFEQTMLRKGGSWIQEINVTEKNWYPQHKIRY
                     AKRKLAGANPAVITCDELYLGHEASSAFRSYTAVARGNRDYNIRAQEPESGLSEETQV
                     KCLVDQATDPNILGRTWEGWEPWM"
     exon            178..254
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            255..347
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            348..422
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            423..531
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            532..644
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            645..744
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            745..800
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            801..831
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            832..989
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1136
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1301
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1470
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1520
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1646
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..1799
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1912
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..2072
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2073..2159
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2160..2279
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2280..2439
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2440..2546
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2547..2637
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2638..2798
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2799..2948
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2949..3056
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            3057..3283
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            3284..3378
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            3379..3478
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            3479..3612
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            3613..3867
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            3868..4088
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            4089..4297
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            4298..4430
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            4431..4589
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            4590..4790
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            4791..4976
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            4977..5081
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            5082..5249
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            5250..5377
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            5378..5585
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            5586..5764
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            5765..5933
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            5934..5999
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            6000..6072
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            6073..6221
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            6222..6359
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            6360..6479
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            6480..6620
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            6621..6772
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            6773..6904
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            6905..7016
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            7017..7141
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            7142..7291
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            7292..7465
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            7466..7564
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            7565..7772
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            7773..7962
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            7963..8178
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            8179..8291
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            8292..8423
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            8424..8603
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            8604..8809
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            8810..8948
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            8949..9137
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            9138..9362
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            9363..9471
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            9472..9583
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            9584..9770
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            9771..9945
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            9946..10139
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            10140..10335
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            10336..10481
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            10482..10693
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            10694..10781
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            10782..10925
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            10926..11130
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            11131..11198
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            11199..11419
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            11420..11512
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            11513..11602
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            11603..11674
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            11675..11876
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            11877..12065
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            12066..12205
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            12206..12674
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      12650..12655
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /note="hexamer: AATAAA"
     polyA_site      12669
                     /gene="Prkdc"
                     /gene_synonym="DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH;
                     dxnph; HYRC1; p460; scid; slip; XRCC7"
                     /note="major polyA site"
ORIGIN      
        1 atgcgcgaag cggtgccggc gtgatggcgg aggagggaac cggcgtacgg tgttggctac
       61 tgcagctgca ggagttcctg tccgcagcag accgctgcag tgctgccggg gccagttacc
      121 agctgattcg tagtctgggg caggagtgcg tgctgagcac tagctctgca gtgcaggcat
      181 tgcagatttc cttagttttt tccagagact ttggtttgct tgtgtttatc cggaagtcgc
      241 ttagcattga ggactttcgt gattgtagag aagaagccct aaagttttta tgtgttttct
      301 tagagaaaat tgaccagaag gttatgcatt actctcttga tattaagaat acttgtacca
      361 gtgtttacac aaaagataga actgctaagt gtaaaattcc agccttagac cttctgatta
      421 agttacttca gatactaaga agtaccagac tcatggatga atttaagatt ggagaattat
      481 ttaacaaatt ctatggagaa cttgcatcaa aatcaaaact acctgataca gttttagaaa
      541 aagtctatga gctcctggga gtattaggtg aagttcatcc tagtgagatg ataaaccatt
      601 cagaaaacct gttccgagct tttctgggag aacttaagac ccagatgaca tccacagtaa
      661 gagaacctaa atttcctgtc ttagctggct gtctgaaggg actatcctca cttctgtgca
      721 acttcactaa gtccatggaa gaagatcccc agacttcaaa ggaaattttt ggttttacat
      781 ttaaagcaat tcgtcctcag attgagatga agcgatatgc tgtgccctta gctggcctac
      841 gattacttac cctgcatgca tctcaattca ctgcctgcct tctggacaac tatattactt
      901 tatttgaagt actgtctaag tggtgtagcc atacaaatgt ggaattaaaa aaagctgcac
      961 attcagccct ggagtccttc ctgagacaga tttcgtttac tgtggcagaa gatgcagagt
     1021 tgcataagag caggctgaag tactttatgg aacagttcta tggaatcatc agaaatacag
     1081 actcgaacaa caaggaatta gccattgcta ttcgcggata tggactattt gcaggacctt
     1141 gcaaggttat aaatgcaaaa gatgttgact tcatgtacgt ggagctcatt cagcgctgta
     1201 agcagatgtt cctcacccac gcagatgctt ctgaggatca tgtttaccag atgccaagtt
     1261 tccttcagtc tattgcaagt gtcttgcttt accttgacac ggttccggag gtatatactc
     1321 cagtactgga acatctcatg gtggtacaga tagacagctt ccctcagtat agtcccaaaa
     1381 tgcagttggt gtgctgtaaa gcaataataa aacttttcct agccttatca gagaaaggac
     1441 cagttcactg gaattgcatt agtgctgtgg tgcaccaagg tttaattaga atatgttcta
     1501 aaccagtggt ccttcaaaag gatgttgagt ctaggtctga taaccgttcg gcctccgagg
     1561 aagtcagaac tggcaggtgg aaagtaccta cgtacaaaga ctatgtggat ctttttcagc
     1621 atcttttagg ctgtgaccag atggaggatt ttattttagg agatgaaaca tttctctttg
     1681 tgaactcctc ccttaaaagt ctgaatcatt tactctatga tgaatttata agatcagttt
     1741 tgaagattgt ggaaaaattg gatcttacac tggaaaaaca gactgttgga gagcaggagg
     1801 atggaagcac tgctgatgtc tgggtgatcc caacttcaga tccagcagct aatttgcacc
     1861 ctgctaaacc aagtgatttt tcagctctca ttaacctggt ggagttttgc agggagattc
     1921 ttcctaggaa acatgtaggc ttttttgagc catgggtgta ctcatttgca tatgagttaa
     1981 ttttgcagtc tacacgattg ccactcatca gtggtttcta caaattgctt tctattgcag
     2041 tgaaaaatgc caggaaaata aaatattttg agggaatcag cccaaagagt ctgaaacatt
     2101 ctcctgaaga tacagaaaag tattcttgct ttgctttatt tgcaaagttt ggcaaagagg
     2161 tatcagttaa aatgaagcaa tacaaggatg aactgttggc ctcttgttta acctttgttc
     2221 tgtccttgcc acatgacatc attgaacttg atgttagagc ctacgttcct gcattgcaga
     2281 tggctttcaa gctgggcctg agccatatgc cactggcaga aataggtcta catgccctta
     2341 aagagtggtc agttcacatt gataagtcta tactgcagcc ttactacaaa gacattctcc
     2401 cctgccttga tggatatctg aatacttcaa ccttatcaga tgaaaccaag agccactggg
     2461 gattgtctgc actttctcgg gctgcccaga agggatttaa tagacatgta gtgaagcatc
     2521 taaaaaggac tagaaatagt tcgcctgatg aagcactgtc cttagaagag ataagaatta
     2581 aagtagtaca aatacttggc tctctgggag gacaaataaa caaaagcctt gtaacagcta
     2641 catccggaga aaggatgaag aagtacgtgg cgtgggatgc ggagagaaga ctcagctttg
     2701 cagtgccctt cagagagatg aagcctgtca tttatctgga tgtctttctg cctcgggtca
     2761 ctgaattggc tctttctgct agcgaccgac aaactaaagt agcagcttgt gaactgttac
     2821 acagcatggt tatgtttatg ttgggaagag cgactcagat gcctgaaggt caggggttgc
     2881 cgcccatgta ccagctttat aagcacacgt ttcctgtgct gcttcaactt gcgtgtgatg
     2941 tggatcaagt gacaaggcag ctctatgaac cgcttgttat gcagctgatc cactggttga
     3001 ctaacaataa aaaatttgaa agtcaagata ctgttgcctt attagaagcc atactggatg
     3061 gtattgtgga ccctgttgac agtactttaa gagatttttg tggacggtgc gttcaagaat
     3121 tcctcaaatg gtccattaag caaacaacac ctcagcagca agagaagagt ccagtaaaca
     3181 gcaagtcact tttcaagcgg ctctacagcc ttgcacttca tcctaatgct ttcaagaggc
     3241 taggtgcagc acttgctttt aatcacatct acaaggaatt cagggaagaa ggatccctgg
     3301 tagaacagtt tgtgtttgaa gccttagtga catatatgga aagtctggcc ttggcacatg
     3361 aagatgagaa atccttaggc acagttcagc agtgctgtga tgccatcgat cacctaagac
     3421 gcatcattga aaagaagcat gtctctttaa acaaagcaaa aaagcgacgt ttgccacagg
     3481 gatttccacc tttgacatca ttatgtttat tggatctggt cgagtggctt ttggctcact
     3541 gtggaaggcc ccagacagaa tgtcgacaca agtccatgga actcttttat aaatttgttc
     3601 ctttactgcc aggcaacaaa tccccttctt tatggttgaa agaccttata aaaaagaaag
     3661 gtatttcttt tctcataaac acatttgaag gaggggcaag cagcagtgat cagccagcag
     3721 gcattcttgc tcagccaacc ctcgtctact tacaagggcc aatcagcctg cgaggagtgc
     3781 tacaatggct ggacctcctc cttgcagcac tggagtgcta caacacattt attgagaagg
     3841 agactgtgca aggacaagag gtcctgggtg ctgaagtaca gtcttcactt ttgaagtcag
     3901 tggctttctt tttagaaagc atagcaaccc atagcgctag agcagtagaa caacgctttg
     3961 gctccggggc gccgggccct cccagcctcc acgaggaaga gaagtacaat tacagcaagt
     4021 gcacagtctt agtccggatc atggaattca ccacaaccct gctcatcgcc tctccagagg
     4081 actgcaagct cctggagaag gacttgtgta atacaaatct tatgcaggtc ttagtgaaaa
     4141 tgatctgtga gcccatgagc ttaggtttca atattggcga tgtccaggtt atgaaccatc
     4201 ttcccagcat ttgtgtgaac ctgctgaaag ctcttaggaa gtccccgtac agagacatgc
     4261 tggagactca cctgaaggag aaagtgacag tacagagtgt tgaagagctc tgttccatta
     4321 acttgtgtag ctctggggct cgccaagaaa ggtctaagtt actttctatc ttatcagcct
     4381 gtaaacagct tcacaaagct ggtttctctc atgttatatc accatctcag tctacagcat
     4441 tgaaccattc cgttggcatg agactgctgt ccttggttta taaaggcatt gtgcctgcag
     4501 aggaaaggca gtgcctgcag tctttggacc ccagctgtaa gagcctagcc aatggactcc
     4561 tggaattagc ctttggtttt ggaggactgt gtgaccatct tgtgagtttg ctcctgaatt
     4621 cggcaatgct gtctacacaa tatctgggca gttcacagag aaatattagc ttctcccatg
     4681 gggaatattt ctacagtttg ttctcagaag tgatcaacag tgagctgttg aagaatcttg
     4741 atattgctgt atcaaggctc atggagtcat cttcggataa tcccaaaatg gtgagcactg
     4801 ttttaaatgg tatgctagac acaagcttca gggatcgagc tgttcagaaa caccaaggac
     4861 tgaagcttgc aactgcaatt ctgcagaact ggaggaagtg tgattcatgg tgggccccag
     4921 attctgcccc agagagcaaa acaactgtgc tgtctttgct ggcaaagatg ttgcagattg
     4981 attcagcttt atcttttgat acaaatcaca gctcattttc tgaaatcttc acaacatacg
     5041 ctagtctact tgctgataca aagttgggtc tacacttaaa gggccaagct atcattcttc
     5101 ttccattctt caccagtctt agagaaggca gtctagaaaa cctaaagcat attctggaaa
     5161 aactcattgt ttgcaatttc cccatgaagt ctgatgaatt tcctcctgat tccctaaagt
     5221 acaataatta tgtggactgc atgaaaaagt ttctagatgc actggagtta tctcagagtc
     5281 ctatgttgtt tcagttgatg acagatatac tttgtcggga acagcgacat attatggaag
     5341 aattgttcca aaccactttc aaaaggattg ctaggcagag tccatgtgtc acacagttaa
     5401 atcttctgga aagtgtgtac acaatgttcc ggaaggctga cctcccttca aatgtcactc
     5461 gccaggcatt tgtagatcgc tctctcctca ccttgttgtg gcactgtgac ttggacacac
     5521 tgaaagagtt ctttagtaga attgtggtag atgccattga tgtgttgaag tccagattta
     5581 caaagctaaa tgaatttact tttgacactc aaatcaccaa gaagatgtgc tattacaaga
     5641 tgctagctgt gatgtattct cgtcttttaa aagatgatgt tcactctaaa gaagctaaaa
     5701 ttaatcaagc ttttcatggc tcccgtgttg cagaaggaaa tgaactcaca aagacacttc
     5761 ttaagttgtg ccatgatgca tttacagaga acatggtggg ggagagccag ttgctggaga
     5821 agagaagact ttatcattgt gctgcataca actgtgccat ttctctgata agctgtgtct
     5881 tcaatgagtt gaaattttac caaggttttt tatttaatga aaaaccagaa aagaacttgt
     5941 ttatttttga aaatttgata gacctgaaac gttgctatac atttcctata gaagttgagg
     6001 ttcctatgga aagaaagaaa aagtacattg aaattaggaa agaggccagg gatgcagcaa
     6061 atggggcttc aggcagtcct cattatatgt cttcattgtc atatttgaca gacagtagcc
     6121 taagtgaaga aatgagtcaa tttgatttct caactggagt tcagagctat tcatacagtt
     6181 ctcaagatcg taaacctacc actggccatt ttcagagacg ggagcatcaa gattccatga
     6241 cccaggatga catcatggag ttagagatgg atgagctcaa tcaacatgaa tgtatggctc
     6301 ccatgatagc cctgattaag cacatgcaga gaaatgtgat tgcacctaag ggagaagagg
     6361 gttcaatacc aaaagatctt ccaccgtgga tgaaatttct tcatgacaaa ctaggaaatg
     6421 catcagtatc tttaaatatc cgtctcttct tagccaagct tgttattaat acagaagagg
     6481 tctttcgccc ttatgcaaag cactggctca gccccctgct acagctagct gtttgcgaga
     6541 acaacagaga aggaattcac tacatgatgg tagaaatagt agctaccatt ctctcttgga
     6601 ctggcttggc tacacctaca ggagtcccta aagatgaagt gttagcaaat cgattgcttc
     6661 gttttctaat gaagcatgtc ttccatccca aaagagctgt gtttaggcac aaccttgaaa
     6721 ttattaaaac ccttgttgaa tgctggaagg agtgtctttc catcccttac aggttaatat
     6781 ttgaaaaatt ttcccataag gaccctaatt ctaaagacaa ttctgtggga attcagttat
     6841 taggcattgt gatagctaat aacttgcctc cctatgaccc aaattgtgac ataaccagtg
     6901 ccatgtattt tgaagcttta gtcaataaca tgtcctttgt gaagtataaa gaagtatatg
     6961 cagctgcagc agaagtttta ggacttattc ttcaatacat tactgagaga aaacacgtga
     7021 tagcagagtt ggtatgtgaa ctggttataa aacaactgaa gcaacatcaa aatactatgg
     7081 aagacaaatt tattgtttgc ttaaacaaaa tagcgaaggg cttccctcct cttgctgaca
     7141 ggttcttgaa tgctttgttc tttctgctgc caaaatttca tggagtaatg aagacacttt
     7201 gtctggaagt tgtactttgt cgagcagagg agatcacagg cctatactta cagttaaaga
     7261 gtaaagactt tcttcaagtc atgagacata gagatgatga aagacaaaag gtgtgtttgg
     7321 atatagttta taagatggtg gcaaaattaa aaccaataga actccgagaa cttctgaatc
     7381 ctgttgtgga atttgtttcc catccttctc caacatgtag agaacaaatg tataatattc
     7441 ttatgtggat tcatgacaat tacagagatc aagagagtca aaatgatgaa gattcccagg
     7501 aaatatttaa actggcaaaa gatgtactga ttcaaggact gatcgacgag aacgttggac
     7561 tccaactaat tattcggaat ttctggagcc atgaaaccag attgccttcc aatacattgg
     7621 accgattgct ggcattaaat tctttatatt cccccaagat agaagtccac tttttaagtt
     7681 tagcaacaaa ctttctgctt gaaatgacca ggatgagccc agattatcta aaccccattt
     7741 ttgagcatcc tctgtcagaa tgtgaatttc aggaatatac tatagatcct gactggcgtt
     7801 ttcgtagtac tgttcttact ccgatgttta ttgagaccca ggcctctcca agtattctcc
     7861 atacccaaac ccaagaaggg cccctctcag accaaaggca gaagcctgga caagtgcggg
     7921 ccacccaaca acaatatgat ttcactccaa cacaagcttc agttgaaagg agctcatttg
     7981 attggctgac tgggagcagc attgacctac tggcggatca caccgtcttc tcttcagaga
     8041 ccttgtcttc ctccttgctg ttttcccaca aaaggactga aaagtcacag agaatgtctt
     8101 gtaagtcagt aggaccggac tttggaacaa aaaagctggg ccttcctgat gatgaggtgg
     8161 ataaccaagt gaaaagtggc actccgagcc aggcagatat tctgagattg cgcagaagat
     8221 ttttaaagga ccgagaaaag ttgagtttgc tgtatgccaa aaggggcctc atggaacaaa
     8281 aactagagaa ggatatcaag agtgagttta aaatgaagca ggatgcgcag gttgttctgt
     8341 acagaagtta tcgtcatggc gatcttcctg atatccagat ccagcacagt ggtctgatca
     8401 cccccttgca ggctgtggcc cagaaagacc caataattgc aaaacaactc ttcagcagct
     8461 tgttttctgg gattttgaaa gaaatgaata aatttaagac aacatctgaa aagaacatca
     8521 tcactcaaaa tttgctccaa gatttcaacc gcttccttaa tacaactttc ttgttctttc
     8581 caccctttgt ctcttgcatc caggaaataa gttgccaaca cccagacttc ctgacacttg
     8641 acccagcctc agttcgagtg ggatgcctgg ctagtctgca gcagccggga ggtatccgtc
     8701 ttctggaaga ggccctactc cggctgatgc ccaaggaacc acccaccaaa agagttcggg
     8761 gcaagacttg cttgcctccc gatgttctcc ggtggatgga acttgctaaa ctctatcgtt
     8821 cgattgggga gtatgatgtt ctccgtggca tttttagcag tgagttagga acaacgcagg
     8881 acactcagaa cgcactatta gcagaagcta gaagtgatta ttgtcaagct gctaagttgt
     8941 atgatgaggc tttaaataaa ctggagtggg tggatggtga acccacagaa gctgagaagg
     9001 agttttggga gctggcatcg cttgactgtt acaacaacct ctctaaatgg aaagaacttg
     9061 agtactgttc tacagtcaat atagtcagtg agaactctct tgacctaagt aaaatgtgga
     9121 gtgaaccatt ttatcaggag acgtatctgc catatgtgat ccgtagcaaa ctaaagctcc
     9181 tgcttcaagg agaaggcaac caatctctgc taacatttgt ggatgaagcc atgaacaagg
     9241 agctgcagaa gacggtcctg gagcttcagt atagtcaaga gctgagtctt ctttacatct
     9301 tgcaggatga tattgacaga gccacatact acattaaaaa tggcattcag attttcatgc
     9361 aaaattattc tagtattgat gttctgttat atagaagtag actcgccaag ttacagtctg
     9421 tacagacttt agcagaaatt gaggagttcc taagttttat atgtaaacat ggtgacttat
     9481 catctctggg tcccctaagg agacttctaa aaacctggac cagcagatac ccagatgttg
     9541 tgacagaccc aatgcacatc tgggatgaca tcatcacaaa tcgctgcttc tttctcagta
     9601 aaatagaaga gagactgact gctccttcag gagatcacag tatgagtgtg gatgaggatg
     9661 aagagtccat tgacagggaa gtgtacgagc caaaggaaga tgttcgttgc atgcttcaga
     9721 gctgcagatt caccatgaaa atgaagatga tagaaagcgc ctggaagcag agtaatttct
     9781 cactctccat gaaactcctg aaagagatgc ataaagaatc aaaaacaaga gaaatttggc
     9841 gagtgcagtg gttgcatagt tactcccagc tgaaccactg ccggagccac actcagagcc
     9901 ctcgggaaca agtcctcaat atgctcaaaa ccatcacgct gttggatgaa agtgatattt
     9961 caaactactt aaataaaaac attcaggcct cttgtgacca gagcattctc ttgggcacaa
    10021 cttgcagaat catggctgat gctctcagca gagagccagc ctgcctgtct gacctggagg
    10081 agaacaaggt gaactcaatc ttgacacttt ccggatctaa tgcagagaac acagagacgg
    10141 taatcacggg tctgtaccag agagcattcc atcacctctc caaggccgtg cagtcagctg
    10201 aagaggaaac ccagctttcc tgctggggcc atgaggctgc tgctgagcgg gcccatgctt
    10261 atatgacact ggtaggcttc tgtgaccaac aactccgaaa ggtagaagag agtgcctcac
    10321 agaagacaag tgcagaaatg gaagcatatc cagcacttgt ggtggaaaaa atgctgagag
    10381 cattaaagtt aaactcttct gaagccaggc tgaaatttcc tagattactt cagattatag
    10441 agcagtattc agaggagacc ttaaacataa tgacaaaaga gatttcatct attccttgct
    10501 ggcagttcat tggctggatc agccacatga tggccttact ggacaaagag gaagctattg
    10561 cagtacaaca tactgtggaa gaaattgctg ataactaccc acaggccatt atctaccctt
    10621 ttataataag cagcgaaagc tactccttta aaaacacttc ttctggtcat aacaataaag
    10681 catttgttga gaggataaaa agtaaacttg atcacggaga agtgattcac agttttatta
    10741 acgccttaga ccagctctcc aatcctgacc tgctcttcaa ggactgggtt tctgatacaa
    10801 aagatgaact aggaaagaat cctgtgaata agaaaaatat tgaaaagttg tatgaaagga
    10861 tgtatgctgc cttgggtgac cttcgtgctc caggcctggg gccctttcgg aggaggttca
    10921 tacaggcgtt tgggaaagaa tttgtcaaga gctttgggaa tggtggttct aagctgctta
    10981 caatgaaggt cgatgacttt tgtaagatca ctggctcgct acttgtaagg atgaaaaaag
    11041 actcaaagct acctgggaac ctgaaagagt attccccctg gatgagtgag ttcaaagcgc
    11101 agttcctgaa aaatgaactg gagattcctg gacaatatga tggaaaaagc aaaccactgc
    11161 ctgaatatca cgtgcggatc tctggatttg atgagcgggt aaaagtgatg ctctccttga
    11221 ggaagccaaa gcgcattgtt attcgaggcc atgatgaaaa ggaatacccg ttcctggtaa
    11281 aaggtggtga ggacctccgt caagaccagc gcattgagca gatctttgag gtcatgaatg
    11341 ccattctctc tcaggatgct gcctgcagtc agagaaacat gcagttaagg acttaccgtg
    11401 tcgtgccaat gacctctaga ttaggattaa ttgaatggat tgaaaatact atgaccttga
    11461 aggatcttct tttgagtaat atgtcacaag aggagaaagt ggctaataac agtgacccca
    11521 aagcgccgat ccgtgactat aaagactggc tgatgaaagt gtcggggaaa agcgatgctg
    11581 gagcctatgt gctaatgtac agccgagcta accgtacaga aacagttgta gctttcagaa
    11641 gaagggaaag tcaagtgccg cctgacctct taaagcgggc ctttgtaaag atgagcacca
    11701 gccctgaggc cttcctggca ctgcgttccc actttgccag ctcccatgca ctgctgtgca
    11761 tcagccactg gctcctcggg attggagaca gacacctgaa caatttcatg gtggccatgg
    11821 agacaggcag tgtgattgga attgactttg gacatgcgtt tggatcagct actcagtttc
    11881 ttccagtccc tgagttgatg ccttttcgtc taacccgcca atttgtcagt ctcatgttgc
    11941 caatgaaaga aacgggtctc atgtgcacgg tcatggtgca tgcactgagg gctttccgct
    12001 cttgtgcagg tctgctcact gacaccatgg aaatttttgt gaaggaaccc tcctttgatt
    12061 ggaagagttt tgagcagaca atgctgagaa aaggaggatc atggattcaa gaaataaatg
    12121 taacggaaaa gaattggtat ccacaacata aaatacgcta tgctaagaga aagttagcag
    12181 gggccaaccc agctgttata acttgtgatg agctatatct aggccatgaa gcttcatccg
    12241 cctttaggag ttatacagct gtagctcgag gcaacagaga ctacaacatt cgtgcacaag
    12301 agccagagag tgggctttca gaagagactc aagtgaagtg cttggtggac caggccacag
    12361 accccaatat ccttggcagg acttgggaag gatgggagcc ctggatgtaa agtctgtggt
    12421 gtcaccaatc ataaagcatt ctgtctccga gaggacctcc tagaccttcg ctgacagcag
    12481 tatatttctg acagacagag gaaatctact ttatggtgct ggcgagatgg tcagataaag
    12541 gcatttgtta ccaatgctaa tggcctaact aacttcaatc ccagaaaccc atattggagg
    12601 cagtgaacca actccaggaa gttgtccttt gacctccaca catgtaaaaa ataaagaata
    12661 tgacaaatat ttct
//
